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Giardia: both a harmless commensal and a devastating pathogen
Herbert L. DuPont
Herbert L. DuPont
Published May 24, 2013
Citation Information: J Clin Invest. 2013;123(6):2352-2354. https://doi.org/10.1172/JCI69932.
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Giardia: both a harmless commensal and a devastating pathogen

Abstract

The highly prevalent protozoan Giardia lamblia is an enteropathogen that can be asymptomatic in some individuals, while leading to persistent diarrhea and substantial morbidity in others. In this issue of the JCI, Bartelt et al. describe a mouse model of the disease and investigate the contribution of coincident malnutrition with the development of symptomatic infection. This work in part explains how Giardia infection can lead to growth retardation, and may offer insights that guide future therapeutic strategies.

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Herbert L. DuPont

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Citations to this article (10)

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Multilocus Genotyping of Giardia duodenalis in Mostly Asymptomatic Indigenous People from the Tapirapé Tribe, Brazilian Amazon
PC Köster, AF Malheiros, JJ Shaw, S Balasegaram, A Prendergast, H Lucaccioni, LM Moreira, LM Lemos, A Dashti, B Bailo, A Marcili, HS Soares, SM Gennari, R Calero-Bernal, D González-Barrio, D Carmena 		Pathogens 2021
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Application of next generation sequencing for detection of protozoan pathogens in shellfish
C DeMone, MH Hwang, Z Feng, JT McClure, SJ Greenwood, R Fung, M Kim, JS Weese, K Shapiro 		2020
Host factors associated with Giardia duodenalis infection in dogs across multiple diagnostic tests
M Uiterwijk, R Nijsse, FN Kooyman, JA Wagenaar, L Mughini-Gras, HW Ploeger 		Parasites & vectors 2019
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KG Weerakoon, CA Gordon, GM Williams, P Cai, GN Gobert, RM Olveda, AG Ross, DU Olveda, DP McManus 		Infectious Diseases of Poverty 2018
Transcriptomic Profiling of High-Density Giardia Foci Encysting in the Murine Proximal Intestine
JK Pham, C Nosala, EY Scott, KF Nguyen, KD Hagen, HN Starcevich, SC Dawson 		Frontiers in Cellular and Infection Microbiology 2017
Giardia Colonizes and Encysts in High-Density Foci in the Murine Small Intestine
NR Barash, C Nosala, JK Pham, SG McInally, S Gourguechon, B McCarthy-Sinclair, SC Dawson, IJ Blader 		mSphere 2017
Giardia's Epithelial Cell Interaction In Vitro: Mimicking Asymptomatic Infection?
MR Kraft, C Klotz, R Bücker, JD Schulzke, T Aebischer 		Frontiers in Cellular and Infection Microbiology 2017
Case–Case Analysis Using 7 Years of Travelers’ Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru
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