Citations to this article

Radiation and ATM inhibition: the heart of the matter
Ester M. Hammond, Ruth J. Muschel
Ester M. Hammond, Ruth J. Muschel
Published July 18, 2014
Citation Information: J Clin Invest. 2014;124(8):3289-3291. https://doi.org/10.1172/JCI77195.
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Commentary

Radiation and ATM inhibition: the heart of the matter

Abstract

Numerous in vitro studies have shown that human cell lines lacking functional ATM are extremely radiosensitive. In this issue, Moding et al. demonstrate using a murine model of sarcoma that deletion of the Atm gene has much less of a radiosensitizing effect on normal cardiac endothelia than on rapidly proliferating tumor endothelia. This work confounds our assumptions about the generality of the role of ATM in radiation sensitivity and the potential use of ATM inhibitors as radiosensitizers.

Authors

Ester M. Hammond, Ruth J. Muschel

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Citations to this article (12)

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Targeted Inhibition of DNA-PKcs, ATM, ATR, PARP, and Rad51 Modulate Response to X Rays and Protons.
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Current and Future Perspectives of the Use of Organoids in Radiobiology
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Brain exposure of the ATM inhibitor AZD1390 in humans—a positron emission tomography study
A Jucaite, P Stenkrona, Z Cselényi, SD Vita, N Buil-Bruna, K Varnäs, A Savage, A Varrone, P Johnström, M Schou, C Davison, A Sykes, VP Reddy, M Hoch, A Vazquez-Romero, MM Moein, C Halldin, MS Merchant, M Pass, L Farde 		Neuro-Oncology 2020
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X Yan, T Wu, M Tang, D Chen, M Huang, S Zhou, H Zhang, X Yang, G Li 		Medicine 2020
Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101
M Chen, P Liu, Y Chen, Z Chen, M Shen, X Liu, X Li, A Li, Y Lin, R Yang, W Ni, X Zhou, L Zhang, Y Tian, J Li, J Chen 		Frontiers in Genetics 2018
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
S Riffle, RS Hegde 		Journal of Experimental & Clinical Cancer Research 2017
The role of the ataxia telangiectasia mutated gene in lung cancer: recent advances in research
Y Xu, P Gao, X Lv, L Zhang, J Zhang 		Therapeutic advances in respiratory disease 2017
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