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Citations to this article

Targeting lactate metabolism for cancer therapeutics
Joanne R. Doherty, John L. Cleveland
Joanne R. Doherty, John L. Cleveland
Published September 3, 2013
Citation Information: J Clin Invest. 2013;123(9):3685-3692. https://doi.org/10.1172/JCI69741.
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Review Series Article has an altmetric score of 29

Targeting lactate metabolism for cancer therapeutics

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Abstract

Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate with increased metastasis, tumor recurrence, and poor outcome. Lactate mediates cancer cell intrinsic effects on metabolism and has additional non–tumor cell autonomous effects that drive tumorigenesis. Tumor cells can metabolize lactate as an energy source and shuttle lactate to neighboring cancer cells, adjacent stroma, and vascular endothelial cells, which induces metabolic reprogramming. Lactate also plays roles in promoting tumor inflammation and in functioning as a signaling molecule that stimulates tumor angiogenesis. Here we review the mechanisms of lactate production and transport and highlight emerging evidence indicating that targeting lactate metabolism is a promising approach for cancer therapeutics.

Authors

Joanne R. Doherty, John L. Cleveland

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 26 60 54 67 81 54 53 42 36 54 38 12 2 1 580
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Prediction of Distant Metastases in Patients with Kidney Cancer Based on Gene Expression and Methylation Analysis
Apanovich N, Matveev A, Ivanova N, Burdennyy A, Apanovich P, Pronina I, Filippova E, Kazubskaya T, Loginov V, Braga E, Alimov A
Diagnostics 2023
A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch.
Sun Y, He Q, Li J, Yang Z, Ahmad M, Lin Y, Wu D, Zheng L, Li J, Wang B, Chen C, Hu Y, Luo H, Luo Y
Cell Death and Disease 2023
Metabolomic and Lipidomic Analysis of the Colorectal Adenocarcinoma Cell Line HT29 in Hypoxia and Reoxygenation
Barrera JC, Ondo-Mendez A, Giera M, Kostidis S
Metabolites 2023
Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression
Michail A, Gkikas D, Stellas D, Kaltezioti V, Politis PK
Cells 2023
Lactate Dehydrogenase Inhibitors Suppress Borrelia burgdorferi Growth In Vitro
Lynch A, Pearson P, Savinov SN, Li AY, Rich SM
Pathogens 2023
The hypoxia-associated genes in immune infiltration and treatment options of lung adenocarcinoma
Liu L, Han L, Dong L, He Z, Gao K, Chen X, Guo JC, Zhao Y
PeerJ 2023
Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression
Pandkar MR, Sinha S, Samaiya A, Shukla S
Translational oncology 2023
Type B Lactic Acidosis in a Patient with Mantle Cell Lymphoma
Nzenwa IC, Berquist M, Brenner TJ, Ansari A, Al-Fadhl HD, Aboukhaled M, Patel SS, Peck EE, Al-Fadhl MD, Thomas AV, Zackariya N, Walsh MM, Bufill JA
Case Reports in Critical Care 2023
Drug Repurposing to Circumvent Immune Checkpoint Inhibitor Resistance in Cancer Immunotherapy
To KK, Cho WC
Pharmaceutics 2023
Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor Microenvironment
Liu T, Han S, Yao Y, Zhang G
Cancer management and research 2023
Small molecule anion carriers facilitate lactate transport in model liposomes and cells
Alonso-Carrillo D, Arias-Betancur A, Carreira-Barral I, Fontova P, Soto-Cerrato V, García-Valverde M, Pérez-Tomás R, Quesada R
iScience 2023
Association between serum lactate dehydrogenase and lymph node metastasis in cervical cancer
Huang Q, Li S, Chen X, He C, Chen Y, Huang Y, Liu Y, Wang Y, Zheng X
Oncology Letters 2023
Is High Score of Preoperative Lactate Dehydrogenase to Albumin Ratio Predicting Poor Survivals in Esophageal Carcinoma Patients?
Shiratori F, Suzuki T, Yajima S, Oshima Y, Nanami T, Funahashi K, Shimada H
Annals of Thoracic and Cardiovascular Surgery 2023
NSG1 promotes glycolytic metabolism to enhance Esophageal squamous cell carcinoma EMT process by upregulating TGF-β
Tu M, Yin X, Zhuang W, Lin X, Xia Y, Huang Z, Zheng Y, Huang Y
Cell Death Discovery 2023
Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases
Han JH, Lee EJ, Park W, Ha KT, Chung HS
Frontiers in pharmacology 2023
The role of oral microbiota in cancer
Lan Z, Liu WJ, Cui H, Zou KL, Chen H, Zhao YY, Yu GT
Frontiers in microbiology 2023
Characteristics of lactate metabolism phenotype in hepatocellular carcinoma
Zhang J, Dong K, Zhang X, Li C, Yu J, Wang W
Scientific Reports 2023
Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma.
Xie F, Niu Y, Lian L, Wang Y, Zhuang A, Yan G, Ren Y, Chen X, Xiao M, Li X, Xi Z, Zhang G, Qin D, Yang K, Zheng Z, Zhang Q, Xia X, Li P, Gu L, Wu T, Luo C, Lin SH, Li W
Frontiers of Medicine 2023
Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy.
Cheng Q, Shi XL, Li QL, Wang L, Wang Z
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Engineering metabolism to modulate immunity.
