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Atsushi Terunuma, … , Arun Sreekumar, Stefan Ambs
Published December 9, 2013
Citation Information: J Clin Invest. 2014;124(1):398-412. https://doi.org/10.1172/JCI71180.
Citation Information: J Clin Invest. 2014;124(1):398-412. https://doi.org/10.1172/JCI71180.
Abstract
Metabolic profiling of cancer cells has recently been established as a promising tool for the development of therapies and identification of cancer biomarkers. Here we characterized the metabolomic profile of human breast tumors and uncovered intrinsic metabolite signatures in these tumors using an untargeted discovery approach and validation of key metabolites. The oncometabolite 2-hydroxyglutarate (2HG) accumulated at high levels in a subset of tumors and human breast cancer cell lines. We discovered an association between increased 2HG levels and MYC pathway activation in breast cancer, and further corroborated this relationship using MYC overexpression and knockdown in human mammary epithelial and breast cancer cells. Further analyses revealed globally increased DNA methylation in 2HG-high tumors and identified a tumor subtype with high tissue 2HG and a distinct DNA methylation pattern that was associated with poor prognosis and occurred with higher frequency in African-American patients. Tumors of this subtype had a stem cell–like transcriptional signature and tended to overexpress glutaminase, suggestive of a functional relationship between glutamine and 2HG metabolism in breast cancer. Accordingly, 13C-labeled glutamine was incorporated into 2HG in cells with aberrant 2HG accumulation, whereas pharmacologic and siRNA-mediated glutaminase inhibition reduced 2HG levels. Our findings implicate 2HG as a candidate breast cancer oncometabolite associated with MYC activation and poor prognosis.
Authors
Atsushi Terunuma, Nagireddy Putluri, Prachi Mishra, Ewy A. Mathé, Tiffany H. Dorsey, Ming Yi, Tiffany A. Wallace, Haleem J. Issaq, Ming Zhou, J. Keith Killian, Holly S. Stevenson, Edward D. Karoly, King Chan, Susmita Samanta, DaRue Prieto, Tiffany Y.T. Hsu, Sarah J. Kurley, Vasanta Putluri, Rajni Sonavane, Daniel C. Edelman, Jacob Wulff, Adrienne M. Starks, Yinmeng Yang, Rick A. Kittles, Harry G. Yfantis, Dong H. Lee, Olga B. Ioffe, Rachel Schiff, Robert M. Stephens, Paul S. Meltzer, Timothy D. Veenstra, Thomas F. Westbrook, Arun Sreekumar, Stefan Ambs
Total citations by year
Citation information
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E Cuyàs, S Verdura, B Martin-Castillo, T Alarcón, R Lupu, J Bosch-Barrera, JA Menendez |
Cancers | 2020 |
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A DNA Methylation-Based Panel for the Prognosis and Dagnosis of Patients With Breast Cancer and Its Mechanisms
XP Liu, J Hou, C Chen, L Guan, HK Hu, S Li |
Frontiers in Molecular Biosciences | 2020 |
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Metabolomics and Multi-Omics Integration: A Survey of Computational Methods and Resources
T Eicher, G Kinnebrew, A Patt, K Spencer, K Ying, Q Ma, R Machiraju, EA Mathé |
Metabolites | 2020 |
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Metabolite sensing and signaling in cancer
YP Wang, JT Li, J Qu, M Yin, QY Lei |
The Journal of biological chemistry | 2020 |
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Scientific Reports | 2020 |
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Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics, and Oncogenesis – Part 2: Acetate and ACSS2 in Health and Disease
JR Moffett, N Puthillathu, R Vengilote, DM Jaworski, AM Namboodiri |
Frontiers in physiology | 2020 |
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W Feng, DC Dean, FJ Hornicek, D Spentzos, RM Hoffman, H Shi, Z Duan |
Therapeutic advances in medical oncology | 2020 |
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Computational models applied to metabolomics data hints at the relevance of glutamine metabolism in breast cancer
L Trilla-Fuertes, A Gámez-Pozo, E López-Camacho, G Prado-Vázquez, A Zapater-Moros, R López-Vacas, JM Arevalillo, M Díaz-Almirón, H Navarro, P Maín, E Espinosa, P Zamora, JÁ Vara |
BMC Cancer | 2020 |
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G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer
M Dragan, MU Nguyen, S Guzman, C Goertzen, M Brackstone, WS Dhillo, PR Bech, S Clarke, A Abbara, AB Tuck, DA Hess, SR Pine, WX Zong, FE Wondisford, X Su, AV Babwah, M Bhattacharya |
Cell Death and Disease | 2020 |
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X Zhang, X Wang, XQ Wang, J Su, N Putluri, T Zhou, Y Qu, M Jeong, A Guzman, C Rosas, Y Huang, A Sreekumar, W Li, MA Goodell |
Blood | 2020 |
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The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer
X Zhao, J Fu, J Du, W Xu |
International journal of biological sciences | 2020 |
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ERR1 and PGC1α associated mitochondrial alterations correlate with pan-cancer disparity in African-Americans.
