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Chinyu G. Su, … , Mitchell A. Lazar, Gary D. Wu
Published August 15, 1999
Citation Information: J Clin Invest. 1999;104(4):383-389. https://doi.org/10.1172/JCI7145.
Citation Information: J Clin Invest. 1999;104(4):383-389. https://doi.org/10.1172/JCI7145.
A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
Abstract
Peroxisome proliferator-activated receptor γ (PPAR-γ), a member of the nuclear hormone receptor superfamily originally shown to play a critical role in adipocyte differentiation and glucose homeostasis, has recently been implicated as a regulator of cellular proliferation and inflammatory responses. Colonic epithelial cells, which express high levels of PPAR-γ protein, have the ability to produce inflammatory cytokines that may play a role in inflammatory bowel disease (IBD). We report here that PPAR-γ ligands dramatically attenuate cytokine gene expression in colon cancer cell lines by inhibiting the activation of nuclear factor-κB via an IκB-α–dependent mechanism. Moreover, thiazolidinedione ligands for PPAR-γ markedly reduce colonic inflammation in a mouse model of IBD. These results suggest that colonic PPAR-γ may be a therapeutic target in humans suffering from IBD.
Authors
Chinyu G. Su, Xiaoming Wen, Shannon T. Bailey, Wen Jiang, Shamina M. Rangwala, Sue A. Keilbaugh, Anne Flanigan, Sreekant Murthy, Mitchell A. Lazar, Gary D. Wu
Total citations by year
Citation information
Citations to this article (642)
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Voluntary exercise protects against ulcerative colitis by up-regulating glucocorticoid-mediated PPAR- γ activity in the colon in mice
WX Liu, F Zhou, Y Wang, T Wang, JW Xing, S Zhang, LX Sang, SZ Gu, HL Wang |
Acta physiologica (Oxford, England) | 2015 |
|
99mTc-Mesalamine as potential agent for diagnosis and monitoring of ulcerative colitis: labelling, characterisation and biological evaluation
OA El-Kawy, MH Sanad, F Marzook |
Journal of Radioanalytical and Nuclear Chemistry | 2015 |
|
Intestinal steroidogenesis controls PPARγ expression in the colon and is impaired during ulcerative colitis
G Bouguen, A Langlois, M Djouina, J Branche, D Koriche, E Dewaeles, A Mongy, J Auwerx, JF Colombel, P Desreumaux, L Dubuquoy, B Bertin |
Gut | 2014 |
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Roles of PPARγ/NF-κB signaling pathway in the pathogenesis of intrahepatic cholestasis of pregnancy
Y Zhang, L Hu, Y Cui, Z Qi, X Huang, L Cai, T Zhang, Y Yin, Z Lu, J Xiang |
PloS one | 2014 |
|
PPAR Gamma agonists regulate tobacco smoke-induced toll like receptor 4 expression in alveolar macrophages
Y Yin, G Hou, E Li, Q Wang, J Kang |
Respiratory Research | 2014 |
|
Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway
P Kundu, TW Ling, A Korecka, Y Li, R D'Arienzo, RM Bunte, T Berger, V Arulampalam, P Chambon, TW Mak, W Wahli, S Pettersson |
PLoS pathogens | 2014 |
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H2O2 Production in Species of the Lactobacillus acidophilus Group: a Central Role for a Novel NADH-Dependent Flavin Reductase
R Hertzberger, J Arents, HL Dekker, RD Pridmore, C Gysler, M Kleerebezem, MJ de Mattos |
Applied and environmental microbiology | 2014 |
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Hydroxysafflor yellow A of Carthamus tinctorius attenuates lung injury of aged rats exposed to gasoline engine exhaust by down-regulating platelet activation
C Wang, C Wang, C Ma, Q Huang, H Sun, X Zhang, X Bai |
Phytomedicine | 2014 |
|
Conjugated Linoleic Acids Attenuate LPS-Induced Pro-Inflammatory Gene Expression by Inhibiting the NF-κB Translocation Through PPARγ in Buffalo Granulosa Cells
VR Yenuganti, R Ravinder, D Singh |
American Journal of Reproductive Immunology | 2014 |
|
Monascin Attenuates Oxidative Stress-Mediated Lung Inflammation via Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-γ) and Nuclear Factor-Erythroid 2 Related Factor 2 (Nrf-2) Modulation
WH Hsu, BH Lee, TM Pan |
Journal of Agricultural and Food Chemistry | 2014 |
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Roles of PPARγ/NF-κB Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy
Y Zhang, L Hu, Y Cui, Z Qi, X Huang, L Cai, T Zhang, Y Yin, Z Lu, J Xiang, BO Williams |
PloS one | 2014 |
|
Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance
PC Calder |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 |
|
Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway
P Kundu, TW Ling, A Korecka, Y Li, R D'Arienzo, RM Bunte, T Berger, V Arulampalam, P Chambon, TW Mak, W Wahli, S Pettersson, DM Monack |
PLoS pathogens | 2014 |
|
Minireview: Challenges and Opportunities in Development of PPAR Agonists
MB Wright, M Bortolini, M Tadayyon, M Bopst |
Molecular Endocrinology | 2014 |
|
The combinatory effects of PPAR-γ agonist and survivin inhibition on the cancer stem-like phenotype and cell proliferation in bladder cancer cells
Y Wang, H Tan, D Xu, A Ma, LI ZHANG, J Sun, Z Yang, Y Liu, G Shi |
International journal of molecular medicine | 2014 |
|
Macrophages: Biology and Role in the Pathology of Diseases
SK Biswas, A Mantovani |
2014 | |
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Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
PC Calder |
British Journal of Clinical Pharmacology | 2013 |
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Pre- and posttherapy assessment of intestinal soluble mediators in IBD: where we stand and future perspectives
F Scaldaferri, V Petito, L Lopetuso, G Bruno, V Gerardi, G Ianiro, A Sgambato, A Gasbarrini, G Cammarota |
Mediators of Inflammation | 2013 |
|
Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats
Z Liu, M Zhao, Q Zheng, H Zhao, W Hou, S Bai |
Acta Pharmacologica Sinica | 2013 |
|
Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD
Ø Brenna, MW Furnes, I Drozdov, AB Granlund, A Flatberg, AK Sandvik, RT Zwiggelaar, R Mårvik, IS Nordrum, M Kidd, BI Gustafsson |
PloS one | 2013 |
|
NLRP6 in infection and inflammation
PK Anand, TD Kanneganti |
Microbes and infection / Institut Pasteur | 2013 |
|
The role of probiotics and prebiotics in inducing gut immunity
AT Vieira, MM Teixeira, FS Martins |
Frontiers in immunology | 2013 |
|
PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis
Y Nozaki, K Harada, T Sanzen, Y Nakanuma |
Medical Molecular Morphology | 2013 |
|
Nutritional protective mechanisms against gut inflammation
M Viladomiu, R Hontecillas, L Yuan, P Lu, J Bassaganya-Riera |
The Journal of Nutritional Biochemistry | 2013 |
|
Association of Pro12Ala (rs1801282) variant of PPAR gamma with Rheumatoid Arthritis in a Pakistani population
SF Jalil, I Ahmed, Z Gauhar, M Ahmed, JM Malik, P John, A Bhatti |
Rheumatology International | 2013 |
|
Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease
R Sharma, RK Tandon |
Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease | 2013 |
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Mechanism of Retinoid X Receptor Partial Agonistic Action of 1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1 H -benzotriazole-5-carboxylic Acid and Structural Development To Increase Potency
F Ohsawa, S Yamada, N Yakushiji, R Shinozaki, M Nakayama, K Kawata, M Hagaya, T Kobayashi, K Kohara, Y Furusawa, C Fujiwara, Y Ohta, M Makishima, H Naitou, A Tai, Y Yoshikawa, H Yasui, H Kakuta |
Journal of Medicinal Chemistry | 2013 |
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The Importance of the Retinoid X Receptor Alpha in Modulating Inflammatory Signaling in Acute Murine Colitis
R Knackstedt, S Shaoli, V Moseley, M Wargovich |
Digestive Diseases and Sciences | 2013 |
|
Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention
K Simmons, WL Wang, M Tenniswood, JE Welsh |
Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention | 2013 |
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The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology
M Kiss, Z Czimmerer, L Nagy |
Journal of Allergy and Clinical Immunology | 2013 |
|
Topical rosiglitazone is an effective anti-scarring agent in the cornea
KR Huxlin, HB Hindman, KI Jeon, J Bühren, S MacRae, M DeMagistris, D Ciufo, PJ Sime, RP Phipps |
PloS one | 2013 |
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Modulatory Effect of Gliadin Peptide 10-mer on Epithelial Intestinal CACO-2 Cell Inflammatory Response
A Capozzi, O Vincentini, P Gizzi, A Porzia, A Longo, C Felli, V Mattei, F Mainiero, M Silano, M Sorice, R Misasi |
PloS one | 2013 |
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Genetic Variation in the Inflammation and Innate Immunity Pathways and Colorectal Cancer Risk
H Wang, D Taverna, DO Stram, BK Fortini, I Cheng, LR Wilkens, T Burnett, KW Makar, NM Lindor, JL Hopper, S Gallinger, JA Baron, R Haile, LN Kolonel, BE Henderson, PA Newcomb, G Casey, D Duggan, CM Ulrich, LL Marchand |
Cancer epidemiology, biomarkers & prevention | 2013 |
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Peroxisome proliferator-activated receptor-γ agonist pioglitazone suppresses experimental autoimmune uveitis
Y Okunuki, Y Usui, H Nakagawa, K Tajima, R Matsuda, S Ueda, T Hattori, T Kezuka, H Goto |
Experimental Eye Research | 2013 |
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Comparative evaluation of different doses of PPAR-γ agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats
PB D.S., B Medhi, A Prakash, A Chakrabarti, K Vaiphei, KL Khanduja |
Pharmacological Reports | 2013 |
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Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: The role of nitric oxide and IL-1β
L Moezi, R Heidari, Z Amirghofran, AA Nekooeian, A Monabati, AR Dehpour |
Pharmacological Reports | 2013 |
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Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis
AH Carlsson, O Yakymenko, I Olivier, F Håkansson, E Postma, ÅV Keita, JD Söderholm |
Scandinavian Journal of Gastroenterology | 2013 |
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Topical Rosiglitazone Is an Effective Anti-Scarring Agent in the Cornea
KR Huxlin, HB Hindman, KI Jeon, J Bühren, S MacRae, M DeMagistris, D Ciufo, PJ Sime, RP Phipps, AV Ljubimov |
PloS one | 2013 |
|
Relevance of TNBS-Colitis in Rats: A Methodological Study with Endoscopic, Histologic and Transcriptomic Characterization and Correlation to IBD
Ø Brenna, MW Furnes, I Drozdov, AB Granlund, A Flatberg, AK Sandvik, RT Zwiggelaar, R Mårvik, IS Nordrum, M Kidd, BI Gustafsson, B Foligne |
PloS one | 2013 |
|
Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?: Omega-3 fatty acids and inflammation
PC Calder |
British Journal of Clinical Pharmacology | 2013 |
|
Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor
S Alex, K Lange, T Amolo, JS Grinstead, AK Haakonsson, E Szalowska, A Koppen, K Mudde, D Haenen, S Al-Lahham, H Roelofsen, R Houtman, B van der Burg, S Mandrup, AM Bonvin, E Kalkhoven, M Muller, GJ Hooiveld, S Kersten |
Molecular and cellular biology | 2013 |
|
Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-Linked Proinflammatory Signals in Two Convergent ATF3-Associated Pathways
SH Park, KH Do, HJ Choi, J Kim, KH Kim, J Park, CG Oh, Y Moon |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity
EL Gautier, A Chow, R Spanbroek, G Marcelin, M Greter, C Jakubzick, M Bogunovic, M Leboeuf, N Rooijen, AJ Habenicht, M Merad, GJ Randolph |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
|
The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases
JM Choi, AL Bothwell |
Molecules and Cells | 2012 |
|
PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
L Sabatino, A Fucci, M Pancione, V Colantuoni |
PPAR Research | 2012 |
|
Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer
SK Bunt, AM Mohr, JM Bailey, PM Grandgenett, MA Hollingsworth |
Cancer Immunology, Immunotherapy | 2012 |
|
The Modulation of PPARγ1 and PPARγ2 mRNA Expression by Ciglitazone in CD3/CD28-Activated Naïve and Memory CD4+ T Cells
MN Norazmi, R Mohamed, AA Nurul, NS Yaacob |
Clinical and Developmental Immunology | 2012 |
|
Pioglitazone, a PPAR-γ activator, attenuates the severity of cerulein-induced acute pancreatitis by modulating early growth response-1 transcription factor
