Interactions between the host and gut microbial community likely contribute to Crohn disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of disease is lacking. Here, we characterized the global pattern of ileal gene expression and the ileal microbial community in 359 treatment-naive pediatric patients with CD, patients with ulcerative colitis (UC), and control individuals. We identified core gene expression profiles and microbial communities in the affected CD ilea that are preserved in the unaffected ilea of patients with colon-only CD but not present in those with UC or control individuals; therefore, this signature is specific to CD and independent of clinical inflammation. An abnormal increase of antimicrobial dual oxidase (
Yael Haberman, Timothy L. Tickle, Phillip J. Dexheimer, Mi-Ok Kim, Dora Tang, Rebekah Karns, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Melvin B. Heyman, Anne M. Griffiths, Wallace V. Crandall, David R. Mack, Susan S. Baker, Curtis Huttenhower, David J. Keljo, Jeffrey S. Hyams, Subra Kugathasan, Thomas D. Walters, Bruce Aronow, Ramnik J. Xavier, Dirk Gevers, Lee A. Denson
Title and authors | Publication | Year |
---|---|---|
The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease
G Oliver, J Kipnis, GJ Randolph, NL Harvey |
Cell | 2020 |
Elucidating potential molecular signatures through host-microbe interactions for reactive arthritis and inflammatory bowel disease using combinatorial approach
A Verma, S Sharda, B Rathi, P Somvanshi, BD Pandey |
Scientific Reports | 2020 |
Probiotics and Probiotic-Derived Functional Factors—Mechanistic Insights Into Applications for Intestinal Homeostasis
F Yan, DB Polk |
Frontiers in immunology | 2020 |
Precision medicine in inflammatory bowel disease: concept, progress and challenges
SP Borg-Bartolo, RK Boyapati, J Satsangi, R Kalla |
F1000Research | 2020 |
Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP
M Moriczi, G Pujol-Muncunill, R Martín-Masot, SJ Treviño, OS Cantón, CO Sangrador, LP Quintana, DG Santana, AR Martínez, AR Camps, H Armas, J Barrio, RG de Caldas, MR Salas, EB Serrano, ED Aliaga, AB Pinedo, EV Sosa, RV López, AS Boga, AM Álvarez, CS Sánchez, MT Hernani, CG Junquera, NM Torres, MR Trabazo, FJ Eizaguirre, MG Peris, EM Benítez, BF Caamaño, AM Álvarez, LC Valderrábano, CA Vicente, JR Santiago, R Galera-Martínez, R García-Romero, IR Arnal, SF Cebrián, HL Garrido, JF Bris, MV Rodríguez-Belvis, JM Porro, MB Rodríguez, PB García, G Botija, FJ Marín, EL Izquierdo, E Crehuá-Gaudiza, VM Navas-López, J Martín-de-Carpi |
Nutrients | 2020 |
Crohn’s Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria
NM Shahir, JR Wang, EA Wolber, MS Schaner, DN Frank, D Ir, CE Robertson, N Chaumont, TS Sadiq, MJ Koruda, R Rahbar, BD Nix, RD Newberry, RB Sartor, SZ Sheikh, TS Furey |
Inflammatory Bowel Diseases | 2020 |
Mechanistic Understanding of the Symbiotic Relationship Between the Gut Microbiota and the Host
F Yan |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2020 |
Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn’s Disease
M Olaisen, A Flatberg, A van Beelen Granlund, ES Røyset, TC Martinsen, AK Sandvik, R Fossmark |
Inflammatory Bowel Diseases | 2020 |
Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn’s Disease
MT Osterman, KL VanDussen, IO Gordon, EM Davis, K Li, K Simpson, M Ciorba, SC Glover, B Abraham, X Guo, EU Yee, FD Allard, JG Perrigoue, B Claggett, B Shen, TS Stappenbeck, JJ Liu |
Inflammatory Bowel Diseases | 2020 |
Nitrate Is Crucial for the Proliferation of Gut Escherichia coli Caused by H9N2 AIV Infection and Effective Regulation by Chinese Herbal Medicine Ageratum-Liquid
X Zhang, Q Zhao, C Wu, Z Xie, X Ci, H Li, W Lin, H Zhang, Q Xie |
Frontiers in microbiology | 2020 |
Rotavirus infection induces glycan availability to promote ileum-specific changes in the microbiome aiding rotavirus virulence
MA Engevik, LD Banks, KA Engevik, AL Chang-Graham, JL Perry, DS Hutchinson, NJ Ajami, JF Petrosino, JM Hyser |
