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mTOR: a pharmacologic target for autophagy regulation
Young Chul Kim, Kun-Liang Guan
Young Chul Kim, Kun-Liang Guan
Published January 2, 2015
Citation Information: J Clin Invest. 2015;125(1):25-32. https://doi.org/10.1172/JCI73939.
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mTOR: a pharmacologic target for autophagy regulation

Abstract

mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment.

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Young Chul Kim, Kun-Liang Guan

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Upadhyay A 		2024
Sinomenine increases osteogenesis in mice with ovariectomy-induced bone loss by modulating autophagy
Xiao HX, Yu L, Xia Y, Chen K, Li WM, Ge GR, Zhang W, Zhang Q, Zhang HT, Geng DC 		World journal of stem cells 2024
The Dual Role of Sulforaphane-Induced Cellular Stress—A Systems Biological Study
Holczer M, Besze B, Lehel A, Kapuy O 		International journal of molecular sciences 2024
The Effect of Tryptophan-to-Tyrosine Mutation at Position 61 of the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus on Viral Replication through Autophagosome Modulation
Park JY, Senevirathne A, Lloren KK, Lee JH 		International journal of molecular sciences 2024
Exploring the Underlying Mechanisms of Qingxing Granules Treating H1N1 Influenza Based on Network Pharmacology and Experimental Validation
Du H, Zhang L, Sun H, Zheng S, Zhang H, Yuan S, Zhou J, Fang Z, Song J, Mei M, Deng C 		Pharmaceuticals 2024
The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway
Li Y, Yan W, Qin Y, Zhang L, Xiao S 		International journal of molecular sciences 2024
Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration
Zhao R, Huang S, Li J, Gu A, Fu M, Hua W, Mao Y, Lei QY, Lu B, Wen W 		The Journal of Cell Biology 2024
mTOR inhibition by AZD2014 alleviates BCR::ABL1 independent imatinib resistance through enhancing autophagy in CML resistant cells
He W, Liu S, Wei W, Qin R, Tan J, Tang J, Huang Z, Gao M 		American journal of cancer research 2024
Role of AMPK-regulated autophagy in retinal pigment epithelial cell homeostasis: A review
Zhou L, Mo Y, Zhang H, Zhang M, Xu J, Liang S 		Medicine 2024
Effect of autophagy on aging-related changes in orthodontic tooth movement in rats
Xu B, Peng C, Du Y, Li Q, Yang K 		BMC oral health 2024
Pattern-Recognition Receptors and Immunometabolic Reprogramming: What We Know and What to Explore
Kumar V, Stewart IV JH 		Journal of Innate Immunity 2024
Dysfunctional mitochondria elicit bioenergetic decline in the aged heart
Mone P, Agyapong ED, Morciano G, Jankauskas SS, De Luca A, Varzideh F, Pinton P, Santulli G 		2024
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer
Jin X, Jin W, Tong L, Zhao J, Zhang L, Lin N 		Acta pharmaceutica Sinica. B 2024
Wulingsan Alleviates MAFLD by Activating Autophagy via Regulating the AMPK/mTOR/ULK1 Signaling Pathway
Biao Y, Li D, Zhang Y, Gao J, Xiao Y, Yu Z, Li L 		Canadian journal of gastroenterology & hepatology 2024
Recent progress of endoplasmic reticulum stress in the mechanism of atherosclerosis
Ni L, Yang L, Lin Y 		Frontiers in Cardiovascular Medicine 2024
Coffee Bean and Its Chemical Constituent Caffeine and Chlorogenic Acid as Promising Chemoprevention Agents: Updated Biological Studies against Cancer Cells
Aborziza M, Amalia R, Zuhrotun A, Ikram NK, Novitasari D, Muchtaridi M 		Molecules (Basel, Switzerland) 2024
Hepatocyte programmed cell death: the trigger for inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis
Cheng Z, Chu H, Seki E, Lin R, Yang L 		Frontiers in Cell and Developmental Biology 2024
Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms
Kaur A, Venkatesan A, Kandarpa M, Talpaz M, Raghavan M 		Blood Advances 2024
CTLA-4 expression on CD4+ lymphocytes in patients with sepsis-associated immunosuppression and its relationship to mTOR mediated autophagic–lysosomal disorder
Cheng W, Zhang J, Li D, Lei X, Wang H, Cui N 		Frontiers in immunology 2024
Rapamycin Attenuates H(2)O(2)-Induced Oxidative Stress-Related Senescence in Human Skin Fibroblasts.
Tang Y, Yang S, Qiu Z, Guan L, Wang Y, Li G, Tu Y, Guo L 		Tissue Engineering and Regenerative Medicine 2024
Omaveloxolone Ameliorates Cognitive Deficits by Inhibiting Apoptosis and Neuroinflammation in APP/PS1 Mice.
Liu Z, Jia J 		Molecular Neurobiology 2024
mTOR Deletion Alleviates CD4+ T-Cell Dysfunction in Sepsis through Reducing CTLA4 Accumulation Mediated by Rescuing Autophagy
Lei X, Zhao G, Xie Y, Cui N 		Mediators of Inflammation 2024
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis.
Tang L, Ding J, Yang K, Zong Z, Wu R, Li H 		Journal of Molecular Medicine 2024
A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain.
Li K, Yang W, Chen X, Yu Y, Liu Y, Ni F, Xiao Y, Qing X, Liu S, He Y, Wang B, Xu L, Shao Z, Zhao L, Peng Y, Lin H 		Journal of nanobiotechnology 2024
SVIP reduces IGFBP-2 expression and inhibits glioblastoma progression via stabilizing PTEN.
Wang Z, Qiao X, Chen Y, Peng N, Niu C, Wang Y, Li C, Hu Z, Zhang C, Cheng C 		Cell Death Discovery 2024
Research Progress on Mechanisms and Treatment of Sepsis-Induced Myocardial Dysfunction.
Hao Y, Liu R, Wang H, Rui T, Guo J 		International journal of general medicine 2024
Importance of Energy, Dietary Protein Sources, and Amino Acid Composition in the Regulation of Metabolism: An Indissoluble Dynamic Combination for Life
Corsetti G, Pasini E, Scarabelli TM, Romano C, Singh A, Scarabelli CC, Dioguardi FS 		Nutrients 2024
Changes in the Sensitivity of MCF-7 and MCF-7/DX Breast Cancer Cells to Cytostatic in the Presence of Metformin
Płonka-Czerw J, Żyrek L, Latocha M 		Molecules (Basel, Switzerland) 2024
Role and mechanisms of autophagy, ferroptosis, and pyroptosis in sepsis-induced acute lung injury
Shen Y, He Y, Pan Y, Liu L, Liu Y, Jia J 		Frontiers in Pharmacology 2024
Autophagy regulates apoptosis of colorectal cancer cells based on signaling pathways.
Yan Y, Yu W, Guo M, Zhu N, Chen X, Li N, Zhong C, Wang G 		Discover oncology 2024
Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia.
Wei XH, Liao LY, Yin YX, Xu Q, Xie SS, Liu M, Gao LB, Chen HQ, Zhou R 		Cellular and molecular life sciences : CMLS 2024
Therapeutic Potential of Natural Resources Against Endometriosis: Current Advances and Future Perspectives
Gu X, Zhou H, Miao M, Hu D, Wang X, Zhou J, Teichmann AT, Yang Y, Wang C 		Drug Design, Development and Therapy 2024
Targeting cellular adaptive responses to glutaminolysis perturbation for cancer therapy
Kim M, Hwang S, Jeong SM 		Molecules and Cells 2024
Genetic and Pathophysiological Basis of Cardiac and Skeletal Muscle Laminopathies
Bhide S, Chandran S, Rajasekaran NS, Melkani GC 		Genes 2024
A Narrative Review: Immunometabolic Interactions of Host–Gut Microbiota and Botanical Active Ingredients in Gastrointestinal Cancers
Li S, Feng W, Wu J, Cui H, Wang Y, Liang T, An J, Chen W, Guo Z, Lei H 		International Journal of Molecular Sciences 2024
Genipin promotes the apoptosis and autophagy of neuroblastoma cells by suppressing the PI3K/AKT/mTOR pathway
Liu X, Zhou C, Cheng B, Xiong Y, Zhou Q, Wan E, He Y 		Scientific Reports 2024
mTOR Signaling: Roles in Hepatitis B Virus Infection and Hepatocellular Carcinoma.
Mei L, Sun H, Yan Y, Ji H, Su Q, Chang L, Wang L 		International journal of biological sciences 2024
Methionine deficiency inhibited pyroptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella): possibly via activating the ROS-AMPK-autophagy axis.
He Y, Wu P, Jiang W, Liu Y, Jin X, Ren H, Zhang R, Zhou X, Feng L 		Journal of animal science and biotechnology 2024
A Lipid-Sensitive Spider Peptide Toxin Exhibits Selective Anti-Leukemia Efficacy through Multimodal Mechanisms.
Zhang P, Luo W, Zhang Z, Lv M, Sang L, Wen Y, Wang L, Ding C, Wu K, Li F, Nie Y, Zhu J, Liu X, Yi Y, Ding X, Zeng Y, Liu Z 		Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024
Dicer-Mediated mTORC1 Signaling and Parathyroid Gland Integrity and Function
Hassan A, Khalaily N, Kilav-Levin R, Del Castello B, Manley NR, Ben-Dov IZ, Naveh-Many T 		Journal of the American Society of Nephrology : JASN 2024
From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis
Liu Z, Ting Y, Li M, Li Y, Tan Y, Long Y 		Frontiers in Microbiology 2024
Oleanolic acid improves 5-fluorouracil-induced intestinal damage and inflammation by alleviating intestinal senescence.
Bai SR, Zhao BX, Zhao Q, Ge YC, Li M, Zhao CG, Wu XJ, Wang XB 		Scientific reports 2024
Potential Action Mechanism of Erianin in Relieving MNNG-triggered Chronic Atrophic Gastritis.
Jiang Q, Fan G, Wu K 		Cell biochemistry and biophysics 2024
GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy.
Xiao X, Tang T, Bi M, Liu J, Liu M, Jiao Q, Chen X, Yan C, Du X, Jiang H 		Redox biology 2024
Mapping the landscape: A bibliometric perspective on autophagy in spinal cord injury.
Wang F, Zhang S, Xu Y, He W, Wang X, He Z, Shang J, Zhenyu Z 		Medicine 2024
Mechanisms of hepatic and renal injury in lipid metabolism disorders in metabolic syndrome
Rong J, Zhang Z, Peng X, Li P, Zhao T, Zhong Y 		International Journal of Biological Sciences 2024
Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model.
Lu Y, Mohammad NS, Lee J, Aranyos AM, Serban KA, Brantly ML 		PloS one 2024
Gene Expression Regulation and the Signal Transduction of Programmed Cell Death
S, Deng Y, Li K, Yan W, Li K, Wang C 		Current Issues in Molecular Biology 2024
Progress in antitumor mechanisms and applications of phenformin (Review)
Zhong Q, Li D, Yang XP 		Oncology Reports 2024
Metabolic regulation of the immune system in health and diseases: mechanisms and interventions.
Hu T, Liu CH, Lei M, Zeng Q, Li L, Tang H, Zhang N 		Signal transduction and targeted therapy 2024
Possible involvement of a MEG3-miR-21-SPRY1-NF-κB feedback loop in spermatogenic cells proliferation, autophagy, and apoptosis.
Fang X, Lu X, Ma Y, Sun N, Jiao Y, Meng H, Song M, Jin H, Yao G, Song N, Wu Z, Wen S, Guo H, Xiong H, Song W 		iScience 2024
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice.
Zheng S, Zhu J, Wang C, Wu Y, Sun S, Guo H, Chang Y, Ma R, Li G 		Cell communication and signaling : CCS 2024
Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling
Zhang G, Liang Z, Wang Y, Zhang Z, Hoi PM 		Antioxidants 2024
Exosomes on the development and progression of renal fibrosis
Wang P, Chen W, li B, Yang S, Li W, Zhao S, Ning J, Zhou X, Cheng F 		Cell Proliferation 2024
Deciphering the multifaceted role of microRNAs in hepatocellular carcinoma: Integrating literature review and bioinformatics analysis for therapeutic insights
Rahdan F, Saberi A, Saraygord-Afshari N, Hadizadeh M, Fayeghi T, Ghanbari E, Dianat-Moghadam H, Alizadeh E 		Heliyon 2024
通塞颗粒阻抑巨噬细胞炎症反应改善大鼠慢性阻塞性肺疾病急性加重
Journal of Southern Medical University 2024
IL-32γ Induced Autophagy Through Suppression of MET and mTOR Pathways in Liver Tumor Growth Inhibition
Seo JW, Lee YS, Jeon IS, Yu JE, Yoo JS, Koo JK, Son DJ, Yoon JS, Han SB, Yoon DY, Roh YS, Hong JT, Shim JH 		International Journal of Molecular Sciences 2024
Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights
Chowdhury R, Bhuia MS, Al Hasan MS, Hossain Snigdha S, Afrin S, Büsselberg D, Habtemariam S, Sönmez Gürer E, Sharifi\u2010Rad J, Ahmed Aldahish A, Аkhtayeva N, Islam MT 		Food Science & Nutrition 2024
mTOR Inhibitors Modulate the Biological Nature of TGF-β2-Treated or -Untreated Human Trabecular Meshwork Cells in Different Manners
Watanabe M, Sato T, Yano T, Higashide M, Ogawa T, Nishikiori N, Furuhashi M, Ohguro H 		Biomedicines 2024
Beyond Wolfram Syndrome 1: The WFS1 Gene’s Role in Alzheimer’s Disease and Sleep Disorders
Caruso V, Rigoli L 		Biomolecules 2024
Intermittent fasting reduces inflammation and joint damage in a murine model of rheumatoid arthritis: insights from transcriptomic and metagenomic analyses
Cuevas-Martínez R, González-Chávez SA, Bermúdez M, Salas-Leiva JS, Vázquez-Olvera G, Hinojos-Gallardo LC, Chaparro-Barrera E, Pacheco-Silva C, Romero-Sánchez C, Villegas-Mercado CE, Pacheco-Tena C 		BMC Rheumatology 2024
Treatment of Melanoma Cells with Chloroquine and Everolimus Activates the Apoptosis Process and Alters Lipid Redistribution
Ciołczyk-Wierzbicka D, Zarzycka M, Placha W, Zemanek G, Wierzbicki K 		International Journal of Molecular Sciences 2024
Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets
Qian S, Long Y, Tan G, Li X, Xiang B, Tao Y, Xie Z, Zhang X 		MedComm 2024
Ultrasound-targeted sirolimus-loaded microbubbles improves acute rejection of heart transplantation in rats by inhibiting TGF-β1-Smad signaling pathway, promoting autophagy and reducing inflammation
Bao H, Dai L, Wang H, Jiang T 		International Journal of Pharmaceutics: X 2024
Immunomodulatory potential of primary cilia in the skin
Sun J, Yuan H, Yu Y, Li A, Zhao Z, Tang Y, Zheng F 		Frontiers in Immunology 2024
Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment
Cao Z, Tian K, Ran Y, Zhou H, Zhou L, Ding Y, Tang X 		Frontiers in Immunology 2024
Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
Shang J, Zhao F, Xie L, Wang Y, Li B, Jin C 		Open Medicine 2024
MTOR maintains endothelial cell integrity to limit lung vascular injury
Millar MW, Najar RA, Slavin SA, Shadab M, Tahir I, Mahamed Z, Lin X, Abe JI, Wright TW, Dean DA, Fazal F, Rahman A 		The Journal of Biological Chemistry 2024
JAG1 mediates apoptosis in herpes simplex keratitis by suppressing autophagy via ROS/JAG1/NOTCH1/pULK1 signaling pathway
Chang J, Yao Y, Sun X, Wang W, Qian H, Liu Y, Xue C, Ye W, Jiang F 		Cell Biology and Toxicology 2024
Phillygenin rescues impaired autophagy flux by modulating the PI3K/Akt/mToR signaling pathway in a rat model of severe acute pancreatitis
Li J, Duan J, Sun Y, Yang R, Yang H, Li W 		International Journal of Immunopathology and Pharmacology 2024
Autophagy-targeting modulation to promote peripheral nerve regeneration
Chen Y, Deng H, Zhang N 		Neural Regeneration Research 2024
木犀草素通过增加ROS的产生和下调AKT/mTOR通路及HO-1蛋白表达抑制肺癌A549细胞增殖
Journal of Southern Medical University 2024
Molecular Mechanisms Underlying Initiation and Activation of Autophagy
Wei Z, Hu X, Wu Y, Zhou L, Zhao M, Lin Q 		Biomolecules 2024
Ginsenoside Rg1 Alleviates Blood–Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy
Yang S, Fang Z, Duan H, Dong W, Xiao L 		Antioxidants 2024
The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR‐99a/mTOR‐Mediated Autophagy and Apoptosis
Hu H, Fu J, Han L, Gao G, Zhang W, Yu S, Li N, Li Y, Lu Y, Ding X, Pan Y, Wang Y, He Q 		Advanced Science 2024
Oscillatory autophagy induction is enabled by an updated AMPK-ULK1 regulatory wiring
Kapuy O, Holczer M, Csabai L, Korcsmáros T 		PLOS ONE 2024
BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway
Sun W, Lei Y, Jiang Z, Wang K, Liu H, Xu T 		Journal of Advanced Research 2024
Novel Insights from Comprehensive Bioinformatics Analysis Utilizing Large-Scale Human Transcriptomes and Experimental Validation: The Role of Autophagy in Periodontitis
Liu F, Zhu Z, Zou H, Huang Z, Xiao S, Li Z 		Journal of Inflammation Research 2024
The autophagy initiation factor ATG13 mRNA is stabilized by the RNA‐binding protein YBX3
Pfuhler L, Awad S, Skipper W, Lavietes J, Sah T, Ho K, Ivanova R, Cooke A 		Febs Letters 2024
The survivin/XIAP suppressant YM155 impairs clonal growth and induces apoptosis in JAK2V617F cells
Carlos JA, Lima K, Rego EM, Costa-Lotufo LV, Machado-Neto JA 		Hematology, Transfusion and Cell Therapy 2024
Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia
Amabebe E, Huang Z, Jash S, Krishnan B, Cheng S, Nakashima A, Li Y, Li Z, Wang R, Menon R, Zhou XZ, Lu KP, Sharma S 		Biomedicines 2024
ATP6V1D drives hepatocellular carcinoma stemness and progression via both lysosome acidification-dependent and -independent mechanisms
Xu Z, Liu R, Ke H, Xu F, Yang P, Zhang W, Zhan Y, Zhao Z, Xiao F 		Autophagy 2024
Treating human cancer by targeting EZH2
Xu M, Xu C, Wang R, Tang Q, Zhou Q, Wu W, Wan X, Mo H, Pan J, Wang S 		Genes & Diseases 2024
Autophagy in erectile dysfunction: focusing on apoptosis and fibrosis
Luo PY, Zou JR, Chen T, Zou J, Li W, Chen Q, Cheng L, Zheng LY, Qian B 		Asian Journal of Andrology 2024
The dichotomic role of cytokines in aging.
Silva RCMC 		Biogerontology 2024
Sulforaphane alleviates renal fibrosis through dual regulation on mTOR-mediated autophagy pathway.
Zhang D, Zhang H, Lv S, Zhu C, Gong S, Yu X, Wang Y, Huang X, Yuan S, Ding X, Zhang X 		International urology and nephrology 2024
Treatment of Rheumatoid Arthritis Based on the Inherent Bioactivity of Black Phosphorus Nanosheets
Zhuang C, Sun R, Zhang Y, Zou Q, Zhou J, Dong N, Zhao X, Fu W, Geng X, Wang J, Li Q, Zhao RC 		Aging and Disease 2024
Reserpine maintains photoreceptor survival in CEP290 retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
Holly Chen, Manju Swaroop, Samantha Papal, Anupam Mondal, Gregory Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia Val, Samuel Jacobson, Wei Zheng, Anand Swaroop 		eLife 2023
Transplanting Old Organs Accelerates Aging in Young Recipients
Jasper Iske, Maximilian Julius Roesel, Andreas Schroeter, Tomohisa Matsunaga, Ryoichi Maenosono, Utkarsh Tripath, Yao Xiao, Yeqi Nian, Barbara Caldarone, Florian Vondran, Peter Sage, Haruhito Azuma, Reza Abdi, Abdallah Elkhal, Tamar Pirtskhalava, Tamara Tchkonia, James Kirkland, Hao Zhou, Stefan Tullius 		American Journal of Transplantation 2023
Identification and characterization of CD8+CD27+CXCR3- T cell dysregulation and progression-associated biomarkers in systemic lupus erythematosus
Lulu Zhang, Fang Du, Qiqi Jin, Li Sun, Boqian Wang, Ziyang Tan, Xinyu Meng, Baozhen Huang, Yifan Zhan, Wenqiong Su, Luonan Chen, Xiaoxiang Chen, Xianting Ding 		Advanced Science 2023
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Li Q, Tie Y, Alu A, Ma X, Shi H 		Signal Transduction and Targeted Therapy 2023
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis
Pei F, Ma L, Jing J, Feng J, Yuan Y, Guo T, Han X, Ho TV, Lei J, He J, Zhang M, Chen JF, Chai Y 		Nature Communications 2023
Biological and Clinical Impacts of Glucose Metabolism in Pancreatic Ductal Adenocarcinoma.
Liu Z, Hayashi H, Matsumura K, Uemura N, Shiraishi Y, Sato H, Baba H 		Cancers 2023
SDF-1α Promotes Chondrocyte Autophagy through CXCR4/mTOR Signaling Axis.
