Basal autophagy is a crucial mechanism in cellular homeostasis, underlying both normal cellular recycling and the clearance of damaged or misfolded proteins, organelles and aggregates. We showed here that enhanced levels of autophagy induced by either autophagic gene overexpression or voluntary exercise ameliorated desmin-related cardiomyopathy (DRC). To increase levels of basal autophagy, we generated an inducible Tg mouse expressing autophagy-related 7 (
Md. Shenuarin Bhuiyan, J. Scott Pattison, Hanna Osinska, Jeanne James, James Gulick, Patrick M. McLendon, Joseph A. Hill, Junichi Sadoshima, Jeffrey Robbins
Title and authors | Publication | Year |
---|---|---|
BAG3 plays a central role in proteostasis in the heart
Wataru Mizushima, Junichi Sadoshima |
Journal of Clinical Investigation | 2017 |
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
L Galluzzi, JM Pedro, B Levine, DR Green, G Kroemer |
Nature Reviews Drug Discovery | 2017 |
Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy
X Wang, T Cui |
American journal of physiology. Heart and circulatory physiology | 2017 |
Myocardial stress and autophagy: mechanisms and potential therapies
LM Delbridge, KM Mellor, DJ Taylor, RA Gottlieb |
Nature Reviews Cardiology | 2017 |
Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes
S Alam, CS Abdullah, R Aishwarya, AW Orr, J Traylor, S Miriyala, M Panchatcharam, CB Pattillo, MS Bhuiyan |
Bioscience Reports | 2017 |
New and revisited approaches to preserving the reperfused myocardium
RA Kloner, DA Brown, M Csete, W Dai, JM Downey, RA Gottlieb, SL Hale, J Shi |
Nature Reviews Cardiology | 2017 |
Proteostasis in cardiac health and disease
RH Henning, BJ Brundel |
Nature Reviews Cardiology | 2017 |
TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux
B Pan, H Zhang, T Cui, X Wang |
Journal of Molecular and Cellular Cardiology | 2017 |
Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor
J Hartupee, GD Szalai, W Wang, X Ma, A Diwan, DL Mann |
Circulation. Heart failure | 2017 |
Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets
GE Gilca, G Stefanescu, O Badulescu, DM Tanase, I Bararu, M Ciocoiu |
Journal of Diabetes Research | 2017 |
STAT3 balances myocyte hypertrophy vis-à-vis autophagy in response to Angiotensin II by modulating the AMPKα/mTOR axis
L Chen, L Zhao, A Samanta, SM Mahmoudi, T Buehler, A Cantilena, RJ Vincent, M Girgis, J Breeden, S Asante, YT Xuan, B Dawn, R Kukreja |
PloS one | 2017 |
Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy
J Li, W Ma, G Yue, Y Tang, I Kim, NL Weintraub, X Wang, H Su |
Journal of Molecular and Cellular Cardiology | 2017 |
An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate LevelsNovelty and Significance
PM McLendon, G Davis, J Gulick, SR Singh, N Xu, N Salomonis, JD Molkentin, J Robbins |
Circulation research | 2017 |
The role of αB-crystallin in skeletal and cardiac muscle tissues
I Dimauro, A Antonioni, N Mercatelli, D Caporossi |
Cell Stress and Chaperones | 2017 |
Myofibrillar Myopathies: New Perspectives from Animal Models to Potential Therapeutic Approaches
S Batonnet-Pichon, A Behin, E Cabet, F Delort, P Vicart, A Lilienbaum |
Journal of neuromuscular diseases | 2017 |
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure
JC Campos, BB Queliconi, LH Bozi, LR Bechara, PM Dourado, AM Andres, PR Jannig, KM Gomes, VO Zambelli, C Rocha-Resende, S Guatimosim, PC Brum, D Mochly-Rosen, RA Gottlieb, AJ Kowaltowski, JC Ferreira |
Autophagy | 2017 |
Neuromuscular electrical stimulation prevents skeletal muscle dysfunction in adjuvant-induced arthritis rat
K Himori, D Tatebayashi, K Kanzaki, M Wada, H Westerblad, JT Lanner, T Yamada, L Csernoch |
PloS one | 2017 |
Potential signaling pathways of acute endurance exercise-induced cardiac autophagy and mitophagy and its possible role in cardioprotection
Y Lee, I Kwon, Y Jang, W Song, LM Cosio-Lima, MH Roltsch |
The Journal of Physiological Sciences | 2017 |
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice
K Tyml, S Swarbreck, C Pape, D Secor, J Koropatnick, Q Feng, RA Veldhuizen, SE Gill |
Critical Care | 2017 |
Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer
N Xu, G Bitan, T Schrader, FG Klärner, H Osinska, J Robbins |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2017 |