Danthasinghe Waduge Badrajee Piyarathna, Akhila Balasubramanian, James M Arnold, Stacy Lloyd, Balasubramanyam Karanam, Patricia Castro, Michael Ittmann, NAGIREDDY PUTLURI, Nora Navone, Jeffrey Jones, Wendong Yu, Vlad C Sandulache, Andrew Sikora, George Michailidis, Arun Sreekumar |
Journal of Clinical Investigation | 2019 |
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The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
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Experimental & molecular medicine | 2019 |
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Special issue on hypoxia
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Experimental & molecular medicine | 2019 |
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Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion
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Molecular Metabolism | 2019 |
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Oncometabolites in renal cancer
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The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension
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Metabolic alterations and the potential for targeting metabolic pathways in the treatment of multiple myeloma
D Rizzieri, B Paul, Y Kang |
Journal of Cancer Metastasis and Treatment | 2019 |
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Metabolic Plasticity and Epithelial-Mesenchymal Transition
TM Thomson, C Balcells, M Cascante |
Journal of Clinical Medicine | 2019 |
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Large-scale profiling of serum metabolites in African American and European American patients with bladder cancer reveals metabolic pathways associated with patient survival: Bladder Cancer Disparity
V Vantaku, SR Donepudi, DW Piyarathna, CS Amara, CR Ambati, W Tang, V Putluri, DS Chandrashekar, S Varambally, MK Terris, K Davies, S Ambs, R Bollag, AB Apolo, A Sreekumar, N Putluri |
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Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer
DM Demas, S Demo, Y Fallah, R Clarke, KP Nephew, S Althouse, G Sandusky, W He, AN Shajahan-Haq |
Frontiers in Oncology | 2019 |
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Defining a metabolic landscape of tumours: genome meets metabolism
CS Nanda, SV Venkateswaran, N Patani, M Yuneva |
British Journal of Cancer | 2019 |
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Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
D Jia, M Lu, KH Jung, JH Park, L Yu, JN Onuchic, BA Kaipparettu, H Levine |
Proceedings of the National Academy of Sciences | 2019 |
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Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications
N Gandhi, G Das |
Cells | 2019 |
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EYA2 Correlates With Clinico-Pathological Features of Breast Cancer, Promotes Tumor Proliferation, and Predicts Poor Survival
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Frontiers in Oncology | 2019 |
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Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B
M Rosso, L Lapyckyj, MJ Besso, M Monge, J Reventós, F Canals, JO Cuenca, ML Matos, MH Vazquez-Levin |
Cancer & Metabolism | 2019 |
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The roles of glucose metabolic reprogramming in chemo- and radio-resistance
J Lin, L Xia, J Liang, Y Han, H Wang, L Oyang, S Tan, Y Tian, S Rao, X Chen, Y Tang, M Su, X Luo, Y Wang, H Wang, Y Zhou, Q Liao |
Journal of Experimental & Clinical Cancer Research | 2019 |
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A four‑gene signature for prognosis in breast cancer patients with hypermethylated IL15RA
H Yang, L Zhou, J Chen, J Su, W Shen, B Liu, J Zhou, S Yu, J Qian |
Oncology Letters | 2019 |
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Co-expression of key gene modules and pathways of human breast cancer cell lines
Y Wu, F liu, S Luo, X Yin, D He, J Liu, Z Yue, J Song |
Bioscience Reports | 2019 |
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Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective
S Chu, M Huang, R Kelly, E Benedetti, J Siddiqui, O Zeleznik, A Pereira, D Herrington, C Wheelock, J Krumsiek, M McGeachie, S Moore, P Kraft, E Mathé, J Lasky-Su |
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Epigenetic Dysregulation at the Crossroad of Women’s Cancer
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Liver- and Microbiome-derived Bile Acids Accumulate in Human Breast Tumors and Inhibit Growth and Improve Patient Survival
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Clinical cancer research | 2019 |
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MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study
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Annals of translational medicine | 2019 |