Li J, Chen H, Cai L, Guo D, Zhang D, Zhou X, Xie J 		International journal of molecular sciences 2023
The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
Smith JK, Mellick GD, Sykes AM 		Frontiers in cellular neuroscience 2023
Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR
Huangfu Y, Yu X, Wan C, Zhu Y, Wei Z, Li F, Wang Y, Zhang K, Li S, Dong Y, Li Y, Niu H, Xin G, Huang W 		Frontiers in pharmacology 2023
Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis
Gong Y, Li S, Wu J, Zhang T, Fang S, Feng D, Luo X, Yuan J, Wu Y, Yan X, Zhang Y, Zhu J, Wu J, Lian J, Xiang W, Ni Z 		Burns & Trauma 2023
Autophagy Requirements for Eye Lens Differentiation and Transparency
Brennan L, Costello MJ, Hejtmancik JF, Menko AS, Riazuddin SA, Shiels A, Kantorow M 		Cells 2023
Cardiovascular Protection with a Long-Acting GLP-1 Receptor Agonist Liraglutide: An Experimental Update
Vandemark C, Nguyen J, Zhao ZQ 		Molecules (Basel, Switzerland) 2023
Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD
Abdulghani A, Poghosyan M, Mehren A, Philipsen A, Anderzhanova E 		Frontiers in molecular neuroscience 2023
Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells
Wang J, Wang Z, Dai L, Zhu X, Guan X, Wang J, Li J, Zhang M, Bai Y, Guo H 		International journal of molecular sciences 2023
Chaperone-assisted selective autophagy targets filovirus VP40 as a client and restricts egress of virus particles
Liang J, Djurkovic MA, Shtanko O, Harty RN 		Proceedings of the National Academy of Sciences 2023
Gene mutations in the PI3K/Akt signaling pathway were related to immune thrombocytopenia pathogenesis
Ruan JS, Sun RJ, Wang JP, Sui XH, Qu HT, Yuan D, Shan NN 		Medicine 2023
High-Intensity Focused Ultrasound Decreases Subcutaneous Fat Tissue Thickness by Increasing Apoptosis and Autophagy.
Byun KA, Park HJ, Oh S, Batsukh S, Sun HJ, Kim T, Kim S, Kang D, Son KH, Byun K 		Biomolecules 2023
MiRNA Profiling and Its Potential Roles in Rapid Growth of Velvet Antler in Gansu Red Deer (Cervus elaphus kansuensis).
Zhang Z, He C, Bao C, Li Z, Jin W, Li C, Chen Y 		Genes & development 2023
Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells.
Seliger C, Rauer L, Wüster AL, Moeckel S, Leidgens V, Jachnik B, Ammer LM, Heckscher S, Dettmer K, Riemenschneider MJ, Oefner PJ, Proescholdt M, Vollmann-Zwerenz A, Hau P 		International journal of molecular sciences 2023
Suppression of small nucleolar RNA host gene 8 (SNHG8) inhibits the progression of colorectal cancer cells.
Islam Khan MZ, Law HKW 		Non-coding RNA Research 2023
CurQ+, a Next-Generation Formulation of Curcumin, Ameliorates Growth Plate Chondrocyte Stress and Increases Limb Growth in a Mouse Model of Pseudoachondroplasia.
Hecht JT, Veerisetty AC, Hossain MG, Chiu F, Posey KL 		International journal of molecular sciences 2023
Treatment of Rapamycin and Evaluation of an Autophagic Response in the Gut of Bactericera cockerelli (Sulč).
Oh J, Tamborindeguy C 		Insects 2023
mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder.
Thomas SD, Jha NK, Ojha S, Sadek B 		Molecules (Basel, Switzerland) 2023
Autophagy dysregulation in trichloroethene-mediated inflammation and autoimmune response.
Wang H, Banerjee N, Wang G, Firoze Khan M 		Toxicology 2023
The Effects of Treatment with Icariin on Immune Tolerance in the Recurrent Spontaneous Abortion Mice.
Peng F, Han Z, Chen H, Zhang Q, Liu C, Liang X 		Reproductive sciences (Thousand Oaks, Calif.) 2023
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux
Ji X, Hong J, Yang W, Yao M, Wang J, Jiang G, Wang Y, Li C, Lin J, Mou H, Li C, Li S, Chen Y, Shi M, Wang W, Lu F, Wu H, Zhao X, Qi Y, Yan S 		Redox Biology 2023
Evaluation of the mTORC activity in the presence of Toxoplasma gondii and azathioprine in human monocyte cell line
Nemati S, Mohammad Rahimi H, Meyfour A, Pazoki H, Asadzadeh Aghdaei H, Shahrokh S, Mirjalali H 		BMC Microbiology 2023
Comprehensive analysis of autophagy-related clusters and individual risk model for immunotherapy response prediction in gastric cancer
Yao Y, Hu X, Ma J, Wu L, Tian Y, Chen K, Liu B 		Frontiers in Oncology 2023
The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
Tan X, Huang X, Lu Z, Chen L, Hu J, Tian X, Qiu Z 		Frontiers in pharmacology 2023
Fasting: From Physiology to Pathology.
Tang D, Tang Q, Huang W, Zhang Y, Tian Y, Fu X 		2023
Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy.
Zurlo M, Gasparello J, Cosenza LC, Breveglieri G, Papi C, Zuccato C, Gambari R, Finotti A 		Genes & development 2023
The Role of Regulated Programmed Cell Death in Osteoarthritis: From Pathogenesis to Therapy.
Liu S, Pan Y, Li T, Zou M, Liu W, Li Q, Wan H, Peng J, Hao L 		International journal of molecular sciences 2023
MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice
Sikora M, Śmieszek A, Pielok A, Marycz K 		Stem Cell Research & Therapy 2023
Daurisoline attenuates H2O2-induced chondrocyte autophagy by activating the PI3K/Akt/mTOR signaling pathway
Zhang Y, Liu W, Liu Z, Liu Y 		Journal of orthopaedic surgery and research 2023
ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation of Giardia infection-related tight junction protein and nitric oxide levels
Wu J, Yang Y, Liu L, Zhu W, Liu M, Yu X, Li W 		Frontiers in immunology 2023
Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation.
Kamihara T, Hirashiki A, Kokubo M, Shimizu A 		2023
Genetic Evidence Supporting Causal Roles of mTOR-Dependent Proteins in Rheumatic Fever: A Two-Sample Randomized Mendelian Study.
Mu YF, Wang Q, Hu JX, Wang Q, Zhang YC, Fan KY, Han ZY, Zhang HY, Cheng T, Zhao R, Song S, Qiao J, Zhang SX, Wang CH 		Advances in Therapy 2023
lncRNA TINCR knockdown inhibits colon cancer cells via regulation of autophagy
Xu J, Zeng W, Liu T, Wan Z, Yang X, Chen J, Liu F 		Food Science & Nutrition 2023
Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy
Lin DS, Huang YW, Lee TH, Chang L, Huang ZD, Wu TY, Wang TJ, Ho CS 		Cells 2023
Hyperglycemia Aggravates Periodontitis via Autophagy Impairment and ROS-Inflammasome-Mediated Macrophage Pyroptosis
Zhao Z, Ming Y, Li X, Tan H, He X, Yang L, Song J, Zheng L 		International journal of molecular sciences 2023
Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota
Micheli L, Bertini L, Bonato A, Villanova N, Caruso C, Caruso M, Bernini R, Tirone F 		Nutrients 2023
ApoM Activates Autophagy and Suppresses Lyosomal Lethargy to Combat Doxorubicin Cardiomyopathy
Kazmirczak F, Prins KW 		JACC: Basic to Translational Science 2023
Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction.
Zhao JY, Yuan XK, Luo RZ, Wang LX, Gu W, Yamane D, Feng H 		Frontiers in immunology 2023
New insights into autophagy in inflammatory subtypes of asthma
Dong H, Yang W, Li W, Zhu S, Zhu L, Gao P, Hao Y 		Frontiers in immunology 2023
Bioinformatics analysis and experimental validation of a novel autophagy-related signature relevant to immune infiltration for recurrence prediction after curative hepatectomy
Wang H, Yang C, Li D, Wang R, Li Y, Lv L 		Aging 2023
The N-degron pathway mediates lipophagy: the chemical modulation of lipophagy in nonalcoholic fatty liver disease
Eui Jung Jung, Ki Woon Sung, Tae Hyun Bae, Hee-Yeon Kim, Ha Rim Choi, Sung Hyun Kim, Chan Hoon Jung, Yeon Sung Son, Shin Kim, Young Ho Suh, Anna Kashina, Joo-Won Park, Yong Tae Kwon 		Metabolism: clinical and experimental 2023
Autophagy and Breast Cancer: Connected in Growth, Progression, and Therapy
Wu Q, Sharma D 		Cells 2023
Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis.
Chakraborty A, Kabashi A, Wilk S, Rahme LG 		mBio 2023
Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway.
Wu C, Zeng L, Yi W, Miao Y, Liu Y, Wang Q, Liu S, Peng G, Zheng Z, Xia J 		Frontiers in immunology 2023
Oscillation of Autophagy Induction under Cellular Stress and What Lies behind It, a Systems Biology Study.
Hajdú B, Csabai L, Márton M, Holczer M, Korcsmáros T, Kapuy O 		International journal of molecular sciences 2023
In vitro methods in autophagy research: Applications in neurodegenerative diseases and mood disorders
Sánchez-Vidaña DI, Li J, Abokyi S, Chan JN, Ngai SP, Lau BW 		Frontiers in molecular neuroscience 2023
The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5
Fu L, Lu K, Jiao Q, Chen X, Jia F 		Cells 2023
Euchromatic Histone Lysine Methyltransferase 2 Inhibition Enhances Carfilzomib Sensitivity and Overcomes Drug Resistance in Multiple Myeloma Cell Lines
Mereu E, Abbo D, Paradzik T, Cumerlato M, Bandini C, Labrador M, Maccagno M, Ronchetti D, Manicardi V, Neri A, Piva R 		Cancers 2023
Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells
Payne A, Taka E, Adinew GM, Soliman KF 		Brain Sciences 2023
The emerging roles of Shank3 in cardiac function and dysfunction.
Kim Y, Ko TH, Jin C, Zhang Y, Kang HR, Ma R, Li H, Choi JI, Han K 		Frontiers in Cell and Developmental Biology 2023
CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration.
Pandey R, Bakay M, Hakonarson H 		International journal of molecular sciences 2023
G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis
Parija M, Adhya AK, Mishra SK 		Oncotarget 2023
mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines
Germano CA, Clemente G, Storniolo A, Romeo MA, Ferretti E, Cirone M, Di Renzo L 		Biology 2023
Cardiovascular Protective Effects of NP-6A4, a Drug with the FDA Designation for Pediatric Cardiomyopathy, in Female Rats with Obesity and Pre-Diabetes
Belenchia AM, Boukhalfa A, DeMarco VG, Mehm A, Mahmood A, Liu P, Tang Y, Gavini MP, Mooney B, Chen HH, Pulakat L 		Cells 2023
Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review
Liu S, Jia Y, Meng S, Luo Y, Yang Q, Pan Z 		International journal of molecular sciences 2023
Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
Cayo A, Venturini W, Rebolledo-Mira D, Moore-Carrasco R, Herrada AA, Nova-Lamperti E, Valenzuela C, Brown NE 		International journal of molecular sciences 2023
Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology
Katarachia SA, Markaki SP, Velentzas AD, Stravopodis DJ 		International journal of molecular sciences 2023
PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase
Ghosh A, Venugopal A, Shinde D, Sharma S, Krishnan M, Mathre S, Krishnan H, Saha S, Raghu P 		Life science alliance 2023
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Tang Q, Markby GR, MacNair AJ, Tang K, Tkacz M, Parys M, Phadwal K, MacRae VE, Corcoran BM 		Cell Proliferation 2023
The role of lysosomal peptidases in glioma immune escape: underlying mechanisms and therapeutic strategies
Liu H, Peng J, Huang L, Ruan D, Li Y, Yuan F, Tu Z, Huang K, Zhu X 		Frontiers in immunology 2023
Starvation Protects Hepatocytes from Inflammatory Damage through Paradoxical mTORC1 Signaling
Hussain I, Sureshkumar HK, Bauer M, Rubio I 		Cells 2023
mTOR Inhibition Is Effective against Growth, Survival and Migration, but Not against Microglia Activation in Preclinical Glioma Models
Lisi L, Pizzoferrato M, Ciotti GM, Martire M, Navarra P 		International journal of molecular sciences 2023
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma
Jiang Z, Gao L, Liu C, Wang J, Han Y, Pan J 		Journal of Clinical and Translational Hepatology 2023
LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral
SHAN F, LIANG L, FENG C, XU H, WANG Z, LIU W, PU L, CHEN Z, CHEN G, WANG X 		Oncology research 2023
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice.
Gong K, Zhang Z, Chen SS, Zhu XR, Wang MY, Yang XY, Ding C, Han JH, Li QS, Duan YJ 		Acta Pharmacologica Sinica 2023
Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer’s disease patient lymphocytes
Wang HY, Pei Z, Lee KC, Nikolov B, Doehner T, Puente J, Friedmann N, Burns LH 		2023
Astragaloside IV Blunts Epithelial–Mesenchymal Transition and G2/M Arrest to Alleviate Renal Fibrosis via Regulating ALDH2-Mediated Autophagy
Li D, Liu Y, Zhan Q, Zeng Y, Peng Z, He Q, Tan Q, Cao W, Wang S, Wang J 		Cells 2023
Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression.
He L, Liu R, Yue H, Zhang X, Pan X, Sun Y, Shi J, Zhu G, Qin C, Guo Y 		Signal Transduction and Targeted Therapy 2023
An Autophagy-Associated MITF–GAS5–miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis
Cheng J, Ding C, Tang H, Zhou H, Wu M, Chen Y 		Biomedicines 2023
Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer
Zeng XY, Qiu XZ, Wu JN, Liang SM, Huang JA, Liu SQ 		World journal of gastrointestinal oncology 2023
The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1
Luo H, Wu X, Huo B, Liu L, Jiang DS, Yi X 		Cell division 2023
Syntaxin-6 promotes the progression of hepatocellular carcinoma and alters its sensitivity to chemotherapies by activating the USF2/LC3B axis
Zhou L, Wang Z, Chen X, Li X, Ge C, Min X, Zhao F, Chen T, Li J 		International journal of biological sciences 2023
Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis
Ren Y, Wang R, Weng S, Xu H, Zhang Y, Chen S, Liu S, Ba Y, Zhou Z, Luo P, Cheng Q, Dang Q, Liu Z, Han X 		Molecular Cancer 2023
Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer.
Chen M, Wang G, Xu Z, Sun J, Liu B, Chang L, Gu J, Ruan Y, Gao X, Song S 		Cellular oncology (Dordrecht) 2023
Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals.
Yang F, Liu X, Li Y, Yu Z, Huang X, Yang G, Xu S 		BMC Genomics 2023
The release of zearalenone-induced heterophil extracellular traps in chickens is associated with autophagy, glycolysis, PAD enzyme, and P2X1 receptor
Wu H, Li X, Zhang Z, Ye Y, Chen Y, Wang J, Yang Z, Zhou E 		Poultry science 2023
Aging under endocrine hormone regulation
Xing Y, Xuan F, Wang K, Zhang H 		Frontiers in Endocrinology 2023
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Li N, Chen L, Zhao X, Gu C, Chang Y, Feng S 		Cell Death Discovery 2023
miR-926-3p influences myocardial injury in septic mice through regulation of mTOR signaling pathway by targeting TSC1.
Yan F, Wang Q, Yang H, Lv H, Qin W 		Aging 2023
Chaperone‐mediated autophagy: Molecular mechanisms, biological functions, and diseases
Yao R, Shen J 		2023
A Novel Aniline Derivative from Peganum harmala L. Promoted Apoptosis via Activating PI3K/AKT/mTOR-Mediated Autophagy in Non-Small Cell Lung Cancer Cells
Wu Z, Li W, Tang Q, Huang L, Zhan Z, Li Y, Wang G, Dai X, Zhang Y 		International journal of molecular sciences 2023
Quercetin Alleviated Inflammasome-Mediated Pyroptosis and Modulated the mTOR/P70S6/P6/eIF4E/4EBP1 Pathway in Ischemic Stroke
Alattar A, Alshaman R, Althobaiti YS, Soliman GM, Ali HS, Khubrni WS, Koh PO, Rehman NU, Shah FA 		Pharmaceuticals 2023
NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis
Biswas VK, Sen K, Ahad A, Ghosh A, Verma S, Pati R, Prusty S, Nayak SP, Podder S, Kumar D, Gupta B, Raghav SK 		PLoS Biology 2023
Antitumor activity of miR-188-3p in gastric cancer is achieved by targeting CBL expression and inactivating the AKT/mTOR signaling.
Lin JJ, Luo BH, Su T, Yang Q, Zhang QF, Dai WY, Liu Y, Xiang L 		World journal of gastrointestinal oncology 2023
Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.
Feng HG, Wu CX, Zhong GC, Gong JP, Miao CM, Xiong B 		Journal of Cancer Research and Clinical Oncology 2023
Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment.
Wang Y, Cheng H, Wang T, Zhang K, Zhang Y, Kang X 		Cell Proliferation 2023
Mycobacterium tuberculosis: Pathogenesis and therapeutic targets
Yang J, Zhang L, Qiao W, Luo Y 		2023
Regulating Blood Clot Fibrin Films to Manipulate Biomaterial-Mediated Foreign Body Responses
Zou Y, Shan Z, Han Z, Yang J, Lin Y, Gong Z, Xie L, Xu J, Xie R, Chen Z, Chen Z 		Research 2023
microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis
Qi Z, Liu R, Ju H, Huang M, Li Z, Li W, Wang Y 		International journal of biological sciences 2023
Nanoclay Drug-Delivery System Loading Potassium Iodide Promotes Endocytosis and Targeted Therapy in Anaplastic Thyroid Cancer.
Huang P, Tang N, Mao LF, Zhang Y, Tang XF, Zhou RY, Wei B, Tan HL, Shi QM, Lin J, Li ZC, Chang S 		Nano letters 2023
Nasopharyngeal carcinoma patient-derived xenograft mouse models reveal potential drugs targeting cell cycle, mTOR, and autophagy pathways.
Li HP, Huang CY, Lui KW, Chao YK, Yeh CN, Lee LY, Huang Y, Lin TL, Kuo YC, Huang MY, Fan HC, Lin AC, Hsieh CH, Chang KP, Lin CY, Wang HM, Chao M, Liu JS, Chang YS, Hsu CL 		Translational oncology 2023
Identification of ferroptosis-related proteins in ameloblastoma based on proteomics analysis.
Li H, Ma X, Yang R, Mei S, Zhang X, Li X 		Journal of Cancer Research and Clinical Oncology 2023
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis.
Zhao S, Xiu G, Wang J, Wen Y, Lu J, Wu B, Wang G, Yang D, Ling B, Du D, Xu J 		Journal of nanobiotechnology 2023
Involvement of TLR9 in priming the immune response in oral papillomatosis induced by low-risk HPV
Andrei EC, Munteanu MC, Busuioc CJ, Pisoschi CG, Mateescu GO, Drăcea SA, Baniţă IM 		Romanian Journal of Morphology and Embryology 2023
The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death
Gupta S, Silveira DA, Mombach JC, Hashimoto RF 		Non-coding RNA Research 2023
Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View
Sanghai N, Tranmer GK 		Cells 2023
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
Panwar V, Singh A, Bhatt M, Tonk RK, Azizov S, Raza AS, Sengupta S, Kumar D, Garg M 		Signal Transduction and Targeted Therapy 2023
Inhibition of Dipeptidyl Peptidase-4 Activates Autophagy to Promote Survival of Breast Cancer Cells via the mTOR/HIF-1α Pathway
Kawakita E, Yang F, Shi S, Takagaki Y, Koya D, Kanasaki K 		Cancers 2023
Piperlongumine Induces Apoptosis and Cytoprotective Autophagy via the MAPK Signaling Pathway in Human Oral Cancer Cells
Choi EY, Han EJ, Jeon SJ, Lee SW, Moon JM, Jung SH, Jung JY 		Biomedicines 2023
Unlocking the Molecular Secrets of Antifolate Drug Resistance: A Multi-Omics Investigation of the NCI-60 Cell Line Panel
Rushing BR 		Biomedicines 2023
Unlocking the Potential: Amino Acids’ Role in Predicting and Exploring Therapeutic Avenues for Type 2 Diabetes Mellitus
Ding Y, Wang S, Lu J 		Metabolites 2023
NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma
Topchu I, Bychkov I, Gursel D, Makhov P, Boumber Y 		2023
TOR‐mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly
Yao W, Chen Y, Chen Y, Zhao P, Liu J, Zhang Y, Jiang Q, Wu C, Xie Y, Fan S, Ye M, Wang Y, Feng Y, Bai X, Fan M, Feng S, Wang J, Cui Y, Xia H, Ma C, Xie Z, Zhang L, Sun Q, Liu W, Yi C 		The EMBO Journal 2023
ARNTL inhibits the malignant behaviors of oral cancer by regulating autophagy in an AKT/mTOR pathway‐dependent manner
Chen K, Li H, Li Y, Yang Z, Luo J, Zhou Z 		Cancer Science 2023
The role of heat shock proteins in the pathogenesis of heart failure (Review)
Sklifasovskaya AP, Blagonravov M, Ryabinina A, Goryachev V, Syatkin S, Chibisov S, Akhmetova K, Prokofiev D, Agostinelli E 		International journal of molecular medicine 2023
Autophagy as a Target for Non-Immune Intrinsic Functions of Programmed Cell Death-Ligand 1 in Cancer
García-Pérez BE, Pérez-Torres C, Baltierra-Uribe SL, Castillo-Cruz J, Castrejón-Jiménez NS 		International journal of molecular sciences 2023
Autophagy impairment in human bile duct carcinoma cells
Petrungaro S, de Franchis V, Filippini A, Facchiano A, Gaudio E, Giampietri C 		Frontiers in physiology 2023
KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression
Guo W, Li S, Qian Y, Li L, Wang F, Tong Y, Li Q, Zhu Z, Gao W, Liu Y 		Clinical and Translational Medicine 2023
Role of glycolysis in inflammatory bowel disease and its associated colorectal cancer
Xia Y, Zhang L, Ocansey DK, Tu Q, Mao F, Sheng X 		Frontiers in Endocrinology 2023
Neuron-Derived Extracellular Vesicles to Examine Brain mTOR Target Engagement with Sirolimus in Patients with Multiple System Atrophy: A secondary analysis of the sirolimus trial in MSA
Pucha KA, Ma TC, York W, Kang UJ, Kaufmann H, Kapogiannis D, Palma JA 		Parkinsonism & Related Disorders 2023
New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death
Bu LL, Yuan HH, Xie LL, Guo MH, Liao DF, Zheng XL 		International journal of molecular sciences 2023
PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease
Wang Q, Wang Y, Li S, Shi J 		Alzheimer's research & therapy 2023
Making the Case for Autophagy Inhibition as a Therapeutic Strategy in Combination with Androgen-Targeted Therapies in Prostate Cancer
Elshazly AM, Gewirtz DA 		Cancers 2023
Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects
Zhao H, Song G, Zhu H, Qian H, Pan X, Song X, Xie Y, Liu C 		Nutrients 2023
Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma
Lin CY, Wu KY, Chi LM, Tang YH, Huang HJ, Lai CH, Tsai CN, Tsai CL 		Autophagy 2023
Revealing a Natural Model of Pre-Osteoarthritis of the Hip Through Study of Femoroacetabular Impingement
Pascual-Garrido C, Kikuchi K, Clohisy JC, O\u2019Keefe RJ, Kamenaga T 		HSS Journal 2023
Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
Wang Q, Su W, Liu J, Zhao D 		Medicine 2023
Antidepressants as Autophagy Modulators for Cancer Therapy
He L, Fu Y, Tian Y, Wang X, Zhou X, Ding RB, Qi X, Bao J 		Molecules (Basel, Switzerland) 2023
FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies
Wang W, Jiang K, Liu X, Li J, Zhou W, Wang C, Cui J, Liang T 		Frontiers in pharmacology 2023
Autophagy Modulation and Its Implications on Glioblastoma Treatment
Chen J, Rodriguez AS, Morales MA, Fang X 		Current issues in molecular biology 2023
Activation of Lysosomal Function Ameliorates Amyloid-β-Induced Tight Junction Disruption in the Retinal Pigment Epithelium
Jo DH, Lee SH, Jeon M, Cho CS, Kim DE, Kim H, Kim JH 		Molecules and Cells 2023
Causal influences of osteoarthritis on COVID-19: a Mendelian randomization study
Fu L, Baranova A, Cao H, Zhang F 		Frontiers in Medicine 2023
Vardenafil alleviates cigarette smoke-induced chronic obstructive pulmonary disease by activating autophagy via the AMPK/mTOR signalling pathway: an in vitro and in vivo study.