H Wan, Y Yuan, J Liu, G Chen |
Translational Research | 2012 |
|
Histopathological Study of Evening Primrose Oil Effects on Experimental Diabetic Neuropathy
OM Omran |
Ultrastructural Pathology | 2012 |
|
PPARgamma, Bioactive Lipids, and Cancer Progression
GT Robbins, D Nie |
Frontiers in bioscience : a journal and virtual library | 2012 |
|
15-deoxy-Δ12,14-prostaglandin J2 reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice
Z Han, T Zhu, X Liu, C Li, S Yue, X Liu, L Yang, L Yang, L Li |
Hepatology | 2012 |
|
Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A
S Mohan, SI Abdelwahab, B Kamalidehghan, S Syam, KS May, NS Harmal, N Shafifiyaz, AH Hadi, NM Hashim, M Rahmani, MM Taha, SC Cheah, A Zajmi |
Phytomedicine | 2012 |
|
Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions
J Noel, S Chatterjee |
Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions | 2012 |
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Peptidoglycan induced expression of peroxisome proliferator-activated receptor γ in mouse peritoneal macrophages: Role of ERK and JNK MAP kinases
KH Bhatt, A Sodhi, R Chakraborty |
Cytokine | 2012 |
|
Interferon-α, -β and -γ induce CXCL11 secretion in human thyrocytes: Modulation by peroxisome proliferator-activated receptor γ agonists
A Antonelli, SM Ferrari, C Mancusi, V Mazzi, C Pupilli, M Centanni, C Ferri, E Ferrannini, P Fallahi |
Immunobiology | 2012 |
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Tetradecylthioacetic Acid Attenuates Inflammation and Has Antioxidative Potential During Experimental Colitis in Rats
B Bjørndal, T Grimstad, D Cacabelos, K Nylund, OG Aasprong, R Omdal, M Portero-Otin, R Pamplona, GA Lied, T Hausken, RK Berge |
Digestive Diseases and Sciences | 2012 |
|
Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis
K Mbodji, C Charpentier, C Guérin, C Querec, C Bole-Feysot, M Aziz, G Savoye, P Déchelotte, R Marion-Letellier |
The Journal of Nutritional Biochemistry | 2012 |
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Simultaneous Inhibition of COX-2 and Activation of PPAR-γ Resulted in the Same Level and Pattern of Neuroprotection as They were Targeted Separately
SB Abraki, L Khalaj, F Shaerzadeh, F Khodagholi |
Journal of Molecular Neuroscience | 2012 |
|
Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes
KH Do, HJ Choi, J Kim, SH Park, HH Kim, CG Oh, Y Moon |
Biochemical Pharmacology | 2012 |
|
15-Deoxy-Δ12,14-prostaglandin J2 attenuates the biological activities of monocyte/macrophage cell lines
X Liu, H Yu, L Yang, C Li, L Li |
European Journal of Cell Biology | 2012 |
|
META060 protects against diet-induced obesity and insulin resistance in a high-fat–diet fed mouse
IO Vroegrijk, JA van Diepen, SA van Berg, JA Romijn, LM Havekes, KW van Dijk, G Darland, V Konda, ML Tripp, JS Bland, PJ Voshol |
Nutrition | 2012 |
|
Colitis ulcerosa: Immunfunktion, Gewebefibrose und aktuelle Therapieansätze
J Maul, M Zeitz |
Coloproctology | 2012 |
|
Integrated stress response-altered proinflammatory signals in mucosal immune-related cells
SH Park, Y Moon |
Immunopharmacology and Immunotoxicology | 2012 |
|
Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtype
L Belmonte, SB Youmba, N Bertiaux-Vandaële, M Antonietti, S Lecleire, A Zalar, G Gourcerol, AM Leroi, P Déchelotte, M Coëffier, P Ducrotté |
PloS one | 2012 |
|
Influence of Rosiglitazone on the Expression of PPARγ, NF-κB, and TNF-α in Rat Model of Ulcerative Colitis
JW Mao, HY Tang, YD Wang |
Gastroenterology Research and Practice | 2012 |
|
Retinoic acid signalling in gastrointestinal parasite infections: lessons from mouse models
RJ Hurst, KJ Else |
Parasite Immunology | 2012 |
|
Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
E Hovsepian, F Penas, GA Mirkin, NB Goren |
PPAR Research | 2012 |
|
PPAR γ in Inflammatory Bowel Disease
V Annese, F Rogai, A Settesoldi, S Bagnoli |
PPAR Research | 2012 |
|
Dietary Conjugated Linoleic Acid Activates PPARγ and the Intestinal Trefoil Factor in SW480 Cells and Mice with Dextran Sulfate Sodium-Induced Colitis
S Borniquel, C Jädert, JO Lundberg |
The Journal of nutrition | 2012 |
|
PPARs and Lipid Ligands in Inflammation and Metabolism
GS Harmon, MT Lam, CK Glass |
Chemical Reviews | 2011 |
|
PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
T Varga, Z Czimmerer, L Nagy |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2011 |
|
β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway
AF Bento, R Marcon, RC Dutra, RF Claudino, M Cola, DF Leite, JB Calixto |
The American Journal of Pathology | 2011 |
|
Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations
J Maul, M Zeitz |
Langenbeck's Archives of Surgery | 2011 |
|
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
S Lee, X Zuo, I Shureiqi |
Cancer and Metastasis Reviews | 2011 |
|
Oxidative Stress and Disease
I Paur, M Carlsen, B Halvorsen, R Blomhoff |
Herbal Medicine | 2011 |
|
Activation of farnesoid X receptor attenuates liver injury in systemic lupus erythematosus
F Lian, Y Wang, J Chen, H Xu, X Yang, L Liang, Z Zhan, Y Ye, M Chen |
Rheumatology International | 2011 |
|
Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2
O Vincentini, MG Quaranta, M Viora, C Agostoni, M Silano |
Clinical Nutrition | 2011 |
|
Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells
G Zanello, M Berri, J Dupont, PY Sizaret, R D'Inca, H Salmon, F Meurens |
PloS one | 2011 |
|
Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media
A Overman, CC Chuang, M McIntosh |
International Journal of Obesity | 2011 |
|
Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice
J Bassaganya-Riera, M DiGuardo, M Climent, C Vives, A Carbo, ZE Jouni, AW Einerhand, M O'Shea, R Hontecillas |
British Journal of Nutrition | 2011 |
|
Preventive action of curcumin in experimental acute pancreatitis in mouse
WG Yu, G Xu, GJ Ren, X Xu, HQ Yuan, XL Qi, KL Tian |
The Indian journal of medical research | 2011 |
|
Mycobacterium bovis Bacillus Calmette-Guérin Killed by Extended Freeze-Drying Reduces Colitis in Mice
M Lagranderie, C Kluge, H Kiefer–Biasizzo, M Abolhassani, MA Nahori, C Fitting, M Huerre, A Bandeira, H Bercovier, G Marchal |
Gastroenterology | 2011 |
|
Thiazolidinedione Use and Ulcerative Colitis-related Flares: An exploratory analysis of administrative data
JL Lund, T Stürmer, CQ Porter, RS Sandler, MD Kappelman |
Inflammatory Bowel Diseases | 2011 |
|
Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors
ML Batista, SB Peres, ME McDonald, PS Alcantara, M Olivan, JP Otoch, SR Farmer, M Seelaender |
Cytokine | 2011 |
|
Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats
T Grimstad, B Bjørndal, D Cacabelos, OG Aasprong, EA Janssen, R Omdal, A Svardal, T Hausken, P Bohov, M Portero-Otin, R Pamplona, RK Berge |
Scandinavian Journal of Gastroenterology | 2011 |
|
Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPARγ pathway during acute endotoxemia
AW Feng, W Gao, GR Zhou, R Yu, N Li, XL Huang, QR Li, JS Li |
International Immunopharmacology | 2011 |
|
Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort
S Poliska, A Penyige, PL Lakatos, M Papp, K Palatka, L Lakatos, T Molnar, L Nagy |
Inflammatory Bowel Diseases | 2011 |
|
Inhibitory effect of rosiglitazone on the acid-induced intracellular generation of hydrogen peroxide in cultured feline esophageal epithelial cells
SY Park, UD Sohn |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2011 |
|
15-Deoxy-Δ12,14-prostaglandin J2 interferes inducible synthesis of prostaglandins E2 and F2α that suppress subsequent adipogenesis program in cultured preadipocytes
AA Chowdhury, MS Rahman, K Nishimura, M Jisaka, T Nagaya, T Ishikawa, F Shono, K Yokota |
Prostaglandins & Other Lipid Mediators | 2011 |
|
Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia
AW Feng, C Yu, Q Mao, N Li, QR Li, JS Li |
Fitoterapia | 2011 |
|
Challenge of Creating Single-agents for the Treatment of Type 1 and 2 Diabetes by Targeting Retinoid X Receptor
H KAKUTA |
YAKUGAKU ZASSHI | 2011 |
|
Saccharomyces cerevisiae Modulates Immune Gene Expressions and Inhibits ETEC-Mediated ERK1/2 and p38 Signaling Pathways in Intestinal Epithelial Cells
G Zanello, M Berri, J Dupont, PY Sizaret, R D'Inca, H Salmon, F Meurens, D Ojcius |
PloS one | 2011 |
|
Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine
SL Kempster, G Belteki, AJ Forhead, AL Fowden, RD Catalano, BY Lam, I McFarlane, DS Charnock-Jones, GC Smith |
AJP Gastrointestinal and Liver Physiology | 2011 |
|
Beneficial Effects of THSG on Acetic Acid-Induced Experimental Colitis: Involvement of Upregulation of PPAR-γ and Inhibition of the Nf-Κb Inflammatory Pathway
C Zeng, JH Xiao, MJ Chang, JL Wang |
Molecules (Basel, Switzerland) | 2011 |
|
Inflammatory Bowel Disease
A Kaser, S Zeissig, RS Blumberg |
Annual Review of Immunology | 2010 |
|
Structural requirement for PPARγ binding revealed by a meta analysis of holo-crystal structures
AS Nascimento |
Biochimie | 2010 |
|
Effects of rosiglitazone on inflammation in Otsuka long-evans Tokushima Fatty rats
JW Lee, IS Nam-Goong, JG Kim, CH Yun, SJ Kim, JI Choi, YI Kim, ES Kim |
Korean Diabetes Journal | 2010 |
|
Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice
HY Cho, W Gladwell, X Wang, B Chorley, D Bell, SP Reddy, SR Kleeberger |
American journal of respiratory and critical care medicine | 2010 |
|
The PXR is a drug target for chronic inflammatory liver disease
K Wallace, DE Cowie, DK Konstantinou, SJ Hill, TE Tjelle, A Axon, M Koruth, SA White, H Carlsen, DA Mann, MC Wright |
The Journal of Steroid Biochemistry and Molecular Biology | 2010 |
|
Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice
GS Harmon, DS Dumlao, DT Ng, KE Barrett, EA Dennis, H Dong, CK Glass |
Nature Medicine | 2010 |
|
Endoplasmic Reticulum Stress-activated C/EBP Homologous Protein Enhances Nuclear Factor-κB Signals via Repression of Peroxisome Proliferator-activated Receptor γ*
SH Park, HJ Choi, H Yang, KH Do, J Kim, DW Lee, Y Moon |
The Journal of biological chemistry | 2010 |
|
Peroxisome proliferator activated receptor-γ and traumatic brain injury
L Qi, A Jacob, P Wang, R Wu |
International journal of clinical and experimental medicine | 2010 |
|
Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media
A Overman, A Bumrungpert, A Kennedy, K Martinez, CC Chuang, T West, B Dawson, W Jia, M McIntosh |
International Journal of Obesity | 2010 |
|
Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine
SL Kempster, G Belteki, AJ Forhead, AL Fowden, RD Catalano, BY Lam, I McFarlane, DS Charnock-Jones, GC Smith |
AJP Gastrointestinal and Liver Physiology | 2010 |
|
Peroxisome proliferator-activated receptors in chronic inflammation and colorectal cancer
D Wang, RN DuBois |
Gastroenterology Clinics of North America | 2010 |
|
Beneficial Effects of Probiotic and Food Borne Yeasts on Human Health
S Moslehi-Jenabian, LL Pedersen, L Jespersen |
Nutrients | 2010 |
|
Chronic Kidney Disease, Dialysis, and Transplantation
IH de Boer |
Chronic Kidney Disease, Dialysis, and Transplantation | 2010 |
|
Biological therapies of inflammatory bowel disease
A Bai, Z Peng |
Immunotherapy | 2010 |
|
Distribution of peroxisome proliferator–activated receptor–gamma polymorphisms in Chinese and Dutch patients with inflammatory bowel disease:
UK Shrestha, O Karimi, BJ Crusius, F Zhou, Z Wang, Z Chen, AA van Bodegraven, J Xiao, SA Morré, H Wang, J Li, B Xia |
Inflammatory Bowel Diseases | 2010 |
|
Anti-allergic function and regulatory mechanisms of KR62980 in allergen-induced airway inflammation
HY Won, HJ Min, JH Ahn, SE Yoo, MA Bae, JH Hong, ES Hwang |
Biochemical Pharmacology | 2010 |
|
Oxidation in foods and beverages and antioxidant applications
K Eder, R Ringseis |
Oxidation in foods and beverages and antioxidant applications | 2010 |
|
15-DEOXY-Δ12,14 PROSTAGLANDIN GJ2 BUT NOT ROSIGLITAZONE REGULATES METALLOPROTEINASE 9, NOS-2, AND CYCLOOXYGENASE 2 EXPRESSION AND FUNCTIONS BY PEROXISOME PROLIFERATORYACTIVATED RECEPTOR γ-DEPENDENT AND -INDEPENDENT MECHANISMS IN CARDIAC CELLS:
E Hovsepian, F Penas, NB Goren |
Shock | 2010 |
|
Effects of 15-deoxy-∆12,14-prostaglandin J2 on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide
YI Kim, JW Lee, MH Lee, SW Park, BN Cho, HK Lee |
Molecular Biology Reports | 2010 |
