Versatile roles of extracellular vesicles in cancer
Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya
Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya
Published April 1, 2016
Citation Information: J Clin Invest. 2016;126(4):1163-1172. doi:10.1172/JCI81130.
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Category: Review Series

Versatile roles of extracellular vesicles in cancer

Abstract

Numerous studies have shown that non–cell-autonomous regulation of cancer cells is an important aspect of tumorigenesis. Cancer cells need to communicate with stromal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive. Recently, extracellular vesicles (EVs) have also been shown to be involved in cell-cell communication between cancer cells and the surrounding microenvironment and to be important for the development of cancer. In addition, these EVs contain small noncoding RNAs, including microRNAs (miRNAs), which contribute to the malignancy of cancer cells. Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells.

Authors

Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya

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EVs from cancer cells manipulate the cells in their microenvironment. EV...

Figure 1

EVs from cancer cells manipulate the cells in their microenvironment.

EVs are involved in every step of cancer development. During cancer initiation (A), normal cells (epithelial cells) attempt to prevent the outgrowth of precancerous cells (or cancer cells) by secreting antiproliferative miRNAs through EVs; however, the cancer cells can circumvent this inhibitory machinery, finally resulting in tumor expansion (B). Cancer cells utilize EVs to mediate horizontal transfer of genes that promote proliferation to cancer cells that do not harbor those genes (B). Cancer cell–derived EVs promote cancer malignancy (i.e., the induction of inflammation by infiltrating neutrophils) (C and D). Additionally, cancer cell–derived EVs activate fibroblasts, leading to extracellular matrix degradation and the induction of cancer-promoting cytokines (C and D). When the tumor microenvironment is hypoxic, cancer cells secrete angiogenesis-inducing EVs that help to overcome oxygen and nutrition deficiency by activating endothelial cells to stimulate vascularization (C and D), contributing to further cancer development, such as metastasis (D).