Li W, Yan J, Xu J, Zhu L, Zhai C, Wang Y, Wang Y, Feng Y, Cao H 		In vitro cellular & developmental biology. Animal 2023
The Role of Autophagy in Type 2 Diabetic Kidney Disease Management
Tseng CH, Shah KM, Chiu IJ, Hsiao LL 		Cells 2023
Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury.
Chu LK, Cao X, Wan L, Diao Q, Zhu Y, Kan Y, Ye LL, Mao YM, Dong XQ, Xiong QW, Fu MC, Zhang T, Zhou HT, Cai SZ, Ma ZR, Hsu SW, Wu R, Chen CH, Yan XM, Liu J 		Nature Communications 2023
Advances in the regulatory mechanisms of mTOR in necroptosis.
Xie Y, Zhao G, Lei X, Cui N, Wang H 		Frontiers in immunology 2023
Sinapic Acid Attenuates Chronic DSS-Induced Intestinal Fibrosis in C57BL/6J Mice by Modulating NLRP3 Inflammasome Activation and the Autophagy Pathway
Li WY, Liu JY, Wang ZX, Wang KY, Huang CX, He W, Song JL 		ACS Omega 2023
COPI Vesicle Disruption Inhibits Mineralization via mTORC1-Mediated Autophagy
Nie J, Ma S, Zhang Y, Yu S, Yang J, Li A, Pei D 		International journal of molecular sciences 2023
A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors
Sonis ST, Villa A 		Cancers 2023
Proteostasis in T cell aging
Gressler AE, Leng H, Zinecker H, Simon AK 		Seminars in Immunology 2023
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
Ryan CB, Choi JS, Kang B, Herr S, Pereira C, Moraes CT, Al-Ali H, Lee JK 		Neurobiology of Disease 2023
(−)‐Epigallocatechin gallate alleviates chronic unpredictable mild stress‐induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation
Zhang Y, Wu H, Xu C, Li S, Hu Y, Zhang Z, Wu G, Liu Y, Yang L, Huang Y, Lu W, Hu L 		Food Science & Nutrition 2023
Electroacupuncture pretreatment preserves telomerase reverse transcriptase function and alleviates postoperative cognitive dysfunction by suppressing oxidative stress and neuroinflammation in aged mice.
Wang W, Chen C, Wang Q, Ma JG, Li YS, Guan Z, Wang R, Chen X 		CNS Neuroscience & Therapeutics 2023
AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.
Zhu L, Wang J, Wu Z, Chen S, He Y, Jiang Y, Luo G, Wu Z, Li Y, Xie J, Zou S, Zhou C 		Cell Proliferation 2023
T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation
Li T, Sun W, Zhu S, He C, Chang T, Zhang J, Chen Y 		Advanced Science 2023
Treatment with Rapamycin in Animal Models of Traumatic Brain Injuries; a Systematic Review and Meta-Analysis.
Kiah M, Azimi A, Hajisoltani R, Yousefifard M 		Archives of academic emergency medicine 2023
β-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice
Chu Y, Hua Y, He L, He J, Chen Y, Yang J, Mahmoud I, Zeng F, Zeng X, Benavides GA, Darley-Usmar VM, Young ME, Ballinger SW, Prabhu SD, Zhang C, Xie M 		Journal of Molecular and Cellular Cardiology 2023
CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins
Hoenigsperger H, Koepke L, Acharya D, Hunszinger V, Freisem D, Grenzner A, Wiese S, Kirchhoff F, Gack MU, Sparrer KM 		Autophagy 2023
The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels
Zhao G, Lyu J, Huang X, Huang G, Chen F, Wei Y, Wang S, Xia J, Chen J, Shi J 		Archives of Medical Science : AMS 2023
Molecular mechanisms of autophagy and implications in liver diseases
Wu Y, Tan HW, Lin JY, Shen HM, Wang H, Lu G 		Liver Research 2023
Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through activation of autophagy and the aryl hydrocarbon receptor signaling pathway
Ge Peng, Saya Tsukamoto, Risa Ikutama, Hai Le Thanh Nguyen, Yoshie Umehara, Juan V. Trujillo-Paez, Hainan Yue, Miho Takahashi, Takasuke Ogawa, Ryoma Kishi, Mitsutoshi Tominaga, Kenji Takamori, Jiro Kitaura, Shun Kageyama, Masaaki Komatsu, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, François Niyonsaba 		Journal of Clinical Investigation 2022
A novel role of CRTC2 in promoting nonalcoholic fatty liver disease
HS Han, SG Kim, YS Kim, SH Jang, Y Kwon, D Choi, T Huh, E Moon, E Ahn, JK Seong, HS Kweon, GS Hwang, DH Lee, KW Cho, SH Koo 		Molecular Metabolism 2022
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Y Wu, S Shen, Y Shi, N Tian, Y Zhou, X Zhang 		Frontiers in Bioengineering and Biotechnology 2022
2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling
Y Wen, H Lin, J Lin, G Tseng, C Hwang, C Lin, C Hsu, H Wu 		International journal of molecular medicine 2022
Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives
S Eltayeb, G Ciarimboli, K Beul, G Marco, V Barz 		International journal of molecular sciences 2022
Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers
He L, Zhong Z, Chen M, Liang Q, Wang Y, Tan W 		Frontiers in pharmacology 2022
Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3
Wang T, Woodman P, Humphrey SJ, Petersen J 		Life science alliance 2022
Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells
Gupta S, Panda PK, Hashimoto RF, Samal SK, Mishra S, Verma SK, Mishra YK, Ahuja R 		Scientific Reports 2022
Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells
Amirkavei M, Plastino F, Kvanta A, Kaarniranta K, André H, Koskelainen A 		Cells 2022
Increased homocysteine regulated by androgen activates autophagy by suppressing the mammalian target of rapamycin pathway in the granulosa cells of polycystic ovary syndrome mice
Li T, Dong G, Kang Y, Zhang M, Sheng X, Wang Z, Liu Y, Kong N, Sun H 		Bioengineered 2022
Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer
Wu X, Sheng H, Zhao L, Jiang M, Lou H, Miao Y, Cheng N, Zhang W, Ding D, Li W 		Cell Death and Disease 2022
Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice
Xia Z, Gao M, Sheng P, Shen M, Zhao L, Gao L, Yan B 		International journal of molecular sciences 2022
Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K/AKT/mTOR Signaling Pathway in Developing Rat Ovaries
Jalouli M, Mofti A, Elnakady YA, Nahdi S, Feriani A, Alrezaki A, Sebei K, Bizzarri M, Alwasel S, Harrath AH 		International journal of molecular sciences 2022
Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model.
Gao J, Min F, Wang S, Lv H, Liang H, Cai B, Jia X, Gao Q, Yu Y 		Cardiovascular Therapeutics 2022
Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone.
Gheyas R, Ortega-Alvarez R, Chauss D, Kantorow M, Menko AS 		Experimental Cell Research 2022
Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell lines.
Li F, Deng Y, Zhang S, Zhu B, Wang J, Wang J, Wang X, Zhao Z, Deng W, Mao R, Shen Z, Chen J, Broering R, Lin Y, Lu M, Zhang J 		Emerging Microbes & Infections 2022
Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions.
Feng W, Argüello-Miranda O, Qian S, Wang F 		The Journal of Cell Biology 2022
Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids
Lee SH, Han JW, Yang JY, Jun HO, Bang JH, Shin H, Choi JH, Lee J, Madrakhimov SB, Chung KH, Chang HS, Lyu J, Park TK 		Cell Death Discovery 2022
Unraveling the Role of STK11/LKB1 in Non-small Cell Lung Cancer
Sumbly V, Landry I 		Cureus 2022
The Role of Macroautophagy and Chaperone-Mediated Autophagy in the Pathogenesis and Management of Hepatocellular Carcinoma
Karampa AD, Goussia AC, Glantzounis GK, Mastoridou EM, Anastasopoulos NA, Charchanti AV 		Cancers 2022
Metformin as a Potential Treatment Option for Endometriosis
Kimber-Trojnar Ż, Dłuski DF, Wierzchowska-Opoka M, Ruszała M, Leszczyńska-Gorzelak B 		Cancers 2022
Effect of FKBP12-Derived Intracellular Peptides on Rapamycin-Induced FKBP–FRB Interaction and Autophagy
Parada CA, de Oliveira IP, Gewehr MC, Machado-Neto JA, Lima K, Eichler RA, Lopes LR, Bechara LR, Ferreira JC, Festuccia WT, Censoni L, Tersariol IL, Ferro ES 		Cells 2022
The PI3K/AKT/mTOR signaling pathway is aberrantly activated in primary central nervous system lymphoma and correlated with a poor prognosis.
Zhang X, Wu Y, Sun X, Cui Q, Bai X, Dong G, Gao Z, Wang Y, Gao C, Sun S, Ji N, Liu Y 		BMC Cancer 2022
Sorafenib-Induced Autophagy Promotes Glycolysis by Upregulating the p62/HDAC6/HSP90 Axis in Hepatocellular Carcinoma Cells.
Yan X, Tian R, Sun J, Zhao Y, Liu B, Su J, Li M, Sun W, Xu X 		Frontiers in pharmacology 2022
The Mitochondrial Deubiquitinase USP30 Regulates AKT/mTOR Signaling.
Zhang R, Ozgen S, Luo H, Krigman J, Zhao Y, Xin G, Sun N 		Frontiers in pharmacology 2022
Identification of Prognostic Biomarkers in Patients With Malignant Rhabdoid Tumor of the Kidney Based on mTORC1 Signaling Pathway-Related Genes.
Zhanghuang C, Yao Z, Tang H, Zhang K, Wu C, Li L, Xie Y, Yang Z, Yan B 		Frontiers in Molecular Biosciences 2022
Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway.
Gong W, Liu M, Zhang Q, Zhang Q, Wang Y, Zhao Q, Xiang L, Zheng C, Zhang Q, Qin L 		Oxidative medicine and cellular longevity 2022
Copper-induced Genotoxicity, Oxidative Stress, and Alteration in Transcriptional Level of Autophagy-associated Genes in Snakehead Fish Channa punctatus.
Kumar M, Singh S, Dwivedi S, Trivedi A, Dubey I, Trivedi SP 		Biological Trace Element Research 2022
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats.
Sharma A, Bhalla S, Mehan S 		Metabolic Brain Disease 2022
Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity.
Ryczkowska M, Maciejewska N, Olszewski M, Witkowska M, Makowiec S 		Scientific Reports 2022
Autophagy inducer rapamycin treatment reduces IFN-I mediated Inflammation and improves anti-HIV-1 T Cell response in vivo
Wenli Mu, Valerie Rezek, Heather Martin, Mayra A. Carrillo, Shallu Tomer, Philip Hamid, Miguel A. Lizarraga, Otto O Yang, Beth D. Jamieson, Scott G. Kitchen, Anjie Zhen 		JCI Insight 2022
Analysis of miRNAs Involved in Mouse Heart Injury Upon Coxsackievirus A2 Infection
Wu Z, Zhu S, Qian J, Hu Y, Ji W, Li D, Zhu P, Liang R, Jin Y 		Frontiers in Cellular and Infection Microbiology 2022
Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier Formation
Wang J, Eming SA, Ding X 		Biology 2022
Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury.
Zhou Q, Doherty J, Akk A, Springer LE, Fan P, Spasojevic I, Halade GV, Yang H, Pham CTN, Wickline SA, Pan H 		2022
Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy.
Huan J, Grivas P, Birch J, Hansel DE 		Cancers 2022
Effects of Dietary Protein Level on the Microbial Composition and Metabolomic Profile in Postweaning Piglets.
Gao J, Liu Z, Wang C, Ma L, Chen Y, Li T 		Oxidative medicine and cellular longevity 2022
A Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas
Molinaro C, Wambang N, Bousquet T, Vercoutter-Edouart AS, Pélinski L, Cailliau K, Martoriati A 		Frontiers in Oncology 2022
Baicalin improves the functions of granulosa cells and the ovary in aged mice through the mTOR signaling pathway
Fan H, He J, Bai Y, He Q, Zhang T, Zhang J, Yang G, Xu Z, Hu J, Yao G 		Journal of Ovarian Research 2022
Liquiritigenin Inhibits Lipid Accumulation in 3T3-L1 Cells via mTOR-Mediated Regulation of the Autophagy Mechanism
Qin H, Song Z, Zhao C, Yang J, Xia F, Wang L, Ali A, Zheng W 		Nutrients 2022
FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
Shen W, Zhou Q, Peng C, Li J, Yuan Q, Zhu H, Zhao M, Jiang X, Liu W, Ren C 		Frontiers in Oncology 2022
F-box and WD repeat-containing protein 7 ameliorates angiotensin II-induced myocardial hypertrophic injury via the mTOR-mediated autophagy pathway
Liu Q, Han C, Wu X, Zhou J, Zang W 		Experimental and therapeutic medicine 2022
Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model.
Chin MY, Ang KH, Davies J, Alquezar C, Garda VG, Rooney B, Leng K, Kampmann M, Arkin MR, Kao AW 		ACS Chemical Neuroscience 2022
Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models.
Cocco S, Leone A, Roca MS, Lombardi R, Piezzo M, Caputo R, Ciardiello C, Costantini S, Bruzzese F, Sisalli MJ, Budillon A, De Laurentiis M 		Journal of Translational Medicine 2022
Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
Zhang Y, Sun T, Li M, Lin Y, Liu Y, Tang S, Dai C 		Antioxidants 2022
Roles of mTOR in the Regulation of Pancreatic β-Cell Mass and Insulin Secretion
Asahara SI, Inoue H, Watanabe H, Kido Y 		Biomolecules 2022
Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?
Vilar JB, Christmann M, Tomicic MT 		Cancers 2022
Ad-VT enhances the sensitivity of chemotherapy-resistant lung adenocarcinoma cells to gemcitabine and paclitaxel in vitro and in vivo.
Song G, Shang C, Sun L, Li Y, Zhu Y, Xiu Z, Liu Z, Li Y, Yang X, Ge C, Fang J, Jin N, Li X 		Investigational New Drugs 2022
High glucose represses the proliferation of tendon fibroblasts by inhibiting autophagy activation in tendon injury.
Song FC, Yuan JQ, Zhu MD, Li Q, Liu SH, Zhang L, Zhao C 		Bioscience Reports 2022
Repurposing Autophagy Regulators in Brain Tumors
Petrosyan E, Fares J, Cordero A, Rashidi A, Arrieta VA, Kanojia D, Lesniak MS 		International Journal of Cancer 2022
mTOR inhibition with sirolimus in multiple system atrophy: a randomized, double-blind, placebo-controlled futility trial and 1-year biomarker longitudinal analysis
Palma JA, Martinez J, Millar Vernetti P, Ma T, Perez MA, Zhong J, Qian Y, Dutta S, Maina KN, Siddique I, Bitan G, Ades-Aron B, Shepherd TM, Kang UJ, Kaufmann H 		Movement disorders : official journal of the Movement Disorder Society 2022
D-allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy
Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K 		Oncology reports 2022
Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases
Wan W, Hua F, Fang P, Li C, Deng F, Chen S, Ying J, Wang X 		Frontiers in aging neuroscience 2022
Autophagy Dysfunction as a Phenotypic Readout in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Diseases.
Sun C, Rosenstock TR, Cohen MA, Sarkar S 		Methods in molecular biology (Clifton, N.J.) 2022
mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes
Spitz D, Comas M, Gerstner L, Kayser S, Helmstädter M, Walz G, Hermle T 		Cells 2022
MRTF-A-mediated protection against amyloid-β-induced neuronal injury correlates with restoring autophagy via miR-1273g-3p/mTOR axis in Alzheimer models
Zhang W, Yang Y, Xiang Z, Cheng J, Yu Z, Wang W, Hu L, Ma F, Deng Y, Jin Z, Hu X 		Aging 2022
Multi-Omics Integration Analysis Identifies Lipid Disorder of a Non-Alcoholic Fatty Liver Disease (NAFLD) Mouse Model Improved by Zexie–Baizhu Decoction
Cao Y, Shi J, Song L, Xu J, Lu H, Sun J, Hou J, Chen J, Wu W, Gong L 		Frontiers in pharmacology 2022
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Lu G, Wang Y, Shi Y, Zhang Z, Huang C, He W, Wang C, Shen H 		2022
Protective effect of phillyrin against cerebral ischemia/reperfusion injury in rats and oxidative stress-induced cell apoptosis and autophagy in neurons
Chen S, Zhang S, Wu H, Zhang D, You G, You J, Zheng N 		Bioengineered 2022
Modulation of mTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation
Kaldirim M, Lang A, Pfeiler S, Fiegenbaum P, Kelm M, Bönner F, Gerdes N 		Frontiers in Cardiovascular Medicine 2022
Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy
Zhou J, Chen H, Du J, Tai H, Han X, Huang N, Wang X, Gong H, Yang M, Xiao H 		Frontiers in pharmacology 2022
Mesenchymal Stem Cells Alleviate Renal Fibrosis and Inhibit Autophagy via Exosome Transfer of miRNA-122a
Li D, Qu J, Yuan X, Zhuang S, Wu H, Chen R, Wu J, Zhang M, Ying L 		Stem Cells International 2022
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression
Xue WJ, He CF, Zhou RY, Xu XD, Xiang LX, Wang JT, Wang XR, Zhou HG, Guo JC 		Molecular brain 2022
mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling
Wang Y, Li Q, Zhang Z, Peng K, Zhang DM, Yang Q, Passerini AG, Simon SI, Sun C 		2022
Dapagliflozin Improves Diabetic Cardiomyopathy by Modulating the Akt/mTOR Signaling Pathway
Ren M, Pan D, Zha D, Shan Z 		BioMed Research International 2022
Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease
Zhou XG, Qiu WQ, Yu L, Pan R, Teng JF, Sang ZP, Law BY, Zhao Y, Zhang L, Yan L, Tang Y, Sun XL, Wong VK, Yu CL, Wu JM, Qin DL, Wu AG 		Ensho Saisei 2022
Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala
Zhang J, Liu D, Fu P, Liu ZQ, Lai C, Yang CQ, Chen K, Bao WD, Hu F, Du HY, Yang W, Wang J, Man HY, Lu Y, Zhu LQ 		Molecular Psychiatry 2022
Chrysin Induces Apoptosis and Autophagy in Human Melanoma Cells via the mTOR/S6K Pathway
Lee JH, Yoo ES, Han SH, Jung GH, Han EJ, Choi EY, Jeon SJ, Jung SH, Kim B, Cho SD, Nam JS, Choi C, Che JH, Jung JY 		Biomedicines 2022
A Quassinoid Diterpenoid Eurycomanone from Eurycoma longifolia Jack Exerts Anti-Cancer Effect through Autophagy Inhibition
Ye G, Xu M, Shu Y, Sun X, Mai Y, Hong Y, Zhang J, Tian J 		Molecules (Basel, Switzerland) 2022
Therapeutic Mechanisms of Berberine to Improve the Intestinal Barrier Function via Modulating Gut Microbiota, TLR4/NF-κ B/MTORC Pathway and Autophagy in Cats
Cao J, Chen M, Xu R, Guo M 		Frontiers in microbiology 2022
Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19
Yong YY, Zhang L, Hu YJ, Wu JM, Yan L, Pan YR, Tang Y, Yu L, Law BY, Yu CL, Zhou J, Li M, Qin DL, Zhou XG, Wu AG 		Clinical Immunology 2022
The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved
Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M 		Cells 2022
Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
Noh SH, Kim YJ, Lee MG 		Frontiers in Cell and Developmental Biology 2022
Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome
Noh B, McCullough LD, Moruno-Manchon JF 		Neural Regeneration Research 2022
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Qin C, Yang S, Chu YH, Zhang H, Pang XW, Chen L, Zhou LQ, Chen M, Tian DS, Wang W 		Signal Transduction and Targeted Therapy 2022
Target of Rapamycin Signaling Involved in the Regulation of Photosynthesis and Cellular Metabolism in Chlorella sorokiniana
Li L, Zhu T, Huang L, Ren M 		International journal of molecular sciences 2022
A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux.
Guo H, Wei D, Liu R, Zhang C, Jiang S, Wang W, Hu H, Shen L, Liang X 		Journal of Physiology and Biochemistry 2022
Antitumor Activity of Chitosan-Coated Iron Oxide Nanocomposite Against Hepatocellular Carcinoma in Animal Models.
Badawy MMM, Abdel-Hamid GR, Mohamed HE 		Biological Trace Element Research 2022
Zinc Deficiency Induces Autophagy in HT-22 Mouse Hippocampal Neuronal Cell Line.
Kim SY, Lee JH, Kim SA 		International journal of molecular sciences 2022
Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway.