Kapnick SM, Martin CA, Jewell CM
Advanced Drug Delivery Reviews 2023
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer
Liao M, Yao D, Wu L, Luo C, Wang Z, Zhang J, Liu B
Acta pharmaceutica Sinica. B 2023
Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells
Rajala RV, Rajala A
2023
LDHA activates small GTPase Rac1 independently of its glycolytic enzyme activity to promote cancer progression
Juan Liu, Cen Zhang, Shan Huang, Tianliang Zhang, Jianming Wang, Chun-Yuan Chang, Ludvinna Bazile, Bruce Haffty, Wenwei Hu, Zhaohui Feng
Nature metabolism 2022
Role of Lactate in Inflammatory Processes: Friend or Foe
C Manosalva, J Quiroga, A Hidalgo, P Alarcón, N Anseoleaga, M Hidalgo, R Burgos
Frontiers in immunology 2022
Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas
Maeda M, Ko M, Mane MM, Cohen IJ, Shindo M, Vemuri K, Serganova I, Blasberg R
Cancers 2022
The Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients
Gupta GS
Inflammation 2022
Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities
Kalyanaraman B, Cheng G, Hardy M
Frontiers in Oncology 2022
Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids
Wu Y, Wang Z, Du Q, Zhu Z, Chen T, Xue Y, Wang Y, Zeng Q, Shen C, Jiang C, Liu L, Zhu H, Liu Q
Evidence-based complementary and alternative medicine : eCAM 2022
Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4–dependent manner
Min X, Cheng H, Cao X, Chen Z, Zhang X, Li Y, Mao Q, Xue B, Fang L, Liu L, Ding Z
Cell Stress & Chaperones 2022
Interplay Between m6A RNA Methylation and Regulation of Metabolism in Cancer
Mobet Y, Liu X, Liu T, Yu J, Yi P
Frontiers in Cell and Developmental Biology 2022
Monocarboxylate Transporters 1 and 4 and Prognosis in Small Bowel Neuroendocrine Tumors
Hiltunen N, Rintala J, Väyrynen JP, Böhm J, Karttunen TJ, Huhta H, Helminen O
Cancers 2022
Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity
Wang R, Li J, Zhang C, Guan X, Qin B, Jin R, Qin L, Xu S, Zhang X, Liu R, Ye Q, Cheng L
Frontiers in Oncology 2022
A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer
Padilla J, Lee BS, Zhai K, Rentz B, Bobo T, Dowling NM, Lee J
Cells 2022
Development and Validation of Lactate Metabolism-Related lncRNA Signature as a Prognostic Model for Lung Adenocarcinoma
Mai S, Liang L, Mai G, Liu X, Diao D, Cai R, Liu L
Frontiers in Endocrinology 2022
Caudatin blocks the proliferation, stemness and glycolysis of non-small cell lung cancer cells through the Raf/MEK/ERK pathway
Hou J, Chen Q, Huang Y, Wu Z, Ma D
Pharmaceutical Biology 2022
Lactic Acid Metabolism and Transporter Related Three Genes Predict the Prognosis of Patients with Clear Cell Renal Cell Carcinoma
Guo T, Zhang J, Wang T, Yuan Z, Tang H, Zhang D, Chen S, Wang X
Genes & development 2022
Construction of a Lactate-Related Prognostic Signature for Predicting Prognosis, Tumor Microenvironment, and Immune Response in Kidney Renal Clear Cell Carcinoma
Sun Z, Tao W, Guo X, Jing C, Zhang M, Wang Z, Kong F, Suo N, Jiang S, Wang H
Frontiers in immunology 2022
The novel pretreatment immune prognostic index discriminates survival outcomes in locally advanced non-operative esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy: a 6-year retrospective study
Yu Y, Wu H, Qiu J, Ke D, Wu Y, Lin M, Zheng Q, Zheng H, Wang Z, Li H, Liu L, Li J, Yao Q
Translational oncology 2022
The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer.
Ishihara S, Hata K, Hirose K, Okui T, Toyosawa S, Uzawa N, Nishimura R, Yoneda T
Scientific Reports 2022
Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis.
Cho MK, Jin L, Han JH, Jin JS, Cheon SY, Shin S, Bae SJ, Park JK, Ha KT
Frontiers in pharmacology 2022
Epigenetic Underpinnings of Inflammation: A Key to Unlock the Tumor Microenvironment in Glioblastoma
Chen N, Peng C, Li D
Frontiers in immunology 2022
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Hao Q, Huang Z, Li Q, Liu D, Wang P, Wang K, Li J, Cao W, Deng W, Wu K, Su R, Liu Z, Vadgama J, Wu Y
2022
Metabolomic biomarkers for hepatocellular carcinoma: A systematic review.
Feng N, Yu F, Yu F, Feng Y, Zhu X, Xie Z, Zhai Y
Medicine 2022
The role of non-Helicobacter pylori bacteria in the pathogenesis of gastroduodenal diseases.
Waskito LA, Rezkitha YAA, Vilaichone RK, Sugihartono T, Mustika S, Dewa Nyoman Wibawa I, Yamaoka Y, Miftahussurur M
Gut pathogens 2022
How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression.
Elingaard-Larsen LO, Rolver MG, Sørensen EE, Pedersen SF
Reviews of Physiology, Biochemistry and Pharmacology 2022
Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma.
Wang X, Xie X, Zhang Y, Ma F, Pang M, Laster KV, Li X, Liu K, Dong Z, Kim DJ
Cellular oncology (Dordrecht) 2022
Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage
Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM
Cellular and Molecular Life Sciences 2022
Detachment stress mediated bioenergetic switch of malignant melanoma cells into anti-Warburg phenotype.
Uen W, Tseng T, Wu CP, Lee S
Aging 2022
Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma.