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2-hydroxyglutarate in cancer cells
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Antioxidants & Redox Signaling | 2019 |
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Current Advances and Future Perspectives of Cerebrospinal Fluid Biopsy in Midline Brain Malignancies
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Current Treatment Options in Oncology | 2019 |
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Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression
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Scientific Reports | 2019 |
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The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer
AI Aljohani, MS Toss, S Kurozumi, C Joseph, MA Aleskandarany, IM Miligy, RE Ansari, NP Mongan, IO Ellis, AR Green, EA Rakha |
Breast Cancer Research and Treatment | 2019 |
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Frontiers in Oncology | 2019 |
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Disparity in Tumor Immune Microenvironment of Breast Cancer and Prognostic Impact: Asian Versus Western Populations
CH Chen, YS Lu, AL Cheng, CS Huang, WH Kuo, MY Wang, M Chao, IC Chen, CW Kuo, TP Lu, CH Lin |
The oncologist | 2019 |
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2-Hydroxyglutarate Derived from Glutamine is Associated with Disease Progression in Plasma Cell Malignancies
Wilson Gonsalves, Vijay Ramakrishnan, Taro Hitosugi, Toshi Ghosh, Dragan Jevremovic, Tumpa Dutta, Dhananjay Sakrikar, Xuan-Mai Persson, Linda Wellik, Shaji Kumar, K Sreekumaran Nair |
JCI Insight | 2018 |
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Applications of metabolomics to study cancer metabolism
AK Kaushik, RJ DeBerardinis |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2018 |
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Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer
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Proceedings of the National Academy of Sciences | 2018 |
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The Heterogeneity of Cancer Metabolism
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Analysis of Tumor Biology to Advance Cancer Health Disparity Research
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The American Journal of Pathology | 2018 |
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AR negative triple negative or “quadruple negative” breast cancers in African American women have an enriched basal and immune signature
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PloS one | 2018 |
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Methylation-to-Expression Feature Models of Breast Cancer Accurately Predict Overall Survival, Distant-Recurrence Free Survival, and Pathologic Complete Response in Multiple Cohorts
JA Thompson, BC Christensen, CJ Marsit |
Scientific Reports | 2018 |
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Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health
F Cheng, H Liang, AJ Butte, C Eng, R Nussinov, MM Gottesman |
Pharmacological reviews | 2018 |
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Metabolism and Transcription in Cancer: Merging Two Classic Tales
N Martín-Martín, A Carracedo, V Torrano |
Frontiers in Cell and Developmental Biology | 2018 |
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Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
C Dai, J Arceo, J Arnold, A Sreekumar, NJ Dovichi, J Li, LE Littlepage |
Cancer & Metabolism | 2018 |
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Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates
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Trends in Cancer | 2018 |
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
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Cell | 2018 |
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Signaling Pathways Regulating Redox Balance in Cancer Metabolism
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Frontiers in Oncology | 2018 |
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The Omics Revolution Continues: The Maturation of High-Throughput Biological Data Sources
E Mathé, J Hays, D Stover, J Chen |
Yearbook of medical informatics | 2018 |
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Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers
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Cell Reports | 2018 |
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Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer
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Theranostics | 2018 |
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RaMP: A Comprehensive Relational Database of Metabolomics Pathways for Pathway Enrichment Analysis of Genes and Metabolites
B Zhang, S Hu, E Baskin, A Patt, J Siddiqui, E Mathé |
Metabolites | 2018 |
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S Fan, A Yeon, M Shahid, JT Anger, KS Eilber, O Fiehn, J Kim |
