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Citations to this article

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype–targeted drugs
Herbert Y. Meltzer, Bryan L. Roth
Herbert Y. Meltzer, Bryan L. Roth
Published December 2, 2013
Citation Information: J Clin Invest. 2013;123(12):4986-4991. https://doi.org/10.1172/JCI70678.
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Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype–targeted drugs

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Abstract

Serotonin (5-hydroxytryptamine, or 5-HT) receptors mediate a plethora of physiological phenomena in the brain and the periphery. Additionally, serotonergic dysfunction has been implicated in nearly every neuropsychiatric disorder. The effects of serotonin are mediated by fourteen GPCRs. Both the therapeutic actions and side effects of commonly prescribed drugs are frequently due to nonspecific actions on various 5-HT receptor subtypes. For more than 20 years, the search for clinically efficacious drugs that selectively target 5-HT receptor subtypes has been only occasionally successful. This review provides an overview of 5-HT receptor pharmacology and discusses two recent 5-HT receptor subtype–selective drugs, lorcaserin and pimavanserin, which target the 5HT2C and 5HT2A receptors and provide new treatments for obesity and Parkinson’s disease psychosis, respectively.

Authors

Herbert Y. Meltzer, Bryan L. Roth

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2009 Total
Citations: 1 1 9 5 4 3 3 3 7 6 8 1 1 52
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Citations to this article (52)

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2024
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Pogorelov VM, Rodriguiz RM, Roth BL, Wetsel WC
2023
Recent advancements in pharmacological strategies to modulate energy balance for combating obesity
Pati B, Sendh S, Sahu B, Pani S, Jena N, Bal NC
2023
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