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Citations to this article

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant
G. Paolo Dotto
G. Paolo Dotto
Published April 1, 2014
Citation Information: J Clin Invest. 2014;124(4):1446-1453. https://doi.org/10.1172/JCI72589.
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Review Article has an altmetric score of 3

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

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Abstract

It is increasingly evident that cancer results from altered organ homeostasis rather than from deregulated control of single cells or groups of cells. This applies especially to epithelial cancer, the most common form of human solid tumors and a major cause of cancer lethality. In the vast majority of cases, in situ epithelial cancer lesions do not progress into malignancy, even if they harbor many of the genetic changes found in invasive and metastatic tumors. While changes in tumor stroma are frequently viewed as secondary to changes in the epithelium, recent evidence indicates that they can play a primary role in both cancer progression and initiation. These processes may explain the phenomenon of field cancerization, i.e., the occurrence of multifocal and recurrent epithelial tumors that are preceded by and associated with widespread changes of surrounding tissue or organ “fields.”

Authors

G. Paolo Dotto

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2009 Total
Citations: 2 7 10 9 9 10 13 5 5 11 9 1 91
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (11)

Title and authors Publication Year
Sexual dimorphism in cancer
A Clocchiatti, E Cora, Y Zhang, GP Dotto
Nature Reviews Cancer 2016
Tracking Cancer Genetic Evolution using OncoTrack
AK Talukder, M Agarwal, KH Buetow, PP Denèfle
Scientific Reports 2016
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics
GP Dotto, AK Rustgi
Cancer Cell 2016
Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors
Y Sei, J Feng, X Zhao, J Forbes, D Tang, K Nagashima, J Hanson, MM Quezado, MS Hughes, SA Wank
Gastroenterology 2016
Prognostic significance of the methylation of Wnt pathway antagonists—CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling—ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas
J Paluszczak, D Wiśniewska, M Kostrzewska-Poczekaj, K Kiwerska, R Grénman, D Mielcarek-Kuchta, M Jarmuż-Szymczak
Clinical Oral Investigations 2016
Deubiquitylating enzyme, USP9X, regulates proliferation of cells of head and neck cancer lines
DM Nanayakkara, MN Nguyen, SA Wood
Cell Proliferation 2016
Cancer-associated fibroblasts in hepatocellular carcinoma
N Kubo, K Araki, H Kuwano, K Shirabe
World journal of gastroenterology : WJG 2016
CSL-p53: From senescence to CAF activation
MG Procopio, C Laszlo, GP Dotto
Cell cycle (Georgetown, Tex.) 2016
Negative control of CSL gene transcription by stress/DNA damage response and p53
E Menietti, X Xu, P Ostano, JM Joseph, K Lefort, GP Dotto
Cell cycle (Georgetown, Tex.) 2016
PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation
SH Jo, DE Kim, A Clocchiatti, GP Dotto
Oncotarget 2016
Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages
M Antsiferova, A PiwkoCzuchra, M Cangkrama, M Wietecha, D Sahin, K Birkner, VC Amann, M Levesque, D Hohl, R Dummer, S Werner
EMBO Molecular Medicine 2016

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Referenced in 2 patents
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