|
Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARγ activation: Antiinflammatory activity of Azelaic acid
A Mastrofrancesco, M Ottaviani, N Aspite, G Cardinali, E Izzo, K Graupe, CC Zouboulis, E Camera, M Picardo |
Experimental Dermatology | 2010 |
|
Peroxisome proliferator-activated receptor γ 2 mutation may cause a subset of ulcerative colitis: PPARγ2 mutation in ulcerative colitis
Y Aoyagi, S Nagata, T Kudo, T Fujii, M Wada, Y Chiba, Y Ohtsuka, Y Yamashiro, T Shimizu, T Ohkusa |
Pediatrics International | 2010 |
|
PPARs in Irradiation-Induced Gastrointestinal Toxicity
C Linard, M Souidi |
PPAR Research | 2010 |
|
Gastrointestinal Cytoprotection by PPAR Ligands
Y Naito, T Takagi, T Yoshikawa |
PPAR Research | 2010 |
|
Endoplasmic Reticulum Stress-activated C/EBP Homologous Protein Enhances Nuclear Factor-κB Signals via Repression of Peroxisome Proliferator-activated Receptor γ
SH Park, HJ Choi, H Yang, KH Do, J Kim, DW Lee, Y Moon |
The Journal of biological chemistry | 2010 |
|
Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers
F Ohsawa, K Morishita, S Yamada, M Makishima, H Kakuta |
ACS Medicinal Chemistry Letters | 2010 |
|
Repression of Peroxisome Proliferator-Activated Receptor γ by Mucosal Ribotoxic Insult-Activated CCAAT/Enhancer-Binding Protein Homologous Protein
SH Park, HJ Choi, H Yang, KH Do, J Kim, Y Moon |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
|
Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches
KJ Bosma, R Taneja, JF Lewis |
Drugs | 2010 |
|
Mesalamine suppresses the expression of TC22, a novel tropomyosin isoform associated with colonic neoplasia
KK Das, M Bajpai, Y Kong, J Liu, X Geng, KM Das |
Molecular pharmacology | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
Inflammation and Cancer
SV Kozlov |
Inflammation and Cancer | 2009 |
|
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity
P Vavassori, A Mencarelli, B Renga, E Distrutti, S Fiorucci |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
|
Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ
AB Carter, SA Misyak, R Hontecillas, J Bassaganya-Riera |
PPAR Research | 2009 |
|
Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program
M Radonjic, JR de Haan, MJ van Erk, KW van Dijk, SA van Berg, PJ de Groot, M Müller, B Ommen |
PloS one | 2009 |
|
No association of multiple type 2 diabetes loci with type 1 diabetes
SM Raj, JM Howson, NM Walker, JD Cooper, DJ Smyth, SF Field, HE Stevens, JA Todd |
Diabetologia | 2009 |
|
Fatty Acids and Immune Function: Relevance to Inflammatory Bowel Diseases
PC Calder |
International Reviews of Immunology | 2009 |
|
Rosiglitazone Attenuates the Severity of Sodium Taurocholate-induced Acute Pancreatitis and Pancreatitis-associated Lung Injury
C Chen, S Xu, WX Wang, YM Ding, KH Yu, B Wang, XY Chen |
Archives of Medical Research | 2009 |
|
Chemoprevention of colorectal cancer in inflammatory bowel disease
JR Butterworth |
Digestive and Liver Disease | 2009 |
|
Bases celulares y moleculares de la disfunción de la barrera intestinal inducida por estrés experimental
L Menchén |
Gastroenterología y Hepatología | 2009 |
|
Nitrated oleic acid up-regulates PPARγ and attenuates experimental inflammatory bowel disease
S Borniquel, EA Jansson, MP Cole, BA Freeman, JO Lundberg |
Free radical biology & medicine | 2009 |
|
Transcription Factors
IM Adcock, G Caramori |
Asthma and COPD | 2009 |
|
15-Deoxy-Δ,12,14-prostaglandin J2 Suppresses Nuclear Factor-κB-Mediated Apoptosis of Helicobacter pylori-Infected Gastric Epithelial Cells
B Cha, KH Kim, H Kim |
Annals of the New York Academy of Sciences | 2009 |
|
Immunotoxicity of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and the Role of Peroxisome Proliferator-Activated Receptor Alpha
JC DeWitt, A Shnyra, MZ Badr, SE Loveless, D Hoban, SR Frame, R Cunard, SE Anderson, BJ Meade, MM Peden-Adams, RW Luebke, MI Luster |
Critical Reviews in Toxicology | 2009 |
|
Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program
M Radonjic, JR de Haan, MJ van Erk, KW van Dijk, SA van Berg, PJ de Groot, M Müller, B Ommen, TI Sorensen |
PloS one | 2009 |
|
Activation of PPARγ by rosiglitazone attenuates intestinal Cl − secretion
PJ Bajwa, JW Lee, DS Straus, C Lytle |
AJP Gastrointestinal and Liver Physiology | 2009 |
|
Monokine Induced by Interferon γ (IFNγ) (CXCL9) and IFNγ Inducible T-Cell α-Chemoattractant (CXCL11) Involvement in Graves’ Disease and Ophthalmopathy: Modulation by Peroxisome Proliferator-Activated Receptor-γ Agonists
A Antonelli, SM Ferrari, P Fallahi, S Frascerra, E Santini, SS Franceschini, E Ferrannini |
The Journal of clinical endocrinology and metabolism | 2009 |
|
The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury
BJ Kerr, EI Girolami, N Ghasemlou, SY Jeong, S David |
Glia | 2008 |
|
NF-kappaB in carcinoma therapy and prevention
M Brown, J Cohen, P Arun, Z Chen, CV Waes |
Expert Opinion on Therapeutic Targets | 2008 |
|
Regulation of Lymphocyte Function by PPARγ: Relevance to Thyroid Eye Disease-Related Inflammation
GM Lehmann, TM Garcia-Bates, TJ Smith, SE Feldon, RP Phipps |
PPAR Research | 2008 |
|
Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies
TM Garcia-Bates, GM Lehmann, PJ Simpson-Haidaris, SH Bernstein, PJ Sime, RP Phipps |
PPAR Research | 2008 |
|
Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease
M Kiaei |
PPAR Research | 2008 |
|
Clinical Use of PPARgamma Ligands in Cancer
JL Hatton, LD Yee |
PPAR Research | 2008 |
|
Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages
BM Necela, W Su, EA Thompson |
Immunology | 2008 |
|
PPARgamma and PPARdelta as Modulators of Neoplasia and Cell Fate
RI Glazer, H Yuan, Z Xie, Y Yin |
PPAR Research | 2008 |
|
PPARs Mediate Lipid Signaling in Inflammation and Cancer
L Michalik, W Wahli |
PPAR Research | 2008 |
|
Gut Flora, Nutrition, Immunity and Health
S Macfarlane, GT Macfarlane |
Gut Flora, Nutrition, Immunity and Health | 2008 |
|
Handbook of Prebiotics
F Guarner |
Handbook of Prebiotics | 2008 |
|
Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease
CP Kovesdy, K Kalantar-Zadeh |
Expert Opinion on Investigational Drugs | 2008 |
|
Peroxisome Proliferator-Activated Receptors (PPARs) and the Human Skin
P Sertznig, M Seifert, W Tilgen, J Reichrath |
American Journal of Clinical Dermatology | 2008 |
|
PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis
N Baregamian, JM Mourot, AR Ballard, BM Evers, DH Chung |
Biochemical and Biophysical Research Communications | 2008 |
|
The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer
S Hazra, KA Peebles, S Sharma, JT Mao, SM Dubinett |
PPAR Research | 2008 |
|
Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1
BM Necela, W Su, EA Thompson |
The Journal of biological chemistry | 2008 |
|
Pathophysiological Roles of PPARgamma in Gastrointestinal Epithelial Cells
BM Necela, EA Thompson |
PPAR Research | 2008 |
|
The peroxisome: still a mysterious organelle
M Schrader, HD Fahimi |
Histochemistry and Cell Biology | 2008 |
|
Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes
A Kennedy, S Chung, K LaPoint, O Fabiyi, MK McIntosh |
The Journal of nutrition | 2008 |
|
Activation of peroxisome proliferator-activated receptor γ inhibits TNF-α-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression
H Hounoki, E Sugiyama, SG Mohamed, K Shinoda, H Taki, HO Abdel-Aziz, M Maruyama, M Kobayashi, T Miyahara |
Bone | 2008 |
|
Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
PC Calder |
Molecular Nutrition & Food Research | 2008 |
|
Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis
K Shimizu |
Journal of Gastroenterology | 2008 |
|
Fat and Beyond: The Diverse Biology of PPARγ
P Tontonoz, BM Spiegelman |
Annual Review of Biochemistry | 2008 |
|
The many faces of PPARγ: Anti-inflammatory by any means?
A Szanto, L Nagy |
Immunobiology | 2008 |
|
Systemic PPARγ Ligation Inhibits Allergic Immune Response in the Skin
A Dahten, C Koch, D Ernst, C Schnöller, S Hartmann, M Worm |
Journal of Investigative Dermatology | 2008 |
|
α-Tocopherol modulates human umbilical vein endothelial cell expression of Cu/Zn superoxide dismutase and catalase and lipid peroxidation
YK Nakamura, ST Omaye |
Nutrition Research | 2008 |
|
Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-Δ12,14-prostaglandin J2 in murine macrophages
HY Hong, WK Jeon, BC Kim |
FEBS Letters | 2008 |
|
A gut feeling of the PXR, PPAR and NF-κB connection
W Wahli |
Journal of Internal Medicine | 2008 |
|
Lactobacillus crispatus M247-Derived H2O2 Acts as a Signal Transducing Molecule Activating Peroxisome Proliferator Activated Receptor-γ in the Intestinal Mucosa
S Voltan, D Martines, M Elli, P Brun, S Longo, A Porzionato, V Macchi, R D'Incà, M Scarpa, G Palù, GC Sturniolo, L Morelli, I Castagliuolo |
Gastroenterology | 2008 |
|
Anti-inflammatory effects and changes in prostaglandin patterns induced by 7β-hydroxy-epiandrosterone in rats with colitis
O Hennebert, MA Pelissier, SL Mee, E Wülfert, R Morfin |
The Journal of Steroid Biochemistry and Molecular Biology | 2008 |
|
Peroxisome proliferator-activated receptor-γ ligand reduced tumor necrosis factor-α-induced interleukin-8 production and growth in endometriotic stromal cells
Y Ohama, T Harada, T Iwabe, F Taniguchi, Y Takenaka, N Terakawa |
Fertility and Sterility | 2008 |
|
Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-κB pathway: New lessons from endotoxin and ribotoxic deoxynivalenol
Y Moon, H Yang, SH Park |
Toxicology and Applied Pharmacology | 2008 |
|
Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease
CP Kovesdy, K Kalantar-Zadeh |
Expert Opinion on Investigational Drugs | 2008 |
|
Peroxisome Proliferator-activated Receptor γ Down-regulates Follistatin in Intestinal Epithelial Cells through SP1
BM Necela, W Su, EA Thompson |
The Journal of biological chemistry | 2008 |
|
Endotoxin downregulates peroxisome proliferator-activated receptor-γ via the increase in TNF-α release
M Zhou, R Wu, W Dong, A Jacob, P Wang |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2008 |
|
Comparison of cytokine modulation by natural peroxisome proliferator–activated receptor γ ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells—potential for dietary modulation of peroxisome proliferator–activated receptor γ in intestinal inflammation
R Marion-Letellier, M Butler, P Déchelotte, RJ Playford, S Ghosh |
The American journal of clinical nutrition | 2008 |
|
Trans-10, Cis-12 Conjugated Linoleic Acid Antagonizes Ligand-Dependent PPARγ Activity in Primary Cultures of Human Adipocytes
A Kennedy, S Chung, K LaPoint, O Fabiyi, MK McIntosh |
The Journal of nutrition | 2008 |
|
Intestinal Inflammation and Colorectal Cancer
C Gasche, JM Gutiérrez, M Gassull, E Monterio |
2008 | |
|
The 15-Deoxy-Δ 12,14 -Prostaglandin J 2 Suppresses Monocyte Chemoattractant Protein-1 Expression in IFN-γ-Stimulated Astrocytes through Induction of MAPK Phosphatase-1
JH Lee, JH Woo, SU Woo, KS Kim, SM Park, E Joe, I Jou |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Role of Chemokines in Endocrine Autoimmune Diseases
M Rotondi, L Chiovato, S Romagnani, M Serio, P Romagnani |
Endocrine reviews | 2007 |
|
15-Deoxy-Δ 12,14 -Prostaglandin J 2 Negatively Regulates rankl Gene Expression in Activated T Lymphocytes: Role of NF-κB and Early Growth Response Transcription Factors
C Fionda, F Nappi, M Piccoli, L Frati, A Santoni, M Cippitelli |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
|
PPARs and molecular mechanisms of transrepression
M Ricote, CK Glass |
Biochimica et Biophysica Acta | 2007 |
|
Inflammation and lung carcinogenesis: applying findings in prevention and treatment
KA Peebles, JM Lee, JT Mao, S Hazra, KL Reckamp, K Krysan, M Dohadwala, EL Heinrich, TC Walser, X Cui, FE Baratelli, E Garon, S Sharma, SM Dubinett |
Expert Review of Anticancer Therapy | 2007 |
|
Peroxisome Proliferator-Activated Receptor-γ Ligand, 15-Deoxy-Δ 12,14 -Prostaglandin J 2 , Reduces Neutrophil Migration via a Nitric Oxide Pathway
MH Napimoga, SM Vieira, D Dal-Secco, A Freitas, FO Souto, FL Mestriner, JC Alves-Filho, R Grespan, T Kawai, SH Ferreira, FQ Cunha |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
|
A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: inhibition of NF-kappaB?