Lu G, Wang X, Li F, Wang S, Zhao J, Wang J, Liu J, Lyu C, Ye P, Tan H, Li W, Ma G, Wei W
Nature Communications 2022
lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization.
Zhao K, Wang X, Zhao D, Lin Q, Zhang Y, Hu Y
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Regulation of tumor metabolism by post translational modifications on metabolic enzymes.
Sawant Dessai A, Kalhotra P, Novickis AT, Dasgupta S
Cancer Gene Therapy 2022
Chemotherapy drug potency assessment method of ovarian cancer cells by digital holography microscopy
Liu Y, Xiao W, Zhang H, Xin L, Li X, Pan F
Biomedical Optics Express 2022
The roles of glycolysis in osteosarcoma
Feng Z, Ou Y, Hao L
Frontiers in pharmacology 2022
Comparison of dual mTORC1/2 inhibitor AZD8055 and mTORC1 inhibitor rapamycin on the metabolism of breast cancer cells using proton nuclear magnetic resonance spectroscopy metabolomics.
Ni Z, Xu S, Yu Z, Ye Z, Li R, Chen C, Yang J, Liu H, Zhou Z, Zhang X
Investigational New Drugs 2022
COVID-19 in cancer patients with diabetes in Pakistan: Clinical features and management
Asghar K, Abu Bakar M, Ashfaq S, Alvi AM, Shafiq W, Azmat U, Siddiqi AI, Farooq A, Raza R, Siddique K
Frontiers in Oncology 2022
Small leucine zipper protein functions as a modulator for metabolic reprogramming of colorectal cancer cells by inducing nutrient stress-mediated autophagy.
Kim S, Oh M, Kang M, Ko J
Cellular and molecular life sciences : CMLS 2022
Targeting RNA N6-methyladenosine modification: a precise weapon in overcoming tumor immune escape.
Li W, Hao Y, Zhang X, Xu S, Pang D
Molecular Cancer 2022
Comprehensive analysis of fatty acid and lactate metabolism–related genes for prognosis value, immune infiltration, and therapy in osteosarcoma patients
Wu Z, Han T, Su H, Xuan J, Wang X
Frontiers in Oncology 2022
Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas
Bayley JP, Rebel HG, Scheurwater K, Duesman D, Zhang J, Schiavi F, Korpershoek E, Jansen JC, Schepers A, Devilee P
PloS one 2022
Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies
Zhang Y, Li Q, Huang Z, Li B, Nice EC, Huang C, Wei L, Zou B
Cancers 2022
PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages
Wang L, Li S, Luo H, Lu Q, Yu S
Journal of experimental & clinical cancer research : CR 2022
A lactate-related LncRNA model for predicting prognosis, immune landscape and therapeutic response in breast cancer
Li J, Zhang Y, Li C, Wu H, Feng C, Wang W, Liu X, Zhang Y, Cai Y, Jia Y, Qiao H, Wu F, Zhang S
Frontiers in Genetics 2022
A novel hypoxia- and lactate metabolism-related signature to predict prognosis and immunotherapy responses for breast cancer by integrating machine learning and bioinformatic analyses
Li J, Qiao H, Wu F, Sun S, Feng C, Li C, Yan W, Lv W, Wu H, Liu M, Chen X, Liu X, Wang W, Cai Y, Zhang Y, Zhou Z, Zhang Y, Zhang S
Frontiers in immunology 2022
Direct cell-to-cell transfer in stressed tumor microenvironment aggravates tumorigenic or metastatic potential in pancreatic cancer.
Jang G, Oh J, Jun E, Lee J, Kwon JY, Kim J, Lee SH, Kim SC, Cho SY, Lee C
npj Genomic Medicine 2022
Oral microbiota may predict the presence of esophageal squamous cell carcinoma.
Jiang Z, Wang J, Qian X, Zhang Z, Wang S
Journal of Cancer Research and Clinical Oncology 2022
Hyperglycemia Enhances Immunosuppression and Aerobic Glycolysis of Pancreatic Cancer Through Upregulating Bmi1-UPF1-HK2 Pathway.
Wu S, Zhang H, Gao C, Chen J, Li H, Meng Z, Bai J, Shen Q, Wu H, Yin T
Cellular and Molecular Gastroenterology and Hepatology 2022
Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy
Kumar R, Mishra A, Gautam P, Feroz Z, Vijayaraghavalu S, Likos EM, Shukla GC, Kumar M
Cancers 2022
4D label-free quantitative proteomics analysis to screen potential drug targets of Jiangu Granules treatment for postmenopausal osteoporotic rats
Lin H, Zhang W, Xu Y, You Z, Zheng M, Liu Z, Li C
Frontiers in pharmacology 2022
Tumor microenvironment-associated lactate metabolism regulates the prognosis and precise checkpoint immunotherapy outcomes of patients with lung adenocarcinoma
Qiu S, Wang Y, Rao H, Que Q, Wu Y, Zhu R, Feng X, Chi J, Lai W, Sun Y, Xiao Q, Shi H, Xiang Y
European Journal of Medical Research 2022
Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets
di Meo NA, Lasorsa F, Rutigliano M, Loizzo D, Ferro M, Stella A, Bizzoca C, Vincenti L, Pandolfo SD, Autorino R, Crocetto F, Montanari E, Spilotros M, Battaglia M, Ditonno P, Lucarelli G
International journal of molecular sciences 2022
Quxie Capsule Alleviates Colitis-associated Colorectal Cancer Through Modulating the Gut Microbiota and Suppressing A. fumigatus-induced Aerobic Glycolysis
Zhang Z, Chen Y, Zheng Y, Wang L, Shen S, Yang G, Yang Y, Wang T
Integrative Cancer Therapies 2022
Prognostic ability of lung immune prognostic index in limited-stage small cell lung cancer
Sun B, Hou Q, Liang Y, Xue S, Yao N, Wei L, Cao X, Li H, Si H, Cao J
BMC Cancer 2022
Oral Microbiota and Tumor-A New Perspective of Tumor Pathogenesis.
