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Cryptococcosis: a model for the understanding of infectious diseases
John R. Perfect
John R. Perfect
Published April 17, 2014
Citation Information: J Clin Invest. 2014;124(5):1893-1895. https://doi.org/10.1172/JCI75241.
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Cryptococcosis: a model for the understanding of infectious diseases

Abstract

The increase in immunosuppressed patient populations has correlated with a rise in clinical fungal infections, including cryptococcosis. Patient outcome following Cryptococcus infection is linked to initial fungal burden in cerebrospinal fluid (CSF) and fungal clearance following treatment; however, the role of the pathogen in disease prognosis is poorly defined. In this issue of the JCI, Sabiiti and colleagues have directly correlated phenotypic traits of Cryptococcus neoformans with clinical outcome of infected patients. A better understanding of both the host and pathogen contributions to disease etiology will provide more options for targeted treatment strategies.

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John R. Perfect

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Citations to this article (14)

Title and authors Publication Year
Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence of Cryptococcus neoformans
Kwon S, Choi Y, Kim ES, Lee KT, Bahn YS, Jung KW 		Frontiers in Cellular and Infection Microbiology 2024
Cryptococcus neoformans Csn1201 Is Associated With Pulmonary Immune Responses and Disseminated Infection
Yang YL, Fan YB, Gao L, Zhang C, Gu JL, Pan WH, Fang W 		Frontiers in immunology 2022
The Cryptococcus gattii species complex: Unique pathogenic yeasts with understudied virulence mechanisms.
Saidykhan L, Onyishi CU, May RC 		PLoS neglected tropical diseases 2022
Simplified All-In-One CRISPR-Cas9 Construction for Efficient Genome Editing in Cryptococcus Species
P Zhang, Y Wang, C Li, X Ma, L Ma, X Zhu 		Journal of Fungi 2021
Integrative Proteome and Acetylome Analyses of Murine Responses to Cryptococcus neoformans Infection
H Li, Y Li, T Sun, W Du, Z Zhang, D Li, C Ding 		Frontiers in microbiology 2020
Comparison of Clinical Features and Prognostic Factors of Cryptococcal Meningitis Caused by Cryptococcus neoformans in Patients With and Without Pulmonary Nodules
W Cao, C Jian, H Zhang, S Xu 		Mycopathologia 2018
Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans
SD Arras, JL Chitty, MS Wizrah, PE Erpf, BL Schulz, M Tanurdzic, JA Fraser 		Scientific Reports 2017
RNA Interference Screening Reveals Host CaMK4 as a Regulator of Cryptococcal Uptake and Pathogenesis
D Srikanta, CR Hole, M Williams, SA Khader, TL Doering, GS Deepe 		Infection and immunity 2017
GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans
JL Chitty, TL Tatzenko, SJ Williams, YQ Koh, EC Corfield, MS Butler, AA Robertson, MA Cooper, U Kappler, B Kobe, JA Fraser 		The Journal of biological chemistry 2017
Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic
SD Arras, KL Ormerod, PE Erpf, MI Espinosa, AC Carpenter, RD Blundell, SR Stowasser, BL Schulz, M Tanurdzic, JA Fraser 		Scientific Reports 2017
Antimicrobial Octapeptin C4 Analogues Active against Cryptococcus Species
JL Chitty, MS Butler, A Suboh, DJ Edwards, MA Cooper, JA Fraser, AA Robertson 		Antimicrobial agents and chemotherapy 2017
Chemical Inhibitors of Non-Homologous End Joining Increase Targeted Construct Integration in Cryptococcus neoformans
SD Arras, JA Fraser, AJ Lustig 		PloS one 2016
Targeted Genome Editing via CRISPR in the Pathogen Cryptococcus neoformans
SD Arras, SM Chua, MS Wizrah, JA Faint, AS Yap, JA Fraser, K Nielsen 		PloS one 2016
A Genomic Safe Haven for Mutant Complementation in Cryptococcus neoformans
SD Arras, JL Chitty, KL Blake, BL Schulz, JA Fraser, K Nielsen 		PloS one 2015

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