A Axon, DE Cowie, DA Mann, MC Wright |
Toxicology | 2007 |
|
Present concepts and future outlook: Function of peroxisome proliferator-activated receptors (PPARs) for pathogenesis, progression, and therapy of cancer
P Sertznig, M Seifert, W Tilgen, J Reichrath |
Journal of Cellular Physiology | 2007 |
|
Fenofibrate Represses Interleukin-17 and Interferon-γ Expression and Improves Colitis in Interleukin-10–Deficient Mice
JW Lee, PJ Bajwa, MJ Carson, DR Jeske, Y Cong, CO Elson, C Lytle, DS Straus |
Gastroenterology | 2007 |
|
Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts
MP Diamond, G Saed |
Fertility and Sterility | 2007 |
|
PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages
EL Paukkeri, T Leppänen, O Sareila, K Vuolteenaho, H Kankaanranta, E Moilanen |
British Journal of Pharmacology | 2007 |
|
Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells
JD Ramakers, RP Mensink, G Schaart, J Plat |
Lipids | 2007 |
|
The PPARgamma agonist rosiglitazone impairs colonic inflammation in mice with experimental colitis
JD Ramakers, MI Verstege, G Thuijls, AA Velde, RP Mensink, J Plat |
Journal of Clinical Immunology | 2007 |
|
Expression of Peroxisome Proliferator-Activated Receptor-γ in Colon Cancer: Correlation with Histopathological Parameters, Cell Cycle-Related Molecules, and Patients’ Survival
S Theocharis, C Giaginis, A Parasi, A Margeli, J Kakisis, E Agapitos, G Kouraklis |
Digestive Diseases and Sciences | 2007 |
|
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
DS Straus, CK Glass |
Trends in Immunology | 2007 |
|
Long-term Pharmacological Activation of PPARγDoes not Prevent Left Ventricular Remodeling in Dogs with Advanced Heart Failure
G Suzuki, S Khanal, S Rastogi, H Morita, T Mishima, PV Anagnostopoulos, O Nass, VG Sharov, EJ Tanhehco, S Goldstein, HN Sabbah |
Cardiovascular Drugs and Therapy | 2007 |
|
PPARβ/δ Protects Against Experimental Colitis Through a Ligand-Independent Mechanism
HE Hollingshead, K Morimura, M Adachi, MJ Kennett, AN Billin, TM Willson, FJ Gonzalez, JM Peters |
Digestive Diseases and Sciences | 2007 |
|
Anti- and Proinflammatory Effects of 15-Deoxy-Δ12,14-Prostaglandin J2(15d-PGJ2) on Human Eosinophil Functions
S Ueki, H Kato, Y Kobayashi, W Ito, T Adachi, H Nagase, K Ohta, H Kayaba, J Chihara |
International Archives of Allergy and Immunology | 2007 |
|
PGJ2 Inhibition of LPS-induced Inflammatory Mediator Expression from Rat Alveolar Macrophages
DW Porter, M Wolfarth, SH Young, MK Rao, T Meighan, M Barger, ME Andrew, LJ Huffman |
Journal of Toxicology and Environmental Health, Part A | 2007 |
|
Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content
S Poncin, AC Gérard, M Boucquey, M Senou, PB Calderon, B Knoops, B Lengelé, MC Many, IM Colin |
Endocrinology | 2007 |
|
Rosiglitazone, a PPARγ ligand, modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats
M Sánchez-Hidalgo, AR Martín, I Villegas, CA de la Lastra |
European Journal of Pharmacology | 2007 |
|
Rosiglitazone attenuates NF-κB-dependent ICAM-1 and TNF-α production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation
YP Bai, YH Liu, J Chen, T Song, Y You, ZY Tang, YJ Li, GG Zhang |
Biochemical and Biophysical Research Communications | 2007 |
|
THE PPAR?? LIGAND 15d-PGJ2 MODULATES MACROPHAGE ACTIVATION AFTER INJURY IN A MURINE TRAUMA MODEL:
MA Monroy, KK Opperman, M Pucciarelli, S Yerrum, DA Berg, JM Daly |
Shock | 2007 |
|
EFFECT OF CYCLOPENTANONE PROSTAGLANDIN 15-deoxy-Δ12,14PGJ2 ON EARLY FUNCTIONAL RECOVERY FROM EXPERIMENTAL SPINAL CORD INJURY:
T Genovese, E Esposito, E Mazzon, RD Paola, C Muià, R Meli, P Bramanti, S Cuzzocrea |
Shock | 2007 |
|
HDAC Activity Is Required for p65/RelA-Dependent Repression of PPARδ-Mediated Transactivation in Human Keratinocytes
L Aarenstrup, EN Flindt, K Otkjaer, M Kirkegaard, JS Andersen, K Kristiansen |
Journal of Investigative Dermatology | 2007 |
|
Biliary innate immunity and cholangiopathy
K Harada, Y Nakanuma |
Hepatology Research | 2007 |
|
The Role of PPARγ on Restoration of Colonic Homeostasis After Experimental Stress-Induced Inflammation and Dysfunction
Á Ponferrada, JR Caso, L Alou, A Colón, D Sevillano, MA Moro, I Lizasoain, P Menchén, ML Gómez–Lus, P Lorenzo, E Cos, JC Leza, L Menchén |
Gastroenterology | 2007 |
|
Nutritional modulation of the inflammatory response in inflammatory bowel disease--from the molecular to the integrative to the clinical
GE Wild, L Drozdowski, C Tartaglia, MT Clandinin, AB Thomson |
World journal of gastroenterology : WJG | 2007 |
|
Pioglitazone attenuates the severity of sodium taurocholate-induced severe acute pancreatitis
P Xu, XJ Zhou, LQ Chen, J Chen, Y Xie, LH Lv, XH Hou |
World journal of gastroenterology : WJG | 2007 |
|
Nutritional modulation of the inflammatory response in inflammatory bowel disease- From the molecular to the integrative to the clinical
GE Wild, L Drozdowski, C Tartaglia, MT Clandinin, AB Thomson |
World journal of gastroenterology : WJG | 2007 |
|
Comprehensive Medicinal Chemistry II
E Littler, XX Zhou |
Comprehensive Medicinal Chemistry II | 2007 |
|
CLA differently regulates adipogenesis in stromal vascular cells from porcine subcutaneous adipose and skeletal muscle
X Zhou, D Li, J Yin, J Ni, B Dong, J Zhang, M Du |
Journal of lipid research | 2007 |
|
Expression of peroxisome proliferator-activated receptor-γ in macrophage suppresses experimentally induced colitis
YM Shah, K Morimura, FJ Gonzalez |
AJP Gastrointestinal and Liver Physiology | 2007 |
|
Involvement of RelA-Associated Inhibitor in Regulation of Trophoblast Differentiation via Interaction with Transcriptional Factor Specificity Protein-1
R Minekawa, M Sakata, Y Okamoto, M Hayashi, A Isobe, T Takeda, T Yamamoto, M Koyama, M Ohmichi, K Tasaka, K Imai, T Okamoto, Y Murata |
Endocrinology | 2007 |
|
Peroxisome Proliferator-Activated Receptor γ Is Required for Regulatory CD4 + T Cell-Mediated Protection against Colitis
R Hontecillas, J Bassaganya-Riera |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
|
15d-Prostaglandin J 2 Inhibits Inflammatory Hypernociception: Involvement of Peripheral Opioid Receptor
MH Napimoga, GR Souza, TM Cunha, LF Ferrari, JT Clemente-Napimoga, CA Parada, WA Verri, FQ Cunha, SH Ferreira |
The Journal of pharmacology and experimental therapeutics | 2007 |
|
Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial.
Lewis JD, Lichtenstein GR, Deren JJ, Sands BE, Hanauer SB, Katz JA, Lashner B, Present DH, Chuai S, Ellenberg JH, Nessel L, Wu GD |
Gastroenterology | 2007 |
|
Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis
X Han, B Osuntokun, N Benight, K Loesch, SJ Frank, LA Denson |
The American Journal of Pathology | 2006 |
|
Anti-inflammatory Effects of PPAR-γ Agonists Directly Correlate With PPAR-γ Expression During Acute Pancreatitis
M Rollins, S Sudarshan, M Firpo, B Etherington, B Hart, H Jackson, J Jackson, L Emerson, D Yang, S MULVIHILL |
Journal of Gastrointestinal Surgery | 2006 |
|
Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis
YM Shah, K Morimura, FJ Gonzalez |
American journal of physiology. Gastrointestinal and liver physiology | 2006 |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
|
Tumour necrosis factor alpha blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis
X Han, N Benight, B Osuntokun, K Loesch, SJ Frank, LA Denson |
Gut | 2006 |
|
Attenuation of Colonic Inflammation by PPARγ in Intestinal Epithelial Cells: Effect on Toll-like Receptor Pathway
CS Eun, DS Han, SH Lee, CH Paik, YW Chung, J Lee, JS Hahm |
Digestive Diseases and Sciences | 2006 |
|
PPARgamma as a new therapeutic target in inflammatory bowel diseases
L Dubuquoy, C Rousseaux, X Thuru, L Peyrin-Biroulet, O Romano, P Chavatte, M Chamaillard, P Desreumaux |
Gut | 2006 |
|
Up-Regulated Membrane and Nuclear Leukotriene B4 Receptors in COPD
E Marian, S Baraldo, A Visentin, A Papi, M Saetta, LM Fabbri, P Maestrelli |
Chest | 2006 |
|
The Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligands 15-Deoxy-Δ 12,14 -Prostaglandin J 2 and Ciglitazone Induce Human B Lymphocyte and B Cell Lymphoma Apoptosis by PPARγ-Independent Mechanisms
DM Ray, F Akbiyik, RP Phipps |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Non-viral delivery of nuclear factor-kappaB decoy ameliorates murine inflammatory bowel disease and restores tissue homeostasis
CG de Vry, S Prasad, L Komuves, C Lorenzana, C Parham, T Le, S Adda, J Hoffman, N Kahoud, R Garlapati, R Shyamsundar, K Mai, J Zhang, T Muchamuel, M Dajee, B Schryver, LM McEvoy, RO Ehrhardt |
Gut | 2006 |
|
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity
C Berruyer, L Pouyet, V Millet, FM Martin, A LeGoffic, A Canonici, S Garcia, C Bagnis, P Naquet, F Galland |
Journal of Experimental Medicine | 2006 |
|
Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor α Agonists in Colitis
M Osanai, N Nishikiori, M Murata, H Chiba, T Kojima, N Sawada |
Molecular pharmacology | 2006 |
|
Evolving knowledge and therapy of inflammatory bowel disease
JR Korzenik, DK Podolsky |
Nature Reviews Drug Discovery | 2006 |
|
HMG-CoA reductase and PPARα are involved in clofibrate-induced apoptosis in human keratinocytes
G Muzio, G Martinasso, A Trombetta, D Simone, RA Canuto, M Maggiora |
Apoptosis | 2006 |
|
Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats
IA Leclercq, C Sempoux, P Stärkel, Y Horsmans |
Gut | 2006 |
|
5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint
MG Luciani, C Campregher, JM Fortune, TA Kunkel, C Gasche |
Gastroenterology | 2006 |
|
Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes
CX Zhang-Gandhi, PD Drew |
Journal of Neuroimmunology | 2006 |
|
Significance of anti-inflammatory effects of PPARgamma agonists?
G Rogler |
Gut | 2006 |
|
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease
M Adachi, R Kurotani, K Morimura, Y Shah, M Sanford, BB Madison, DL Gumucio, HE Marin, JM Peters, HA Young, FJ Gonzalez |
Gut | 2006 |
|
Receptor Ck-dependent signaling regulates hTERT gene transcription
K Sikand, D Kaul, N Varma |
BMC cell biology | 2006 |
|
Nuclear receptors and autoimmune disease: the potential of PPAR agonists to treat multiple sclerosis
MK Racke, AR Gocke, M Muir, A Diab, PD Drew, AE Lovett-Racke |
The Journal of nutrition | 2006 |
|
Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus
Y Suresh, UN Das |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2006 |
|
Regulation of apoptosis during homeostasis and disease in the intestinal epithelium
KL Edelblum, F Yan, T Yamaoka, DB Polk |
Inflammatory Bowel Diseases | 2006 |
|
NF-κB/PPARγ and/or AP-1/PPARγ ‘on/off’ switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression
PA Konstantinopoulos, GP Vandoros, G Sotiropoulou-Bonikou, A Kominea, AG Papavassiliou |
International Journal of Colorectal Disease | 2006 |
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Identifying and defusing weapons of mass inflammation in carcinogenesis
LJ Hofseth, L Ying |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2006 |
|
Peroxisome Proliferator-Activated Receptor Gamma Agonists: Their Role as Vasoprotective Agents in Diabetes
F Blaschke, E Caglayan, WA Hsueh |
Endocrinology & Metabolism Clinics of North America | 2006 |
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Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
RB Sartor |
Nature Clinical Practice Gastroenterology & Hepatology | 2006 |
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Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?
J Becker, C Delayre-Orthez, N Frossard, F Pons |
Fundamental and Clinical Pharmacology | 2006 |
|
Intestinal-specific PPARγ deficiency enhances tumorigenesis in ApcMin/+ mice
CA McAlpine, Y Barak, I Matise, RT Cormier |
International Journal of Cancer | 2006 |
|
Peroxisome proliferator-activated receptor-α and retinoid X receptor agonists inhibit inflammatory responses of astrocytes
J Xu, JA Chavis, MK Racke, PD Drew |
Journal of Neuroimmunology | 2006 |
|
Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma
M Zhang, C Deng, J Zheng, J Xia, D Sheng |
International Immunopharmacology | 2006 |
|
Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs
M Hojo, I Takada, W Kimura, K Fukuda, S Yasugi |
Gene Expression Patterns | 2006 |
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Platelets as a Novel Target for PPAR?? Ligands: Implications for Inflammation, Diabetes, and Cardiovascular Disease
DM Ray, SL Spinelli, JJ O???Brien, N Blumberg, RP Phipps |
BioDrugs | 2006 |
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Nutrients, nuclear receptors, inflammation, immunity lipids, PPAR, and allergic asthma
A August, C Mueller, V Weaver, TA Polanco, ER Walsh, MT Cantorna |
The Journal of nutrition | 2006 |
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Can NF-κB be a target for novel and efficient anti-cancer agents?