Chong CM, Tan Y, Tong J, Ke M, Zhang K, Yan L, Cen X, Lu JH, Chen G, Su H, Qin D 		Cell & Bioscience 2022
Nanoparticle Internalization Promotes the Survival of Primary Macrophages
Jarai BM, Fromen CA 		2022
Ferroptosis in sepsis: The mechanism, the role and the therapeutic potential
XL L, GY Z, R G, N C 		Frontiers in immunology 2022
Research progress on the relationship between autophagy and chronic complications of diabetes
Ge X, Wang L, Fei A, Ye S, Zhang Q 		Frontiers in physiology 2022
PD-L1 maintains neutrophil extracellular traps release by inhibiting neutrophil autophagy in endotoxin-induced lung injury
Zhu CL, Xie J, Zhao ZZ, Li P, Liu Q, Guo Y, Meng Y, Wan XJ, Bian JJ, Deng XM, Wang JF 		Frontiers in immunology 2022
Overview of Research into mTOR Inhibitors
Mao B, Zhang Q, Ma L, Zhao DS, Zhao P, Yan P 		Molecules (Basel, Switzerland) 2022
Role of PI3K/Akt/mTOR pathway in mediating endocrine resistance: concept to clinic
Skolariki A, D\u2019Costa J, Little M, Lord S 		2022
Impact of Omega-3 Fatty Acids Nano-Formulation on Growth, Antioxidant Potential, Fillet Quality, Immunity, Autophagy-Related Genes and Aeromonas hydrophila Resistance in Nile Tilapia (Oreochromis niloticus)
Ibrahim D, Arisha AH, Khater SI, Gad WM, Hassan Z, Abou-Khadra SH, Mohamed DI, Ahmed Ismail T, Gad SA, Eid SA, Abd El-Wahab RA, Kishawy AT 		Antioxidants 2022
Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity—An Update
Andrei EC, Baniță IM, Munteanu MC, Busuioc CJ, Mateescu GO, Mălin RD, Pisoschi CG 		Medicina 2022
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy
Han C, Qian X, Ren X, Zhang S, Hu L, Li J, Huang Y, Huang R, Ooi K, Lin H, Xia C 		Molecular Neurobiology 2022
Altered transcriptional levels of autophagy-related genes, induced by oxidative stress in fish Channa punctatus exposed to chromium.
Kumar M, Singh S, Dwivedi S, Dubey I, Trivedi SP 		Fish Physiology and Biochemistry 2022
Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy
Di Lorenzo G, Iavarone F, Maddaluno M, Plata-Gómez AB, Aureli S, Quezada Meza CP, Cinque L, Palma A, Reggio A, Cirillo C, Sacco F, Stolz A, Napolitano G, Marin O, Pinna LA, Ruzzene M, Limongelli V, Efeyan A, Grumati P, Settembre C 		Science Advances 2022
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression
Hou T, Dan W, Liu T, Liu B, Wei Y, Yue C, Que T, Ma B, Lei Y, Wang Z, Zeng J, Fan Y, Li L 		Cell Death and Disease 2022
The progress and prospect of natural components in rhubarb (Rheum ribes L.) in the treatment of renal fibrosis
Wang Y, Yu F, Li A, He Z, Qu C, He C, Ma X, Zhan H 		Frontiers in pharmacology 2022
The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
Yuan Y, Zhang X, Fan X, Peng Y, Jin Z 		Cell Death Discovery 2022
An autophagy-associated lncRNAs model for predicting the survival in non-small cell lung cancer patients
Hu J, Zhang PJ, Zhang D, Chen ZH, Cao XC, Yu Y, Ge J 		Frontiers in Genetics 2022
White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp
Hong PP, Li C, Niu GJ, Zhao XF, Wang JX 		PLoS pathogens 2022
Downregulation of fibulin‐4 inhibits autophagy and promotes the sensitivity of esophageal squamous cell carcinoma cells to apatinib by activating the Akt‐mTOR signaling pathway
Chen X, Wang J, Song L, Yu Y, Shi M, Jiang W, Liu X, He X 		Thoracic Cancer 2022
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway
Lin Y, Zhang Q, Xie B, Jiang H, Shen J, Tang S, Dai C 		Antioxidants 2022
Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome
Hong S, Ghandriz R, Siddiqi S, Zhu XY, Saadiq IM, Jordan KL, Tang H, Ali KA, Lerman A, Eirin A, Lerman LO 		Cells 2022
Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway
Zapevalova MV, Shchegravina ES, Fonareva IP, Salnikova DI, Sorokin DV, Scherbakov AM, Maleev AA, Ignatov SK, Grishin ID, Kuimov AN, Konovalova MV, Svirshchevskaya EV, Fedorov AY 		International journal of molecular sciences 2022
Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy
Liu X, Hussain R, Mehmood K, Tang Z, Zhang H, Li Y 		BioMed Research International 2022
Histocompatibility Minor 13 (HM13), targeted by miR-760, exerts oncogenic role in breast cancer by suppressing autophagy and activating PI3K-AKT-mTOR pathway
Yang H, Li Z, Wang Z, Zhang X, Dai X, Zhou G, Ding Q 		Cell Death and Disease 2022
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine
Wang X, Hua P, He C, Chen M 		Acta pharmaceutica Sinica. B 2022
Snake venom induces an autophagic cell death via activation of the JNK pathway in colorectal cancer cells
Yu JE, Yeo IJ, Lee DW, Chang JY, Son DJ, Yun J, Han SB, Hong JT 		Journal of Cancer 2022
Assessment of mitophagy in human iPSC-derived cardiomyocytes
Yang M, Fu JD, Zou J, Sridharan D, Zhao MT, Singh H, Krigman J, Khan M, Xin G, Sun N 		Autophagy 2022
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions
Zhou Z, Wang H, Zhang X, Song M, Yao S, Jiang P, Liu D, Wang Z, Lv H, Li R, Hong Y, Dai J, Hu Y, Zhao G 		Autophagy 2022
Lead Exposure Induced Neural Stem Cells Death via Notch Signaling Pathway and Gut-Brain Axis
Sun L, Zou Y, Su P, Xue C, Wang D, Zhao F, Luo W, Zhang J 		Oxidative medicine and cellular longevity 2022
Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells
Li JK, Sun HT, Jiang XL, Chen YF, Zhang Z, Wang Y, Chen WQ, Zhang Z, Sze SC, Zhu PL, Yung KK 		International journal of molecular sciences 2022
6,6′-((Methylazanedyl)bis(methylene))bis(2,4-dimethylphenol) Induces Autophagic Associated Cell Death through mTOR-Mediated Autophagy in Lung Cancer
Sriratanasak N, Wattanathana W, Chanvorachote P 		Molecules (Basel, Switzerland) 2022
Autophagy plays an essential role in ultraviolet radiation-driven skin photoaging
Ma J, Teng Y, Huang Y, Tao X, Fan Y 		Frontiers in pharmacology 2022
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress.
Shrestha S, Erikson G, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Dos Santos C, Shokhirev M, Cartailler JP, Hetzer MW, MacDonald PE, Arrojo E Drigo R 		Science Advances 2022
The emerging role of autophagy and mitophagy in tauopathies: From pathogenesis to translational implications in Alzheimer's disease.
Liu X, Ye M, Ma L 		Frontiers in aging neuroscience 2022
The natural medicinal fungus Huaier promotes the anti-hepatoma efficacy of sorafenib through the mammalian target of rapamycin-mediated autophagic cell death.
Zhang Z, Shen C, Zhou F 		Medical Oncology 2022
Motor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice.
Zhong K, Huang Y, Zilundu PLM, Wang Y, Zhou Y, Yu G, Fu R, Chung SK, Tang Y, Cheng X, Zhou L 		Journal of Neuroinflammation 2022
FIP200 Methylation by SETD2 Prevents Trim21-Induced Degradation and Preserves Autophagy Initiation
Dai Y, Luo W, Li W, Chen Z, Wang X, Chang J 		Cells 2022
Exploring the Interactive Effects of Thymol and Thymoquinone: Moving towards an Enhanced Performance, Gross Margin, Immunity and Aeromonas sobria Resistance of Nile Tilapia (Oreochromis niloticus)
Ibrahim D, Shahin SE, Alqahtani LS, Hassan Z, Althobaiti F, Albogami S, Soliman MM, El-Malt RM, Al-Harthi HF, Alqadri N, Elabbasy MT, El-Hamid MI 		2022
Hallmarks of neurodegenerative disease: A systems pharmacology perspective
Bloomingdale P, Karelina T, Ramakrishnan V, Bakshi S, Véronneau\u2010Veilleux F, Moye M, Sekiguchi K, Meno\u2010Tetang G, Mohan A, Maithreye R, Thomas VA, Gibbons F, Cabal A, Bouteiller J, Geerts H 		The Journal of Pathology 2022
Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies
Izuegbuna OO 		Frontiers in Nutrition 2022
Mycobacterium tuberculosis: Implications of Ageing on Infection and Maintaining Protection in the Elderly
Bonavida V, Frame M, Nguyen KH, Rajurkar S, Venketaraman V 		Human vaccines 2022
Non-alcoholic fatty liver disease and liver secretome
Khan MS, Lee C, Kim SG 		Archives of Pharmacal Research 2022
Fine-Tuning of mTORC1-ULK1-PP2A Regulatory Triangle Is Crucial for Robust Autophagic Response upon Cellular Stress
Hajdú B, Holczer M, Horváth G, Szederkényi G, Kapuy O 		Biomolecules 2022
Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS
Martins AF, Neto AC, Rodrigues AR, Oliveira SM, Sousa-Mendes C, Leite-Moreira A, Gouveia AM, Almeida H, Neves D 		Biomedicines 2022
Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling and Mitochondrial Dysfunction
Sharma S, Sharma P, Bailey T, Bhattarai S, Subedi U, Miller C, Ara H, Kidambi S, Sun H, Panchatcharam M, Miriyala S 		Biomolecules 2022
Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy
Yang H, Xu S, Tang L, Gong J, Fang H, Wei J, Su D 		Frontiers in pharmacology 2022
miRNA–mRNA–protein dysregulated network in COPD in women
Li CX, Gao J, Sköld CM, Wheelock ÅM 		Frontiers in Genetics 2022
Modulating autophagy and mitophagy as a promising therapeutic approach in neurodegenerative disorders
Mishra J, Bhatti GK, Sehrawat A, Singh C, Singh A, Reddy AP, Reddy PH, Bhatti JS 		Life Sciences 2022
The role of SIRT1 in the process of Toxoplasma gondii infection of RAW 264.7 macrophages
Dong K, Jiang Z, Zhang J, Qin H, Chen J, Chen Q 		Frontiers in microbiology 2022
Cirsilineol Treatment Attenuates PM2.5-Induced Lung Injury in Mice
Kim C, Kim GO, Bae JS 		International journal of molecular sciences 2022
A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion
Tang Y, Xie J, Chen X, Sun L, Xu L, Chen X 		Frontiers in neuroscience 2022
Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells
Hernandez A, Sonavane M, Smith KR, Seiger J, Migaud ME, Gassman NR 		PloS one 2022
Autophagy: A Double-Edged Sword in Male Reproduction
Yan Q, Zhang Y, Wang Q, Yuan L 		International journal of molecular sciences 2022
Analysis of shared underlying mechanism in neurodegenerative disease
Butler R, Bradford D, Rodgers KE 		Frontiers in aging neuroscience 2022
Regulation of programmed cell death by Brd4
Hu J, Pan D, Li G, Chen K, Hu X 		Cell Death and Disease 2022
Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate.
Maheshwari M, Yadav N, Hasanain M, Pandey P, Sahai R, Choyal K, Singh A, Nengroo MA, Saini KK, Kumar D, Mitra K, Datta D, Sarkar J 		Cell Death and Disease 2022
Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
Lashgari NA, Roudsari NM, Zadeh SS, Momtaz S, Abbasifard M, Reiner Ž, Abdolghaffari AH, Sahebkar A 		InflammoPharmacology 2022
Overexpression of LINC00551 promotes autophagy-dependent ferroptosis of lung adenocarcinoma via upregulating DDIT4 by sponging miR-4328
Peng X, Yang R, Peng W, Zhao Z, Tu G, He B, Cai Q, Shi S, Yin W, Yu F, Tao Y, Wang X 		PeerJ 2022
The clinicopathological and prognostic significance of mTOR and p-mTOR expression in patients with non-small cell lung cancer: A meta-analysis
Qiu W, Ren M, Wang C, Fu Y, Liu Y 		Medicine 2022
Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells
Qu N, Qu J, Huang N, Zhang K, Ye T, Shi J, Chen B, Kan C, Zhang J, Han F, Hou N, Sun X, Pan R 		Frontiers in pharmacology 2022
Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration.
Chen HW, Zhou JW, Zhang GZ, Luo ZB, Li L, Kang XW 		Cell Proliferation 2022
Acupuncture promotes nerve repair through the benign regulation of mTOR-mediated neuronal autophagy in traumatic brain injury rats.
Zhao S, Wang S, Cao L, Zeng H, Lin S, Lin Z, Chen M, Zhu M, Pang Z, Zhang Y 		CNS Neuroscience & Therapeutics 2022
Redox Regulation of Autophagy in Cancer: Mechanism, Prevention and Therapy.
He J, Dong L, Luo L, Wang K 		2022
Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming
Wang D, Gu X, Ma X, Chen J, Zhang Q, Yu Z, Li J, Hu M, Tan X, Tang Y, Xu J, Xu M, Song Q, Song H, Jiang G, Tang Z, Gao X, Chen H 		Acta pharmaceutica Sinica. B 2022
Subversion of autophagy machinery and organelle-specific autophagy by SARS-CoV-2 and coronaviruses
Sun Q, Li X, Kuang E 		Autophagy 2022
Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective
Elshazly AM, Wright PA, Xu J, Gewirtz DA 		2022
Molecular mechanism underlying impaired hepatic autophagy in glycogen storage disease type Ib
Gautam S, Zhang L, Lee C, Arnaoutova I, Chen HD, Resaz R, Eva A, Mansfield BC, Chou JY 		Human Molecular Genetics 2022
Targeted Protein Degradation via Lysosomes
Paudel RR, Lu D, Chowdhury SR, Monroy EY, Wang J 		Biochemistry 2022
Protective role of autophagy in triptolide-induced apoptosis of TM3 Leydig cells.
Ye X, Chen L 		Journal of Translational Internal Medicine 2022
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation
Gao J, Zheng M, Wu X, Zhang H, Su H, Dang Y, Ma M, Wang F, Xu J, Chen L, Liu T, Chen J, Zhang F, Yang L, Xu Q, Hu X, Wang H, Fei Y, Chen C, Liu H 		EMBO reports 2022
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes
HJ Kim, YH Han, JY Kim, MO Lee 		Hepatology Communications 2021
Role and mechanisms of autophagy in lung metabolism and repair
X Li, F Zhao, A Wang, P Cheng, H Chen 		Cellular and Molecular Life Sciences 2021
The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration
M Gunawan, C Low, K Neo, S Yeo, C Ho, VA Barathi, AS Chan, NA Sharif, M Kageyama 		International journal of molecular sciences 2021
Targeting autophagy in disease: established and new strategies
M Kocak, SE Erdi, G Jorba, I Maestro, J Farrés, V Kirkin, A Martinez, O Pless 		Autophagy 2021
Autophagy Paradox of Cancer: Role, Regulation, and Duality
AK Verma, PS Bharti, S Rafat, D Bhatt, Y Goyal, KK Pandey, S Ranjan, SA Almatroodi, MA Alsahli, AH Rahmani, A Almatroudi, K Dev, MC Albertini 		Oxidative Medicine & Cellular Longevity 2021
Autophagy in Viral Development and Progression of Cancer
A Suares, MV Medina, O Coso 		Frontiers in Oncology 2021
Autophagy and tumorigenesis
M Rangel, J Kong, V Bhatt, K Khayati, J Guo 		The FEBS journal 2021
Understanding Host Immunity and the Gut Microbiota Inspires the New Development of Vaccines and Adjuvants
K Yakabe, J Uchiyama, M Akiyama, YG Kim 		Pharmaceutics 2021
Sirt1 coordinates with ERα to regulate autophagy and adiposity
Z Tao, L Shi, J Parke, L Zheng, W Gu, XC Dong, D Liu, Z Wang, AF Olumi, Z Cheng 		Cell Death Discovery 2021
Pharmacological insights into autophagy modulation in autoimmune diseases
MY Wu, EJ Wang, D Feng, M Li, RD Ye, JH Lu 		Acta pharmaceutica Sinica. B 2021
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth
Z Deng, X Li, MB Ramirez, K Purtell, I Choi, JH Lu, Q Yu, Z Yue 		Proceedings of the National Academy of Sciences 2021
Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities
X Sun, MW Feinberg 		Frontiers in physiology 2021
Melatonin and its protective role in attenuating warm or cold hepatic ischaemia/reperfusion injury
C Hu, L Zhao, F Zhang, L Li 		Cell Proliferation 2021
The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule
M Figueiredo, A Daryadel, G Sihn, DN Müller, E Popova, A Rouselle, G Nguyen, M Bader, CA Wagner 		Pflügers Archiv - European Journal of Physiology 2021
Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions
CD Gonzalez, MP Negueruela, CN Santamarina, R Resnik, MI Vaccaro 		Cells 2021
Involvement of Autophagy in Ageing and Chronic Cholestatic Diseases
C Pinto, E Ninfole, A Benedetti, M Marzioni, L Maroni 		Cells 2021
Activation of mTORC1 by Free Fatty Acids Suppresses LAMP2 and Autophagy Function via ER Stress in Alcohol-Related Liver Disease
W Guo, W Zhong, L Hao, X Sun, Z Zhou 		Cells 2021
Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders
T Rana, T Behl, A Sehgal, V Mehta, S Singh, S Bhatia, A Al-Harrasi, S Bungau 		Molecular Neurobiology 2021
Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer
YZ Wang, N Wu, N Jiang 		Cell Death and Disease 2021
Podocyte Autophagy in Homeostasis and Disease
Q Lin, K Banu, Z Ni, JS Leventhal, MC Menon 		Journal of Clinical Medicine 2021
m 6 A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin
D Liang, WJ Lin, M Ren, J Qiu, C Yang, X Wang, N Li, T Zeng, K Sun, L You, L Yan, W Wang 		Autophagy 2021
Cancer-Associated Fibroblasts Regulate Bladder Cancer Invasion and Metabolic Phenotypes through Autophagy
D Dong, Y Yao, J Song, L Sun, G Zhang, H Himmerich 		Disease Markers 2021
Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy
Y Li, C Wang, T Xu, P Pan, Q Yu, L Xu, X Xiong, T Hou, S Cui, Y Sun 		Acta pharmaceutica Sinica. B 2021
Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure
O Hahad, K Frenis, M Kuntic, A Daiber, T Münzel 		International journal of molecular sciences 2021
MTORC1 inhibition drives crinophagic degradation of glucagon
S Rajak, S Xie, A Tewari, S Raza, Y Wu, BH Bay, PM Yen, RA Sinha 		Molecular Metabolism 2021
Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer
AA Al-Bari, Y Ito, S Ahmed, N Radwan, HS Ahmed, N Eid 		International journal of molecular sciences 2021
Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds
L Marx-Blümel, C Marx, J Sonnemann, F Weise, J Hampl, J Frey, L Rothenburger, E Cirri, N Rahnis, P Koch, M Groth, A Schober, ZQ Wang, JF Beck 		Scientific Reports 2021
A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
P Mosaddeghi, M Eslami, M Farahmandnejad, M Akhavein, R Ranjbarfarrokhi, M Khorraminejad-Shirazi, F Shahabinezhad, M Taghipour, M Dorvash, A Sakhteman, MM Zarshenas, N Nezafat, M Mobasheri, Y Ghasemi 		Scientific Reports 2021
Autophagy and the hallmarks of aging
S Kaushik, I Tasset, E Arias, O Pampliega, E Wong, M Martinez-Vicente, AM Cuervo 		Ageing Research Reviews 2021
Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals
J Kacprzyk, AG Locatelli, GM Hughes, Z Huang, M Clarke, V Gorbunova, C Sacchi, GS Stewart, EC Teeling 		Aging 2021
Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19
GJ da Silva Pereira, AH Leão, AG Erustes, IB de Melo Morais, TA de Moraes Vrechi, L dos Santos Zamarioli, CA Pereira, L de Oliveira Marchioro, LP Sperandio, ÍV Lins, M Piacentini, GM Fimia, P Reckziegel, SS Smaili, C Bincoletto 		International journal of molecular sciences 2021
Sorafenib prevents the proliferation and induces the apoptosis of liver cancer cells by regulating autophagy and hypoxia-inducible factor-1
Q Yang, L Gao, X Huang, J Weng, Y Chen, S Lin, Q Yin 		Experimental and therapeutic medicine 2021
Anticancer Mechanism of Curcumin on Human Glioblastoma
SC Wong, MN Kamarudin, R Naidu 		Nutrients 2021
Novel Therapies for Parkinsonian Syndromes–Recent Progress and Future Perspectives
D Przewodowska, W Marzec, N Madetko 		Frontiers in molecular neuroscience 2021
Advances in Cancer Treatment by Targeting the Neddylation Pathway
W Gai, Z Peng, CH Liu, L Zhang, H Jiang 		Frontiers in Cell and Developmental Biology 2021
Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises
CS Lei, HJ Kung, JW Shih 		International journal of molecular sciences 2021
CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-κB Pathways
L Liu, Y Wang, C Geng, A Wang, S Han, X You, Y Sun, J Zhang, W Lu, Y Zhang 		Frontiers in Oncology 2021
Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy
R Smyth, S Berton, N Rajabalee, T Chan, J Sun 		Frontiers in microbiology 2021
Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3γ-mediated autophagy augmentation
Y Qiao, L Wang, T Hu, D Yin, H He, M He 		Frontiers in pharmacology 2021
Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue
WW Yau, KA Wong, J Zhou, NK Thimmukonda, Y Wu, BH Bay, BK Singh, PM Yen 		iScience 2021
GnRHa protects the ovarian reserve by reducing endoplasmic reticulum stress during cyclophosphamide-based chemotherapy
X Li, S Liu, X Chen, R Huang, L Ma, H Weng, Y Yu, X Zong 		npj Breast Cancer 2021
Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
L Li, Q Li, W Huang, Y Han, H Tan, M An, Q Xiang, R Zhou, L Yang, Y Cheng 		Frontiers in pharmacology 2021
Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy
D Nie, J Zhang, Y Zhou, J Sun, W Wang, JH Wang, M Maioli 		Stem Cells International 2021
Novel Applications of NSAIDs: Insight and Future Perspectives in Cardiovascular, Neurodegenerative, Diabetes and Cancer Disease Therapy
E Kaduševičius 		International journal of molecular sciences 2021
Activation of Autophagy Ameliorates Age-Related Neurogenesis Decline and Neurodysfunction in Adult Mice
N Yang, X Liu, X Niu, X Wang, R Jiang, N Yuan, J Wang, C Zhang, KL Lim, L Lu 		Stem Cell Reviews and Reports 2021
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation
Y Xu, X Hu, F Li, H Zhang, J Lou, X Wang, H Wang, L Yin, W Ni, J Kong, X Wang, Y Li, K Zhou, H Xu, X Ke 		Oxidative Medicine & Cellular Longevity 2021
Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells
G Li, C Zhang, W Liang, Y Zhang, Y Shen, X Tian 		Pharmaceutical Biology 2021
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
JH Lee, SY Lin, JW Liu, SZ Lin, HJ Harn, TW Chiou 		International journal of molecular sciences 2021
Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer
Y Xiao, L Jin, C Deng, Y Guan, E Kalogera, U Ray, P Thirusangu, J Staub, SS Bhattacharya, H Xu, X Fang, V Shridhar 		Oncogene 2021
Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration
IV Saltykova, A Elahi, PM Pitale, OS Gorbatyuk, M Athar, MS Gorbatyuk 		Cell Death and Disease 2021
IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination
Q Bie, H Song, X Chen, X Yang, S Shi, L Zhang, R Zhao, L Wei, B Zhang, H Xiong, B Zhang 		Oncogene 2021
Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response
I Vargova, LM Urdzikova, K Karova, B Smejkalova, T Sursal, V Cimermanova, K Turnovcova, CD Gandhi, M Jhanwar-Uniyal, P Jendelova 		Biomedicines 2021
Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body
W Chen, W Xiao, X Liu, P Yuan, S Zhang, Y Wang, W Wu 		Bioactive Materials 2021
Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity
X Zhou, X Zhu, C Li, Y Li, Z Ye, VS Shapiro, JA Copland, T Hitosugi, DA Bernlohr, J Sun, H Zeng 		Cell Reports 2021
Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan
C Geier, A Perl 		Autoimmunity Reviews 2021
Sestrins in Physiological Stress Responses
M Kim, AH Kowalsky, JH Lee 		Annual Review of Physiology 2021
Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice
A Jeong, S Cheng, R Zhong, DA Bennett, MO Bergö, L Li 		Acta Neuropathologica Communications 2021
Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?