Scientific Reports | 2018 |
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A Landscape of Metabolic Variation across Tumor Types
E Reznik, A Luna, BA Aksoy, EM Liu, K La, I Ostrovnaya, CJ Creighton, AA Hakimi, C Sander |
Cell Systems | 2018 |
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BM Ryan |
Carcinogenesis | 2018 |
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ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer
P Mishra, W Tang, S Ambs |
Molecular & Cellular Oncology | 2018 |
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A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines
GA Gowda, GA Barding, J Dai, H Gu, DH Margineantu, DM Hockenbery, D Raftery |
Frontiers in Molecular Biosciences | 2018 |
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Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies
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Metabolomics | 2018 |
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D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization
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PloS one | 2018 |
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BMC bioinformatics | 2018 |
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Amino Acid Transporters and Glutamine Metabolism in Breast Cancer
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International journal of molecular sciences | 2018 |
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Medical science monitor : international medical journal of experimental and clinical research | 2018 |
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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib
TP Miettinen, J Peltier, A Härtlova, M Gierliński, VM Jansen, M Trost, M Björklund |
The EMBO Journal | 2018 |
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Evidence-based approaches to reduce cancer health disparities: Discover, develop, deliver, and disseminate
PP Desai, JB Lampe, SA Bakre, RM Basha, HP Jones, JK Vishwanatha |
Journal of carcinogenesis | 2018 |
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Onco-Multi-OMICS Approach: A New Frontier in Cancer Research
S Chakraborty, I Hosen, M Ahmed, HU Shekhar |
BioMed Research International | 2018 |
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Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets
V Miranda-Gonçalves, A Lameirinhas, R Henrique, C Jerónimo |
Frontiers in Genetics | 2018 |
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Cross-cancer Prediction: A Novel Machine Learning Approach to Discover Molecular Targets for Development of Treatments for Multiple Cancers
K Gao, D Wang, Y Huang |
Cancer informatics | 2018 |
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Integrated proteotranscriptomics of breast cancer reveals globally increased protein-mRNA concordance associated with subtypes and survival
W Tang, M Zhou, TH Dorsey, DR Prieto, XW Wang, E Ruppin, TD Veenstra, S Ambs |
Genome Medicine | 2018 |
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Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor
D Hong, AJ Fritz, KH Finstad, MP Fitzgerald, A Weinheimer, AL Viens, J Ramsey, JL Stein, JB Lian, GS Stein |
Molecular cancer research : MCR | 2018 |
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ADHFE1 is a Breast Cancer Oncogene and Induces Metabolic Reprogramming
Prachi Mishra, Wei Tang, Vasanta Putluri, Tiffany Dorsey, Feng Jin, Fang Wang, Dongwei Zhu, Lauren Amable, Tao Deng, Shaofei Zhang, J. Keith Killian, Yonghong Wang, Tsion Minas, Harris Yfantis, Dong Lee, Arun Sreekumar, Michael Bustin, Wei Liu, NAGIREDDY PUTLURI, Stefan Ambs |
Journal of Clinical Investigation | 2017 |
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Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD
B York, F Li, F Lin, KL Marcelo, J Mao, A Dean, N Gonzales, D Gooden, S Maity, C Coarfa, N Putluri, AR Means |
Scientific Reports | 2017 |
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Promoter Methylation Modulates Indoleamine 2,3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers
SK Noonepalle, F Gu, EJ Lee, JH Choi, Q Han, J Kim, M Ouzounova, AY Shull, L Pei, PY Hsu, R Kolhe, F Shi, J Choi, K Chiou, TH Huang, H Korkaya, L Deng, HB Xin, S Huang, M Thangaraju, A Sreekumar, S Ambs, SC Tang, DH Munn, H Shi |
Cancer immunology research | 2017 |
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Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers
W Song, Y Hwang, VM Youngblood, RS Cook, JM Balko, J Chen, DM Brantley-Sieders |
Oncogene | 2017 |
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Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors
A Morandi, ML Taddei, P Chiarugi, E Giannoni |
Frontiers in Oncology | 2017 |
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Metabolic Footprints and Molecular Subtypes in Breast Cancer