Gut microbes | 2020 |
Tissue-based Gene Expression as Potential Biomarkers for IBD Course
Y Haberman |
Inflammatory Bowel Diseases | 2020 |
Molecular Changes in the Non-Inflamed Terminal Ileum of Patients with Ulcerative Colitis
HS Lee, M Vancamelbeke, S Verstockt, T Wilms, B Verstockt, J Sabino, M Ferrante, S Vermeire, I Cleynen |
Cells | 2020 |
Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation associated gene expression in patients with colorectal cancer
Q Wang, J Ye, D Fang, L Lv, W Wu, D Shi, Y Li, L Yang, X Bian, J Wu, X Jiang, K Wang, Q Wang, MP Hodson, LM Thibaut, JW Ho, E Giannoulatou, L Li |
BMC Microbiology | 2020 |
Mucosal Inflammatory and Wound Healing Gene Programmes Reveal Targets for Stricturing Behaviour in Paediatric Crohn’s Disease
Y Haberman, P Minar, R Karns, PJ Dexheimer, S Ghandikota, S Tegge, D Shapiro, B Shuler, S Venkateswaran, T Braun, A Ta, TD Walters, RN Baldassano, JD Noe, J Rosh, J Markowitz, JL Dotson, DR Mack, R Kellermayer, AM Griffiths, MB Heyman, SS Baker, D Moulton, AS Patel, AS Gulati, SJ Steiner, N LeLeiko, A Otley, M Oliva-Hemker, D Ziring, R Gokhale, S Kim, SL Guthery, SA Cohen, S Snapper, BJ Aronow, M Stephens, G Gibson, JR Dillman, M Dubinsky, JS Hyams, S Kugathasan, AG Jegga, LA Denson |
Journal of Crohn's & colitis | 2020 |
Symbioflor2® Escherichia coli Genotypes Enhance Ileal and Colonic Gene Expression Associated with Mucosal Defense in Gnotobiotic Mice
U Escribano-Vazquez, C Beimfohr, D Bellet, M Thomas, K Zimmermann, P Langella, C Cherbuy |
Microorganisms | 2020 |
Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn’s disease
K Diederen, JV Li, GE Donachie, TG de Meij, DR de Waart, TB Hakvoort, A Kindermann, J Wagner, V Auyeung, AA te Velde, SE Heinsbroek, MA Benninga, J Kinross, AW Walker, WJ de Jonge, J Seppen |
Scientific Reports | 2020 |
Luminal microbiota related to Crohn’s disease recurrence after surgery
AL Hamilton, MA Kamm, PD Cruz, EK Wright, H Feng, J Wagner, JJ Sung, CD Kirkwood, M Inouye, SM Teo |
Gut microbes | 2020 |
Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease—Glutathione peroxide isoenzymes 1 and 2‐double knockout mice on a C57BL background
FF Chu, RS Esworthy, B Shen, JH Doroshow |
MicrobiologyOpen | 2020 |
Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity
G Caio, L Lungaro, N Segata, M Guarino, G Zoli, U Volta, RD Giorgio |
Nutrients | 2020 |
Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn’s Disease
LH Huang, P Deepak, MA Ciorba, B Mittendorfer, BW Patterson, GJ Randolph |
Gastroenterology | 2020 |
EEN Yesterday and Today … CDED Today and Tomorrow
M Herrador-López, R Martín-Masot, VM Navas-López |
Nutrients | 2020 |
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis
S Kitamoto, H Nagao-Kitamoto, Y Jiao, MG Gillilland, A Hayashi, J Imai, K Sugihara, M Miyoshi, JC Brazil, P Kuffa, BD Hill, SM Rizvi, F Wen, S Bishu, N Inohara, KA Eaton, A Nusrat, YL Lei, WV Giannobile, N Kamada |
Cell | 2020 |
Multiple Sclerosis
Lane M, Yadav V |
Textbook of Natural Medicine | 2020 |
Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease.
Bushman FD, Conrad M, Ren Y, Zhao C, Gu C, Petucci C, Kim MS, Abbas A, Downes KJ, Devas N, Mattei LM, Breton J, Kelsen J, Marakos S, Galgano A, Kachelries K, Erlichman J, Hart JL, Moraskie M, Kim D, Zhang H, Hofstaedter CE, Wu GD, Lewis JD, Zackular JP, Li H, Bittinger K, Baldassano R |
Cell Host & Microbe | 2020 |
Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease.
Potdar AA, Dube S, Naito T, Li K, Botwin G, Haritunians T, Li D, Casero D, Yang S, Bilsborough J, Perrigoue JG, Denson LA, Daly M, Targan SR, Fleshner P, Braun J, Kugathasan S, Stappenbeck TS, McGovern DPB |
Gastroenterology | 2020 |
Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn’s disease
Potdar AA, Dube S, Naito T, Botwin G, Haritunians T, Li D, Yang S, Bilsborough J, Denson LA, Daly M, Targan SR, Fleshner P, Braun J, Kugathasan S, Stappenbeck TS, McGovern DP |
2020 |