M Ala, M Ala 		2021
Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy
, R Lu, J Chen, J Wang, HM Qian, G Chen, RH Wu, ZL Chi 		Frontiers in neuroscience 2021
Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture
N Kaplan, S Wang, J Wang, W Yang, R Ventrella, A Majekodunmi, B White, S Getsios, B Mitchell, H Peng, R Lavker 		The ocular surface 2021
Autophagy: a multifaceted player in the fate of sperm
M Wang, L Zeng, P Su, L Ma, M Zhang, Y zhen Zhang 		Human Reproduction Update 2021
Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path
E Iessi, R Vona, C Cittadini, P Matarrese 		Biomedicines 2021
Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins
GS Coombs, JL Rios-Monterrosa, S Lai, Q Dai, AC Goll, MR Ketterer, MF Valdes, N Uche, IJ Benjamin, LL Wallrath 		Redox Biology 2021
Tumor metastasis: Mechanistic insights and therapeutic interventions
M Liu, J Yang, B Xu, X Zhang 		2021
Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells
Zhang X, Rodriguez-Niño A, Pastene DO, Pallavi P, van den Born J, Bakker SJ, Krämer BK, Yard BA 		Scientific Reports 2021
Rapamycin protects against aristolochic acid nephropathy in mice by potentiating mammalian target of rapamycin-mediated autophagy
Lin F, Liu Y, Tang L, Xu X, Zhang X, Song Y, Chen B, Ren Y, Yang X 		Molecular medicine reports 2021
Cisplatin and Pemetrexed Have Distinctive Growth-inhibitory Effects in Monotherapy and Combination Therapy on KRAS-dependent A549 Lung Cancer Cells
MOHIUDDIN M, KASAHARA K 		Cancer genomics & proteomics 2021
Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma
He L, Jiang H, Lai Z, Zhong Z, Huang Z 		BMC Cancer 2021
The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised
Montella-Manuel S, Pujol-Carrion N, de la Torre-Ruiz MA 		Journal of Fungi 2021
Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy
Peng X, Zhang S, Jiao W, Zhong Z, Yang Y, Claret FX, Elkabets M, Wang F, Wang R, Zhong Y, Chen ZS, Kong D 		Journal of experimental & clinical cancer research : CR 2021
BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism.
Luo L, Sun W, Zhu W, Li S, Zhang W, Xu X, Fang D, Grahn THM, Jiang L, Zheng Y 		Cell Death and Disease 2021
Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics.
Parate S, Kumar V, Lee G, Rampogu S, Hong JC, Lee KW 		Pharmaceuticals (Basel, Switzerland) 2021
Autophagy is involved in neurofibromatosis type I gene-modulated osteogenic differentiation in human bone mesenchymal stem cells
Li Y, Zhu M, Lin X, Li J, Yuan Z, Liu Y, Xu H 		Experimental and therapeutic medicine 2021
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes
Majumder P, Chanda K, Das D, Singh BK, Chakrabarti P, Jana NR, Mukhopadhyay D 		Biochemical Journal 2021
UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma
Zhang M, Chen H, Qin P, Cai T, Li L, Chen R, Liu S, Chen H, Lin W, Chen H, Strickland AL, Xiong H, Jiang Q 		Aging 2021
Oxidative Stress Promotes Instability of Regulatory T Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Shimojima Y, Kishida D, Ichikawa T, Takamatsu R, Nomura S, Sekijima Y 		Frontiers in immunology 2021
Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells
Waetzig R, Matthes M, Leister J, Penkivech G, Heise T, Corbacioglu S, Sommer G 		International journal of medical sciences 2021
Identification and Validation of Six Autophagy-related Long Non-coding RNAs as Prognostic Signature in Colorectal Cancer
Cheng L, Han T, Zhang Z, Yi P, Zhang C, Zhang S, Peng W 		International journal of medical sciences 2021
Protective Mechanism of Berberine on Human Retinal Pigment Epithelial Cells against Apoptosis Induced by Hydrogen Peroxide via the Stimulation of Autophagy
Li S, Jiang Y, Xing X, Lin R, Li Q, Zhou W, Qiu W, Zheng W 		Oxidative medicine and cellular longevity 2021
Macroautophagy and aging: The impact of cellular recycling on health and longevity
Nieto-Torres JL, Hansen M 		Molecular Aspects of Medicine 2021
AMPK-Mediated Metabolic Switching Is High Effective for Phytochemical Levo-Tetrahydropalmatine (l-THP) to Reduce Hepatocellular Carcinoma Tumor Growth
Yin X, Li W, Zhang J, Zhao W, Cai H, Zhang C, Liu Z, Guo Y, Wang J 		Metabolites 2021
Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications.
Ristic B, Harhaji-Trajkovic L, Bosnjak M, Dakic I, Mijatovic S, Trajkovic V 		Cancers 2021
Modulation of the mTOR pathway plays a central role in dendritic cell functions after Echinococcus granulosus antigen recognition.
Rodriguez Rodrigues C, Nicolao MC, Chop M, Plá N, Massaro M, Loos J, Cumino AC 		Scientific Reports 2021
The Impact of SARS-CoV-2 Infection, and Application of Immunosuppressive Agents in Kidney Transplant Recipients Suffering from COVID-19.
Tseng HT, Wu XC, Huang CY, Shih CM, Lin YW, Lin FY 		Pharmaceuticals (Basel, Switzerland) 2021
Role of the Transcriptional Repressor Zinc Finger with KRAB and SCAN Domains 3 (ZKSCAN3) in Retinal Pigment Epithelial Cells.
Pan HY, Valapala M 		Cells 2021
IL-36α and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling.
Al-Luhaibi ZII, Dernovics Á, Seprényi G, Ayaydin F, Boldogkői Z, Veréb Z, Megyeri K 		Biomedicines 2021
Crosstalk between autophagy and microbiota in cancer progression.
Wang Y, Du J, Wu X, Abdelrehem A, Ren Y, Liu C, Zhou X, Wang S 		Molecular Cancer 2021
A recombinant Chinese measles virus vaccine strain rMV-Hu191 inhibits human colorectal cancer growth through inducing autophagy and apoptosis regulating by PI3K/AKT pathway
Zhang CD, Wang YL, Zhou DM, Zhu MY, Lv Y, Hao XQ, Qu CF, Chen Y, Gu WZ, Wu BQ, Chen PC, Zhao ZY 		Translational oncology 2021
Fluorescent Protein-Based Autophagy Biosensors
Kim H, Seong J 		Materials 2021
Resveratrol protects intestinal epithelial cells against radiation-induced damage by promoting autophagy and inhibiting apoptosis through SIRT1 activation
Qin H, Zhang H, Zhang X, Zhang S, Zhu S, Wang H 		Journal of Radiation Research 2021
Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish
Ping X, Liang J, Shi K, Bao J, Wu J, Yu X, Tang X, Zou J, Shentu X 		Autophagy 2021
MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B
Zhang Y, Ding Y, Li M, Yuan J, Yu Y, Bi X, Hong H, Ye J, Liu P 		Acta pharmaceutica Sinica. B 2021
Moxibustion Improves Chronic Heart Failure by Inhibiting Autophagy and Inflammation via Upregulation of mTOR Expression.
Li Q, Wang W, Ma Q, Xia R, Gao B, Zhu G, Wang J 		Evidence-based complementary and alternative medicine : eCAM 2021
REDD1 (regulated in development and DNA damage-1)/autophagy inhibition ameliorates fine particulate matter (PM2.5) -induced inflammation and apoptosis in BEAS-2B cells.
Li Y, Xu X, Wang L, Li X, Liu R, Zhang L, Xu Y 		Bioengineered 2021
E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer
Li H, Zhao S, Shen L, Wang P, Liu S, Ma Y, Liang Z, Wang G, Lv J, Qiu W 		Aging 2021
IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα
Liu J, Zhuang Y, Wu J, Wu Q, Liu M, Zhao Y, Liu Z, Wang C, Lu L, Meng Y, Lei K, Li X, Wu Q, Leung EL, Guo Z, Liu L, Li T 		Acta pharmaceutica Sinica. B 2021
CD8+ T cell survival in lethal fungal sepsis was ameliorated by T-cell-specific mTOR deletion.
Wang H, Han W, Guo R, Bai G, Chen J, Cui N 		International journal of medical sciences 2021
Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo.
Lv M, Xu Q, Zhang B, Yang Z, Xie J, Guo J, He F, Wang W 		Cancer Cell International 2021
Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.
Zhao L, Luo R, Yu H, Li S, Yu Q, Wang W, Cai K, Xu T, Chen R, Tian W 		Iranian Journal of Basic Medical Sciences 2021
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells
Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B 		Cell Death and Disease 2021
A Screen of Autophagy Compounds Implicates the Proteasome in Mammalian Aminoglycoside-Induced Hair Cell Damage
Draf C, Wyrick T, Chavez E, Pak K, Kurabi A, Leichtle A, Dazert S, Ryan AF 		Frontiers in Cell and Developmental Biology 2021
ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma
Takhsha FS, Vangestel C, Tanc M, De Bruycker S, Berg M, Pintelon I, Stroobants S, De Meyer GR, Van Der Veken P, Martinet W 		Frontiers in Oncology 2021
Evaluating Whether Radiofrequency Irradiation Attenuated UV-B-Induced Skin Pigmentation by Increasing Melanosomal Autophagy and Decreasing Melanin Synthesis.
Kim HM, Oh S, Yang JY, Sun HJ, Jang M, Kang D, Son KH, Byun K 		International journal of molecular sciences 2021
Potentiation of the Anticancer Effects by Combining Docetaxel with Ku-0063794 against Triple-Negative Breast Cancer Cells.
Jeon YW, Kim OH, Shin JS, Hong HE, Kim CH, Kim SJ 		Cancer Research and Treatment 2021
Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice.
Ehinger Y, Zhang Z, Phamluong K, Soneja D, Shokat KM, Ron D 		Nature Communications 2021
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Hu C, Cao Y, Li P, Tang X, Yang M, Gu S, Xiong K, Li T, Xiao T 		Journal of Oncology 2021
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling
Lu J, Qian J, Xu Z, Yin S, Zhou L, Zheng S, Zhang W 		Frontiers in Cell and Developmental Biology 2021
Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells
Liu X, Suo H, Zhou S, Hou Z, Bu M, Liu X, Xu W 		Cell Death and Disease 2021
Hypo-Expression of Tuberin Promotes Adenomyosis via the mTOR1-Autophagy Axis
Gu NH, Li GJ, Yang BX, You M, Lin Y, Sun F, Xu H 		Frontiers in Cell and Developmental Biology 2021
Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1
Zhang W, Wu C, Ni R, Yang Q, Luo L, He J 		PLoS genetics 2021
Amentoflavone Ameliorates Memory Deficits and Abnormal Autophagy in Aβ25-35-Induced Mice by mTOR Signaling.
Cao B, Zeng M, Zhang Q, Zhang B, Cao Y, Wu Y, Feng W, Zheng X 		Neurochemical Research 2021
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages.
Zheng Y, Kou J, Wang P, Ye T, Wang Z, Gao Z, Cong L, Li M, Dong B, Yang W, Li Q, Li H, Wang R, Yang L 		Aging 2021
AMPK: a key regulator of energy stress and calcium-induced autophagy.
Saikia R, Joseph J 		Journal of Molecular Medicine 2021
Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine.
Zheng Y, Guan H, Yang J, Cai J, Liu Q, Zhang Z 		2021
The tumor-suppressive long noncoding RNA DRAIC inhibits protein translation and induces autophagy by activating AMPK.
Saha S, Zhang Y, Wilson B, Abounader R, Dutta A 		Journal of cell science 2021
Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR Activity in the Placentas of Pregnancies Complicated by Fetal Growth Restriction and Gestational Diabetes Mellitus With Large-For-Gestational Age Infants.
Hung TH, Wu CP, Chen SF 		Frontiers in Medicine 2021
An Inhibitor of Grp94 Inhibits OxLDL-Induced Autophagy and Apoptosis in VECs and Stabilized Atherosclerotic Plaques.
Wei Q, Ren H, Zhang J, Yao W, Zhao B, Miao J 		Frontiers in Cardiovascular Medicine 2021
Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles
Deng Z, Dong Y, Zhou X, Lu JH, Yue Z 		Acta pharmaceutica Sinica. B 2021
The potential of Senolytics in transplantation
T Matsunaga, J Iske, A Schroeter, H Azuma, H Zhou, SG Tullius 		Mechanisms of Ageing and Development 2021
Genetic and Environmental Contributions to Autism Spectrum Disorder Through Mechanistic Target of Rapamycin.
Sato A, Ikeda K 		2021
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer
Yadong Xie, Yifan Zhao, Lei Shi, Wei Li, Kun Chen, Min Li, Xia Chen, Haiwei Zhang, Tiantian Li, Matsuzawa-Ishimoto Yu, Xiaomin Yao, Dianhui Shao, Zunfu Ke, Jian Li, Yan Chen, Xiaoming Zhang, Jun Cui, Shuzhong Cui, Qibin Leng, Ken Cadwell, Xiaoxia Li, Hong Wei, Haibing Zhang, Huabin Li, Hui Xiao 		Journal of Clinical Investigation 2020
The ageing lung under stress
M Korfei, BA MacKenzie, S Meiners 		European Respiratory Review 2020
Regulation of Autophagy Is a Novel Tumorigenesis-Related Activity of Multifunctional Translationally Controlled Tumor Protein
JS Lee, EH Jang, HA Woo, K Lee 		Cells 2020
Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
P Peng, X Zhang, T Qi, H Cheng, Q Kong, L Liu, X Cao, Z Ding 		FEBS Open Bio 2020
Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes
H Jung, SB Seo, T Liu 		PloS one 2020
At a glance: A history of autophagy and cancer
X Wen, DJ Klionsky 		Seminars in Cancer Biology 2020
Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer
AJ Cozzo, MF Coleman, JB Pearce, AJ Pfeil, SK Etigunta, SD Hursting 		Frontiers in Cell and Developmental Biology 2020
Autophagy Takes Center Stage as a Possible Cancer Hallmark
JG Alvarez-Meythaler, Y Garcia-Mayea, C Mir, H Kondoh, ME LLeonart 		Frontiers in Oncology 2020
Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases
F Luo, AF Sandhu, W Rungratanawanich, GE Williams, M Akbar, S Zhou, BJ Song, X Wang 		International journal of molecular sciences 2020
Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system
KR Menikdiwela, L Ramalingam, F Rasha, S Wang, JM Dufour, NS Kalupahana, KK Sunahara, JO Martins, N Moustaid-Moussa 		Cell Death and Disease 2020
Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome
S Saxena, S Kumar 		GeroScience 2020
Tumor Microenvironment: Recent Advances
A Birbrair 		2020
FXR-mediated inhibition of autophagy contributes to FA-induced TG accumulation and accordingly reduces FA-induced lipotoxicity
K Wu, T Zhao, C Hogstrand, YC Xu, SC Ling, GH Chen, Z Luo 		Cell Communication and Signaling 2020
Signaling networks in immunometabolism
J Saravia, JL Raynor, NM Chapman, SA Lim, H Chi 		Cell Research 2020
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling
M Li, J Cheng, Y Ma, H Guo, H Shu, H Huang, Y Kuang, T Yang 		Cancer Cell International 2020
Low‐dose rapamycin‐induced autophagy in cochlear outer sulcus cells
C Saegusa, M Hosoya, T Nishiyama, T Saeki, C Fujimoto, H Okano, M Fujioka, K Ogawa 		Laryngoscope Investigative Otolaryngology 2020
Autophagy is involved in the protective effect of p21 on LPS-induced cardiac dysfunction
S Huang, M Xu, L Liu, J Yang, H Wang, C Wan, W Deng, Q Tang 		Cell Death and Disease 2020
Impaired Autophagic Activity Contributes to the Pathogenesis of Bronchopulmonary Dysplasia. Evidence from Murine and Baboon Models
L Zhang, S Soni, E Hekimoglu, S Berkelhamer, S Çataltepe 		American journal of respiratory cell and molecular biology 2020
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation
A Xu, Y Yang, Y Shao, M Wu, Y Sun 		Cell Communication and Signaling 2020
Roles of Specialized Pro-Resolving Lipid Mediators in Autophagy and Inflammation
A Recchiuti, E Isopi, M Romano, D Mattoscio 		International journal of molecular sciences 2020
Master regulator genes and their impact on major diseases
W Cai, W Zhou, Z Han, J Lei, J Zhuang, P Zhu, X Wu, W Yuan 		PeerJ 2020
AMP‐activated protein kinase activation primes cytoplasmic translocation and autophagic degradation of the BCR‐ABL protein in CML cells
D Koyama, J Kikuchi, Y Kuroda, M Ohta, Y Furukawa 		Cancer Science 2020
PTEN inhibitor VO‑OHpic suppresses TSC2‑/‑ MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway
W Wang, X Wang, H Guo, Y Cai, Y Zhang, H Li 		Experimental and therapeutic medicine 2020
Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis
X Zhang, Y Li, Y Wang, Y Zhuang, X Ren, K Yang, W Ma, M Zhong 		Bioscience Reports 2020
Taming the Autophagy as a Strategy for Treating COVID-19
BE García-Pérez, JA González-Rojas, MI Salazar, C Torres-Torres, NS Castrejón-Jiménez 		Cells 2020
Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept
DH Kim, EJ Bang, HJ Jung, SG Noh, BP Yu, YJ Choi, HY Chung 		Nutrients 2020
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy
A Wei, H Xiao, G Xu, X Yu, J Guo, Z Jing, S Shi, Y Song 		Frontiers in pharmacology 2020
Autophagy and inflammation in ischemic stroke
Y Mo, YY Sun, KY Liu 		NEURAL REGEN RES 2020
The Protective Effects of the Autophagic and Lysosomal Machinery in Vascular and Valvular Calcification: A Systematic Review
CH Neutel, JO Hendrickx, W Martinet, GR Meyer, PJ Guns 		International journal of molecular sciences 2020
The Role of Autophagy for the Regeneration of the Aging Liver
F Xu, C Hua, HM Tautenhahn, O Dirsch, U Dahmen 		International journal of molecular sciences 2020
The neurofibromatosis type I gene promotes autophagy via mTORC1 signalling pathway to enhance new bone formation after fracture
Q Tan, JY Wu, YX Liu, K Liu, J Tang, WH Ye, GH Zhu, HB Mei, G Yang 		Journal of Cellular and Molecular Medicine 2020
Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
A Kloska, M Węsierska, M Malinowska, M Gabig-Cimińska, J Jakóbkiewicz-Banecka 		International journal of molecular sciences 2020
Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease
S Krishnan, Y Shrestha, DP Jayatunga, S Rea, R Martins, P Bharadwaj 		International journal of molecular sciences 2020
PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway
Z Ma, S Lou, Z Jiang 		Aging 2020
Autophagy Contributes to Oxidative Stress-Induced Apoptosis in Porcine Granulosa Cells
JQ Zhang, QL Ren, JF Chen, BW Gao, XW Wang, ZJ Zhang, J Wang, ZJ Xu, BS Xing 		Reproductive sciences (Thousand Oaks, Calif.) 2020
Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress
ZY Zhang, XL Bao, YY Cong, B Fan, GY Li 		Oxidative medicine and cellular longevity 2020
Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death
HC Hung, CC Liu, JY Chuang, CL Su, PW Gean 		Frontiers in Oncology 2020
Crosstalk Between Autophagy and Hypoxia-Inducible Factor-1α in Antifungal Immunity
T Quäschling, D Friedrich, GS Deepe, J Rupp 		Cells 2020
Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy
X Sai, C Qin, Y Wu, Y Zhao, T Bian 		J INT MED RES 2020
FTO – A Common Genetic Basis for Obesity and Cancer
N Lan, Y Lu, Y Zhang, S Pu, , X Nie, J Liu, W Yuan 		Frontiers in Genetics 2020
Decreased expression of autophagy markers in culture-positive patients with chronic otitis media
J Jung, DC Park, YI Kim, EH Lee, MJ Park, SH Kim, SG Yeo 		J INT MED RES 2020
Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium
Z Li, Y Wang, H Wang, J Wu, Y Tan 		Stem Cell Reviews and Reports 2020
Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis
X Zhang, CM Ramírez, B Aryal, J Madrigal-Matute, X Liu, A Diaz, M Torrecilla-Parra, Y Suárez, AM Cuervo, WC Sessa, C Fernández-Hernando 		Arteriosclerosis, thrombosis, and vascular biology 2020
Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
X Feng, J Pan, J Li, C Zeng, W Qi, Y Shao, X Liu, L Liu, G Xiao, H Zhang, X Bai, D Cai 		Aging 2020
The Messenger Apps of the cell: Extracellular Vesicles as Regulatory Messengers of Microglial Function in the CNS
AA Olanrewaju, RM Hakami 		Journal of Neuroimmune Pharmacology 2020
Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment in COVID-19
I Orienti, GA Gentilomi, G Farruggia 		International journal of molecular sciences 2020
Cancer‐secreted miRNAs regulate amino‐acid‐induced mTORC1 signaling and fibroblast protein synthesis
MY Fong, W Yan, M Ghassemian, X Wu, X Zhou, M Cao, L Jiang, J Wang, X Liu, J Zhang, SE Wang 		EMBO reports 2020
Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication
BR Sahoo, A Pattnaik, AS Annamalai, R Franco, AK Pattnaik, S López 		Journal of virology 2020
Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration
CK Mahendra, LT Tan, P Pusparajah, TT Htar, LH Chuah, VS Lee, LE Low, SY Tang, KG Chan, BH Goh 		Oxidative medicine and cellular longevity 2020
Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology
YJ Choi 		Nutrients 2020
MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway
KY Song, XM Guo, HQ Wang, L Zhang, SY Huang, YC Huo, G Zhang, JZ Feng, RR Zhang, Y Ma, QZ Hu, XY Qin 		Cell Death and Disease 2020
The signaling pathways implicated in impairment of hepatic autophagy in glycogen storage disease type Ia
S Gautam, L Zhang, I Arnaoutova, C Lee, BC Mansfield, JY Chou 		Human Molecular Genetics 2020
PI(3,4)P2 Signaling in Cancer and Metabolism
L Gozzelino, MC Santis, F Gulluni, E Hirsch, M Martini 		Frontiers in Oncology 2020
miR-19 Promotes Cell Proliferation, Invasion, Migration, and EMT by Inhibiting SPRED2-mediated Autophagy in Osteosarcoma Cells
C Xie, S Liu, B Wu, Y Zhao, B Chen, J Guo, SH Qiu, Y Cao 		Cell Transplantation 2020
Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
Y Kang, W He, C Ren, J Qiao, Q Guo, J Hu, H Xu, X Jiang, L Wang 		Signal Transduction and Targeted Therapy 2020
Angelicin—A Furocoumarin Compound With Vast Biological Potential
CK Mahendra, LT Tan, WL Lee, WH Yap, P Pusparajah, LE Low, SY Tang, KG Chan, LH Lee, BH Goh 		Frontiers in pharmacology 2020
Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis
Q Shi, F Pei, GA Silverman, SC Pak, DH Perlmutter, B Liu, I Bahar 		International journal of molecular sciences 2020
Rapamycin promotes endothelial–mesenchymal transition during stress-induced premature senescence through the activation of autophagy
N Sasaki, Y Itakura, M Toyoda 		Cell Communication and Signaling 2020
MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury
J Wang, Y Rong, C Ji, C Lv, D Jiang, X Ge, F Gong, P Tang, W Cai, W Liu, J Fan 		Journal of nanobiotechnology 2020

Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy
Y Chen, M Guan, R Ren, C Gao, H Cheng, Y Li, B Gao, Y Wei, J Fu, J Sun, W Xiong 		International Journal of Nanomedicine 2020
Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease
YL Guo, WJ Duan, DH Lu, XH Ma, XX Li, Z Li, W Bi, H Kurihara, HZ Liu, YF Li, RR He 		Acta Pharmacologica Sinica 2020
Multiple Facets of Autophagy and the Emerging Role of Alkylphosphocholines as Autophagy Modulators
F Kaleağasıoğlu, DM Ali, MR Berger 		Frontiers in pharmacology 2020
Autophagy and Inflammation Regulation in Acute Kidney Injury
L Gong, Q Pan, N Yang 		Frontiers in physiology 2020
The Effect of Autophagic Activity on the Function of Apheresis Platelets and on the Efficacy of Clinical Platelet Transfusion
H Tang, M Gao, Y Fu, R Gui, X Ma 		Transfusion Medicine and Hemotherapy 2020
TGFβ signaling-induced miRNA participates in autophagic regulation by targeting PRAS40 in mesenchymal subtype of glioblastoma
Y Xie, L Chen, J Zhou, Q Wang, C Yang, C Xu, X Fan, Y Tan, Y Wang, C Kang, C Fang 		Cancer biology & medicine 2020
mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
N Gremke, P Polo, A Dort, J Schneikert, S Elmshäuser, C Brehm, U Klingmüller, A Schmitt, H Reinhardt, O Timofeev, M Wanzel, T Stiewe 		Nature Communications 2020
STXBP6, reciprocally regulated with autophagy, reduces triple negative breast cancer aggressiveness
Lenka G, Shan J, Halabi N, Abuaqel SW, Goswami N, Schmidt F, Zaghlool S, Romero AR, Subramanian M, Boujassoum S, Al\u2010Bozom I, Gehani S, Khori NA, Bedognetti D, Suhre K, Ma X, Dömling A, Rafii A, Chouchane L 		Clinical and Translational Medicine 2020
Sanqi Oral Solution Ameliorates Renal Ischemia/Reperfusion Injury via Reducing Apoptosis and Enhancing Autophagy: Involvement of ERK/mTOR Pathways
Tian R, Wang P, Huang L, Li C, Lu Z, Lu Z, Wu A, Bao K, Mao W, Huang Q, Xu P 		Frontiers in pharmacology 2020
Hexavalent chromium-induced autophagic death of WRL-68 cells is mitigated by aqueous extract of Cuminum cyminum L. seeds.