V Cappelletti, E Iorio, P Miodini, M Silvestri, M Dugo, MG Daidone |
Disease Markers | 2017 |
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Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
CC Wong, Y Qian, J Yu |
Oncogene | 2017 |
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MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
K Lee, JM Giltnane, JM Balko, LJ Schwarz, AL Guerrero-Zotano, KE Hutchinson, MJ Nixon, MV Estrada, V Sánchez, ME Sanders, T Lee, H Gómez, A Lluch, JA Pérez-Fidalgo, MM Wolf, G Andrejeva, JC Rathmell, SW Fesik, CL Arteaga |
Cell Metabolism | 2017 |
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In vivo Reprogramming of Cancer Metabolism by MYC
R Camarda, J Williams, A Goga |
Frontiers in Cell and Developmental Biology | 2017 |
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Comprehensive molecular biomarker identification in breast cancer brain metastases
HJ Schulten, M Bangash, S Karim, A Dallol, D Hussein, A Merdad, FK Al-Thoubaity, J Al-Maghrabi, A Jamal, F Al-Ghamdi, H Choudhry, SS Baeesa, AG Chaudhary, MH Al-Qahtani |
Journal of Translational Medicine | 2017 |
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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
PL Sulkowski, CD Corso, ND Robinson, SE Scanlon, KR Purshouse, H Bai, Y Liu, RK Sundaram, DC Hegan, NR Fons, GA Breuer, Y Song, K Mishra-Gorur, HM de Feyter, RA de Graaf, YV Surovtseva, M Kachman, S Halene, M Günel, PM Glazer, RS Bindra |
Science Translational Medicine | 2017 |
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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
AM Intlekofer, B Wang, H Liu, H Shah, C Carmona-Fontaine, AS Rustenburg, S Salah, MR Gunner, JD Chodera, JR Cross, CB Thompson |
Nature Chemical Biology | 2017 |
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DACH1 suppresses breast cancer as a negative regulator of CD44
H Xu, S Yu, X Yuan, J Xiong, D Kuang, RG Pestell, K Wu |
Scientific Reports | 2017 |
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Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis
W Zhang, M Zhang, C Gao, Y Zhang, Y Ge, S Guo, X Guo, Z Zhou, Q Liu, Y Zhang, C Ma, F Tao, P Xu |
Proceedings of the National Academy of Sciences | 2017 |
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Multivoxel magnetic resonance spectroscopy identifies enriched foci of cancer stem-like cells in high-grade gliomas
T He, T Qiu, X Wang, H Gui, X Wang, Q Hu, H Xia, G Qi, J Wu, H Ma |
OncoTargets and therapy | 2017 |
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Prognostic genes of breast cancer revealed by gene co‑expression network analysis
H Shi, L Zhang, Y Qu, L Hou, L Wang, M Zheng |
Oncology Letters | 2017 |
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Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
T Xu, KM Stewart, X Wang, K Liu, M Xie, JK Ryu, K Li, T Ma, H Wang, L Ni, S Zhu, N Cao, D Zhu, Y Zhang, K Akassoglou, C Dong, EM Driggers, S Ding |
Nature | 2017 |
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Comparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans
KA Mitchell, A Zingone, L Toulabi, J Boeckelman, BM Ryan |
Clinical cancer research | 2017 |
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Racial disparity in metabolic regulation of cancer.
Attri KS, Murthy D, Singh PK |
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The Emerging Hallmarks of Cancer Metabolism
NN Pavlova, CB Thompson |
Cell Metabolism | 2016 |
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Metabolic Heterogeneity in Human Lung Tumors
CT Hensley, B Faubert, Q Yuan, N Lev-Cohain, E Jin, J Kim, L Jiang, B Ko, R Skelton, L Loudat, M Wodzak, C Klimko, E McMillan, Y Butt, M Ni, D Oliver, J Torrealba, CR Malloy, K Kernstine, RE Lenkinski, RJ DeBerardinis |
Cell | 2016 |
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From Krebs to clinic: glutamine metabolism to cancer therapy
BJ Altman, ZE Stine, CV Dang |
Nature Reviews Cancer | 2016 |
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Heterogeneity in Cancer Metabolism: New Concepts in an Old Field
G Gentric, V Mieulet, F Mechta-Grigoriou |
Antioxidants & Redox Signaling | 2016 |
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Cancer Metabolism: Fueling More than Just Growth
N Lee, D Kim |
Molecules and Cells | 2016 |
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Expression profile of SIX family members correlates with clinic-pathological features and prognosis of breast cancer: A systematic review and meta-analysis
HX Xu, KJ Wu, YJ Tian, Q Liu, N Han, XL He, X Yuan, GS Wu, KM Wu |
Medicine | 2016 |
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Lipid analysis of eight human breast cancer cell lines with ToF-SIMS
MA Robinson, DJ Graham, F Morrish, D Hockenbery, LJ Gamble |
Biointerphases | 2016 |
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Breast cancer classification and prognostication through diverse systems along with recent emerging findings in this respect; the dawn of new perspectives in the clinical applications
