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Citations to this article

Cholecystokinin-B/gastrin receptors enhance wound healing in the rat gastric mucosa
Adrian Schmassmann, Jean Claude Reubi
Adrian Schmassmann, Jean Claude Reubi
Published October 15, 2000
Citation Information: J Clin Invest. 2000;106(8):1021-1029. https://doi.org/10.1172/JCI8115.
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Article Article has an altmetric score of 3

Cholecystokinin-B/gastrin receptors enhance wound healing in the rat gastric mucosa

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Abstract

Although physiological functions of the CCK-B/gastrin receptor are well explored, little is known about its role during healing. Here, we evaluated the role of this receptor in the rat oxyntic mucosa following the introduction of a cryoulcer. In this model, we located and quantified CCK-B/gastrin receptors by reverse transcriptase PCR and receptor autoradiography. Rats with cryoulcers were treated with placebo, omeprazole, the CCK-B/gastrin receptor antagonist YF-476, omeprazole plus YF-476, gastrin-17, and gastrin 17 plus YF-476. During wound healing, CCK-B/gastrin receptors were specifically expressed and localized to the regenerative mucosal ulcer margin. This high expression was limited in time, and the pattern of expression of CCK-B/gastrin receptors correlated closely with the proliferative activity of the regenerative mucosa. Functionally, omeprazole and gastrin-17 caused profound hypergastrinemia, increased cell proliferation in the mucosal ulcer margin and accelerated the late ulcer healing phase. These effects were completely reversed by cotherapy with YF-476. These in vivo and vitro data suggest that CCK-B/gastrin receptors in regenerative rat gastric oxyntic mucosa enhance trophic effects during wound healing.

Authors

Adrian Schmassmann, Jean Claude Reubi

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Total citations by year

Year: 2023 2022 2017 2016 2014 2013 2012 2008 2007 2004 2003 2002 Total
Citations: 1 1 2 1 1 1 1 1 1 2 2 1 15
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2004 (2)

Title and authors Publication Year
Regeneration of gastric mucosa during ulcer healing follows pathways that correspond to the ontogenetic course of rat fundic glands
R Nagaike, A Sawaguchi, J Kawano, F Aoyama, T Oinuma, T Suganuma
Virchows Archiv 2004
Gastrin: old hormone, new functions
G Dockray, R Dimaline, A Varro
Pflügers Archiv - European Journal of Physiology 2004

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