Li S, He M, Lei Y, Liu Y, Li X, Xiang X, Wu Q, Wang Q
Microorganisms 2022
Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications
Duan Q, Zhang S, Wang Y, Lu D, Sun Y, Wu Y
Frontiers in Cell and Developmental Biology 2022
Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo
Chowdhury CS, Wareham E, Xu J, Kumar S, Kofron M, Lakshmikanthan S, Chrzanowska M, Filippi MD
Frontiers in immunology 2022
SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy
Wang H, Wang B, Jiang J, Wu Y, Song A, Wang X, Yao C, Dai H, Xu J, Zhang Y, Ma Q, Xu F, Li R, Wang C
Molecules (Basel, Switzerland) 2022
Energy metabolic shift contributes to the phenotype modulation of maturation stage ameloblasts
Arai H, Inaba A, Ikezaki S, Kumakami-Sakano M, Azumane M, Ohshima H, Morikawa K, Harada H, Otsu K
Frontiers in physiology 2022
The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
Li G, Fu Q, Liu C, Peng Y, Gong J, Li S, Huang Y, Zhang H
Frontiers in Oncology 2022
Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression
Dong S, Li W, Li X, Wang Z, Chen Z, Shi H, He R, Chen C, Zhou W
Frontiers in immunology 2022
Effects of metabolic cancer therapy on tumor microenvironment
Hyroššová P, Milošević M, Škoda J, Vachtenheim Jr J, Rohlena J, Rohlenová K
Frontiers in Oncology 2022
Protein acylation: mechanisms, biological functions and therapeutic targets.
Shang S, Liu J, Hua F
Signal Transduction and Targeted Therapy 2022
Acidic and hypoxic tumor microenvironment regulation by CaO(2)-loaded polydopamine nanoparticles.
Ruan S, Yin W, Chang J, Yang Y, Sun J, Ma X, Liu Y, Zang J, Liu Y, Li Y, Ren T, Dong H
Journal of nanobiotechnology 2022
Breast cancer combined prognostic model based on lactate metabolism genes
Lu N, Guan X, Bao W, Fan Z, Zhang J
Medicine 2022
Understanding the Contribution of Lactate Metabolism in Cancer Progress: A Perspective from Isomers
Cai M, Wan J, Cai K, Song H, Wang Y, Sun W, Hu J
Cancers 2022
Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway
Ksendzovsky A, Bachani M, Altshuler M, Walbridge S, Mortazavi A, Moyer M, Chen C, Fayed I, Steiner J, Edwards N, Inati SK, Jahanipour J, Maric D, Heiss JD, Kapur J, Zaghloul KA
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Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells
Kshitiz, Afzal J, Suhail Y, Chang H, Hubbi ME, Hamidzadeh A, Goyal R, Liu Y, Sun P, Nicoli S, Dang CV, Levchenko A
Cell Systems 2022
Drug repurposing: Metformin’s effect against liver tissue damage in diabetes and prostate cancer model
Aydın PK, Turkyılmaz IB, Gul IB, Bulan OK, Yanardag R
2022
恶性肿瘤饥饿疗法研究现状
LI J, TONG D, LIN J
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Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease
Li X, Zhang Y, Xu L, Wang A, Zou Y, Li T, Huang L, Chen W, Liu S, Jiang K, Zhang X, Wang D, Zhang L, Zhang Z, Zhang Z, Chen X, Jia W, Zhao A, Yan X, Zhou H, Zhu L, Ma X, Ju Z, Jia W, Wang C, Loscalzo J, Yang Y, Zhao Y
Cell Metabolism 2022
Metabolic interventions: A new insight into the cancer immunotherapy
T Yu, T Dong, H Eyvani, Y Fang, X Wang, X Zhang, X Lu
Archives of Biochemistry and Biophysics 2021
Metabolic Interplay between the Immune System and Melanoma Cells: Therapeutic Implications
A Indini, F Grossi, M Mandalà, D Taverna, V Audrito
Biomedicines 2021
Blood–Brain Barrier, Cell Junctions, and Tumor Microenvironment in Brain Metastases, the Biological Prospects and Dilemma in Therapies
Z Guan, H Lan, X Cai, Y Zhang, A Liang, J Li
Frontiers in Cell and Developmental Biology 2021
Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers
R King, C Hayes, CL Donohoe, MR Dunne, M Davern, NE Donlon
World journal of gastrointestinal oncology 2021
The Heterogeneity of Cancer Metabolism
A Le
2021
Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
MH Hung, JS Lee, C Ma, LP Diggs, S Heinrich, CW Chang, L Ma, M Forgues, A Budhu, J Chaisaingmongkol, M Ruchirawat, E Ruppin, TF Greten, XW Wang
Nature Communications 2021
The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells
GJ Yoshida
Metabolites 2021
Lactate shuttle: from substance exchange to regulatory mechanism
X Wang, H Liu, Y Ni, P Shen, X Han
Human Cell 2021
More Than Meets the Eye Regarding Cancer Metabolism
A Kubicka, K Matczak, M Łabieniec-Watała
International journal of molecular sciences 2021
Glucose Metabolism and Glucose Transporters in Breast Cancer
E Shin, JS Koo
Frontiers in Cell and Developmental Biology 2021
Lactate Metabolism and Signaling in Tuberculosis and Cancer: A Comparative Review
D Kiran, RJ Basaraba
Frontiers in Cellular and Infection Microbiology 2021