V Pourteimoor, S Mohammadi-Yeganeh, M Paryan |
Tumor Biology | 2016 |
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Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique
NF Voelxen, S Walenta, M Proescholdt, K Dettmer, S Pusch, W Mueller-Klieser |
Frontiers in Oncology | 2016 |
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In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists
H Kim, S Kim, HH Lee, H Heo |
Korean Journal of Radiology | 2016 |
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Oncometabolic Nuclear Reprogramming of Cancer Stemness
JA Menendez, B Corominas-Faja, E Cuyàs, MG García, S Fernández-Arroyo, AF Fernández, J Joven, MF Fraga, T Alarcón |
Stem Cell Reports | 2016 |
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A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer
N Auslander, K Yizhak, A Weinstock, A Budhu, W Tang, XW Wang, S Ambs, E Ruppin |
Scientific Reports | 2016 |
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Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
H Colvin, N Nishida, M Konno, N Haraguchi, H Takahashi, J Nishimura, T Hata, K Kawamoto, A Asai, K Tsunekuni, J Koseki, T Mizushima, T Satoh, Y Doki, M Mori, H Ishii |
Scientific Reports | 2016 |
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Compartmentation of Metabolites in Regulating Epigenomes of Cancer
Z Zhao, L Wang |
Molecular Medicine | 2016 |
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Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the ApcMin/+ model of colon cancer
DR Soto-Pantoja, JM Sipes, G Martin-Manso, B Westwood, NL Morris, A Ghosh, NJ Emenaker, DD Roberts |
Oncogenesis | 2016 |
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Altered metabolite levels in cancer: implications for tumour biology and cancer therapy
LB Sullivan, DY Gui, MG Heiden |
Nature Reviews Cancer | 2016 |
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Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice
MT Montales, SB Melnyk, SJ Liu, FA Simmen, YL Liu, RC Simmen |
Endocrine Related Cancer | 2016 |
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Metabolomanalyse solider Tumoren
J Budczies |
Der Pathologe | 2016 |
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Oncometabolites: Unconventional triggers of oncogenic signalling cascades
M Sciacovelli, C Frezza |
Free radical biology & medicine | 2016 |
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CEST-MRI detects metabolite levels altered by breast cancer cell aggressiveness and chemotherapy response: Cest-mri for Detecting Metabolites in Breast Cancer cells
KW Chan, L Jiang, M Cheng, JP Wijnen, G Liu, P Huang, PC van Zijl, MT McMahon, K Glunde |
NMR in Biomedicine | 2016 |
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Enrichment of CD44 in basal-type breast cancer correlates with EMT, cancer stem cell gene profile, and prognosis
K Wu, H Xu, X Yuan, Y Tian, Y Liu, Q Liu, H Wu, GS Wu |
OncoTargets and therapy | 2016 |
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Saccharomyces cerevisiae Forms d-2-Hydroxyglutarate and Couples Its Degradation to d-Lactate Formation via a Cytosolic Transhydrogenase
J Becker-Kettern, N Paczia, JF Conrotte, DP Kay, C Guignard, PP Jung, CL Linster |
The Journal of biological chemistry | 2016 |
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Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling
X Tang, CK Ding, J Wu, J Sjol, S Wardell, I Spasojevic, D George, DP McDonnell, DS Hsu, JT Chang, JT Chi |
Oncogene | 2016 |
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Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
E Gaude, C Frezza |
Nature Communications | 2016 |
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Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination
X Fang, W Zhou, Q Wu, Z Huang, Y Shi, K Yang, C Chen, Q Xie, SC Mack, X Wang, AM Carcaboso, AE Sloan, G Ouyang, RE McLendon, X Bian, JN Rich, S Bao |
Journal of Experimental Medicine | 2016 |
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On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer
J Penkert, T Ripperger, M Schieck, B Schlegelberger, D Steinemann, T Illig |
Oncotarget | 2016 |
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On-target inhibition of glutaminase diminishes cell autonomous tumorigenesis
Yan Xiang, Zachary Stine, Jinsong Xia, Yunqi Lu, Roddy O'Connor, Brian J. Altman, Annie Hsieh, Arvin Gouw, Ajit Thomas, Ping Gao, Linchong Sun, Libing Song, Benedict Yan, Barbara Slusher, Jingli Zhuo, London Lucien Ooi, Caroline Lee, Anthony Mancuso, Andrew McCallion, Michael C. Milone, Anne Le, Stephen Rayport, Dean Felsher, Chi Dang |
Journal of Clinical Investigation | 2015 |
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Metabolomic profiling of hormone-dependent cancers: a bird's eye view
SM Lloyd, J Arnold, A Sreekumar |
