Go to
JCI Insight
Citations to this article
Abstract
Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing hearts, autophagy within the cardiovascular system has been widely characterized in cardiomyocytes, cardiac fibroblasts, endothelial cells, vascular smooth muscle cells, and macrophages. In all cases, a window of optimal autophagic activity appears to be critical to the maintenance of cardiovascular homeostasis and function; excessive or insufficient levels of autophagic flux can each contribute to heart disease pathogenesis. In this Review, we discuss the potential for targeting autophagy therapeutically and our vision for where this exciting biology may lead in the future.
Authors
Sergio Lavandero, Mario Chiong, Beverly A. Rothermel, Joseph A. Hill
Total citations by year
Citation information
Citations to this article in year 2023 (16)
| Title and authors | Publication | Year |
|---|---|---|
|
Madder (Rubia cordifolia L.) Alleviates Myocardial Ischemia-Reperfusion Injury by Protecting Endothelial Cells from Apoptosis and Inflammation
Gao J, Wang Z, Ye Z |
Mediators of Inflammation | 2023 |
|
Biochemical Mechanisms beyond Glycosphingolipid Accumulation in Fabry Disease: Might They Provide Additional Therapeutic Treatments?
Bertoldi G, Caputo I, Driussi G, Stefanelli LF, Di Vico V, Carraro G, Nalesso F, Calò LA |
Journal of Clinical Medicine | 2023 |
|
Activation of AMPK promotes cardiac differentiation by stimulating the autophagy pathway.
Kolahdouzmohammadi M, Pahlavan S, Sotoodehnejadnematalahi F, Tahamtani Y, Totonchi M |
Journal of Cell Communication and Signaling | 2023 |
|
Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload.
Ouyang X, Bakshi S, Benavides GA, Sun Z, Hernandez-Moreno G, Collins HE, Kane MS, Litovsky S, Young ME, Chatham JC, Darley-Usmar V, Wende AR, Zhang J |
Physiological Reports | 2023 |
|
STIM1 ablation impairs exercise-induced physiological cardiac hypertrophy and dysregulates autophagy in mouse hearts
Bonilla IM, Baine S, Pokrass A, Mariángelo JI, Kalyanasundaram A, Bogdanov V, Mezache L, Sakuta G, Beard CM, Belevych A, Tikunova S, Terentyeva R, Terentyev D, Davis J, Veeraraghavan R, Carnes CA, Györke S |
Journal of applied physiology | 2023 |
|
Restored autophagy is protective against PAK3-induced cardiac dysfunction
Ruiz-Velasco A, Raja R, Chen X, Ganenthiran H, Kaur N, Alatawi NH, Miller JM, Abouleisa RR, Ou Q, Zhao X, Fonseka O, Wang X, Hille SS, Frey N, Wang T, Mohamed TM, Müller OJ, Cartwright EJ, Liu W |
iScience | 2023 |
|
MicroRNA-216a is essential for cardiac angiogenesis
Juni RP, Kocken JM, Abreu RC, Ottaviani L, Davalan T, Duygu B, Poels EM, Vasilevich A, Hegenbarth JC, Appari M, Bitsch N, Olieslagers S, Schrijvers DM, Stoll M, Heineke J, de Boer J, de Windt LJ, da Costa Martins PA |
Molecular Therapy | 2023 |
|
Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction
Korover N, Etzion S, Cherniak A, Rabinski T, Levitas A, Etzion Y, Ofir R, Parvari R, Cohen S |
Biological research | 2023 |
|
Cellular reprogramming of fibroblasts in heart regeneration
Chi C, Song K |
Journal of Molecular and Cellular Cardiology | 2023 |
|
Effective Attenuation of Arteriosclerosis Following Lymphatic-Targeted Delivery of Hyaluronic Acid-Decorated Rapamycin Liposomes
Liu X, Lin C, Zhong W, Yuan Z, Yan P, Guan S |
International Journal of Nanomedicine | 2023 |
|
The role of heat shock proteins in the pathogenesis of heart failure (Review)
Sklifasovskaya AP, Blagonravov M, Ryabinina A, Goryachev V, Syatkin S, Chibisov S, Akhmetova K, Prokofiev D, Agostinelli E |
International journal of molecular medicine | 2023 |
|
Nuciferine induces autophagy to relieve vascular cell adhesion molecule 1 activation via repressing the Akt/mTOR/AP1 signal pathway in the vascular endothelium
Wei H, Yin Y, Yang W, Zhu J, Chen L, Guo R, Yang Z, Li S |
Frontiers in pharmacology | 2023 |
|
Ginsenoside Rb2 improves heart failure by down-regulating miR-216a-5p to promote autophagy and inhibit apoptosis and oxidative stress.
Peng Y, Liao B, Zhou Y, Zeng W |
Journal of Applied Biomedicine | 2023 |
|
Vericiguat protects against cardiac damage in a pig model of ischemia/reperfusion
Zhu W, Ben Y, Shen Y, Liu W |
PloS one | 2023 |
|
Targeting Autophagy in Atrial Fibrillation.
Ye Q, Chen W, Fu H, Ding Y, Jing Y, Shen J, Yuan Z, Zha K |
2023 | |
|
Proteostasis and resilience in the mechanically-stressed vascular endothelium
Keen A, Zhang F, Reader JS, Tzima E |
Current Opinion in Physiology | 2023 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)