The genes encoding RAS family members are frequently mutated in juvenile myelomonocytic leukemia (JMML) and acute myeloid leukemia (AML). RAS proteins are difficult to target pharmacologically; therefore, targeting the downstream PI3K and RAF/MEK/ERK pathways represents a promising approach to treat RAS-addicted tumors. The p110α isoform of PI3K (encoded by
Kira Gritsman, Haluk Yuzugullu, Thanh Von, Howard Yan, Linda Clayton, Christine Fritsch, Sauveur-Michel Maira, Gregory Hollingworth, Christine Choi, Tulasi Khandan, Mahnaz Paktinat, Rachel O. Okabe, Thomas M. Roberts, Jean J. Zhao
Title and authors | Publication | Year |
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Genetics and biology of pancreatic ductal adenocarcinoma
H Ying, P Dey, W Yao, AC Kimmelman, GF Draetta, A Maitra, RA DePinho |
Genes & development | 2016 |
Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations
W Liu, WM Yu, J Zhang, RJ Chan, ML Loh, Z Zhang, KD Bunting, CK Qu |
Leukemia | 2016 |
Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras
J Akutagawa, TQ Huang, I Epstein, T Chang, M Quirindongo-Crespo, CL Cottonham, M Dail, BS Slusher, LS Friedman, D Sampath, BS Braun |
Leukemia | 2016 |
NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathways
H Yuzugullu, T Von, LM Thorpe, SR Walker, TM Roberts, DA Frank, JJ Zhao |
Cell Discovery | 2016 |
Nf1+/− monocytes/macrophages induce neointima formation via CCR2 activation
WK Bessler, G Kim, FZ Hudson, JA Mund, R Mali, K Menon, R Kapur, DW Clapp, DA Ingram, BK Stansfield |
Human Molecular Genetics | 2016 |
Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia
X Huang, S Schwind, R Santhanam, AK Eisfeld, C Chiang, M Lankenau, B Yu, P Hoellerbauer, Y Jin, SS Tarighat, J Khalife, A Walker, D Perrotti, CD Bloomfield, H Wang, RJ Lee, LJ Lee, G Marcucci |
Oncotarget | 2016 |
Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia
SK Tasian, DT Teachey, Y Li, F Shen, RC Harvey, IM Chen, T Ryan, TL Vincent, CL Willman, AE Perl, SP Hunger, ML Loh, M Carroll, SA Grupp |
Blood | 2016 |
The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation
W Du, S Amarachintha, O Erden, A Wilson, Q Pang |
Oncotarget | 2016 |
KRAS insertion mutations are oncogenic and exhibit distinct functional properties
Y White, A Bagchi, JV Ziffle, A Inguva, G Bollag, C Zhang, H Carias, D Dickens, M Loh, K Shannon, AJ Firestone |
Nature Communications | 2016 |
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
RK Schneider, M Schenone, MV Ferreira, R Kramann, CE Joyce, C Hartigan, F Beier, TH Brümmendorf, U Germing, U Platzbecker, G Büsche, R Knüchel, MC Chen, CS Waters, E Chen, LP Chu, CD Novina, RC Lindsley, SA Carr, BL Ebert |
Nature Medicine | 2016 |