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Usage Information

Building a second brain in the bowel
Marina Avetisyan, … , Ellen Merrick Schill, Robert O. Heuckeroth
Marina Avetisyan, … , Ellen Merrick Schill, Robert O. Heuckeroth
Published February 9, 2015
Citation Information: J Clin Invest. 2015;125(3):899-907. https://doi.org/10.1172/JCI76307.
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Review Series Article has an altmetric score of 3

Building a second brain in the bowel

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Abstract

The enteric nervous system (ENS) is sometimes called the “second brain” because of the diversity of neuronal cell types and complex, integrated circuits that permit the ENS to autonomously regulate many processes in the bowel. Mechanisms supporting ENS development are intricate, with numerous proteins, small molecules, and nutrients that affect ENS morphogenesis and mature function. Damage to the ENS or developmental defects cause vomiting, abdominal pain, constipation, growth failure, and early death. Here, we review molecular mechanisms and cellular processes that govern ENS development, identify areas in which more investigation is needed, and discuss the clinical implications of new basic research.

Authors

Marina Avetisyan, Ellen Merrick Schill, Robert O. Heuckeroth

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,898 374
PDF 115 55
Figure 200 8
Table 50 0
Citation downloads 96 0
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Total Views 2,796
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