S Olivier, P Robe, V Bours |
Biochemical Pharmacology | 2006 |
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Amelioration of age-related inflammation and oxidative stress by PPARγ activator: Suppression of NF-κB by 2,4-thiazolidinedione
B Sung, S Park, BP Yu, HY Chung |
Experimental Gerontology | 2006 |
|
Effect of 15d-PGJ2 on the Expression of CD40 and RANTES Induced by IFN-γ and TNF-α on Renal Tubular Epithelial Cells (HK-2)
YJ Zhang, X Yang, QY Kong, YF Zhang, WY Chen, XQ Dong, XY Li, XQ Yu |
American Journal of Nephrology | 2006 |
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Low and high levels of α-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPAR-γ, IκBα, and apoptotic pathway in activated splenocytes
CC Hsieh, CJ Huang, BF Lin |
Nutrition | 2006 |
|
Advances in Conjugated Linoleic Acid Research, Volume 3: Cellular and Molecular Mechanisms
R Hontecillas, J Bassaganya-Riera |
Advances in Conjugated Linoleic Acid Research, Volume 3: Cellular and Molecular Mechanisms | 2006 |
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Procaterol Upregulates Peroxisome Proliferator-Activated Receptor-γ Expression in Human Eosinophils
S Ueki, A Usami, H Oyamada, N Saito, T Chiba, G Mahemuti, W Ito, H Kato, H Kayaba, J Chihara |
International Archives of Allergy and Immunology | 2006 |
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The long and winding road to gut homeostasis:
V Arulampalam, G Greicius, S Pettersson |
Current Opinion in Gastroenterology | 2006 |
|
RS5444, a novel PPARγ agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells
L Chen, CR Bush, BM Necela, W Su, M Yanagisawa, PZ Anastasiadis, AP Fields, EA Thompson |
Molecular and Cellular Endocrinology | 2006 |
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Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice
A Santana, C Medina, MC Paz-Cabrera, F Díaz-Gonzalez, E Farré, A Salas, MW Radomski, E Quintero |
World journal of gastroenterology : WJG | 2006 |
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Protective and Destructive Immunity in the Periodontium: Part 1—Innate and Humoral Immunity and the Periodontium
YT Teng |
Journal of dental research | 2006 |
|
Immune Mechanisms in Inflammatory Bowel Disease
RS Blumberg, MF Neurath |
2006 | |
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Low-Dose Rosiglitazone Exerts an Antiinflammatory Effect with an Increase in Adiponectin Independently of Free Fatty Acid Fall and Insulin Sensitization in Obese Type 2 Diabetics
H Ghanim, S Dhindsa, A Aljada, A Chaudhuri, P Viswanathan, P Dandona |
The Journal of clinical endocrinology and metabolism | 2006 |
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Peroxisome Proliferator-Activated Receptor γ Promotes Lymphocyte Survival through Its Actions on Cellular Metabolic Activities
SH Jo, C Yang, Q Miao, M Marzec, MA Wasik, P Lu, YL Wang |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
|
Role of Matrix Metalloproteinases in Intestinal Inflammation
C Medina, MW Radomski |
The Journal of pharmacology and experimental therapeutics | 2006 |
|
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma
C Rousseaux, B Lefebvre, L Dubuquoy, P Lefebvre, O Romano, J Auwerx, D Metzger, W Wahli, B Desvergne, GC Naccari, P Chavatte, A Farce, P Bulois, A Cortot, JF Colombel, P Desreumaux |
Journal of Experimental Medicine | 2005 |
|
The Many Faces of PPARγ
M Lehrke, MA Lazar |
Cell | 2005 |
|
Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis
JH Li, JP Yu, HG Yu, XM Xu, LL Yu, J Liu, HS Luo |
Mediators of Inflammation | 2005 |
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CD40 Engagement Prevents Peroxisome Proliferator-Activated Receptor γ Agonist-Induced Apoptosis of B Lymphocytes and B Lymphoma Cells by an NF-κB-Dependent Mechanism
DM Ray, F Akbiyik, SH Bernstein, RP Phipps |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
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Role of poly(ADP-ribose) glycohydrolase (PARG) in shock, ischemia and reperfusion
S Cuzzocrea, ZQ Wang |
Pharmacological Research | 2005 |
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Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood
X ZENG, Y GUAN, DG REMICK, X WANG |
Acta Pharmacologica Sinica | 2005 |
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The peroxisome proliferator-activated receptor γ ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency
C Lytle, TJ Tod, KT Vo, JW Lee, RD Atkinson, DS Straus |
Inflammatory Bowel Diseases | 2005 |
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Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha
M Sasaki, P Jordan, T Welbourne, A Minagar, T Joh, M Itoh, JW Elrod, JS Alexander |
BMC Physiology | 2005 |
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Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis
PD Storer, J Xu, JA Chavis, PD Drew |
Journal of Neuroscience Research | 2005 |
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Evaluation of proinflammatory cytokines and inflammation markers as biomarkers for the action of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
M Doorn, M Kemme, M Ouwens, EJ van Hoogdalem, R Jones, H Romijn, M Kam, R Schoemaker, K Burggraaf, A Cohen |
British Journal of Clinical Pharmacology | 2005 |
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The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes
SC Mills, AC Windsor, SC Knight |
Clinical & Experimental Immunology | 2005 |
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Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands
H Kohno, R Suzuki, S Sugie, T Tanaka |
BMC Cancer | 2005 |
|
Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade
Z Yuan, Y Liu, Y Liu, J Zhang, C Kishimoto, Y Wang, A Ma, Z Liu |
Heart (British Cardiac Society) | 2005 |
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Agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ: A new compound with potent gastroprotective and ulcer healing properties
T Brzozowski, PC Konturek, R Pajdo, S Kwiecień, S Konturek, A Targosz, G Burnat, J Cieszkowski, WW Pawlik, EG Hahn |
InflammoPharmacology | 2005 |
|
15d-PGJ2: The anti-inflammatory prostaglandin?
JU Scher, MH Pillinger |
Clinical Immunology | 2005 |
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Peroxisome Proliferator-Activated Receptors: Potential Therapeutic Targets in Lung Disease?
GM Denning, LL Stoll |
Pediatric Pulmonology | 2005 |
|
Linkage to peroxisome proliferator-activated receptor-γ in SAMP1/YitFc mice and in human Crohn’s disease
K Sugawara, TS Olson, CA Moskaluk, BK Stevens, S Hoang, K Kozaiwa, F Cominelli, KF Ley, M McDuffie |
Gastroenterology | 2005 |
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Agonists for the peroxisome proliferator-activated receptor-α and the retinoid X receptor inhibit inflammatory responses of microglia
J Xu, PD Storer, JA Chavis, MK Racke, PD Drew |
Journal of Neuroscience Research | 2005 |
|
Th1 cytokine-induced downregulation of PPARγ in human biliary cells relates to cholangitis in primary biliary cirrhosis
K Harada, K Isse, T Kamihira, S Shimoda, Y Nakanuma |
Hepatology | 2005 |
|
Combinatorial roles of nuclear receptors in inflammation and immunity
CK Glass, S Ogawa |
Nature Reviews Immunology | 2005 |
|
COX expression and PGE2 and PGD2 production in experimental acute and chronic gastric lesions
V Motilva, CA de la Lastra, L Bruseghini, JM Herrerias, S Sánchez-Fidalgo |
International Immunopharmacology | 2005 |
|
Mucosal Immunology
WR Brown |
Mucosal Immunology | 2005 |
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Agonist of peroxisome proliferator-activated receptor-gamma, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model
S Lee, W Kim, KP Kang, SO Moon, MJ Sung, DH Kim, HJ Kim, SK Park |
Nephrology Dialysis Transplantation | 2005 |
|
Inflammatory modulation of PPAR gamma expression and activity
MB Crosby, J Zhang, TM Nowling, JL Svenson, CJ Nicol, FJ Gonzalez, GS Gilkeson |
Clinical Immunology | 2005 |
|
Intestinal Antiinflammatory Effects of Thiazolidenedione Peroxisome Proliferator-Activated Receptor-γ Ligands on T Helper Type 1 Chemokine Regulation Include Nontranscriptional Control Mechanisms:
KL Schaefer, S Denevich, C Ma, SR Cooley, A Nakajima, K Wada, J Schlezinger, D Sherr, LJ Saubermann |
Inflammatory Bowel Diseases | 2005 |
|
Activation of PPARγ is not involved in butyrate-induced epithelial cell differentiation
S Ulrich, A Wächtershäuser, S Loitsch, A Knethen, B Brüne, J Stein |
Experimental Cell Research | 2005 |
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Ciglitazone induces early cellular proliferation and NF-κB transcriptional activity in colon cancer cells through p65 phosphorylation
F Chen, LE Harrison |
The International Journal of Biochemistry & Cell Biology | 2005 |
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Rosiglitazone combined with insulin preserves islet ? cell function in adult-onset latent autoimmune diabetes (LADA)
Z Zhou, X Li, G Huang, J Peng, L Yang, X Yan, J Wang |
Diabetes/Metabolism Research and Reviews | 2005 |
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Cis-9,Trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: Comparison to Trans-10,Cis-12-CLA and to linoleic acid
A Jaudszus, M Foerster, C Kroegel, I Wolf, G Jahreis |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2005 |
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Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats
M Sánchez-Hidalgo, AR Martín, I Villegas, CA de la Lastra |
Biochemical Pharmacology | 2005 |
|
A novel PPAR response element in the murine iNOS promoter
MB Crosby, J Svenson, GS Gilkeson, TK Nowling |
Molecular Immunology | 2005 |
|
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis
Peter C Konturek, Artur Dembinski, Zygmunt Warzecha, Grzegorz Burnat, Piotr Ceranowicz, Eckhart G Hahn, Marcin Dembinski, Romana Tomaszewska, Stanislaw J Konturek |
World journal of gastroenterology : WJG | 2005 |
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Effect of peroxisome proliferator-activated receptor-gamma ligand on inflammation of human gallbladder epithelial cells
Guang-Dong Pan, Hong Wu, Jiang-Wen Liu, Nan-Sheng Cheng, Xian-Ze Xiong, Sheng-Fu Li, Guo-Fu Zhang, Lu-Nan Yan |
World journal of gastroenterology : WJG | 2005 |
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Conjugated Linoleic Acid Attenuates the Production and Gene Expression of Proinflammatory Cytokines in Weaned Pigs Challenged with Lipopolysaccharide
L Changhua, Y Jindong, L Defa, Z Lidan, Q Shiyan, X Jianjun |
The Journal of nutrition | 2005 |
|
Biologic Therapy for Inflammatory Bowel Disease:
S Ardizzone, GB Porro |
Drugs | 2005 |
|
Agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ: A new compound with potent gastroprotective and ulcer healing properties
T Brzozowski, PC Konturek, R Pajdo, S Kwiecień, S Konturek, A Targosz, G Burnat, J Cieszkowski, WW Pawlik, EG Hahn |
Inflammopharmacology | 2005 |
|
Decreased expression of peroxisome proliferator activated receptor gamma in cftr-/- mice
M Ollero, O Junaidi, MM Zaman, I Tzameli, AA Ferrando, C Andersson, PG Blanco, E Bialecki, SD Freedman |
Journal of Cellular Physiology | 2004 |
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Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease
AE Lovett-Racke, RZ Hussain, S Northrop, J Choy, A Rocchini, L Matthes, JA Chavis, A Diab, PD Drew, MK Racke |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
|
Prevention of colorectal cancer through the use of COX-2 selective inhibitors
RM Peek |
Cancer Chemotherapy and Pharmacology | 2004 |
|
15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway
S Boyault, A Bianchi, D Moulin, S Morin, M Francois, P Netter, B Terlain, K Bordji |
FEBS Letters | 2004 |
|
Blasts from the past
PA Insel, S Kornfeld, PW Majerus, AR Marks, PA Marks, AS Relman, BF Scharschmidt, TP Stossel, AP Varki, SJ Weiss, JD Wilson |
Journal of Clinical Investigation | 2004 |
|
ComPPARtmentalizing NF-κB in the gut
AA Beg |
Nature Immunology | 2004 |
|
Peroxisome proliferator-activated receptor-γ and its ligands attenuate biologic functions of human natural killer cells
X Zhang, MC Rodriguez-Galán, JJ Subleski, JR Ortaldo, DL Hodge, JM Wang, O Shimozato, DA Reynolds, HA Young |
Blood | 2004 |
|
Peroxisome Proliferation-Activated Receptor (PPAR)γ Is Not Necessary for Synthetic PPARγ Agonist Inhibition of Inducible Nitric-Oxide Synthase and Nitric Oxide
MB Crosby, JL Svenson, J Zhang, CJ Nicol, FJ Gonzalez, GS Gilkeson |
The Journal of pharmacology and experimental therapeutics | 2004 |
|
Role of endogenous and exogenous ligands for the peroxisome proliferators activated receptors alpha (PPAR-alpha) in the development of inflammatory bowel disease in mice
S Cuzzocrea, RD Paola, E Mazzon, T Genovese, C Muià, T Centorrino, AP Caputi |
Laboratory Investigation | 2004 |
|
Expression and Localization of Peroxisome Proliferator-Activated Receptors and Nuclear Factor kappaB in Normal and Lesional Psoriatic Skin
M Westergaard, J Henningsen, C Johansen, S Rasmussen, ML Svendsen, UB Jensen, HD Schroder, B Staels, L Iversen, L Bolund, K Kragballe, K Kristiansen |
Journal of Investigative Dermatology | 2004 |
|
Recent developments in the pharmacological treatment of Crohn’s disease
R Srinivasan, GR Lichtenstein |
Expert Opinion on Investigational Drugs | 2004 |
|
War and peace at mucosal surfaces
PJ Sansonetti |
Nature Reviews Immunology | 2004 |
|
Insulin Is an Anti-inflammatory and Anti-atherosclerotic Hormone
P Dandona, A Aljada, A O'donnell, S Dhindsa, R Garg |
Metabolic Syndrome and Related Disorders | 2004 |
|
NUCLEAR RECEPTORS IN MACROPHAGE BIOLOGY: At the Crossroads of Lipid Metabolism and Inflammation
A Castrillo, P Tontonoz |
Annual Review of Cell and Developmental Biology | 2004 |
|
Role of Peroxisome Proliferator-Activated Receptors in Inflammation Control
J Youssef, M Badr |
Journal of biomedicine & biotechnology | 2004 |
|
Conjugated linoleic acids: are they beneficial or detrimental to health?