Mahalakshmi R, Priyanga J, Vedha Hari BN, Bhakta-Guha D, Guha G 		3 Biotech 2020
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Wang L, Tan Z, Zhang Y, Kady Keita N, Liu H, Zhang Y 		International journal of oncology 2020
RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells.
Zhang S, Hamid MR, Wang T, Liao J, Wen L, Zhou Y, Wei P, Zou X, Chen G, Chen J, Zhou G 		Theranostics 2020
S100A10 Accelerates Aerobic Glycolysis and Malignant Growth by Activating mTOR-Signaling Pathway in Gastric Cancer.
Li Y, Li XY, Li LX, Zhou RC, Sikong Y, Gu X, Jin BY, Li B, Li YQ, Zuo XL 		Frontiers in Cell and Developmental Biology 2020
Synergistic Carcinogenesis of HPV18 and MNNG in Het-1A Cells through p62-KEAP1-NRF2 and PI3K/AKT/mTOR Pathway
Zhang Y, Ma Y, Zhao C, Zhang H, Pu Y, Yin L 		Oxidative medicine and cellular longevity 2020
Gene and protein expression of mTOR and LC3 in hepatocellular carcinoma, colorectal liver metastasis and “normal” liver tissues
Bortolami M, Comparato A, Benna C, Errico A, Maretto I, Pucciarelli S, Cillo U, Farinati F 		PloS one 2020
Metformin and rapamycin protect cells from vital dye-induced damage in retinal pigment epithelial cells and in vivo.
Shu CW, Tsen CL, Li MS, Bee YS, Lin SH, Sheu SJ 		2020
Activation of the IRE1α Arm, but not the PERK Arm, of the Unfolded Protein Response Contributes to Fumonisin B1-Induced Hepatotoxicity.
Liu X, Zhang E, Yin S, Zhao C, Fan L, Hu H 		Toxins 2020
Orchestrated efforts on host network hijacking: Processes governing virus replication
Dai X, Hakizimana O, Zhang X, Kaushik AC, Zhang J 		Virulence 2020
Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway
Chen X, Li S, Li D, Li M, Su Z, Lai X, Zhou C, Chen S, Li S, Yang X, Su J, Zhang Y 		Frontiers in pharmacology 2020
Metabolic Control over mTOR-Dependent Diapause-like State
Hussein AM, Wang Y, Mathieu J, Margaretha L, Song C, Jones DC, Cavanaugh C, Miklas JW, Mahen E, Showalter MR, Ruzzo WL, Fiehn O, Ware CB, Blau CA, Ruohola-Baker H 		Developmental Cell 2020
Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
Singla S, Iwamoto-Stohl LK, Zhu M, Zernicka-Goetz M 		Nature Communications 2020
HO-1 induced autophagy protects against IL-1 β-mediated apoptosis in human nucleus pulposus cells by inhibiting NF-κB.
Zou L, Lei H, Shen J, Liu X, Zhang X, Wu L, Hao J, Jiang W, Hu Z 		Aging 2020
Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE.
Cheung CHA, Chang YC, Lin TY, Cheng SM, Leung E 		Journal of biomedical science 2020
Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis.
Bao J, Chen Z, Xu L, Wu L, Xiong Y 		Aging 2020
Berberine Reverses Doxorubicin Resistance by Inhibiting Autophagy Through the PTEN/Akt/mTOR Signaling Pathway in Breast Cancer.
Wang Y, Liu Y, Du X, Ma H, Yao J 		OncoTargets and therapy 2020
Autophagy coupled to translation is required for long-term memory.
Pandey K, Yu XW, Steinmetz A, Alberini CM 		Autophagy 2020
Oxidative-Antioxidant Imbalance and Impaired Glucose Metabolism in Schizophrenia
Bryll A, Skrzypek J, Krzyściak W, Szelągowska M, Śmierciak N, Kozicz T, Popiela T 		Biomolecules 2020
Metformin Promotes Beclin1-Dependent Autophagy to Inhibit the Progression of Gastric Cancer
Liu S, Yue C, Chen H, Chen Y, Li G 		OncoTargets and therapy 2020
Food and Age: It Takes Two to Degenerate
Nicola R, Okun E 		Frontiers in aging neuroscience 2020
Melasolv induces melanosome autophagy to inhibit pigmentation in B16F1 cells
Park HJ, Jo DS, Choi H, Bae JE, Park NY, Kim JB, Choi JY, Kim YH, Oh GS, Chang JH, Kim HJ, Cho DH 		PloS one 2020
Autophagy is induced and supports virus replication in Enterovirus A71-infected human primary neuronal cells
Lin JY, Huang HI 		Scientific Reports 2020
Effect of Calomelanone, a Dihydrochalcone Analogue, on Human Cancer Apoptosis/Regulated Cell Death in an In Vitro Model
Rachakhom W, Banjerdpongchai R 		BioMed Research International 2020
V-ATPase subunit B plays essential roles in the molting process of the Chinese mitten crab, Eriocheir sinensis.
Hou X, Chen X, Yang H, Yue W, Wang J, Han H, Wang C 		Biology Open 2020
Effects of the autophagy modulators d-limonene and chloroquine on vimentin levels in SH-SY5Y cells
Gentile D, Berliocchi L, Russo R, Bagetta G, Corasaniti MT 		Biochemical and Biophysical Research Communications 2020
The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells
Hseu YC, Chiang YC, Vudhya Gowrisankar Y, Lin KY, Huang ST, Shrestha S, Chang GR, Yang HL 		Cancers 2020
BUB1B promotes hepatocellular carcinoma progression via activation of the mTORC1 signaling pathway
Qiu J, Zhang S, Wang P, Wang H, Sha B, Peng H, Ju Z, Rao J, Lu L 		Cancer Medicine 2020
Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway.
Yang G, Yang Y, Tang H, Yang K 		Cancer Science 2020
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone
Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D, Li YF, He RR 		Theranostics 2020
自噬在脂多糖诱导成牙本质细胞凋亡中的作用
2020
Novel PI3K/Akt/mTOR signaling inhibitor, W922, prevents colorectal cancer growth via the regulation of autophagy.
Wang J, Liang D, Zhang XP, He CF, Cao L, Zhang SQ, Xiao X, Li SJ, Cao YX 		International journal of oncology 2020
Circadian regulation of muscle growth independent of locomotor activity
Kelu JJ, Pipalia TG, Hughes SM 		Proceedings of the National Academy of Sciences 2020
Bacterial Cyclodipeptides Target Signal Pathways Involved in Malignant Melanoma.
Durán-Maldonado MX, Hernández-Padilla L, Gallardo-Pérez JC, Díaz-Pérez AL, Martínez-Alcantar L, Reyes De la Cruz H, Rodríguez-Zavala JS, Pacheco-Rodríguez G, Moss J, Campos-García J 		Frontiers in Oncology 2020
NUCKS promotes cell proliferation and suppresses autophagy through the mTOR-Beclin1 pathway in gastric cancer.
Zhao E, Feng L, Bai L, Cui H 		Journal of experimental & clinical cancer research : CR 2020
The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses.
Ko CJ, Zhang L, Jie Z, Zhu L, Zhou X, Xie X, Gao T, Yang JY, Cheng X, Sun SC 		The EMBO Journal 2020
Abat (4-aminobutyrate aminotransferase) inhibition protects against injury-induced osteoarthritis in mice
Jie Shen, Cuicui Wang, Jun Ying, Taotao Xu, Audrey McAlinden, Regis J O'Keefe 		JCI Insight 2019
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death
H Wan, Q Wang, X Chen, Q Zeng, Y Shao, H Fang, X Liao, HS Li, MG Liu, TL Xu, M Diao, D Li, B Meng, B Tang, Z Zhang, L Liao 		Autophagy 2019
Adult stem cell deficits drive Slc29a3 disorders in mice
S Nair, AM Strohecker, AK Persaud, B Bissa, S Muruganandan, C McElroy, R Pathak, M Williams, R Raj, A Kaddoumi, A Sparreboom, AM Beedle, R Govindarajan 		Nature Communications 2019
Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro
R Zeng, Q Zhou, W Zhang, X Fu, Q Wu, Y Lu, J Shi, S Zhou 		Toxicology Reports 2019
mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
T Tian, X Li, J Zhang 		International journal of molecular sciences 2019
Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway
A Kulshrestha, GK Katara, SA Ibrahim, V Riehl, M Sahoo, J Dolan, KW Meinke, MR Pins, KD Beaman 		Journal of Oncology 2019
MIR93 ( microRNA -93 ) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy
T Huang, X Wan, AA Alvarez, CD James, X Song, Y Yang, N Sastry, I Nakano, EP Sulman, B Hu, SY Cheng 		Autophagy 2019
Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes
S Kumar, H Xie, H Shi, J Gao, CC Juhlin, V Björnhagen, A Höög, L Lee, C Larsson, WO Lui 		International Journal of Cancer 2019
Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung Disease
M Bodas, N Vij 		Frontiers in pharmacology 2019
Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells
N Germic, Z Frangez, S Yousefi, HU Simon 		Cell Death and Differentiation 2019
Effect of eNOS on Ischemic Postconditioning-Induced Autophagy against Ischemia/Reperfusion Injury in Mice
J Shao, C Miao, Z Geng, M Gu, Y Wu, Q Li 		BioMed Research International 2019
The Mechanism and Pathways of Dopamine and Dopamine Agonists in Prolactinomas
X Liu, C Tang, G Wen, C Zhong, J Yang, J Zhu, C Ma 		Frontiers in Endocrinology 2019
Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy
X Dong, Y Yang, Y Zhou, X Bi, N Zhao, Z Zhang, L Li, Q Hang, R Zhang, D Chen, P Cao, Z Yin, L Luo 		Cell Death and Differentiation 2019
The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy
WY Ho, YK Tai, JC Chang, J Liang, SH Tyan, S Chen, JL Guan, H Zhou, HM Shen, E Koo, SC Ling 		Autophagy 2019
Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells
P Maiti, J Scott, D Sengupta, A Al-Gharaibeh, G Dunbar 		International journal of molecular sciences 2019
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages
J Schulthess, S Pandey, M Capitani, KC Rue-Albrecht, I Arnold, F Franchini, A Chomka, NE Ilott, DG Johnston, E Pires, J McCullagh, SN Sansom, CV Arancibia-Cárcamo, HH Uhlig, F Powrie 		Immunity 2019
Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma
Y Yang, D Chen, H Liu, K Yang 		Cell Death and Disease 2019
Arsenite-induced apoptosis can be attenuated via depletion of mTOR activity to restore autophagy
CW Wu, PJ Lin, JS Tsai, CY Lin, LY Lin 		Toxicology Research 2019
Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview
M Lunova, B Smolková, A Lynnyk, M Uzhytchak, M Jirsa, Š Kubinová, A Dejneka, O Lunov 		Cancers 2019
mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis
C Li, H Chen, Z Lan, S He, R Chen, F Wang, Z Liu, K Li, L Cheng, Y Liu, K Sun, X Wan, X Chen, H Peng, L Li, Y Zhang, Y Jing, M Huang, Y Wang, Y Wang, J Jiang, X Zha, L Chen, H Zhang 		Cell Death and Differentiation 2019
Investigating the Role of Everolimus in mTOR Inhibition and Autophagy Promotion as a Potential Host-Directed Therapeutic Target in Mycobacterium tuberculosis Infection
S Cerni, D Shafer, K To, V Venketaraman 		Journal of Clinical Medicine 2019
Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells
L Liang, K Hui, C Hu, Y Wen, S Yang, P Zhu, L Wang, Y Xia, Y Qiao, W Sun, J Fei, T Chen, F Zhao, B Yang, X Jiang 		Journal of Experimental & Clinical Cancer Research 2019
Cardiac Autophagy in Sepsis
Y Sun, Y Cai, QS Zang 		Cells 2019
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
IS Harris, JE Endress, JL Coloff, LM Selfors, SK McBrayer, JM Rosenbluth, N Takahashi, S Dhakal, V Koduri, MG Oser, NJ Schauer, LM Doherty, AL Hong, YP Kang, ST Younger, JG Doench, WC Hahn, SJ Buhrlage, GM DeNicola, WG Kaelin, JS Brugge 		Cell Metabolism 2019
Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication
R Gratton, A Agrelli, P Tricarico, L Brandão, S Crovella 		International journal of molecular sciences 2019
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells
L Zhu, G Wu, X Yang, X Jia, J Li, X Bai, W Li, Y Zhao, Y Li, W Cheng, S Liu, S Jin 		Scientific Reports 2019
Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study
A Gallud, K Klöditz, J Ytterberg, N Östberg, S Katayama, T Skoog, V Gogvadze, YZ Chen, D Xue, S Moya, J Ruiz, D Astruc, R Zubarev, J Kere, B Fadeel 		Scientific Reports 2019
Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy
S Li, F Peng, W Gong, J Wu, Y Wang, Z Xu, W Liu, H Li, B Yin, Y Zhang, S Chen, C Luo, P Li, Y Chen, Q Huang, W Zhou, H Long 		Journal of Molecular Medicine 2019
Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases
PK Panda, A Fahrner, S Vats, E Seranova, V Sharma, M Chipara, P Desai, J Torresi, T Rosenstock, D Kumar, S Sarkar 		Frontiers in Cell and Developmental Biology 2019
Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation
L Mele, M la Noce, F Paino, T Regad, S Wagner, D Liccardo, G Papaccio, A Lombardi, M Caraglia, V Tirino, V Desiderio, F Papaccio 		Journal of Experimental & Clinical Cancer Research 2019
Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression
JE Park, SW Tse, G Xue, C Assisi, AS Maqueda, GP Ramon, JK Low, OL Kon, CY Tay, JP Tam, SK Sze 		Oncotarget 2019
Mitochondria in Sepsis-Induced AKI
J Sun, J Zhang, J Tian, GM Virzì, K Digvijay, L Cueto, Y Yin, MH Rosner, C Ronco 		Journal of the American Society of Nephrology : JASN 2019
Significance of Autophagy in Dengue Virus Infection: A Brief Review
B Acharya, S Gyeltshen, W Chaijaroenkul, K Na-Bangchang 		The American journal of tropical medicine and hygiene 2019
Lipophagy and Alcohol-Induced Fatty Liver
L Yang, C Yang, PG Thomes, KK Kharbanda, CA Casey, MA McNiven, TM Donohue 		Frontiers in pharmacology 2019
Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging
J Shi, M Surma, Y Yang, L Wei 		The FASEB Journal 2019
Redox-Related Neuronal Death and Crosstalk as Drug Targets: Focus on Epilepsy
XY Mao, HH Zhou, WL Jin 		Frontiers in neuroscience 2019
The local mammalian target of rapamycin (mTOR) modulation: a promising strategy to counteract neurodegeneration
D Dolcetta, R Dominici 		NEURAL REGEN RES 2019
Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy
P Green, N Sharma, J Santos 		International journal of molecular sciences 2019
Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis
L Che, X Yang, C Ge, SS El-Amouri, QE Wang, D Pan, TJ Herzog, C Du, V Trajkovic 		PloS one 2019
Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin
SD Matteis, E Scarpi, A Granato, U Vespasiani-Gentilucci, GL Barba, F Foschi, E Bandini, M Ghetti, G Marisi, P Cravero, L Gramantieri, A Cucchetti, G Ercolani, D Santini, G Frassineti, L Faloppi, M Scartozzi, S Cascinu, A Casadei-Gardini 		International journal of molecular sciences 2019
Antioxidative Property and Molecular Mechanisms Underlying Geniposide-Mediated Therapeutic Effects in Diabetes Mellitus and Cardiovascular Disease
N Li, L Li, H Wu, H Zhou 		Oxidative medicine and cellular longevity 2019
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
L Fan, X Qiu, Z Zhu, J Lv, J Lu, F Mao, J Zhu, J Wang, X Guan, J Chen, J Ren, J Ye, Y Zhao, J Li, X Shen 		Acta Pharmacologica Sinica 2019
Construction and analysis of a spinal cord injury competitive endogenous RNA network based on the expression data of long noncoding, micro‑ and messenger RNAs
L Wang, B Wang, J Liu, Z Quan 		Molecular medicine reports 2019
Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development
X Liu, P Zhang, C Xie, KW Sham, SS Ng, Y Chen, CH Cheng 		Cell Death and Disease 2019
Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress
B Pan, MT Lewno, P Wu, X Wang 		Frontiers in physiology 2019
NOS2 inhibitor 1400W Induces Autophagic Flux and Influences Extracellular Vesicle Profile in Human Glioblastoma U87MG Cell Line
P Palumbo, F Lombardi, FR Augello, I Giusti, S Luzzi, V Dolo, MG Cifone, B Cinque 		International journal of molecular sciences 2019
α-Ketoglutarate inhibits autophagy
EE Baracco, F Castoldi, S Durand, DP Enot, J Tadic, K Kainz, F Madeo, A Chery, V Izzo, MC Maiuri, F Pietrocola, G Kroemer 		Aging 2019
Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway
Z Yue, X Guan, R Chao, C Huang, D Li, P Yang, S Liu, T Hasegawa, J Guo, M Li 		Molecules (Basel, Switzerland) 2019
Knockdown of Hypoxia-Inducible Factor 1α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells
J Huang, L Gao, B Li, C Liu, S Hong, J Min, L Hong 		Medical science monitor : international medical journal of experimental and clinical research 2019
Enhancing autophagy protects platelets in immune thrombocytopenia patients
CY Wang, S Ma, SJ Bi, L Su, SY Huang, JY Miao, CH Ma, CJ Gao, M Hou, J Peng 		Annals of translational medicine 2019
Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G1 cell cycle arrest and apoptosis: A quantitative proteomic study
J Xia, Q Luo, S Huang, F Jiang, L Wang, G Wang, J Xie, J Liu, Y Xu 		Chinese Journal of Cancer Research 2019
Enhanced autophagy alleviates injury during hindlimb ischemia/reperfusion in mice
C Liu, M Peng, L Zheng, Y Zhao, R Wang, Q Su, S Chen, Z Li 		Experimental and therapeutic medicine 2019
SOCS5 inhibition induces autophagy to impair metastasis in hepatocellular carcinoma cells via the PI3K/Akt/mTOR pathway
M Zhang, S Liu, MS Chua, H Li, D Luo, S Wang, S Zhang, B Han, C Sun 		Cell Death and Disease 2019
The effects of Tel2 on cardiomyocyte survival
N Yorichika, Y Baba, BK Shimada, M Thakore, SM Wong, M Kobayashi, JK Higa, T Matsui 		Life Sciences 2019
PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics
A Ghoneum, N Said 		Cancers 2019
Docosahexaenoic Acid Enhances Oxaliplatin-Induced Autophagic Cell Death via the ER Stress/Sesn2 Pathway in Colorectal Cancer
S Jeong, DY Kim, SH Kang, HK Yun, JL Kim, BR Kim, SH Park, YJ Na, MJ Jo, YA Jeong, BG Kim, DH Lee, SC Oh 		Cancers 2019
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway
J Lin, A Jiao, W Lv, C Zhang, Y Shi, Z Yang, N Sun, X Li, J Zhang 		Frontiers in pharmacology 2019
Resveratrol Activates Autophagy via the AKT/mTOR Signaling Pathway to Improve Cognitive Dysfunction in Rats With Chronic Cerebral Hypoperfusion
N Wang, J He, C Pan, J Wang, M Ma, X Shi, Z Xu 		Frontiers in neuroscience 2019
Biomedical Implications of Autophagy in Macromolecule Storage Disorders
AM Palhegyi, E Seranova, S Dimova, S Hoque, S Sarkar 		Frontiers in Cell and Developmental Biology 2019
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling
A Martin-Hurtado, R Martin-Morales, N Robledinos-Antón, R Blanco, I Palacios-Blanco, I Lastres-Becker, A Cuadrado, FR Garcia-Gonzalo 		Scientific Reports 2019
Connexin 43‑autophagy loop in the podocyte injury of diabetic nephropathy
J Ji, Y Zhao, C Na, M Yang, X Zhu, H Shi, W Gan, A Zhang 		International journal of molecular medicine 2019
NSAIDs disrupt intestinal homeostasis by suppressing macroautophagy in intestinal epithelial cells
AM Chamoun-Emanuelli, LK Bryan, ND Cohen, TL Tetrault, JA Szule, R Barhoumi, CM Whitfield-Cargile 		Scientific Reports 2019
Yizhiqingxin Formula Alleviates Cognitive Deficits and Enhances Autophagy via mTOR Signaling Pathway Modulation in Early Onset Alzheimer’s Disease Mice
Y Yang, Z Wang, Y Cao, J Liu, P Li, H Li, M Liu 		Frontiers in pharmacology 2019
Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice
AL Lang, AM Krueger, RD Schnegelberger, BR Kaelin, MJ Rakutt, L Chen, GE Arteel, JI Beier 		Toxicology and Applied Pharmacology 2019

Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation
MS Jeong, JH Jung, H Lee, CG Kim, SH Kim 		OncoTargets and therapy 2019
Perturbed mitochondria–ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease
PV Adami, Z Nichtová, DB Weaver, A Bartok, T Wisniewski, DR Jones, SD Carmo, EM Castaño, AC Cuello, G Hajnóczky, L Morelli 		Journal of cell science 2019
A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity
J Ochaba, AF Powers, KA Tremble, S Greenlee, NM Post, JE Matson, AR MacLeod, S Guo, M Aghajan 		Nucleic Acids Research 2019
The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression
GH Nam, KJ Jo, YS Park, HW Kawk, JG Yoo, JD Jang, SM Kang, SY Kim, YM Kim 		Scientific Reports 2019
Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway
G Wang, T Wang, Y Zhang, F Li, B Yu, J Kou 		Molecules (Basel, Switzerland) 2019
Pathogenetical and Neurophysiological Features of Patients with Autism Spectrum Disorder: Phenomena and Diagnoses
Y Jin, J Choi, S Lee, JW Kim, Y Hong 		Journal of Clinical Medicine 2019
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
BR Malik, DC Maddison, GA Smith, OM Peters 		Molecular brain 2019
Protective Role of mTOR in Liver Ischemia/Reperfusion Injury: Involvement of Inflammation and Autophagy
T Zhang, J Guo, J Gu, K Chen, H Li, J Wang 		Oxidative medicine and cellular longevity 2019
The (pro)renin receptor in health and disease
A Ichihara, MS Yatabe 		Nature Reviews Nephrology 2019
Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven Photoaging
M Wang, P Charareh, X Lei, JL Zhong 		Oxidative medicine and cellular longevity 2019
Podocytes maintain high basal levels of autophagy independent of mtor signaling
T Bork, W Liang, K Yamahara, P Lee, Z Tian, S Liu, C Schell, K Thedieck, B Hartleben, K Patel, PL Tharaux, O Lenoir, TB Huber 		Autophagy 2019
Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1
SY Choi, JS Park, CH Shon, CY Lee, JM Ryu, DJ Son, BY Hwang, HS Yoo, YC Cho, J Lee, JW Kim, YS Roh 		Nutrients 2019
The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention
KW Chung, HY Chung 		Nutrients 2019
Autophagy and LRRK2 in the Aging Brain
F Albanese, S Novello, M Morari 		Frontiers in neuroscience 2019
Assessing the efficacy of mammalian target of rapamycin inhibitors by phosphorylation of p70S6K in CD4-positive cells of liver transplant patients
JY Wang, H Fan 		Medicine 2019
Autophagy and Akt-mTOR signaling display periodic oscillations during torpor-arousal cycles in oxidative skeletal muscle of Daurian ground squirrels (Spermophilus dauricus)
H Chang, X Peng, X Yan, J Zhang, S Xu, H Wang, Z Wang, X Ma, Y Gao 		Journal of Comparative Physiology B 2019
Dl‑3n‑butylphthalide improves spatial learning and memory in rats with vascular dementia by reducing autophagy via regulation of the mTOR signaling pathway
A Tian, X Ma, H Li, R Zhang 		Experimental and therapeutic medicine 2019
A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3
K Liu, C Guo, Y Lao, J Yang, F Chen, Y Zhao, Y Yang, J Yang, J Yi 		Autophagy 2019
CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells
K Zahid, M Rogowski, C Ponce, M Choudhury, N Moustaid-Moussa, SM Rahman 		Molecular and Cellular Biochemistry 2019
Autophagy in corneal health and disease: A concise review
Martin LM, Jeyabalan N, Tripathi R, Panigrahi T, Johnson PJ, Ghosh A, Mohan RR 		The ocular surface 2019
Survival of the fittest: How myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment
Ostrand-Rosenberg S, Beury DW, Parker KH, Horn LA 		Cancer Immunology, Immunotherapy 2019
Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells.
Srivastava RK, Li C, Khan J, Banerjee NS, Chow LT, Athar M 		Proceedings of the National Academy of Sciences 2019
Mechanistic target of rapamycin inhibitors: successes and challenges as cancer therapeutics.
Bhaoighill MN, Dunlop EA 		2019
MicroRNAs play an essential role in autophagy regulation in various disease phenotypes
Zhao Y, Wang Z, Zhang W, Zhang L 		BioFactors (Oxford, England) 2019
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection.
Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mösbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Müller-Myhsok B, Drosten C, Müller MA, Rein T 		Nature Communications 2019
The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
Wang H, Liu Y, Wang D, Xu Y, Dong R, Yang Y, Lv Q, Chen X, Zhang Z 		Cells 2019
Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling
Hu H, Wu J, Yu X, Zhou J, Yu H, Ma L 		Biological research 2019
W941, a new PI3K inhibitor, exhibits preferable anti-proliferative activities against nonsmall cell lung cancer with autophagy inhibitors.
Liang D, Wang HY, Fan S, Wang J, Shen Y, Gao CY, Wu ML, Lu SM, Zhang SQ, Han W 		Investigational new drugs 2019
Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals
T Komai, M Inoue, T Okamura, K Morita, Y Iwasaki, S Sumitomo, H Shoda, K Yamamoto, K Fujio 		Frontiers in immunology 2018
Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
K Huang, Y Chen, R Zhang, Y Wu, Y Ma, X Fang, S Shen 		Cell Death and Disease 2018
18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma
J Chen, Z Zhang, J Song, Q Liu, C Wang, Z Huang, L Chu, H Liang, B Zhang, X Chen 		Scientific Reports 2018
Human Papilloma Virus and Autophagy
D Mattoscio, A Medda, S Chiocca 		International journal of molecular sciences 2018
The Roles of Autophagy in Cancer
C Yun, S Lee 		International journal of molecular sciences 2018
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
S Masaldan, SA Clatworthy, C Gamell, PM Meggyesy, AT Rigopoulos, S Haupt, Y Haupt, D Denoyer, PA Adlard, AI Bush, MA Cater 		Redox Biology 2018
Rapamycin Prolongs Graft Survival and Induces CD4+IFN-γ+IL-10+ Regulatory Type 1 Cells in Old Recipient Mice:
M Quante, T Heinbokel, K Edtinger, K Minami, H Uehara, Y Nian, H Azuma, R Abdi, A Elkhal, SG Tullius 		Transplantation 2018
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
K Frudd, T Burgoyne, JR Burgoyne 		Nature Communications 2018
Protein kinase C alpha drives fibroblast activation and kidney fibrosis by stimulating autophagic flux
X Xue, J Ren, X Sun, Y Gui, Y Feng, B Shu, W Wei, Q Lu, Y Liang, W He, J Yang, C Dai 		The Journal of biological chemistry 2018
Critical role for the Tsc1-mTORC1 pathway in β-cell mass in Pdx1 deficient mice
J Sun, L Mao, H Yang, D Ren 		Journal of Endocrinology 2018
Classical and alternative roles for autophagy in lipid metabolism:
X Zhang, TD Evans, SJ Jeong, B Razani 		Current Opinion in Lipidology 2018
The independence of and associations among apoptosis, autophagy, and necrosis
Q Chen, J Kang, C Fu 		Signal Transduction and Targeted Therapy 2018
Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers
KE Bairi, M Amrani, S Afqir 		Cancer Medicine 2018
Anti-apoptotic effects of autophagy via ROS regulation in microtubule-targeted and PDGF-stimulated vascular smooth muscle cells
HS Park, JH Han, SH Jung, DH Lee, KS Heo, CS Myung 		The Korean Journal of Physiology & Pharmacology 2018
Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates
F Zhang, R Zhong, H Qi, S Li, C Cheng, X Liu, Y Liu, W Le 		Frontiers in neuroscience 2018
mTOR Pathways in Cancer and Autophagy
M Paquette, L El-Houjeiri, A Pause 		Cancers 2018
Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases
A Samidurai, RC Kukreja, A Das 		Oxidative medicine and cellular longevity 2018
Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
J Jiang, H Li, E Qaed, J Zhang, Y Song, R Wu, X Bu, Q Wang, Z Tang 		Journal of Experimental & Clinical Cancer Research 2018
STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer
F Wu, P Gao, W Wu, Z Wang, J Yang, J Di, B Jiang, X Su 		Journal of Experimental & Clinical Cancer Research 2018
Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux
K Wang, T Zhang, Y Lei, X Li, J Jiang, J Lan, Y Liu, H Chen, W Gao, N Xie, Q Chen, X Zhu, X Liu, K Xie, Y Peng, EC Nice, M Wu, C Huang, Y Wei 		Autophagy 2018
The characteristics of vessel lining cells in normal spleens and their role in the pathobiology of myelofibrosis
J Qiu, ME Salama, CS Hu, Y Li, X Wang, R Hoffman 		Blood Advances 2018
CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation
SK Mishra, YG Gao, Y Deng, CE Chalfant, EH Hinchcliffe, RE Brown 		Autophagy 2018
Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing
S Wedel, M Manola, M Cavinato, I Trougakos, P Jansen-Dürr 		Molecules (Basel, Switzerland) 2018
Autophagy in Neutrophils: From Granulopoiesis to Neutrophil Extracellular Traps
P Skendros, I Mitroulis, K Ritis 		Frontiers in Cell and Developmental Biology 2018
Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death
D Lv, L Chen, W Ding, W Zhang, H Wang, S Wang, W Liu 		Chinese medicine 2018
Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics
V Oikonomou, G Renga, AD Luca, M Borghi, M Pariano, M Puccetti, G Paolicelli, C Stincardini, C Costantini, A Bartoli, T Zelante, L Romani 		Mediators of Inflammation 2018
Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy
JH Kim, TG Choi, S Park, HR Yun, NN Nguyen, YH Jo, M Jang, J Kim, J Kim, I Kang, J Ha, MP Murphy, DG Tang, SS Kim 		Cell Death and Differentiation 2018
Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling
H Woo, CJ Hong, S Jung, S Choe, SW Yu 		Molecular brain 2018
Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells
CC Chang, TY Huang, HY Chen, TC Huang, LC Lin, YJ Chang, SM Hsia 		Oxidative medicine and cellular longevity 2018
Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring
YL Tain, S Leu, WC Lee, K Wu, J Chan 		Molecules (Basel, Switzerland) 2018
GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling
CC Chang, TC Lin, HL Ho, CY Kuo, HH Li, T Korolenko, WJ Chen, TJ Lai, YJ Ho, CL Lin 		International journal of molecular sciences 2018
The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson’s Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy
B Wang, CJ Su, TT Liu, Y Zhou, Y Feng, Y Huang, X Liu, ZH Wang, LH Chen, WF Luo, T Liu 		Frontiers in molecular neuroscience 2018
Ataxia telangiectasia mutated kinase deficiency impairs the autophagic response early during myocardial infarction
PR Thrasher, SL Scofield, S Dalal, CC Crawford, M Singh, K Singh 		American journal of physiology. Heart and circulatory physiology 2018
The curious case of vacuolar ATPase: regulation of signaling pathways
S Pamarthy, A Kulshrestha, GK Katara, KD Beaman 		Molecular Cancer 2018
The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma
H Xiaoyu, Y Yiru, S Shuisheng, C Keyan, Y Zixing, C Shanglin, W Yuan, C Dongming, Z Wangliang, B Xudong, M Jie 		Technology in cancer research & treatment 2018
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis
W Wang, Z Xia, JC Farré, S Subramani 		Autophagy 2018
Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells
YW Wu, CF Lin, YS Lin, WC Su, WH Chiu 		Cell Death Discovery 2018
Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
S Masaldan, SA Clatworthy, C Gamell, ZM Smith, PS Francis, D Denoyer, PM Meggyesy, SL Fontaine, MA Cater 		Redox Biology 2018
Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis
Q Li, L Li, X Fei, Y Zhang, C Qi, S Hua, F Gong, M Fang 		Innate immunity 2018
Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury
YY Zheng, M Wang, XB Shu, PY Zheng, G Ji 		World journal of gastroenterology : WJG 2018
The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease
S Wang, Y Huang, C Zhou, H Wu, J Zhao, L Wu, M Zhao, F Zhang, H Liu 		Gastroenterology Research and Practice 2018
EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation
M Linder, M Hecking, E Glitzner, K Zwerina, M Holcmann, L Bakiri, MG Ruocco, J Tuckermann, G Schett, EF Wagner, M Sibilia 		Cell Death and Differentiation 2018
Identification of abnormally expressed lncRNAs induced by PM2.5 in human bronchial epithelial cells
X Li, M Zheng, J Pu, Y Zhou, W Hong, X Fu, Y Peng, W Zhou, H Pan, B Li, P Ran 		Bioscience Reports 2018
Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide
MJ Back, HC Ha, Z Fu, JM Choi, Y Piao, JH Won, JM Jang, IC Shin, DK Kim 		Cell Death and Disease 2018
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
L Zhu, X Xie, L Zhang, H Wang, Z Jie, X Zhou, J Shi, S Zhao, B Zhang, X Cheng, SC Sun 		Nature Communications 2018
SeMet attenuates OTA-induced PCV2 replication promotion by inhibiting autophagy by activating the AKT/mTOR signaling pathway
G Qian, D Liu, J Hu, F Gan, L Hou, N Zhai, X Chen, K Huang 		Veterinary Research 2018
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance
Z Liang, L Zhang, H Su, R Luan, N Na, L Sun, Y Zhao, X Zhang, Q Zhang, J Li, L Zhang, Y Zhao 		Autophagy 2018
CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer
W Xu, Q Wei, M Han, B Zhou, H Wang, J Zhang, Q Wang, J Sun, L Feng, S Wang, Y Ye, X Wang, J Zhou, H Jin 		International journal of biological sciences 2018
Chronic Alcohol Consumption Inhibits Autophagy and Promotes Apoptosis in the Liver
M Menk, JA Graw, D Poyraz, N Möbius, CD Spies, C von Haefen 		International journal of medical sciences 2018
Triptolide induces autophagy and apoptosis through ERK activation in human breast cancer MCF‑7 cells
H Gao, Y Zhang, L Dong, XY Qu, LN Tao, YM Zhang, JH Zhai, YQ Song 		Experimental and therapeutic medicine 2018
Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis
Y Saito, S Moriya, H Kazama, K Hirasawa, K Miyahara, H Kokuba, H Hino, H Kikuchi, N Takano, M Hiramoto, K Tsukahara, K Miyazawa 		International journal of oncology 2018
Pexophagy: Molecular Mechanisms and Implications for Health and Diseases
Dong-Hyung Cho, Yi Sak Kim, Doo Sin Jo, Seong-Kyu Choe, Eun-Kyeong Jo 		Molecules and Cells 2018
Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease
B Khambu, S Yan, N Huda, G Liu, XM Yin 		Liver Research 2018
Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
J Durand, Q Zhang, A Baldwin 		Cells 2018
Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells
S Zielke, N Meyer, M Mari, K Abou-El-Ardat, F Reggiori, SJ van Wijk, D Kögel, S Fulda 		Cell Death and Disease 2018
MicroRNA‑99b promotes Helicobacter pylori‑induced autophagyand suppresses carcinogenesis by targeting mTOR
L Yang, C Li, Y Jia 		Oncology Letters 2018
ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
M Liu, T Zeng, X Zhang, C Liu, Z Wu, L Yao, C Xie, H Xia, Q Lin, L Xie, D Zhou, X Deng, HL Chan, TJ Zhao, HR Wang 		Nature Communications 2018
Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms
AJ Scott, JJ Arcaroli, SM Bagby, R Yahn, KM Huber, NJ Serkova, A Nguyen, J Kim, A Thorburn, J Vogel, KS Quackenbush, A Capasso, A Schreiber, P Blatchford, PJ Klauck, TM Pitts, SG Eckhardt, WA Messersmith 		Molecular cancer therapeutics 2018
On the Role of Basal Autophagy in Adult Neural Stem Cells and Neurogenesis
L Casares-Crespo, I Calatayud-Baselga, L García-Corzo, H Mira 		Frontiers in cellular neuroscience 2018
Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
MB Menon, S Dhamija 		Frontiers in Cell and Developmental Biology 2018
MicroRNA-495-3p inhibits multidrug resistance by modulating autophagy through GRP78/mTOR axis in gastric cancer
S Chen, J Wu, K Jiao, Q Wu, J Ma, D Chen, J Kang, G Zhao, Y Shi, D Fan, G Zhao 		Cell Death and Disease 2018
Autophagy, selective autophagy, and necroptosis in COPD
K Mizumura, S Maruoka, T Shimizu, Y Gon 		International journal of chronic obstructive pulmonary disease 2018
Intraphagolysosomal conditions predispose to Staphylococcus epidermidis small colony variants persistence in macrophages
A Magryś, K Deryło, A Bogut, A Olender, M Tchórzewski, H Rohde 		PloS one 2018
Activation of CREBZF Increases Cell Apoptosis in Mouse Ovarian Granulosa Cells by Regulating the ERK1/2 and mTOR Signaling Pathways
F Chen, X Wen, P Lin, H Chen, A Wang, Y Jin 		International journal of molecular sciences 2018
Beclin-1-Dependent Autophagy Protects the Heart During Sepsis
Y Sun, X Yao, QJ Zhang, M Zhu, ZP Liu, B Ci, Y Xie, D Carlson, BA Rothermel, Y Sun, B Levine, JA Hill, SE Wolf, JP Minei, QS Zang 		Circulation 2018
Exploiting Nanomaterial-Mediated Autophagy for Cancer Therapy
W Wei, ZT Rosenkrans, QY Luo, X Lan, W Cai 		Small Methods 2018
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
KA Escobar, NH Cole, CM Mermier, TA VanDusseldorp 		Aging Cell 2018
Naïve CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells
F Nicoli, L Papagno, JJ Frere, MP Cabral-Piccin, E Clave, E Gostick, A Toubert, DA Price, A Caputo, V Appay 		Frontiers in immunology 2018
Effect of Trehalose Supplementation on Autophagy and Cystogenesis in a Mouse Model of Polycystic Kidney Disease
LF Chou, YL Cheng, CY Hsieh, CY Lin, HY Yang, YC Chen, CC Hung, YC Tian, CW Yang, MY Chang 		Nutrients 2018
Nutmeg Extract Increases Skeletal Muscle Mass in Aging Rats Partly via IGF1-AKT-mTOR Pathway and Inhibition of Autophagy
YS Pratiwi, R Lesmana, H Goenawan, N Sylviana, I Setiawan, VM Tarawan, K Lestari, R Abdulah, L Dwipa, A Purba, U Supratman 		Evidence-Based Complementary and Alternative Medicine 2018
Autophagy Induction by HIV-Tat and Methamphetamine in Primary Midbrain Neuronal Cells of Tree Shrews via the mTOR Signaling and ATG5/ATG7 Pathway
J Li, W Wang, P Tong, CK Leung, G Yang, Z Li, N Li, X Sun, Y Han, C Lu, D Kuang, J Dai, X Zeng 		Frontiers in neuroscience 2018
Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders
W Ge, E Jakobsson 		Frontiers in neuroscience 2018
Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis
X Xiong, X Liu, H Li, H He, Y Sun, Y Zhao 		Cell Death and Disease 2018
Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells
SD Merkley, CJ Chock, XO Yang, J Harris, EF Castillo 		Frontiers in immunology 2018
Essential Role of mTOR Signaling in Human Retinal Pigment Epithelial Cell Regeneration After Laser Photocoagulation
SB Madrakhimov, JY Yang, HY Park, TK Park 		Lasers in Medical Science 2018
Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis: Early onset myopathy due to loss of muscle mTOR activity
Q Zhang, A Duplany, V Moncollin, S Mouradian, E Goillot, L Mazelin, K Gauthier, N Streichenberger, C Angleraux, J Chen, S Ding, L Schaeffer, YG Gangloff 		Journal of Cachexia, Sarcopenia and Muscle 2018
Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling
H Liu, K Zhou, L Liao, T Zhang, M Yang, C Sun 		Respiratory Research 2018
Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR‐18a‐5p
L Zhang, X Deng, X Shi, X Dong 		Journal of Cellular Biochemistry 2018
Preconditioning of umbilical cord‐derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice via the CXCR4/CXCL12 axis
J Zheng, H Li, L He, Y Huang, J Cai, L Chen, C Zhou, H Fu, T Lu, Y Zhang, J Yao, Y Yang 		Cell Proliferation 2018
The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization
R Lima, D Sousa, A Gomes, N Mendes, R Matthiesen, M Pedro, F Marques, M Pinto, E Sousa, M Vasconcelos 		Molecules (Basel, Switzerland) 2018
Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy
B Wang, Y Zhong, Q Li, L Cui, G Huang 		Aging 2018
Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling
S Chandran, JA Suggs, BJ Wang, A Han, S Bhide, DE Cryderman, SA Moore, SI Bernstein, LL Wallrath, GC Melkani 		Human Molecular Genetics 2018
The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells
D Yang, H Zhang, J Wu, R Ma, Z Li, K Wang, F Yang 		Bioscience Reports 2018
p62/ SQSTM 1: ‘Jack of all trades’ in health and cancer
P SánchezMartín, T Saito, M Komatsu 		The FEBS journal 2018
Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress.