The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets
JE Burns, CD Hurst, MA Knowles, RM Phillips, SJ Allison
Cancer Science 2021
Dissecting the mechanism of temozolomide resistance and its association with the regulatory roles of intracellular reactive oxygen species in glioblastoma
CH Chien, WT Hsueh, JY Chuang, KY Chang
Journal of Biomedical Science 2021
NOX5 mediates the crosstalk between tumor cells and cancer‐associated fibroblasts via regulating cytokine network
J Chen, Y Wang, W Zhang, D Zhao, L Zhang, J Zhang, J Fan, Q Zhan
Clinical and Translational Medicine 2021
Small Molecule-Based Enzyme Inhibitors in the Treatment of Primary Hyperoxalurias
MD Moya-Garzon, JA Gomez-Vidal, A Alejo-Armijo, J Altarejos, JR Rodriguez-Madoz, MX Fernandes, E Salido, S Salido, M Diaz-Gavilan
Journal of Personalized Medicine 2021
MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target
K Takenaga, N Koshikawa, M Akimoto, Y Tatsumi, J Lin, M Itami, H Nagase
Scientific Reports 2021
HO-1 Modulates Aerobic Glycolysis through LDH in Prostate Cancer Cells
F Cascardo, N Anselmino, A Páez, E Labanca, P Sanchis, V Antico-Arciuch, N Navone, G Gueron, E Vázquez, J Cotignola
Antioxidants 2021
Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer
M Xie, X Fu, K Jiang
Cell Death and Disease 2021
Metabolic reprogramming in renal cancer: Events of a metabolic disease
S Chakraborty, M Balan, A Sabarwal, TK Choueiri, S Pal
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2021
VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges
KA Heslop, V Milesi, EN Maldonado
Frontiers in physiology 2021
LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes
PK Sanchez, M Khazaei, E Gatineau, S Geravandi, B Lupse, H Liu, R Dringen, A Wojtusciszyn, P Gilon, K Maedler, A Ardestani
Biochemical and Biophysical Research Communications 2021
Pan-cancer analysis of clinical significance and associated molecular features of glycolysis
Y Liu, P Lin, Y Zhao, LY Wu, Y Wu, J Peng, Y He, H Yang
Bioengineered 2021
The Application of Combined Immune Checkpoint Inhibitor Modalities in Previously Treated Non-Small Cell Lung Cancer Patients and the Associations Thereof With the Lung Immune Prognostic Index
T Zhang, X Yang, J Zhao, L Xia, Q Wang, R Jin, L Zhou, B Zhang, J Zhao, H Li, W Li, Y Xia
Frontiers in Oncology 2021
Hypoxia-induced PTTG3P contributes to colorectal cancer glycolysis and M2 phenotype of macrophage
Y Wang, G Yu, Y Liu, L Xie, J Ge, G Zhao, J Lin
Bioscience Reports 2021
Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
I Manoharan, PD Prasad, M Thangaraju, S Manicassamy
Frontiers in immunology 2021
Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma
FM Uckun
Cancers 2021
Lactate in the tumour microenvironment: From immune modulation to therapy
ZH Wang, WB Peng, P Zhang, XP Yang, Q Zhou
EBioMedicine 2021
Oral microbiota and Helicobacter pylori in gastric carcinogenesis: what do we know and where next?
SZ Bakhti, S Latifi-Navid
BMC Microbiology 2021
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis
Y Qing, L Dong, L Gao, C Li, Y Li, L Han, E Prince, B Tan, X Deng, C Wetzel, C Shen, M Gao, Z Chen, W Li, B Zhang, D Braas, J ten Hoeve, GJ Sanchez, H Chen, LN Chan, CW Chen, D Ann, L Jiang, M Müschen, G Marcucci, DR Plas, Z Li, R Su, J Chen
Molecular Cell 2021
The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models
C Brito, A Tomás, S Silva, MR Bronze, AT Serra, M Pojo
Molecules (Basel, Switzerland) 2021
Clinical Characteristics of COVID-19-Infected Cancer Patients in Pakistan: Differences Between Survivors and Non-Survivors
K Asghar, MA Bakar, MJ Akram, A Farooq, K Siddique, IA Rana, J Ali, MU Rashid, AA Khan, A Loya
Frontiers in Oncology 2021
Metabolic Reprogramming in Cancer: Role of HPV 16 Variants
A Arizmendi-Izazaga, N Navarro-Tito, H Jiménez-Wences, MA Mendoza-Catalán, DN Martínez-Carrillo, AE Zacapala-Gómez, M Olea-Flores, R Dircio-Maldonado, FI Torres-Rojas, DG Soto-Flores, B Illades-Aguiar, J Ortiz-Ortiz
Pathogens 2021
Overcoming chemoresistance by targeting reprogrammed metabolism: the Achilles' heel of pancreatic ductal adenocarcinoma
A Tuerhong, J Xu, S Shi, Z Tan, Q Meng, J Hua, J Liu, B Zhang, W Wang, X Yu, C Liang
Cellular and Molecular Life Sciences 2021
Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
G Ariceta, K Barrios, BD Brown, B Hoppe, R Rosskamp, CB Langman
Kidney International Reports 2021
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
F Almouhanna, B Blagojevic, S Can, A Ghanem, S Wölfl
Cancer & Metabolism 2021