KW Wahle, SD Heys, D Rotondo |
Progress in Lipid Research | 2004 |
|
PPARα activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells
S Ryoo, M Won, DU Kim, L Kim, G Han, SK Park, N Mukaida, P Maeng, HS Yoo, KL Hoe |
Biochemical and Biophysical Research Communications | 2004 |
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Association of peroxisome proliferator–activated receptor gamma 2 Pro-12-Ala polymorphism with endometriosis
S Dogan, F Machicao, D Wallwiener, HU Haering, K Diedrich, D Hornung |
Fertility and Sterility | 2004 |
|
Role of PPARγ in macrophage biology and atherosclerosis
L Zhang, A Chawla |
Trends in Endocrinology & Metabolism | 2004 |
|
Thiazolidinediones increase arachidonic acid release and subsequent prostanoid production in a peroxisome proliferator-activated receptor γ-independent manner
H Tsukamoto, T Hishinuma, N Suzuki, R Tayama, M Hiratsuka, Y Tomioka, M Mizugaki, J Goto |
Prostaglandins & Other Lipid Mediators | 2004 |
|
Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects
T Yatagai, T Nakamura, S Nagasaka, I Kusaka, S Ishikawa, A Yoshitaka, S Ishibashi |
Diabetes Research and Clinical Practice | 2004 |
|
Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury
S Cuzzocrea |
Vascular Pharmacology | 2004 |
|
Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
A Diab, RZ Hussain, AE Lovett-Racke, JA Chavis, PD Drew, MK Racke |
Journal of Neuroimmunology | 2004 |
|
Pro-inflammatory properties for thiazolidinediones
C Desmet, B Warzée, P Gosset, D Mélotte, A Rongvaux, L Gillet, L Fiévez, G Seumois, A Vanderplasschen, B Staels, P Lekeux, F Bureau |
Biochemical Pharmacology | 2004 |
|
El ácido acetilsalicílico incrementa la expresión de CD36 en macrófagos THP-1 de forma independiente del receptor activado por proliferadores peroxisómicos gamma
M Viñals, I Bermúdez, JC Laguna |
Clínica e Investigación en Arteriosclerosis | 2004 |
|
Nuclear receptor signaling in macrophages
AF Valledor, M Ricote |
Biochemical Pharmacology | 2004 |
|
An overview of the effect of linoleic and conjugated-linoleic acids on the growth of several human tumor cell lines
M Maggiora, M Bologna, MP Cerù, L Possati, A Angelucci, A Cimini, A Miglietta, F Bozzo, C Margiotta, G Muzio, RA Canuto |
International Journal of Cancer | 2004 |
|
The intricate interface between immune system and metabolism
G Matarese, AL Cava |
Trends in Immunology | 2004 |
|
Anti‐inflammatory Effect of PPARγ in Cultured Human Mesangial Cells
Z Xiong, H Huang, J Li, Y Guan, H Wang |
Renal Failure | 2004 |
|
Troglitazone Inhibits the Progression of Chronic Pancreatitis and the Profibrogenic Activity of Pancreatic Stellate Cells via a PPARγ-Independent Mechanism:
K Shimizu, K Shiratori, M Kobayashi, H Kawamata |
Pancreas | 2004 |
|
A CLA’s act: Feeding away inflammation
G Greicius, V Arulampalam, S Pettersson |
Gastroenterology | 2004 |
|
Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
J Bassaganya-Riera, K Reynolds, S Martino-Catt, Y Cui, L Hennighausen, F Gonzalez, J Rohrer, AU Benninghoff, R Hontecillas |
Gastroenterology | 2004 |
|
Statin, Inflammation, and Sepsis
K Inoue, H Takano, R Yanagisawa, M Sakurai, T Yoshikawa |
Chest | 2004 |
|
Peroxisome Proliferator-activated Receptor-γ Down-regulates Chondrocyte Matrix Metalloproteinase-1 via a Novel Composite Element
M François, P Richette, L Tsagris, M Raymondjean, MC Fulchignoni-Lataud, C Forest, JF Savouret, MT Corvol |
The Journal of biological chemistry | 2004 |
|
Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E 2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1
S Cheng, H Afif, J Martel-Pelletier, JP Pelletier, X Li, K Farrajota, M Lavigne, H Fahmi |
The Journal of biological chemistry | 2004 |
|
15-Deoxy-Δ 12,14 -prostaglandin J 2 Induces Heme Oxygenase-1 Gene Expression in a Reactive Oxygen Species-dependent Manner in Human Lymphocytes
M Álvarez-Maqueda, RE Bekay, G Alba, J Monteseirín, P Chacón, A Vega, J Martín-Nieto, FJ Bedoya, E Pintado, F Sobrino |
The Journal of biological chemistry | 2004 |
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15-Deoxy-Δ 12,14 -prostaglandin J 2 -mediated ERK Signaling Inhibits Gram-negative Bacteria-induced RelA Phosphorylation and Interleukin-6 Gene Expression in Intestinal Epithelial Cells through Modulation of Protein Phosphatase 2A Activity
PA Ruiz, SC Kim, RB Sartor, D Haller |
The Journal of biological chemistry | 2004 |
|
Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
SH Itzkowitz, X Yio |
AJP Gastrointestinal and Liver Physiology | 2004 |
|
Protective effect of endogenous PPARγ against acute gastric mucosal lesions associated with ischemia-reperfusion
K Wada, A Nakajima, H Takahashi, M Yoneda, N Fujisawa, E Ohsawa, T Kadowaki, N Kubota, Y Terauchi, N Matsuhashi, LJ Saubermann, N Nakajima, RS Blumberg |
AJP Gastrointestinal and Liver Physiology | 2004 |
|
Human breast milk suppresses the transcriptional regulation of IL-1β-induced NF-κB signaling in human intestinal cells
R Minekawa, T Takeda, M Sakata, M Hayashi, A Isobe, T Yamamoto, K Tasaka, Y Murata |
American journal of physiology. Cell physiology | 2004 |
|
Repression of IFN-γ Expression by Peroxisome Proliferator-Activated Receptor γ
R Cunard, Y Eto, JT Muljadi, CK Glass, CJ Kelly, M Ricote |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
|
Growth Hormone Inhibits Apoptosis in Human Colonic Cancer Cell Lines: Antagonistic Effects of Peroxisome Proliferator Activated Receptor-γ Ligands
F Bogazzi, F Ultimieri, F Raggi, D Russo, R Vanacore, C Guida, S Brogioni, C Cosci, M Gasperi, L Bartalena, E Martino |
Endocrinology | 2004 |
|
Human bone marrow megakaryocytes and platelets express PPARγ, and PPARγ agonists blunt platelet release of CD40 ligand and thromboxanes
F Akbiyik, DM Ray, KF Gettings, N Blumberg, CW Francis, RP Phipps |
Blood | 2004 |
|
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis
L Dubuquoy, EA Jansson, S Deeb, S Rakotobe, M Karoui, JF Colombel, J Auwerx, S Pettersson, P Desreumaux |
Gastroenterology | 2003 |
|
Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma
H Hammad, HJ de Heer, T Soullié, V Angeli, F Trottein, HC Hoogsteden, BN Lambrecht |
The American Journal of Pathology | 2003 |
|
Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung
X Lian, C Yan, L Yang, Y Xu, H Du |
American journal of physiology. Lung cellular and molecular physiology | 2003 |
|
Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD)
JR Brown, D Goldblatt, J Buddle, L Morton, AJ Thrasher |
Journal of leukocyte biology | 2003 |
|
Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response
A Ianaro, A Ialenti, P Maffia, PD Meglio, MD Rosa, MG Santoro |
Molecular pharmacology | 2003 |
|
Peroxisome Proliferator–activated Receptors α and γ Down-regulate Allergic Inflammation and Eosinophil Activation
G Woerly, K Honda, M Loyens, JP Papin, J Auwerx, B Staels, M Capron, D Dombrowicz |
Journal of Experimental Medicine | 2003 |
|
PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
JS Welch, M Ricote, TE Akiyama, FJ Gonzalez, CK Glass |
Proceedings of the National Academy of Sciences | 2003 |
|
Peroxisome Proliferator Activator Receptor-γ Ligands, 15-Deoxy-Δ 12,14 -Prostaglandin J 2 and Ciglitazone, Reduce Systemic Inflammation in Polymicrobial Sepsis by Modulation of Signal Transduction Pathways
B Zingarelli, M Sheehan, PW Hake, M OConnor, A Denenberg, JA Cook |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
|
The PPARγ Ligand, 15d-PGJ2, Attenuates the Severity of Cerulein-Induced Acute Pancreatitis
K Hashimoto, RT Ethridge, H Saito, S Rajaraman, BM Evers |
Pancreas | 2003 |
|
Cholesterol-receptor-mediated genomics in health and disease
D Kaul |
Trends in Molecular Medicine | 2003 |
|
PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect
A Trifilieff, A Bench, M Hanley, D Bayley, E Campbell, P Whittaker |
British Journal of Pharmacology | 2003 |
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The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat
S Cuzzocrea, A Ianaro, NS Wayman, E Mazzon, B Pisano, L Dugo, I Serraino, RD Paola, PK Chatterjee, MD Rosa, AP Caputi, C Thiemermann |
British Journal of Pharmacology | 2003 |
|
Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus
Y Suresh, UN Das |
Nutrition | 2003 |
|
Effects of peroxisome proliferator-activated receptor-? agonists on central nervous system inflammation
T Kielian, PD Drew |
Journal of Neuroscience Research | 2003 |
|
Noradrenergic depletion increases inflammatory responses in brain: effects on IκB and HSP70 expression
MT Heneka, V Gavrilyuk, GE Landreth, MK O'Banion, G Weinberg, DL Feinstein |
Journal of Neurochemistry | 2003 |
|
Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation
C Blanquart, O Barbier, JC Fruchart, B Staels, C Glineur |
The Journal of Steroid Biochemistry and Molecular Biology | 2003 |
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A novel PPARγ gene therapy to control inflammation associated with inflammatory bowel disease in a murine model
K Katayama, K Wada, A Nakajima, H Mizuguchi, T Hayakawa, S Nakagawa, T Kadowaki, R Nagai, Y Kamisaki, RS Blumberg, T Mayumi |
Gastroenterology | 2003 |
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Activation of PPARγ increases PTEN expression in pancreatic cancer cells
B Farrow, BM Evers |
Biochemical and Biophysical Research Communications | 2003 |
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Therapeutic potential of thiazolidinediones as anticancer agents
D Panigrahy, LQ Shen, MW Kieran, A Kaipainen |
Expert Opinion on Investigational Drugs | 2003 |
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Inhibition of IgE-Production by Peroxisome Proliferator-Activated Receptor Ligands
R Ruhl, A Dahten, FJ Schweigert, U Herz, M Worm |
Journal of Investigative Dermatology | 2003 |
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Peroxisome proliferator-activated receptor γ ligands attenuate immunological symptoms of experimental allergic asthma
C Mueller, V Weaver, JP Heuvel, A August, MT Cantorna |
Archives of Biochemistry and Biophysics | 2003 |
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The potential role of peroxisome proliferator–activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis
J Plutzky |
The American Journal of Cardiology | 2003 |
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Insulin as an anti-inflammatory and antiatherosclerotic hormone
P Dandona, S Dhindsa, A Aljada, R Garg |
Clinical Cornerstone | 2003 |
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Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Orbital Adipose/Connective Tissues is Increased During the Active Stage of Graves' Ophthalmopathy
LY Mimura, SM Villares, ML Monteiro, IC Guazzelli, W Bloise |
Thyroid | 2003 |
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Is there a role for PPARγ in IBD? yes, no, maybe
GD Wu |
Gastroenterology | 2003 |
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Bacterial colonization leads to the colonic secretion of RELMβ/FIZZ2, a novel goblet cell-specific protein
W He, ML Wang, HQ Jiang, CM Steppan, ME Shin, MC Thurnheer, JJ Cebra, MA Lazar, GD Wu |
Gastroenterology | 2003 |
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A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
T Tanaka, H Kohno, R Suzuki, Y Yamada, S Sugie, H Mori |
Cancer Science | 2003 |
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PPAR.GAMMA.-gene therapy using an adenovirus vector for inflammatory bowel disease
A NAKAJIMA, K KATAYAMA, T MAYUMI |
Folia Pharmacologica Japonica | 2003 |
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Effect of 15-deoxy-Δ12,14-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in mice
K Inoue, H Takano, R Yanagisawa, M Morita, T Ichinose, K Sadakane, S Yoshino, K Yamaki, Y Kumagai, K Uchiyama, T Yoshikawa |
European Journal of Pharmacology | 2003 |
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Pioglitazone, a Specific Ligand of the Peroxisome Proliferator-Activated Receptor Gamma Reduces Gastric Mucosal Injury Induced by Ischaemia/Reperfusion in Rat
PC Konturek, T Brzozowski, J Kania, V Kukharsky, K Bazela, S Kwiecien, I Harsch, SJ Konturek, EG Hahn |
Scandinavian Journal of Gastroenterology | 2003 |
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Peroxisome Proliferator-activated Receptor γ and Ligands Inhibit Surfactant Protein B Gene Expression in the Lung
L Yang, D Yan, C Yan, H Du |
The Journal of biological chemistry | 2003 |
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15-Deoxy-Δ 12,14 -prostaglandin J 2 Regulates Endogenous Cot MAPK Kinase Kinase 1 Activity Induced by Lipopolysaccharide
M Caivano, C Rodriguez, P Cohen, S Alemany |
The Journal of biological chemistry | 2003 |
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Glitazones Differentially Regulate Primary Astrocyte and Glioma Cell Survival: INVOLVEMENT OF REACTIVE OXYGEN SPECIES AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ
JM Pérez-Ortiz, P Tranque, CF Vaquero, B Domingo, F Molina, S Calvo, J Jordán, V Ceña, J Llopis |
The Journal of biological chemistry | 2003 |
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15d-PGJ 2 and Rosiglitazone Suppress Janus Kinase-STAT Inflammatory Signaling through Induction of Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 in Glia
EJ Park, SY Park, E Joe, I Jou |
The Journal of biological chemistry | 2003 |
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Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
D Kelly, JI Campbell, TP King, G Grant, EA Jansson, AG Coutts, S Pettersson, S Conway |
Nature Immunology | 2003 |
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Aminosalicylates and colorectal cancer in IBD: a not-so bitter pill to swallow
BM Ryan, MG Russel, E Langholz, RW Stockbrugger |
The American Journal of Gastroenterology | 2003 |
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Phosphorylation of PPAR? via active ERK1/2 leads to its physical association with p65 and inhibition of NF-??
