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Usage Information

Mechanisms of lymphatic metastasis
Sinem Karaman, Michael Detmar
Sinem Karaman, Michael Detmar
Published March 3, 2014
Citation Information: J Clin Invest. 2014;124(3):922-928. https://doi.org/10.1172/JCI71606.
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Review Series Article has an altmetric score of 20

Mechanisms of lymphatic metastasis

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Abstract

Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell survival, and immune modulation. New imaging approaches allow the sensitive visualization of the earliest LN metastases and the quantitative, noninvasive measurement of the function of tumor-draining lymphatic vessels, with potential applications in the development of biomarkers for prognosis and measurement of therapeutic response.

Authors

Sinem Karaman, Michael Detmar

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,753 1,493
PDF 181 173
Figure 493 12
Citation downloads 96 0
Totals 2,523 1,678
Total Views 4,201
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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Referenced in 4 patents
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