Trends in Endocrinology & Metabolism | 2015 |
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An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers
RL Prueitt, TA Wallace, SA Glynn, M Yi, W Tang, J Luo, TH Dorsey, KE Stagliano, JW Gillespie, RS Hudson, A Terunuma, JL Shoe, DC Haines, HG Yfantis, M Han, DN Martin, SV Jordan, JF Borin, MJ Naslund, RB Alexander, RM Stephens, CA Loffredo, DH Lee, N Putluri, A Sreekumar, AA Hurwitz, S Ambs |
Cancer research | 2015 |
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Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis
Z Wang, D Katsaros, Y Shen, Y Fu, EM Canuto, C Benedetto, L Lu, WM Chu, HA Risch, H Yu, WB Coleman |
PloS one | 2015 |
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Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment
IL Romero, A Mukherjee, HA Kenny, LM Litchfield, E Lengyel |
Clinical cancer research | 2015 |
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Novel Therapeutic Targets of Tumor Metabolism:
RJ Kishton, JC Rathmell |
The Cancer Journal | 2015 |
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Metabolic control of cancer cell stemness: Lessons from iPS cells
JA Menendez |
Cell cycle (Georgetown, Tex.) | 2015 |
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ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
M Geldermalsen, Q Wang, R Nagarajah, AD Marshall, A Thoeng, D Gao, W Ritchie, Y Feng, CG Bailey, N Deng, K Harvey, JM Beith, CI Selinger, SA O'Toole, JE Rasko, J Holst |
Oncogene | 2015 |
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Glutamine at focus: versatile roles in cancer
HD Vitto, J Pérez-Valencia, JA Radosevich |
Tumor Biology | 2015 |
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Metabolic Signatures of Human Breast Cancer
P Mishra, S Ambs |
Molecular & Cellular Oncology | 2015 |
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The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate
VJ Hwang, J Kim, A Rand, C Yang, S Sturdivant, B Hammock, PD Bell, LM Guay-Woodford, RH Weiss |
American journal of physiology. Renal physiology | 2015 |
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Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
L Chen, H Cui |
International journal of molecular sciences | 2015 |
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Hypoxia Induces Production of L-2-Hydroxyglutarate
AM Intlekofer, RG Dematteo, S Venneti, LW Finley, C Lu, AR Judkins, AS Rustenburg, PB Grinaway, JD Chodera, JR Cross, CB Thompson |
Cell Metabolism | 2015 |
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Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
B Evans, E Griner |
eLife | 2015 |
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Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d -2-Hydroxyglutarate
J Fan, X Teng, L Liu, KR Mattaini, RE Looper, MG Heiden, JD Rabinowitz |
ACS chemical biology | 2015 |
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Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
S Pellegatta, L Valletta, C Corbetta, M Patanè, I Zucca, FR Sirtori, MG Bruzzone, G Fogliatto, A Isacchi, B Pollo, G Finocchiaro |
Acta Neuropathologica Communications | 2015 |
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Oncometabolites: tailoring our genes
S Nowicki, E Gottlieb |
FEBS Journal | 2015 |
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Anti-protozoal and anti-bacterial Antibiotics that inhibit protein synthesis kill Cancer subtypes enriched for stem cell-like properties
E Cuyàs, B Martin-Castillo, B Corominas-Faja, A Massaguer, J Bosch-Barrera, JA Menendez |
Cell cycle (Georgetown, Tex.) | 2015 |
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Hidden among the crowd: differential DNA methylation-expression correlations in cancer occur at important oncogenic pathways
AM Orgueira |
Frontiers in Genetics | 2015 |
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Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation
GD Falco, MR Ambrosio, F Fuligni, A Onnis, C Bellan, BJ Rocca, M Navari, M Etebari, L Mundo, S Gazaneo, F Facchetti, SA Pileri, L Leoncini, PP Piccaluga |
BMC Cancer | 2015 |
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LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer
Y Shen, Z Wang, LW Loo, Y Ni, W Jia, P Fei, HA Risch, D Katsaros, H Yu |
Breast Cancer Research and Treatment | 2015 |
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HOT mutation screening in human glioblastomas
D Krell, P Mulholland, J Stebbing, I Tomlinson, C Bardella |
Future Science OA | 2015 |
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Analysis of Matched Tumor and Normal Profiles Reveals Common Transcriptional and Epigenetic Signals Shared across Cancer Types
AM Gross, JF Kreisberg, T Ideker, J Yu |
PloS one | 2015 |
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EMT-induced metabolite signature identifies poor clinical outcome.
