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The cystine/glutamate antiporter: when too much of a good thing goes bad
Kathryn J. Reissner
Kathryn J. Reissner
Published July 18, 2014
Citation Information: J Clin Invest. 2014;124(8):3279-3281. https://doi.org/10.1172/JCI76627.
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The cystine/glutamate antiporter: when too much of a good thing goes bad

Abstract

Glutamate excitotoxicity represents a major cellular component of ischemic brain injury. In this issue of the JCI, Soria and colleagues reveal that the cystine/glutamate exchanger is an important source of excitotoxic glutamate in response to ischemia induced by oxygen and glucose deprivation. As the exchanger is a primary determinant of both extracellular glutamate and intracellular glutathione, the findings from this study not only provide important insight into the mechanisms of brain ischemia but also demonstrate the complexity of the yin and yang of glutamate homeostasis and cellular redox balance.

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Kathryn J. Reissner

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Hameed MQ, Hodgson N, Lee HH, Pascual-Leone A, MacMullin PC, Jannati A, Dhamne SC, Hensch TK, Rotenberg A 		Cerebral Cortex 2022
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BN Dulka, AK Bourdon, CT Clinard, MB Muvvala, SR Campagna, MA Cooper 		Neurobiology of Stress 2017
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J Fazzari, K Linher-Melville, G Singh 		Current neuropharmacology 2017

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