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Usage Information

Cellular and molecular mechanisms in kidney fibrosis
Jeremy S. Duffield
Jeremy S. Duffield
Published June 2, 2014
Citation Information: J Clin Invest. 2014;124(6):2299-2306. https://doi.org/10.1172/JCI72267.
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Review Series

Cellular and molecular mechanisms in kidney fibrosis

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Abstract

Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of pathological matrix in the interstitial space and within the walls of glomerular capillaries as well as the cellular processes resulting in this deposition are increasingly recognized as important factors amplifying kidney injury and accelerating nephron demise. Recent insights into the cellular and molecular mechanisms of fibrogenesis herald the promise of new therapies to slow kidney disease progression. This review focuses on new findings that enhance understanding of cellular and molecular mechanisms of fibrosis, the characteristics of myofibroblasts, their progenitors, and molecular pathways regulating both fibrogenesis and its resolution.

Authors

Jeremy S. Duffield

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 2,650 253
PDF 206 94
Figure 218 0
Citation downloads 84 0
Totals 3,158 347
Total Views 3,505
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