Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Special delivery: microRNA-200–containing extracellular vesicles provide metastatic message to distal tumor cells
David M. Epstein
David M. Epstein
Published November 17, 2014
Citation Information: J Clin Invest. 2014;124(12):5107-5108. https://doi.org/10.1172/JCI79191.
View: Text | PDF
Commentary Article has an altmetric score of 1

Special delivery: microRNA-200–containing extracellular vesicles provide metastatic message to distal tumor cells

  • Text
  • PDF
Abstract

An emerging view is that breast cancer is a systemic disease that utilizes intrinsic and extrinsic tumor cell processes to support both primary tumor growth and metastatic dissemination into distal tissue. Delineation of factors involved in these processes should facilitate a better understanding for both assessing and preventing disease relapse. In this issue of the JCI, Le et al. investigate whether intrinsic properties of metastatic breast cancer cell growth can be regulated through an extrinsic process — contact with tumor cell–derived extracellular vesicles containing microRNAs of the miR-200 family. The authors provide compelling evidence that miR-200s within extracellular vesicles secreted from highly metastatic tumor cells can be internalized by weakly metastatic cells. Thus, internalization and delivery of this metastatic “donor” cell–derived message provide plausible mechanisms by which oncogenic and regulatory factors confer the capability of tumor growth at metastatic lesions. This study provides a strong rationale for detailed assessment of the prognostic and predictive value of circulating extracellular vesicle–bound miR-200s in breast cancer progression and treatment.

Authors

David M. Epstein

×

Total citations by year

Year: 2025 2024 2023 2021 2020 2018 2015 Total
Citations: 1 1 2 2 1 3 3 13
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (13)

Title and authors Publication Year
Exosomes derived from ccRCC cells confers fibroblasts activation to foster tumor progression through Warburg effect by downregulating PANK3
Yang Y, Qiang C, Jie Z, Ce H, Yan H, Xiu-bin L, Wen-mei F, Xu Z, Yu G
Cell Death Discovery 2025
Extracellular vesicle-mediated drug delivery in breast cancer theranostics.
Abdul-Rahman T, Roy P, Herrera-Calderón RE, Khidri FF, Omotesho QA, Rumide TS, Fatima M, Roy S, Wireko AA, Atallah O, Roy S, Amekpor F, Ghosh S, Agyigra IA, Horbas V, Teslyk T, Bumeister V, Papadakis M, Alexiou A
Discover. Oncology 2024
Integrated Predictors by Propensity Scoring With Tumor Markers and Plasma Levels of microRNA-21-5p, IL-17, and IL-10 Complement Early Detection of Hepatocellular Carcinoma in Patients With Liver Cirrhosis
Machida M, Ambo M, Mishina R, Hada N, Tachibana F, Yamashita M, Konda A, Tsuji K
Technology in cancer research & treatment 2023
Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
Wang S, Wu W, Lin X, Zhang KM, Wu Q, Luo M, Zhou J
Cell & Bioscience 2023
Circulating exosomal miR‐363‐5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer
X Wang, T Qian, S Bao, H Zhao, H Chen, Z Xing, Y Li, M Zhang, X Meng, C Wang, J Wang, H Gao, J Liu, M Zhou, X Wang
Molecular Oncology 2021
All-trans retinoic acid reverses malignant biological behavior of hepatocarcinoma cells by regulating miR-200 family members
J Cui, M Gong, S Fang, C Hu, Y Wang, J Zhang, N Tang, Y He
Genes & Diseases 2021
The Extracellular Matrix and Vesicles Modulate the Breast Tumor Microenvironment
J Yang, G Bahcecioglu, P Zorlutuna
Bioengineering 2020
Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
T Fang, H Lv, G Lv, T Li, C Wang, Q Han, L Yu, B Su, L Guo, S Huang, D Cao, L Tang, S Tang, M Wu, W Yang, H Wang
Nature Communications 2018
MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages
G Curtale
Cells 2018
Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts
Y Zhou, H Ren, B Dai, J Li, L Shang, J Huang, X Shi
Journal of Experimental & Clinical Cancer Research 2018
Advances in Experimental Medicine and Biology
G Santulli
Advances in experimental medicine and biology 2015
Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes
S Bhatt, MK Gupta, M Khamaisi, R Martinez, MA Gritsenko, BK Wagner, P Guye, V Busskamp, J Shirakawa, G Wu, CW Liew, TR Clauss, I Valdez, A El Ouaamari, E Dirice, T Takatani, HA Keenan, RD Smith, G Church, R Weiss, AJ Wagers, WJ Qian, GL King, RN Kulkarni
Cell Metabolism 2015
Signaling by exosomal microRNAs in cancer
G Falcone, A Felsani, I D’Agnano
Journal of Experimental & Clinical Cancer Research 2015

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Posted by 1 X users
43 readers on Mendeley
See more details