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Citations to this article

Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk
Agnieszka Dejda, … , Nathalie Labrecque, Przemyslaw Sapieha
Agnieszka Dejda, … , Nathalie Labrecque, Przemyslaw Sapieha
Published October 1, 2014
Citation Information: J Clin Invest. 2014;124(11):4807-4822. https://doi.org/10.1172/JCI76492.
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Research Article Immunology Article has an altmetric score of 6

Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk

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Abstract

Immunological activity in the CNS is largely dependent on an innate immune response and is heightened in diseases, such as diabetic retinopathy, multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s disease. The molecular dynamics governing immune cell recruitment to sites of injury and disease in the CNS during sterile inflammation remain poorly defined. Here, we identified a subset of mononuclear phagocytes (MPs) that responds to local chemotactic cues that are conserved among central neurons, vessels, and immune cells. Patients suffering from late-stage proliferative diabetic retinopathy (PDR) had elevated vitreous semaphorin 3A (SEMA3A). Using a murine model, we found that SEMA3A acts as a potent attractant for neuropilin-1–positive (NRP-1–positive) MPs. These proangiogenic MPs were selectively recruited to sites of pathological neovascularization in response to locally produced SEMA3A as well as VEGF. NRP-1–positive MPs were essential for disease progression, as NRP-1–deficient MPs failed to enter the retina in a murine model of oxygen-induced retinopathy (OIR), a proxy for PDR. OIR mice with NRP-1–deficient MPs exhibited decreased vascular degeneration and diminished pathological preretinal neovascularization. Intravitreal administration of a NRP-1–derived trap effectively mimicked the therapeutic benefits observed in mice lacking NRP-1–expressing MPs. Our findings indicate that NRP-1 is an obligate receptor for MP chemotaxis, bridging neural ischemia to an innate immune response in neovascular retinal disease.

Authors

Agnieszka Dejda, Gaelle Mawambo, Agustin Cerani, Khalil Miloudi, Zhuo Shao, Jean-Francois Daudelin, Salix Boulet, Malika Oubaha, Felix Beaudoin, Naoufal Akla, Sullivan Henriques, Catherine Menard, Andreas Stahl, Jean-Sébastien Delisle, Flavio A. Rezende, Nathalie Labrecque, Przemyslaw Sapieha

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 1 5 5 9 10 5 2 3 2 9 1 52
Citation information
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Citations to this article in year 2023 (5)

Title and authors Publication Year
HIF1a-dependent hypoxia response in myeloid cells requires IRE1a
Gaëlle Mawambo, Malika Oubaha, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal Kaufman, El Affar, Frédérick Mallette, Ariel Wilson, Przemyslaw Sapieha
Journal of Neuroinflammation 2023
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.
Gui X, Zhang H, Zhang R, Li Q, Zhu W, Nie Z, Zhao J, Cui X, Hao W, Wen X, Shen W, Song H
2023
Mechanisms of Acquired Resistance to Anti-VEGF Therapy for Neovascular Eye Diseases
Sharma D, Zachary I, Jia H
Investigative ophthalmology & visual science 2023
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses.
Khor YS, Wong PF
Biogerontology 2023
Unveiling Neuroprotection and Regeneration Mechanisms in Optic Nerve Injury: Insight from Neural Progenitor Cell Therapy with Focus on Vps35 and Syntaxin12
Shin HA, Park M, Lee HJ, Duong VA, Kim HM, Hwang DY, Lee H, Lew H
Cells 2023

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Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 2 patents
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