F Chen, M Wang, JP O'Connor, M He, T Tripathi, LE Harrison |
Journal of Cellular Biochemistry | 2003 |
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Inflammatory Bowel Disease: From Bench to Bedside
SR Targan, F Shanahan, LC Karp |
2003 | |
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Progress in Drug Research
H Wu, EJ Lien, LL Lien, RM Schultz, VJ Ram, E Domingo, P Spence, SP Gupta, SP Bhat, EC Villarreal, E Jucker |
2003 | |
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Activation of Peroxisome Proliferator-Activated Receptors in Human Airway Smooth Muscle Cells Has a Superior Anti-inflammatory Profile to Corticosteroids: Relevance for Chronic Obstructive Pulmonary Disease Therapy
HJ Patel, MG Belvisi, D Bishop-Bailey, MH Yacoub, JA Mitchell |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
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The Macrophage as Therapeutic Target
S Gordon |
2003 | |
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IL-4 Induces Apoptosis in A549 Lung Adenocarcinoma Cells: Evidence for the Pivotal Role of 15-Hydroxyeicosatetraenoic Acid Binding to Activated Peroxisome Proliferator-Activated Receptor γ Transcription Factor
P Shankaranarayanan, S Nigam |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
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PPARγ ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator‐activated receptor‐γ antagonist
D Bishop-Bailey, TD Warner |
The FASEB Journal | 2003 |
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The Cyclopentenone-Type Prostaglandin 15-Deoxy-Δ 12,14 -Prostaglandin J 2 Inhibits CD95 Ligand Gene Expression in T Lymphocytes: Interference with Promoter Activation Via Peroxisome Proliferator-Activated Receptor-γ-Independent Mechanisms
M Cippitelli, C Fionda, DD Bona, A Lupo, M Piccoli, L Frati, A Santoni |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
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Cyclopentenone Prostaglandins Induce Lymphocyte Apoptosis by Activating the Mitochondrial Apoptosis Pathway Independent of External Death Receptor Signaling
A Nencioni, K Lauber, F Grünebach, LV Parijs, C Denzlinger, S Wesselborg, P Brossart |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
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The Role of Peroxisome Proliferator–Activated Receptor γ in Colon Cancer and Inflammatory Bowel Disease
AW Bull |
Archives of pathology & laboratory medicine | 2003 |
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Peroxisome Proliferator-Activated Receptor-γ-Deficient Heterozygous Mice Develop an Exacerbated Neural Antigen-Induced Th1 Response and Experimental Allergic Encephalomyelitis
JJ Bright, C Natarajan, G Muthian, Y Barak, RM Evans |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
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A novel inflammation‐related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H |
Cancer Science | 2003 |
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Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis
DL Feinstein, E Galea, V Gavrilyuk, CF Brosnan, CC Whitacre, L Dumitrescu-Ozimek, GE Landreth, HA Pershadsingh, G Weinberg, MT Heneka |
Annals of Neurology | 2002 |
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The mechanisms of action of PPARs
J Berger, DE Moller |
Annual Review of Medicine | 2002 |
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Helicobacter pylori and gastrointestinal tract adenocarcinomas
RM Peek, MJ Blaser |
Nature Reviews Cancer | 2002 |
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Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy
P Paueksakon, MP Revelo, LJ Ma, C Marcantoni, AB Fogo |
Kidney International | 2002 |
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Corneal Protection by the Ocular Mucin Secretagogue 15(S)-HETE in a Rabbit Model of Desiccation-induced Corneal Defect
DA Gamache, ZY Wei, LK Weimer, ST Miller, JM Spellman, JM Yanni |
Journal of Ocular Pharmacology and Therapeutics | 2002 |
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Ligands of Peroxisome Proliferator-activated Receptor-γ Induce Apoptosis in AR42J Cells
A Masamune, K Satoh, Y Sakai, M Yoshida, A Satoh, T Shimosegawa |
Pancreas | 2002 |
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Physiological and Therapeutic Roles of Peroxisome Proliferator-Activated Receptors
J Berger, JA Wagner |
Diabetes Technology & Therapeutics | 2002 |
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Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: correlation with histological type and grade
S Theocharis, H Kanelli, E Politi, A Margeli, C Karkandaris, T Philippides, A Koutselinis |
Lung Cancer | 2002 |
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Inflammatory bowel disease: new insights into pathogenesis and treatment
S Ardizzone, GB Porro |
Journal of Internal Medicine | 2002 |
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Novel insulin sensitizers: pharmacogenomic aspects
C Otto, M Lehrke, B Göke |
Pharmacogenomics | 2002 |
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PPARgamma and the thiazolidinediones: molecular basis for a treatment of 'Syndrome X'?
C Sewter, A Vidal-Puig |
Diabetes, Obesity and Metabolism | 2002 |
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Thiazolidinedione Derivatives as Novel Therapeutic Agents to Prevent the Development of Chronic Pancreatitis
K Shimizu, K Shiratori, N Hayashi, M Kobayashi, T Fujiwara, H Horikoshi |
Pancreas | 2002 |
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Role of peroxisome proliferator-activated receptor γ and retinoid X receptor heterodimer in hepatogastroenterological diseases
L Dubuquoy, S Dharancy, S Nutten, S Pettersson, J Auwerx, P Desreumaux |
The Lancet | 2002 |
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Roles of peroxisome proliferator-activated receptor γ in lipid homeostasis and inflammatory responses of macrophages
GW Klappacher, CK Glass |
Current Opinion in Lipidology | 2002 |
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Roles of peroxisome proliferator-activated receptor γ in cardiovascular disease
H Takano, I Komuro |
Journal of Diabetes and its Complications | 2002 |
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Peroxisome proliferator-activated receptor gamma agonists: potential use for treating chronic inflammatory diseases
JC Oates, CM Reilly, MB Crosby, GS Gilkeson |
Arthritis & Rheumatism | 2002 |
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Peroxisome Proliferator-Activated Receptor Gamma Agonist Ligands Stimulate a Th2 Cytokine Response and Prevent Acute Colitis:
LJ Saubermann, A Nakajima, K Wada, S Zhao, Y Terauchi, T Kadowaki, H Aburatani, N Matsuhashi, R Nagai, RS Blumberg |
Inflammatory Bowel Diseases | 2002 |
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The Dawn of the SPPARMs?
SM Rangwala, MA Lazar |
Science signaling | 2002 |
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Prostaglandins as modulators of immunity
SG Harris, J Padilla, L Koumas, D Ray, RP Phipps |
Trends in Immunology | 2002 |
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Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
A Galli, DW Crabb, E Ceni, R Salzano, T Mello, G Svegliati-Baroni, F Ridolfi, L Trozzi, C Surrenti, A Casini |
Gastroenterology | 2002 |
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Biological and novel therapies for inflammatory bowel disease in children
P Mamula, MR Mascarenhas, RN Baldassano |
Pediatric Clinics of North America | 2002 |
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The immunology of inflammatory bowel disease
S Plevy |
Gastroenterology Clinics of North America | 2002 |
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Effects of different PPARγ-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis
U Panzer, A Schneider, Y Guan, R Reinking, G Zahner, S Harendza, G Wolf, F Thaiss, RA Stahl |
Kidney International | 2002 |
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Chemoprevention of colorectal cancer: problems, progress, and prospects
JL Viner, A Umar, ET Hawk |
Gastroenterology Clinics of North America | 2002 |
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Fatty Acid Modulation of Atherosclerosis by Peroxisome Proliferator- Activated Receptors
KL Erickson, NE Hubbard, LM Meinecke |
Nutraceuticals and food | 2002 |
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Nutrition impact of conjugated linoleic acid: A model functional food ingredient
J Bassaganya-Riera, R Hontecillas, MJ Wannemuehler |
In Vitro Cellular & Developmental Biology | 2002 |
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Butyrate reduces colonic paracellular permeability by enhancing PPARγ activation
M Kinoshita, Y Suzuki, Y Saito |
Biochemical and Biophysical Research Communications | 2002 |
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Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and Nf-kB in human colon cancer
GG Chen, JF Lee, SH Wang, UP Chan, PC Ip, WY Lau |
Life Sciences | 2002 |
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Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma
Christoph A Meier, Rachel Chicheportiche, Cristiana E Juge-Aubry, Magali G Dreyer, Jean-Michel Dayer |
Cytokine | 2002 |
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Pioglitazone, a PPAR-γ ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-κB-cytokine cascade
T Takagi, Y Naito, N Tomatsuri, O Handa, H Ichikawa, N Yoshida, T Yoshikawa |
Redox Report | 2002 |
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Suppression of intestinal ischemia-reperfusion injury by a specific peroxisome proliferator-activated receptor-γ ligand, pioglitazone, in rats
Y Naito, T Takagi, K Uchiyama, O Handa, N Tomatsuri, E Imamoto, S Kokura, H Ichikawa, N Yoshida, T Yoshikawa |
Redox Report | 2002 |
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Constitutive Activation of Peroxisome Proliferator-activated Receptor-γ Suppresses Pro-inflammatory Adhesion Molecules in Human Vascular Endothelial Cells
N Wang, L Verna, NG Chen, J Chen, H Li, BM Forman, MB Stemerman |
The Journal of biological chemistry | 2002 |
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Biology and toxicology of PPARg ligands
JD Tugwood, CT Montague |
Human & Experimental Toxicology | 2002 |
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Generation and functional confirmation of a conditional null PPAR? allele in mice
JR Jones, KD Shelton, Y Guan, MD Breyer, MA Magnuson |
Genesis (New York, N.Y. : 2000) | 2002 |
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Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation
C Natarajan, JJ Bright |
Genes and Immunity | 2002 |
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PPAR-γ ligands modulate effects of LPS in stimulated rat synovial fibroblasts
MA Simonin, K Bordji, S Boyault, A Bianchi, E Gouze, P Bécuwe, M Dauça, P Netter, B Terlain |
American journal of physiology. Cell physiology | 2002 |
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I. PPARγ in the gastrointestinal tract: gain or pain?
J Auwerx |
AJP Gastrointestinal and Liver Physiology | 2002 |
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15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis and causes downregulation of Stat3 in human oral SCCa cells
NG Nikitakis, H Siavash, C Hebert, MA Reynolds, AW Hamburger, JJ Sauk |
British Journal of Cancer | 2002 |
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Nutritional Regulation of Porcine Bacterial-Induced Colitis by Conjugated Linoleic Acid
R Hontecillas, MJ Wannemeulher, DR Zimmerman, DL Hutto, JH Wilson, DU Ahn, J Bassaganya-Riera |
The Journal of nutrition | 2002 |
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Pioglitazone, a Peroxisome Proliferator–Activated Receptor-γ Agonist, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction
T Shiomi, H Tsutsui, S Hayashidani, N Suematsu, M Ikeuchi, J Wen, M Ishibashi, T Kubota, K Egashira, A Takeshita |
Circulation | 2002 |
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Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications
JC Fruchart, AM Gotto, R Paoletti, B Staels, AL Catapano |
2002 | |
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Peroxisome Proliferator-Activated Receptor-γ Agonist 15-Deoxy-Δ 12,1412,14 -Prostaglandin J 2 Ameliorates Experimental Autoimmune Encephalomyelitis
A Diab, C Deng, JD Smith, RZ Hussain, B Phanavanh, AE Lovett-Racke, PD Drew, MK Racke |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
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Regulation of Cytokine Expression by Ligands of Peroxisome Proliferator Activated Receptors
R Cunard, M Ricote, D DiCampli, DC Archer, DA Kahn, CK Glass, CJ Kelly |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
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WY14,643, a PPARα Ligand, Has Profound Effects on Immune Responses In Vivo
R Cunard, D DiCampli, DC Archer, JL Stevenson, M Ricote, CK Glass, CJ Kelly |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
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Dendritic Cell Immunogenicity Is Regulated by Peroxisome Proliferator-Activated Receptor γ
A Nencioni, F Grünebach, A Zobywlaski, C Denzlinger, W Brugger, P Brossart |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
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Becoming fat
MA Lazar |
Genes & development | 2002 |
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Regulation of peroxisome proliferator-activated receptor gamma expression in human asthmatic airways: relationship with proliferation, apoptosis, and airway remodeling
L Benayoun, S Letuve, A Druilhe, J Boczkowski, MC Dombret, P Mechighel, J Megret, G Leseche, M Aubier, M Pretolani |
American journal of respiratory and critical care medicine | 2001 |
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Hypoxia-Inducible Factor 1-Mediated Inhibition of Peroxisome Proliferator-Activated Receptor α Expression During Hypoxia
S Narravula, SP Colgan |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
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Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats
LJ Ma, C Marcantoni, MF Linton, S Fazio, AB Fogo |
Kidney International | 2001 |
|
Peroxisome proliferator-activated receptors in endothelial cell biology
J Plutzky |
Current Opinion in Lipidology | 2001 |
|
Novel therapies in the treatment of ulcerative colitis
SV Kane |
Expert Opinion on Investigational Drugs | 2001 |
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Novel therapeutics in inflammatory bowel disease
CN Bernstein |
Expert Opinion on Therapeutic Patents | 2001 |
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Production of Matrix Metalloproteinase-9 in CaCO-2 Cells in Response to Inflammatory Stimuli
X Gan, B Wong, SD Wright, TQ Cai |
Journal of Interferon & Cytokine Research | 2001 |
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Heat shock proteins: new keys to the development of cytoprotective therapies
M Tytell1, PL Hooper |
Expert Opinion on Therapeutic Targets | 2001 |
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Peroxisome proliferator-activated receptor ? activators inhibit interleukin-1?-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes
H Fahmi, JA di Battista, JP Pelletier, F Mineau, P Ranger, J Martel-Pelletier |
Arthritis & Rheumatism | 2001 |
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The Future of Colon Cancer Prevention
A Umar, JL Viner, ET Hawk |
Annals of the New York Academy of Sciences | 2001 |
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Peroxisome proliferator-activated receptor gamma (PPARγ) activation and its consequences in humans
J Bar-Tana |
Toxicology Letters | 2001 |
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Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies
P Desreumaux, L Dubuquoy, S Nutten, M Peuchmaur, W Englaro, K Schoonjans, B Derijard, B Desvergne, W Wahli, P Chambon, MD Leibowitz, JF Colombel, J Auwerx |
Journal of Experimental Medicine | 2001 |
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Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus
Y Suresh, UN Das |
Prostaglandins Leukotrienes and Essential Fatty Acids | 2001 |
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Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids
IK Mohan, UN Das |
Nutrition | 2001 |
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Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?