The Uniqueness of Clear Cell Renal Cell Carcinoma: Summary of the Process and Abnormality of Glucose Metabolism and Lipid Metabolism in ccRCC
X Qi, Q Li, X Che, Q Wang, G Wu
Frontiers in Oncology 2021
Rewiring of Lactate–Interleukin-1β Autoregulatory Loop with Clock-Bmal1: a Feed-Forward Circuit in Glioma
P Gowda, K Lathoria, S Sharma, S Patrick, SB Umdor, E Sen
Molecular and cellular biology 2021
Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas
EN Bonglack, JE Messinger, JM Cable, J Chng, KM Parnell, NM Reinoso-Vizcaíno, AP Barry, VS Russell, SS Dave, HR Christofk, MA Luftig
Proceedings of the National Academy of Sciences 2021
Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform
J Yu, Z Wei, Q Li, F Wan, Z Chao, X Zhang, L Lin, H Meng, L Tian
Advanced Science 2021
Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer
C Gaiddon, I Gross, X Meng, M Sidhoum, G Mellitzer, B Romain, JB Delhorme, A Venkatasamy, AC Jung, M Pfeffer
Molecules (Basel, Switzerland) 2021
Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming
R Yang, G Ying, B Li
Frontiers of Medicine 2021
Harnessing Lactate Metabolism for Radiosensitization
KX Liu, E Everdell, S Pal, DA Haas-Kogan, MG Milligan
Frontiers in Oncology 2021
Adrenal Hormone Interactions and Metabolism: A Single Sample Multi-Omics Approach
N Bechmann, D Watts, C Steenblock, PW Wallace, A Schürmann, SR Bornstein, B Wielockx, G Eisenhofer, M Peitzsch
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2021
Obesity and Energy Substrate Transporters in Ovarian Cancer—Review
M Baczewska, K Bojczuk, A Kołakowski, J Dobroch, P Guzik, P Knapp
Molecules (Basel, Switzerland) 2021
Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer
R Ma, Y Wu, S Li, X Yu
Frontiers in Cell and Developmental Biology 2021
lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1
J Luo, H Wang, L Wang, G Wang, Y Yao, K Xie, X Li, L Xu, Y Shen, B Ren
Molecular Therapy — Nucleic Acids 2021
Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response
BP Rickard, C Conrad, AJ Sorrin, MK Ruhi, JC Reader, SA Huang, W Franco, G Scarcelli, WJ Polacheck, DM Roque, MG del Carmen, HC Huang, U Demirci, I Rizvi
Cancers 2021
Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment
M Koncošová, N Vrzáčková, I Křížová, P Tomášová, S Rimpelová, A Dvořák, L Vítek, M Rumlová, T Ruml, J Zelenka
International journal of molecular sciences 2021
Inhibition of glucose use improves structural recovery of injured Achilles tendon in mice
S Izumi, T Oichi, SS Shetye, K Zhang, K Wilson, M Iwamoto, CK Kuo, N Akabudike, N Adachi, LJ Soslowsky, M EnomotoIwamoto
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021
PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness
N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, SW Tait, P Gammage, LL Soares, IR Macpherson, JC Norman
The Journal of Cell Biology 2021
Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy
GO Rivera, HM Knochelmann, CJ Dwyer, AS Smith, MM Wyatt, AM Rivera-Reyes, JE Thaxton, CM Paulos
Frontiers in immunology 2021
miR-1224-3p Promotes Breast Cancer Cell Proliferation and Migration through PGM5-Mediated Aerobic Glycolysis
F Ran, Y Zhang, Y Shi, J Liu, H Li, L Ding, Q Ye, N Silvestris
Journal of Oncology 2021
Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides
L Thabault, M Liberelle, K Koruza, E Yildiz, N Joudiou, J Messens, L Brisson, J Wouters, P Sonveaux, R Frédérick
The Journal of biological chemistry 2021
KLF4 Regulates Metabolic Homeostasis in Response to Stress
A Blum, K Mostow, K Jackett, E Kelty, T Dakpa, C Ryan, E Hagos
Cells 2021
Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells
E Saulle, I Spinello, MT Quaranta, L Pasquini, E Pelosi, E Iorio, G Castelli, M Chirico, ME Pisanu, T Ottone, MT Voso, U Testa, C Labbaye
Frontiers in Oncology 2021
Cancer metabolism and intervention therapy
H Zhao, Y Li
2021
SP1-Regulated Non-Coding RNA SNHG22 Promotes Ovarian Cancer Growth and Glycolysis
N Guan, H Zheng, X Wu, L Xie, X Tong
Cancer management and research 2021
The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism
M Caterino, M Costanzo, R Fedele, A Cevenini, M Gelzo, AD Minno, I Andolfo, M Capasso, R Russo, A Annunziata, C Calabrese, G Fiorentino, M DAbbraccio, C DellIsola, FM Fusco, R Parrella, G Fabbrocini, I Gentile, G Castaldo, M Ruoppolo
International journal of molecular sciences 2021
Serum lactate level predicts 6-months mortality in patients with hepatitis B virus-related decompensated cirrhosis: a retrospective study
Y Nie, LX Liu, T Chen, Y Zhang, X Zhu
Epidemiology and Infection 2021
Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro
