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Citations to this article

Clinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity
Paul M. Coen, … , Joseph A. Houmard, Bret H. Goodpaster
Paul M. Coen, … , Joseph A. Houmard, Bret H. Goodpaster
Published December 1, 2014
Citation Information: J Clin Invest. 2015;125(1):248-257. https://doi.org/10.1172/JCI78016.
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Clinical Research and Public Health Article has an altmetric score of 101

Clinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity

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Abstract

BACKGROUND. Roux-en-Y gastric bypass (RYGB) surgery causes profound weight loss and improves insulin sensitivity (SI) in obese patients. Regular exercise can also improve SI in obese individuals; however, it is unknown whether exercise and RYGB surgery–induced weight loss would additively improve SI and other cardiometabolic factors.

METHODS. We conducted a single-blind, prospective, randomized trial with 128 men and women who recently underwent RYGB surgery (within 1–3 months). Participants were randomized to either a 6-month semi-supervised moderate exercise protocol (EX, n = 66) or a health education control (CON; n = 62) intervention. Main outcomes measured included SI and glucose effectiveness (SG), which were determined from an intravenous glucose tolerance test and minimal modeling. Secondary outcomes measured were cardiorespiratory fitness (VO2 peak) and body composition. Data were analyzed using an intention-to-treat (ITT) and per-protocol (PP) approach to assess the efficacy of the exercise intervention (>120 min of exercise/week).

RESULTS. 119 (93%) participants completed the interventions, 95% for CON and 91% for EX. There was a significant decrease in body weight and fat mass for both groups (P < 0.001 for time effect). SI improved in both groups following the intervention (ITT: CON vs. EX; +1.64 vs. +2.24 min–1/μU/ml, P = 0.18 for Δ, P < 0.001 for time effect). A PP analysis revealed that exercise produced an additive SI improvement (PP: CON vs. EX; +1.57 vs. +2.69 min–1/μU/ml, P = 0.019) above that of surgery. Exercise also improved SG (ITT: CON vs. EX; +0.0023 vs. +0.0063 min–1, P = 0.009) compared with the CON group. Exercise improved cardiorespiratory fitness (VO2 peak) compared with the CON group.

CONCLUSION. Moderate exercise following RYGB surgery provides additional improvements in SI, SG, and cardiorespiratory fitness compared with a sedentary lifestyle during similar weight loss.

TRIAL REGISTRATION. clinicaltrials.gov identifier: NCT00692367.

FUNDING. This study was funded by the NIH/National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK078192) and an NIH/National Center for Research Resources/Clinical and Translational Science Award (UL1 RR024153).

Authors

Paul M. Coen, Charles J. Tanner, Nicole L. Helbling, Gabriel S. Dubis, Kazanna C. Hames, Hui Xie, George M. Eid, Maja Stefanovic-Racic, Frederico G.S. Toledo, John M. Jakicic, Joseph A. Houmard, Bret H. Goodpaster

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2009 Total
Citations: 3 2 2 6 13 9 7 4 12 2 8 1 69
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (4)

Title and authors Publication Year
Physical training following gastric bypass: effects on physical activity and quality of life—a randomized controlled trial
CR Stolberg, LH Mundbjerg, EM Bladbjerg, P Funch-Jensen, B Gram, CB Juhl
Quality of Life Research 2018
Exercise and Bariatric Surgery: An Effective Therapeutic Strategy
PM Coen, EA Carnero, BH Goodpaster
Exercise and Sport Sciences Reviews 2018
Effect of physical exercise on weight loss and physical function following bariatric surgery: a meta-analysis of randomised controlled trials
ZQ Ren, GD Lu, TZ Zhang, Q Xu
BMJ Open 2018
Functional and systemic effects of whole body electrical stimulation post bariatric surgery: study protocol for a randomized controlled trial
LD André, RP Basso-Vanelli, LD Thommazo-Luporini, PA Ricci, R Cabiddu, SP Jürgensen, CR de Oliveira, R Arena, A Borghi-Silva
Trials 2018

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