KJ Moore, ML Fitzgerald, MW Freeman |
Current Opinion in Lipidology | 2001 |
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Regulatory role of phosphatidylinositol 3-kinase on TNF-α-induced cyclooxygenase 2 expression in colonic epithelial cells
SA Weaver, MP Russo, KL Wright, G Kolios, C Jobin, DA Robertson, SG Ward |
Gastroenterology | 2001 |
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Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs)
MB Sporn, N Suh, DJ Mangelsdorf |
Trends in Molecular Medicine | 2001 |
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Inhibition of the transcription factors AP-1 and NF-κB in CD4 T cells by peroxisome proliferator-activated receptor γ ligands
P Wang, PO Anderson, S Chen, KM Paulsson, HO Sjögren, S Li |
International Immunopharmacology | 2001 |
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Tetradecylthioacetic acid inhibits growth of rat glioma cells ex vivo and in vivo via PPAR-dependent and PPAR-independent pathways
K Berge, KJ Tronstad, EN Flindt, TH Rasmussen, L Madsen, K Kristiansen, RK Berge |
Carcinogenesis | 2001 |
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Peroxisome Proliferator-Activated Receptors
A Elbrecht, A Adams, DE Moller |
2001 | |
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A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis
SH Caldwell, EE Hespenheide, JA Redick, JC Iezzoni, EH Battle, BL Sheppard |
The American Journal of Gastroenterology | 2001 |
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15-Deoxy-Δ12,14-PGJ2, but not troglitazone, modulates IL-1β effects in human chondrocytes by inhibiting NF-κB and AP-1 activation pathways
S Boyault, MA Simonin, A Bianchi, E Compe, B Liagre, D Mainard, P Bécuwe, M Dauça, P Netter, B Terlain, K Bordji |
FEBS Letters | 2001 |
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Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury
A Nakajima, K Wada, H Miki, N Kubota, N Nakajima, Y Terauchi, S Ohnishi, LJ Saubermann, T Kadowaki, RS Blumberg, R Nagai, N Matsuhashi |
Gastroenterology | 2001 |
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Inflammatory pathways in atherosclerosis and acute coronary syndromes
J Plutzky |
The American Journal of Cardiology | 2001 |
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Peroxisome Proliferator–Activated Receptor- γ Regulates Airway Epithelial Cell Activation
AC Wang, X Dai, B Luu, DJ Conrad |
American journal of respiratory cell and molecular biology | 2001 |
|
Inflammatory bowel disease: Immunodiagnostics, immunotherapeutics, and ecotherapeutics
F Shanahan |
Gastroenterology | 2001 |
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Novel Antiinflammatory Targets for Asthma: A Role for PPAR γ ?
CN Serhan, PR Devchand |
American journal of respiratory cell and molecular biology | 2001 |
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A Cyclopentenone Prostaglandin Activates Mesangial MAP Kinase Independently of PPARγ
WA Wilmer, C Dixon, L Lu, T Hilbelink, BH Rovin |
Biochemical and Biophysical Research Communications | 2001 |
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Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-γ
M Niino, K Iwabuchi, S Kikuchi, M Ato, T Morohashi, A Ogata, K Tashiro, K Onoé |
Journal of Neuroimmunology | 2001 |
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Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPARγ-independent manner
A Jozkowicz, J Dulak, M Prager, J Nanobashvili, A Nigisch, B Winter, G Weigel, I Huk |
Prostaglandins & Other Lipid Mediators | 2001 |
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An open-label trial of the PPARgamma ligand rosiglitazone for active ulcerative colitis
JD Lewis, GR Lichtenstein, RB Stein, JJ Deren, TA Judge, F Fogt, EE Furth, EJ Demissie, LB Hurd, CG Su, SA Keilbaugh, MA Lazar, GD Wu |
The American Journal of Gastroenterology | 2001 |
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Modern Nutrition: Constituents and Health Promotion
M Gibney, H Roche |
Modern Nutrition | 2001 |
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Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator-Activated Receptor (Ppar ) Heterodimer: A Basis for New Therapeutic Strategies
P Desreumaux, L Dubuquoy, S Nutten, M Peuchmaur, W Englaro, K Schoonjans, B Derijard, B Desvergne, W Wahli, P Chambon, MD Leibowitz, JF Colombel, J Auwerx |
Journal of Experimental Medicine | 2001 |
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PPARγ and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease
K Wada, A Nakajima, RS Blumberg |
Trends in Molecular Medicine | 2001 |
|
PPARγ agonists for intestinal ischaemia
N Matsuhashi, K Watanabe, H Kanamori, S Ohnishi, M Omata |
The Lancet | 2001 |
|
Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats
Y Naito, T Takagi, K Matsuyama, N Yoshida, T Yoshikawa |
Alimentary Pharmacology & Therapeutics | 2001 |
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The cyclopentone prostaglandin 15-deoxy-Δ12,14 prostaglandin J2 represses nitric oxide, TNF-α, and IL-12 production by microglial cells
PD Drew, JA Chavis |
Journal of Neuroimmunology | 2001 |
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Effect of PPAR Activators on Cytokine-Stimulated Cyclooxygenase-2 Expression in Human Colorectal Carcinoma Cells
H Ikawa, H Kameda, H Kamitani, SJ Baek, JB Nixon, LC Hsi, TE Eling |
Experimental Cell Research | 2001 |
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A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity
S Rocchi, F Picard, J Vamecq, L Gelman, N Potier, D Zeyer, L Dubuquoy, P Bac, M F Champy, K D Plunket, L M Leesnitzer, S G Blanchard, P Desreumaux, D Moras, J P Renaud, J Auwerx |
Molecular Cell | 2001 |
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Peroxisome Proliferator-activated Receptors in Atherosclerosis and Inflammation—An Update
CS Elangbam, RD Tyler, RM Lightfoot |
Toxicologic pathology | 2001 |
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Ligands of Peroxisome Proliferator-activated Receptor-γ Block Activation of Pancreatic Stellate Cells
A Masamune, K Kikuta, M Satoh, Y Sakai, A Satoh, T Shimosegawa |
The Journal of biological chemistry | 2001 |
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Peroxisome Proliferator-activated Receptor γ Ligands Suppress the Transcriptional Activation of Cyclooxygenase-2: EVIDENCE FOR INVOLVEMENT OF ACTIVATOR PROTEIN-1 AND CREB-BINDING PROTEIN/p300
K Subbaramaiah, DT Lin, JC Hart, AJ Dannenberg |
The Journal of biological chemistry | 2001 |
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Activation of Peroxisome Proliferator-activated Receptor γ Suppresses Nuclear Factor κB-mediated Apoptosis Induced by Helicobacter pylori in Gastric Epithelial Cells
RA Gupta, DB Polk, U Krishna, DA Israel, F Yan, RN DuBois, RM Peek |
The Journal of biological chemistry | 2001 |
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Target Genes of Peroxisome Proliferator-activated Receptor γ in Colorectal Cancer Cells
RA Gupta, JA Brockman, P Sarraf, TM Willson, RN DuBois |
The Journal of biological chemistry | 2001 |
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Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells
O Kobayashi, H Miwa, S Watanabe, M Tsujii, RN Dubois, N Sato |
AJP Gastrointestinal and Liver Physiology | 2001 |
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What happened to drug trials in ulcerative colitis? problems, PPARs, placebos, and (possible) progress
A Kornbluth |
The American Journal of Gastroenterology | 2001 |
|
Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats
H Kohno, S Yoshitani , S Takashima, A Okumura, M Hosokawa, N Yamaguchi, T Tanaka |
Japanese journal of cancer research : Gann | 2001 |
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In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-γ Agonist Rosiglitazone
T Yue, J Chen, W Bao, PK Narayanan, A Bril, W Jiang, PG Lysko, JL Gu, R Boyce, DM Zimmerman, TK Hart, RE Buckingham, EH Ohlstein |
Circulation | 2001 |
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Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3)
B Dechairo, C Dimon, D van Heel, I Mackay, M Edwards, P Scambler, D Jewell, L Cardon, N Lench, A Carey |
European Journal of Human Genetics | 2001 |
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Troglitazone Reduces the Expression of PPARγ While Stimulating That of PPARα in Mononuclear Cells in Obese Subjects1
A Aljada, H Ghanim, J Friedman, R Garg, P Mohanty, P Dandona |
The Journal of clinical endocrinology and metabolism | 2001 |
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Trends in Gastroenterology and Hepatology
H Asakura, Y Aoyagi, S Nakazawa |
2001 | |
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Differential Regulation of Chemokine Gene Expression by 15-Deoxy-Δ 12,1412,14 Prostaglandin J 2
X Zhang, JM Wang, WH Gong, N Mukaida, HA Young |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
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Cyclopentenone Prostaglandins Inhibit Cytokine-Induced NF-κB Activation and Chemokine Production by Human Mesangial Cells
BH ROVIN, L Lu, A Cosio |
Journal of the American Society of Nephrology : JASN | 2001 |
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Troglitazone, a Ligand for Peroxisome Proliferator‐activated Receptor γ Inhibits Chemically‐induced Aberrant Crypt Foci in Rats
Kohno H, Yoshitani S, Takashima S, Okumura A, Hosokawa M, Yamaguchi N, Tanaka T |
Japanese journal of cancer research : Gann | 2001 |
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Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
AC Li, KK Brown, MJ Silvestre, TM Willson, W Palinski, CK Glass |
Journal of Clinical Investigation | 2000 |
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Peroxisome proliferator-activated receptors in vascular biology and atherosclerosis: Emerging insights for evolving paradigms
J Plutzky |
Current Atherosclerosis Reports | 2000 |
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NF-κB/Rel/IκB: Implications in gastrointestinal diseases
RM Schmid, G Adler |
Gastroenterology | 2000 |
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Nuclear receptors in metabolic diseases
R Mukherjee, JA Saye, PR Young |
Expert Opinion on Therapeutic Targets | 2000 |
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Peroxisome proliferator-activated receptors (PPARs) and their implications in diseases
J Vamecq, N Latruffe |
Current Opinion in Endocrinology & Diabetes | 2000 |
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Innate immunity and the gut
VK Viswanathan, G Hecht |
Current Opinion in Gastroenterology | 2000 |
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15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway
DS Straus, G Pascual, M Li, JS Welch, M Ricote, CH Hsiang, LL Sengchanthalangsy, G Ghosh, CK Glass |
Proceedings of the National Academy of Sciences | 2000 |
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Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes
U Kintscher, S Goetze, S Wakino, S Kim, S Nagpal, RA Chandraratna, K Graf, E Fleck, WA Hsueh, RE Law |
European Journal of Pharmacology | 2000 |
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Comparative effects of pioglitazone, glibenclamide, and voglibose on urinary endothelin-1 and albumin excretion in diabetes patients
T Nakamura, C Ushiyama, N Shimada, K Hayashi, I Ebihara, H Koide |
Journal of Diabetes and its Complications | 2000 |
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PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer
GJ Murphy, JC Holder |
Trends in Pharmacological Sciences | 2000 |
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Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis
BP Neve, JC Fruchart, B Staels |
Biochemical Pharmacology | 2000 |
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Medical therapy for ulcerative colitis:
SB Hanauer |
Current Opinion in Gastroenterology | 2000 |
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Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPAR? agonists as inducers of apoptosis
N Chattopadhyay, DP Singh, O Heese, MM Godbole, T Sinohara, PM Black, EM Brown |
Journal of Neuroscience Research | 2000 |
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A review of standard and novel therapies in Crohn’s disease
SJ Rulyak, GR Lichtenstein |
Expert Opinion on Therapeutic Patents | 2000 |
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Peroxisome Proliferator-Activated Receptor-γ Activators Inhibit IFN-γ-Induced Expression of the T Cell-Active CXC Chemokines IP-10, Mig, and I-TAC in Human Endothelial Cells1
Nikolaus Marx, François Mach, Alain Sauty, Josephine H. Leung, Mindy N. Sarafi, Richard M. Ransohoff, Peter Libby, Jorge Plutzky, Andrew D. Luster |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
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Peroxisome Proliferator-activated Receptors and Hepatic Stellate Cell Activation
T Miyahara, L Schrum, R Rippe, S Xiong, HF Yee, K Motomura, FA Anania, TM Willson, H Tsukamoto |
The Journal of biological chemistry | 2000 |
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The IκB/NF-κB system: a key determinant of mucosal inflammation and protection
C Jobin, RB Sartor |
American journal of physiology. Cell physiology | 2000 |
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Cyclooxygenase-2-derived prostaglandin D 2 is an early anti-inflammatory signal in experimental colitis
MN Ajuebor, A Singh, JL Wallace |
AJP Gastrointestinal and Liver Physiology | 2000 |
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Role for Peroxisome Proliferator-Activated Receptor in Oxidized Phospholipid-Induced Synthesis of Monocyte Chemotactic Protein-1 and Interleukin-8 by Endothelial Cells
H Lee, W Shi, P Tontonoz, S Wang, G Subbanagounder, CC Hedrick, S Hama, C Borromeo, RM Evans, JA Berliner, L Nagy |
Circulation research | 2000 |
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Peroxisome Proliferator–Activated Receptor-γ Ligands Inhibit Nitric Oxide Synthesis in Vascular Smooth Muscle Cells
U Ikeda, M Shimpo, Y Murakami, K Shimada |
Hypertension | 2000 |
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Peroxisome Proliferator-Activated Receptor-γ Activators Inhibit IFN-γ-Induced Expression of the T Cell-Active CXC Chemokines IP-10, Mig, and I-TAC in Human Endothelial Cells
N Marx, F Mach, A Sauty, JH Leung, MN Sarafi, RM Ransohoff, P Libby, J Plutzky, AD Luster |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
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Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene
M Li, G Pascual, CK Glass |
Molecular and cellular biology | 2000 |
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In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats
L R Fitzpatrick, J Wang, T Le |
Digestive Diseases and Sciences | 2000 |
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Pharmacological peroxisome proliferator-activated receptorγ ligands: emerging clinical indications beyond diabetes
HA Pershadsingh |
Expert Opinion on Investigational Drugs | 1999 |
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In Vivo Models of Inflammation
DW Morgan, LA Marshall |
1999 | |
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Progress in Medicinal Chemistry
JR Brown, SH Imam |
Progress in Medicinal Chemistry | 1985 |
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