PF Lainetti, AF Leis-Filho, PE Kobayashi, LS de Camargo, R Laufer-Amorim, CE Fonseca-Alves, FF Souza
Molecules (Basel, Switzerland) 2021
Targeted Glucose or Glutamine Metabolic Therapy Combined With PD-1/PD-L1 Checkpoint Blockade Immunotherapy for the Treatment of Tumors - Mechanisms and Strategies
G Ma, C Li, Z Zhang, Y Liang, Z Liang, Y Chen, L Wang, D Li, M Zeng, W Shan, H Niu
Frontiers in Oncology 2021
Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
H Takahashi, R Kawabata-Iwakawa, S Ida, I Mito, H Tada, K Chikamatsu
Scientific Reports 2021
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment
W Li, F Li, X Zhang, H Lin, C Xu
Signal Transduction and Targeted Therapy 2021
Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner
Rao Y, Gammon ST, Sutton MN, Zacharias NM, Bhattacharya P, Piwnica-Worms D
The Journal of biological chemistry 2021
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness
Li R, Li H, Zhu L, Zhang X, Liu D, Li Q, Ni B, Hu L, Zhang Z, Zhang Y, Wang X, Jiang SH
Cell Death and Disease 2021
CD90 affects the biological behavior and energy metabolism level of gastric cancer cells by targeting the PI3K/AKT/HIF-1α signaling pathway
Gao L, Li J, He J, Liang L, He Z, Yue C, Jin X, Luo G, Zhou Y
Oncology Letters 2021
Normobaric Hypoxia Exposure on Substrate Oxidation Pattern: Sex Differences
Camacho-Cardenosa M, Gonzalez-Custodio A, Tomas-Carus P, Timon R, Olcina G, Camacho-Cardenosa A
Acta Endocrinologica (Bucharest) 2021
CD73 is a hypoxia-responsive gene and promotes the Warburg effect of human gastric cancer cells dependent on its enzyme activity
Cao X, Zhu Z, Cao Y, Hu J, Min M
Journal of Cancer 2021
Warburg Effect, Glutamine, Succinate, Alanine, When Oxygen Matters
Bouillaud F, Hammad N, Schwartz L
Biology 2021
Metabolic drug survey highlights cancer cell dependencies and vulnerabilities
Pemovska T, Bigenzahn JW, Srndic I, Lercher A, Bergthaler A, César-Razquin A, Kartnig F, Kornauth C, Valent P, Staber PB, Superti-Furga G
Nature Communications 2021
Impact of Hydrogen Sulfide on Mitochondrial and Bacterial Bioenergetics
Borisov VB, Forte E
International journal of molecular sciences 2021
Visual analysis on the research of monocarboxylate transporters based on CiteSpace
Li F, Wang S, Yao Y, Sun X, Wang X, Wang N, You Y, Zhang Y
Medicine 2021
Nanofactory for metabolic and chemodynamic therapy: pro-tumor lactate trapping and anti-tumor ROS transition.
He R, Zang J, Zhao Y, Liu Y, Ruan S, Zheng X, Chong G, Xu D, Yang Y, Yang Y, Zhang T, Gu J, Dong H, Li Y
Journal of nanobiotechnology 2021
Microbiome Signatures in a Fast- and Slow-Progressing Gastric Cancer Murine Model and Their Contribution to Gastric Carcinogenesis
Bali P, Coker J, Lozano-Pope I, Zengler K, Obonyo M
Microorganisms 2021
Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
Chen S, Fang Y, Sun L, He R, He B, Zhang S
Frontiers in Oncology 2021
Elevated Lactate Dehydrogenase Levels Display a Poor Prognostic Factor for Non-Hodgkin’s Lymphoma in Intensive Care Unit: An Analysis of the MIMIC-III Database Combined With External Validation
Qi J, Gu C, Wang W, Xiang M, Chen X, Fu J
Frontiers in Oncology 2021
In Vivo Anticancer Activity of AZD3965: A Systematic Review
Silva A, Antunes B, Batista A, Pinto-Ribeiro F, Baltazar F, Afonso J
Molecules (Basel, Switzerland) 2021
Caesalpinia sappan induces apoptotic cell death in ectopic endometrial 12Z cells through suppressing pyruvate dehydrogenase kinase 1 expression.
Kim BS, Chung TW, Choi HJ, Bae SJ, Cho HR, Lee SO, Choi JH, Joo JK, Ha KT
Experimental and therapeutic medicine 2021
Fecal Streptococcus Alteration Is Associated with Gastric Cancer Occurrence and Liver Metastasis.
Yu D, Yang J, Jin M, Zhou B, Shi L, Zhao L, Zhang J, Lin Z, Ren J, Liu L, Zhang T, Liu H
mBio 2021
Metal Complexes for Therapeutic Applications
Karges J, Stokes RW, Cohen SM
2021
High Expression of Lactate Dehydrogenase A is a Potential Promoter of Malignant Behaviour in Extramammary Paget’s Disease
OGAWA K, SHIMADA K, TAKAI T, MITSUI Y, KUWAHARA M, ASADA H
Acta Dermato Venereologica 2021
Caveolin-1 scaffolding domain peptide regulates glucose metabolism in lung fibrosis
Venkadesaperumal Gopu, Liang Fan, Rashmi Shetty, MR Nagaraja, Sreerama Shetty
JCI Insight 2020
Tumor Microenvironment: The Main Driver of Metabolic Adaptation
J Serpa
2020
Metabolic Plasticity of Melanoma Cells and Their Crosstalk With Tumor Microenvironment
A Avagliano, G Fiume, A Pelagalli, G Sanità, MR Ruocco, S Montagnani, A Arcucci
Frontiers in Oncology 2020
Tailoring precision immunotherapy: coming to a clinic soon?