Bhowmik SK, Ramirez-Peña E, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani SA |
Oncotarget | 2015 |
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Another small molecule in the oncometabolite mix: L-2-Hydroxyglutarate in kidney cancer
Shim EH, Sudarshan S |
Oncoscience | 2015 |
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Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype
Cuyàs E, Fernández-Arroyo S, Corominas-Faja B, Rodríguez-Gallego E, Bosch-Barrera J, Martin-Castillo B, De Llorens R, Joven J, Menendez JA |
Oncotarget | 2015 |
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A network-based method to evaluate quality of reproducibility of differential expression in cancer genomics studies.
Li R, Lin X, Geng H, Li Z, Li J, Lu T, Yan F |
Oncotarget | 2015 |
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Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
R Elkholi, TT Renault, MN Serasinghe, JE Chipuk |
Cancer & Metabolism | 2014 |
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Metabostemness: A New Cancer Hallmark
JA Menendez, Tà Alarcón |
Frontiers in Oncology | 2014 |
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An unexpected alliance between stress responses to drive oncogenesis
MM Keenan, CK Ding, JT Chi |
Breast Cancer Research | 2014 |
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Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites
JA Menendez, T Alarcón, J Joven |
Cell cycle (Georgetown, Tex.) | 2014 |
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Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy
M Natsumeda, H Igarashi, T Nomura, R Ogura, Y Tsukamoto, T Kobayashi, H Aoki, K Okamoto, A Kakita, H Takahashi, T Nakada, Y Fujii |
Acta Neuropathologica Communications | 2014 |
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A joint analysis of metabolomics and genetics of breast cancer
X Tang, CC Lin, I Spasojevic, ES Iversen, JT Chi, JR Marks |
Breast Cancer Research | 2014 |
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Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival and Tamoxifen Resistance
N Putluri, S Maity, R Kommangani, CJ Creighton, V Putluri, F Chen, S Nanda, SK Bhowmik, A Terunuma, T Dorsey, A Nardone, X Fu, C Shaw, TR Sarkar, R Schiff, JP Lydon, BW O’Malley, S Ambs, GM Das, G Michailidis, A Sreekumar |
Neoplasia (New York, N.Y.) | 2014 |
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Metabolic Profiles are Principally Different between Cancers of the Liver, Pancreas and Breast
A Budhu, A Terunuma, G Zhang, SP Hussain, S Ambs, XW Wang |
International journal of biological sciences | 2014 |
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Defects in mitochondrial metabolism and cancer
E Gaude, C Frezza |
Cancer & Metabolism | 2014 |
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MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer
AN Shajahan-Haq, KL Cook, JL Schwartz-Roberts, AE Eltayeb, DM Demas, AM Warri, CO Facey, LA Hilakivi-Clarke, R Clarke |
Molecular Cancer | 2014 |
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A Systems Approach to Predict Oncometabolites via Context-Specific Genome-Scale Metabolic Networks
H Nam, M Campodonico, A Bordbar, DR Hyduke, S Kim, DC Zielinski, BO Palsson, Y Ofran |
PLoS computational biology | 2014 |
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L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
EH Shim, CB Livi, D Rakheja, J Tan, D Benson, V Parekh, EY Kho, AP Ghosh, R Kirkman, S Velu, S Dutta, B Chenna, SL Rea, RJ Mishur, Q Li, TL Johnson-Pais, L Guo, S Bae, S Wei, K Block, S Sudarshan |
Cancer Discovery | 2014 |
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Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma
H Tang, Y Chen, X Liu, S Wang, Y Lv, D Wu, Q Wang, M Luo, H Deng |
Oncotarget | 2014 |
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Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions
Menendez JA, Corominas-Faja B, Cuyàs E, Alarcón T |
Oncoscience | 2014 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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