Luo XN, Yao HL, Song J, Song QQ, Shi BT, Xia D, Han J 		Biomedical and environmental sciences : BES 2018
自噬在肺动脉高压发生和发展中的调节作用
LYU D, YING K 		2018
Activation of DRD5 (Dopamine Receptor D5) Inhibits Tumor Growth by Autophagic Cell Death
ZG Leng, SJ Lin, ZR Wu, YH Guo, L Cai, HB Shang, H Tang, YJ Xue, MQ Lou, W Zhao, WD Le, WG Zhao, X Zhang, ZB Wu 		Autophagy 2017
α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy
SH Park, MK Kang, YJ Choi, YH Kim, LD Antika, DY Kim, EJ Lee, SS Lim, YH Kang 		Oncotarget 2017
From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home
MM Harnett, MA Pineda, PL de Laté, RJ Eason, S Besteiro, W Harnett, G Langsley 		Biomedical journal 2017
Autophagy and Tumor Metabolism
AC Kimmelman, E White 		Cell Metabolism 2017
Autophagy is required for crizotinib-induced apoptosis in MET-amplified gastric cancer cells
RD Schroeder, W Choi, DS Hong, DJ McConkey 		Oncotarget 2017
Implication of Different HIV-1 Genes in the Modulation of Autophagy
Z Liu, Y Xiao, C Torresilla, É Rassart, B Barbeau 		Viruses 2017
Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity
S Faes, N Demartines, O Dormond 		Oxidative medicine and cellular longevity 2017
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy
S Ruf, AM Heberle, M Langelaar-Makkinje, S Gelino, D Wilkinson, C Gerbeth, JJ Schwarz, B Holzwarth, B Warscheid, C Meisinger, MA van Vugt, R Baumeister, M Hansen, K Thedieck 		Autophagy 2017
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy
X Ma, S Zhang, L He, Y Rong, LW Brier, Q Sun, R Liu, W Fan, S Chen, Z Yue, J Kim, KL Guan, D Li, Q Zhong 		Autophagy 2017
Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
GJ Yoshida 		Journal of Hematology & Oncology 2017
Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia
JA Park, CH Lee 		Journal of Veterinary Science 2017
Human T-cell lymphotropic virus type 1 and its oncogenesis
L Zhang, J Wei, L Wang, S Huang, JL Chen 		Acta Pharmacologica Sinica 2017
mTORC1 signaling in hepatic lipid metabolism
J Han, Y Wang 		Protein & Cell 2017
Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy
A Sharma, TJ Simonson, CN Jondle, BB Mishra, J Sharma 		The Journal of Infectious Diseases 2017
Relevance of autophagy to fatty liver diseases and potential therapeutic applications
S Yan, N Huda, B Khambu, XM Yin 		Amino Acids 2017
Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action
C Liu, W Dai, Y Bai, C Chi, Y Xin, G He, K Mai, C Duan 		Scientific Reports 2017
Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy
M Kitada, Y Ogura, I Monno, D Koya 		Current Diabetes Reports 2017
Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK
Q Huang, T Wang, L Yang, HY Wang 		International journal of molecular sciences 2017
The cholangiocyte primary cilium in health and disease
AP Mansini, E Peixoto, KM Thelen, C Gaspari, S Jin, SA Gradilone 		Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2017
Adeno-Associated Viral Vector-Mediated mTOR Inhibition by Short Hairpin RNA Suppresses Laser-Induced Choroidal Neovascularization
TK Park, SH Lee, JS Choi, SK Nah, HJ Kim, HY Park, H Lee, SH Lee, K Park 		Molecular Therapy - Nucleic Acids 2017
The Antiproliferative Effect of Cyclodipeptides from Pseudomonas aeruginosa PAO1 on HeLa Cells Involves Inhibition of Phosphorylation of Akt and S6k Kinases
L Hernández-Padilla, D Vázquez-Rivera, LA Sánchez-Briones, AL Díaz-Pérez, J Moreno-Rodríguez, MA Moreno-Eutimio, V Meza-Carmen, HR la Cruz, J Campos-García 		Molecules (Basel, Switzerland) 2017
The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis
B Davaadelger, RE Perez, Y Zhou, L Duan, S Gitelis, CG Maki 		Cancer biology & therapy 2017
Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
M Blandino-Rosano, R Barbaresso, M Jimenez-Palomares, N Bozadjieva, JP Werneck-de-Castro, M Hatanaka, RG Mirmira, N Sonenberg, M Liu, MA Rüegg, MN Hall, E Bernal-Mizrachi 		Nature Communications 2017
Ibrutinib, a Bruton’s tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma
J Wang, X Liu, Y Hong, S Wang, P Chen, A Gu, X Guo, P Zhao 		Journal of Experimental & Clinical Cancer Research 2017
Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy
AU Nissar, L Sharma, MA Mudasir, LA Nazir, SA Umar, PR Sharma, RA Vishwakarma, SA Tasduq 		Journal of lipid research 2017
5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells
V Dembitz, H Lalic, D Visnjic 		Cell Death Discovery 2017
Transcription factors NRF2 and HSF1 have opposing functions in autophagy
SD Naidu, D Dikovskaya, E Gaurilcikaite, EV Knatko, ZR Healy, H Mohan, G Koh, A Laurell, G Ball, D Olagnier, L la Vega, IG Ganley, P Talalay, AT Dinkova-Kostova 		Scientific Reports 2017
Involvement of mTOR-autophagy in the selection of primitive mesenchymal stem cells in chitosan film 3-dimensional culture
HY Chiu, YG Tsay, SC Hung 		Scientific Reports 2017
Curcumin Induces Autophagy, Apoptosis, and Cell Cycle Arrest in Human Pancreatic Cancer Cells
Y Zhu, S Bu 		Evidence-Based Complementary and Alternative Medicine 2017
Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development
L Wang, Z Ni, Y Liu, S Ji, F Jin, K Jiang, J Ma, C Ren, H Zhang, Z Hu, X Zha 		Oncotarget 2017
Tracking the embryonic stem cell transition from ground state pluripotency
T Kalkan, N Olova, M Roode, C Mulas, HJ Lee, I Nett, H Marks, R Walker, HG Stunnenberg, KS Lilley, J Nichols, W Reik, P Bertone, A Smith 		Development (Cambridge, England) 2017
Inflammasome and Autophagy Regulation: A Two-way Street
Q Sun, J Fan 		Molecular Medicine 2017
PAFR selectively mediates radioresistance and irradiation-induced autophagy suppression in prostate cancer cells
B Yao, B Liu, L Shi, X Li, C Ren, M Cai, W Wang, J Li, Y Sun, Y Wu, J Wen 		Oncotarget 2017
Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism
T Shen, O Alvarez-Garcia, Y Li, M Olmer, MK Lotz 		Osteoarthritis and Cartilage 2017
An Update on AMPK in Hydrogen Sulfide Pharmacology
M Wang, W Tang, YZ Zhu 		Frontiers in pharmacology 2017
Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3 -Targeted Knockin Mice
SR Singh, AT Zech, B Geertz, S Reischmann-Düsener, H Osinska, M Prondzynski, E Krämer, Q Meng, C Redwood, J der Velden, J Robbins, S Schlossarek, L Carrier 		Circulation. Heart failure 2017
Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target
CN Roybal, G Velez, M Toral, SH Tsang, AG Bassuk, VB Mahajan 		American Journal of Ophthalmology 2017
NADPH Oxidase Deficiency: A Multisystem Approach
G Giardino, MP Cicalese, O Delmonte, M Migliavacca, B Palterer, L Loffredo, E Cirillo, V Gallo, F Violi, C Pignata 		Oxidative medicine and cellular longevity 2017
Dysregulation of autophagy as a common mechanism in lysosomal storage diseases
E Seranova, KJ Connolly, M Zatyka, TR Rosenstock, T Barrett, RI Tuxworth, S Sarkar 		Essays in Biochemistry 2017
Autophagy: novel applications of nonsteroidal anti-inflammatory drugs for primary cancer
C Yu, W Li, J Liu, J Lu, J Feng 		Cancer Medicine 2017
PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target
Y Yin, W Dang, X Zhou, L Xu, W Wang, W Cao, S Chen, J Su, X Cai, S Xiao, MP Peppelenbosch, Q Pan 		Virulence 2017
Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity
R Romero, O Erez, M Hüttemann, E Maymon, B Panaitescu, A Conde-Agudelo, P Pacora, BH Yoon, LI Grossman 		American Journal of Obstetrics and Gynecology 2017
Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors
Chude CI, Amaravadi RK 		International journal of molecular sciences 2017
L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury.
Xu J, Huai Y, Meng N, Dong Y, Liu Z, Qi Q, Hu M, Fan M, Jin W, Lv P 		Neurochemical Research 2017
[Inhibiting mammalian target of rapamycin signaling pathway improves cognitive function in mice with chronic cerebral ischemia].
Zhang B, Wu M, Liu L, Zhu Y, Kai J, Zeng L 		Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2017
Convergence and Cooperation of Mechanistically Distinct Cancer-Associated mTOR Activation Clusters
Jianing Xu, Can Pham, Steven Albanese, Yiyu Dong, Toshinao Oyama, Chung-Han Lee, Vanessa Rodrik-Outmezguine, Zhan Yao, Song Han, David Chen, Daniel Parton, John Chodera, Neal Rosen, Emily Cheng, James Hsieh 		Journal of Clinical Investigation 2016
The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer’s disease pathogenesis
Y Kim, C Kim, SM Son, H Song, HS Hong, S Han, I Mook-Jung 		Molecular Neurodegeneration 2016
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions
A Anandhan, S Lei, R Levytskyy, A Pappa, MI Panayiotidis, RL Cerny, O Khalimonchuk, R Powers, R Franco 		Molecular Neurobiology 2016
Roles of mTOR complexes in the kidney: implications for renal disease and transplantation
D Fantus, NM Rogers, F Grahammer, TB Huber, AW Thomson 		Nature Reviews Nephrology 2016
Autophagy: Friend or Foe in Lung Disease?
Kenji Mizumura, Suzanne Cloonan, Mary E Choi, Shu Hashimoto, Kiichi Nakahira, Stefan W Ryter, Augustine M K Choi 		Annals of the American Thoracic Society 2016
Identification of natural products with neuronal and metabolic benefits through autophagy induction
Y Fan, N Wang, A Rocchi, W Zhang, R Vassar, Y Zhou, C He 		Autophagy 2016
G protein γ subunit 7 induces autophagy and inhibits cell division
J Liu, X Ji, Z Li, X Yang, W Wang, X Zhang 		Oncotarget 2016
Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model
P Zhu, CJ Sieben, X Xu, PC Harris, X Lin 		Human Molecular Genetics 2016
mTORC1 and mTORC2 in cancer and the tumor microenvironment
LC Kim, RS Cook, J Chen 		Oncogene 2016
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
CJ Holler, G Taylor, ZT McEachin, Q Deng, WJ Watkins, K Hudson, CA Easley, WT Hu, CM Hales, W Rossoll, GJ Bassell, T Kukar 		Molecular Neurodegeneration 2016
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation
SR Kimball, BS Gordon, JE Moyer, MD Dennis, LS Jefferson 		Cellular Signalling 2016
Protein prenylation: unique fats make their mark on biology
M Wang, PJ Casey 		Nature Reviews Molecular Cell Biology 2016
Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance
TP Fitzgibbons, MP Czech 		Journal of Molecular Medicine 2016
Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
G Musso, M Cassader, R Gambino 		Nature Reviews Drug Discovery 2016
The role of autophagy in cardiac hypertrophy
L Li, J Xu, L He, L Peng, Q Zhong, L Chen, Z Jiang 		Acta Biochimica et Biophysica Sinica 2016
nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
V Gandin, L Masvidal, L Hulea, SP Gravel, M Cargnello, S McLaughlan, Y Cai, P Balanathan, M Morita, A Rajakumar, L Furic, M Pollak, JA Porco, J St-Pierre, J Pelletier, O Larsson, I Topisirovic 		Genome research 2016
Autophagy in acute kidney injury
GP Kaushal, SV Shah 		Kidney International 2016
MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy
A Polak, P Kiliszek, T Sewastianik, M Szydłowski, E Jabłońska, E Białopiotrowicz, P Górniak, S Markowicz, E Nowak, MA Grygorowicz, M Prochorec-Sobieszek, D Nowis, J Gołąb, S Giebel, E Lech-Marańda, K Warzocha, P Juszczyński, JI Park 		PloS one 2016
mTOR Regulation of Lymphoid Cells in Immunity to Pathogens
R Keating, MA McGargill 		Frontiers in immunology 2016
Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals
VP Tan, S Miyamoto 		Journal of Molecular and Cellular Cardiology 2016
Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway
C Huang, Y Zhang, DJ Kelly, CY Tan, A Gill, D Cheng, F Braet, JS Park, CM Sue, CA Pollock, XM Chen 		Scientific Reports 2016
Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells
PB Narasimhan, S Bennuru, Z Meng, RN Cotton, KR Elliott, S Ganesan, R McDonald-Fleming, TD Veenstra, TB Nutman, RT Semnani, JA Appleton 		Infection and immunity 2016
Inflammatory Bowel Disease Drugs: A Focus on Autophagy
KM Hooper, PG Barlow, C Stevens, P Henderson 		Journal of Crohn's & colitis 2016
Defective phosphoinositide metabolism in autism: Lipid Kinases and Phosphatases in Autism
C Gross 		Journal of Neuroscience Research 2016
Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo
F Liu, N Jiang, Z Xiao, J Cheng, Y Mei, P Zheng, L Wang, X Zhang, X Zhou, W Zhou, Y Zhang 		PeerJ 2016
WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes
G David-Morrison, Z Xu, YN Rui, WL Charng, M Jaiswal, S Yamamoto, B Xiong, K Zhang, H Sandoval, L Duraine, Z Zuo, S Zhang, HJ Bellen 		Developmental Cell 2016
Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes
J Justice, JD Miller, JC Newman, SK Hashmi, J Halter, SN Austad, N Barzilai, JL Kirkland 		The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2016
Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis
G Ma, J Yasunaga, M Matsuoka 		Retrovirology 2016
Melatonin Suppresses Autophagy Induced by Clinostat in Preosteoblast MC3T3-E1 Cells
YM Yoo, TY Han, H Kim 		International journal of molecular sciences 2016
Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?
S Aveic, GP Tonini 		Cancer Cell International 2016
Preparation and Preclinical Evaluation of Inhalable Particles Containing Rapamycin and Anti-Tuberculosis Agents for Induction of Autophagy
A Gupta, D Sharma, J Meena, S Pandya, M Sachan, S Kumar, K Singh, K Mitra, S Sharma, AK Panda, P Gupta, UD Gupta, A Misra 		Pharmaceutical Research 2016
Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells
J Liu, Y Zhang, A Liu, J Wang, L Li, X Chen, X Gao, Y Xue, X Zhang, Y Liu 		International journal of molecular sciences 2016
The influence of oxidative stress and autophagy cross regulation on pregnancy outcome
BR de Ramos, SS Witkin 		Cell Stress and Chaperones 2016
mTOR inhibitors in cancer therapy
J Xie, X Wang, CG Proud 		F1000Research 2016
Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism
L He, KJ Weber, A Diwan, JD Schilling 		Journal of leukocyte biology 2016
Challenges and opportunities for checkpoint blockade in T-cell lymphoproliferative disorders
T Phillips, S Devata, RA Wilcox 		Journal for ImmunoTherapy of Cancer 2016
Continuous administration of the mTORC1 inhibitor everolimus induces tolerance and decreases autophagy in mice: Chronic everolimus administration decreases autophagy
A Kurdi, MD Doncker, A Leloup, H Neels, JP Timmermans, K Lemmens, S Apers, GR de Meyer, W Martinet 		British Journal of Pharmacology 2016
New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex: Advances in tuberous sclerosis complex
HC Lam, J Nijmeh, EP Henske 		The Journal of Pathology 2016
Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells
D Li, J Hu, T Wang, X Zhang, L Liu, H Wang, Y Wu, D Xu, F Wen 		Scientific Reports 2016
Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity
J Xiong, Q Kong, L Dai, H Ma, X Cao, L Liu, Z Ding 		Journal of Cellular and Molecular Medicine 2016
Autophagy and its implication in human oral diseases
YQ Tan, J Zhang, G Zhou 		Autophagy 2016
4-hydroxynonenal-mediated signaling and aging
H Zhang, HJ Forman 		Free radical biology & medicine 2016
Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a‐Dependent H3K9 Dimethylation
O Gidlöf, AL Johnstone, K Bader, BB Khomtchouk, JJ O'Reilly, S Celik, DJ van Booven, C Wahlestedt, B Metzler, D Erlinge 		Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2016
Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro
T Takarada, N Nakamichi, R Nakazato, T Kakuda, H Kokubo, S Ikeno, S Nakamura, N Kuramoto, E Hinoi, Y Yoneda 		Biochemistry and Biophysics Reports 2016
Sucrose, But Not Glucose, Blocks IL1-β-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway: S UCROSE A CTIVATES A UTOPHAGY IN H UMAN OA C HONDROCYTES
NM Khan, MY Ansari, TM Haqqi 		Journal of Cellular Biochemistry 2016
Autophagy: a druggable process that is deregulated in aging and multiple human diseases
Guido Kroemer 		Journal of Clinical Investigation 2015
Development of autophagy inducers in clinical medicine
Beth Levine, Milton Packer, Patrice Codogno 		Journal of Clinical Investigation 2015
Regulation of mitophagy in ischemic brain injury
Y Yuan, X Zhang, Y Zheng, Z Chen 		Neuroscience Bulletin 2015
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
DF Egan, MG Chun, M Vamos, H Zou, J Rong, CJ Miller, HJ Lou, D Raveendra-Panickar, CC Yang, DJ Sheffler, P Teriete, JM Asara, BE Turk, ND Cosford, RJ Shaw 		Molecular Cell 2015
Cilia in autophagy and cancer
M Cao, Q Zhong 		Cilia 2015
YAP and TAZ: a nexus for Hippo signaling and beyond
CG Hansen, T Moroishi, KL Guan 		Trends in Cell Biology 2015
Protection and pathology in TB: learning from the zebrafish model
AH Meijer 		Seminars in Immunopathology 2015
The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer’s disease
JS Talboom, R Velazquez, S Oddo 		npj Aging and Mechanisms of Disease 2015
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases
A Perl 		Nature Reviews Rheumatology 2015
Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway
FZ Wei, Z Cao, X Wang, H Wang, MY Cai, T Li, N Hattori, D Wang, Y Du, B Song, LL Cao, C Shen, L Wang, H Wang, Y Yang, D Xie, F Wang, T Ushijima, Y Zhao, WG Zhu 		Autophagy 2015
Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy
R Kishore, P Krishnamurthy, VN Garikipati, C Benedict, E Nickoloff, M Khan, J Johnson, AM Gumpert, WJ Koch, SK Verma 		Journal of Molecular and Cellular Cardiology 2015
Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines
S Mukai, S Moriya, M Hiramoto, H Kazama, H Kokuba, XF Che, T Yokoyama, S Sakamoto, A Sugawara, T Sunazuka, S Ōmura, H Handa, T Itoi, K Miyazawa 		International journal of oncology 2015
Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
T Wu, X Liang, MC Wang, L Jing, ZY Liu, H Guo, Y Liu, YY Bai, YZ Cheng, KJ Nan 		Drug design, development and therapy 2015
Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy
AM Eiden, S Zhang, JM Gary, JK Simmons, BA Mock 		Clinical cancer research 2015
Expression, modulation, and clinical correlates of the autophagy protein Beclin-1 in esophageal adenocarcinoma: BECLIN-1 ANALYSIS IN ESOPHAGEAL ADENOCARCINOMA
KM Weh, AB Howell, LA Kresty 		Molecular Carcinogenesis 2015
Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline
Lin SJ, Leng ZG, Guo YH, Cai L, Cai Y, Li N, Shang HB, Le WD, Zhao WG, Wu ZB 		Oncotarget 2015
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd 		Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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