S Han, WH Shuen, WW Wang, E Nazim, HC Toh
ESMO Open 2020
IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
S Han, Y Liu, SJ Cai, M Qian, J Ding, M Larion, MR Gilbert, C Yang
British Journal of Cancer 2020
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer
LM Becker, JT OConnell, AP Vo, MP Cain, D Tampe, L Bizarro, H Sugimoto, AK McGow, JM Asara, S Lovisa, KM McAndrews, R Zielinski, PL Lorenzi, M Zeisberg, S Raza, VS LeBleu, R Kalluri
Cell Reports 2020
A glycolytic shift in Schwann cells supports injured axons
E Babetto, KM Wong, B Beirowski
Nature Neuroscience 2020
Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy
MF Coleman, AJ Cozzo, AJ Pfeil, SK Etigunta, SD Hursting
Cancers 2020
MIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanoma
RA de Azevedo, E Shoshan, S Whang, G Markel, AR Jaiswal, A Liu, MA Curran, LR Travassos, M Bar-Eli
OncoImmunology 2020
Lactate in the Tumor Microenvironment: An Essential Molecule in Cancer Progression and Treatment
R Pérez-Tomás, I Pérez-Guillén
Cancers 2020
Metabolic Reprogramming and Epithelial-Mesenchymal Plasticity: Opportunities and Challenges for Cancer Therapy
NY Sun, MH Yang
Frontiers in Oncology 2020
Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth
LM Schiffmann, JP Werthenbach, F Heintges-Kleinhofer, JM Seeger, M Fritsch, SD Günther, S Willenborg, S Brodesser, C Lucas, C Jüngst, MC Albert, F Schorn, A Witt, CT Moraes, CJ Bruns, M Pasparakis, M Krönke, SA Eming, O Coutelle, H Kashkar
Nature Communications 2020
Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential
X Sun, M Wang, M Wang, L Yao, X Li, H Dong, M Li, T Sun, X Liu, Y Liu, Y Xu
Frontiers in Cell and Developmental Biology 2020
The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU
GA Brooks
Journal of Sport and Health Science 2020

Physiological and Pathophysiological Roles of Ion Transporter-Mediated Metabolism in the Thyroid Gland and in Thyroid Cancer


H Wang, Z Ma, X Cheng, B Tuo, X Liu, T Li
OncoTargets and therapy 2020
Metabolic Control of Epilepsy: A Promising Therapeutic Target for Epilepsy
Y Fei, R Shi, Z Song, J Wu
Frontiers in neurology 2020
Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells
G Dodard, A Tata, TK Erick, D Jaime, SM Miah, L Quatrini, B Escalière, S Ugolini, E Vivier, L Brossay
Cell Reports 2020
Monocarboxylate Transporter 4 Is a Therapeutic Target in Non-small Cell Lung Cancer with Aerobic Glycolysis Preference
TC Kuo, KY Huang, SC Yang, S Wu, WC Chung, YL Chang, TM Hong, SP Wang, HY Chen, TH Hsiao, PC Yang
Molecular Therapy — Oncolytics 2020
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment
TP Brown, P Bhattacharjee, S Ramachandran, S Sivaprakasam, B Ristic, MO Sikder, V Ganapathy
Oncogene 2020
Immunotherapy on acid: opportunities and challenges
S Damgaci, PM Enriquez-Navas, S Pilon-Thomas, A Guvenis, RJ Gillies, A Ibrahim-Hashim
European Journal of Clinical Nutrition 2020
Loss of miR-192-5p initiates a hyperglycolysis and stemness positive feedback in hepatocellular carcinoma
Y Gu, F Ji, N Liu, Y Zhao, X Wei, S Hu, W Jia, XW Wang, A Budhu, J Ji, B Zhao, S Roessler, X Zheng, J Ji
Journal of Experimental & Clinical Cancer Research 2020
Metabolomics profile in gastrointestinal cancers: Update and future perspectives
G Nannini, G Meoni, A Amedei, L Tenori
World journal of gastroenterology : WJG 2020
Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia
JH Cho, YM Lee, SH Bae, JY Chou
Biochemical and Biophysical Research Communications 2020
Prognostic Significance of Baseline Neutrophil Count and Lactate Dehydrogenase Level in Patients With Esophageal Squamous Cell Cancer Treated With Radiotherapy
HS Luo, HY Xu, ZS Du, XY Li, SX Wu, HC Huang, LX Lin
Frontiers in Oncology 2020
Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy
CY Huang, LH Hsu, CY Chen, GC Chang, HW Chang, YM Hung, KJ Liu, SH Kao
Cancers 2020
Natural Agents Targeting Mitochondria in Cancer
S Mani, G Swargiary, KK Singh
International journal of molecular sciences 2020
Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A
A Friberg, H Rehwinkel, D Nguyen, V Pütter, M Quanz, J Weiske, U Eberspächer, I Heisler, G Langer
ACS Omega 2020
m6A-dependent glycolysis enhances colorectal cancer progression
C Shen, B Xuan, T Yan, Y Ma, P Xu, X Tian, X Zhang, Y Cao, D Ma, X Zhu, Y Zhang, JY Fang, H Chen, J Hong
Molecular Cancer 2020
Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress
C Dai, Q Li, HI May, C Li, G Zhang, G Sharma, AD Sherry, CR Malloy, C Khemtong, Y Zhang, Y Deng, TG Gillette, J Xu, DT Scadden, ZV Wang
Cell Reports 2020
Role of Altered Metabolic Microenvironment in Osteolytic Metastasis
K Tiedemann, O Hussein, SV Komarova
Frontiers in Cell and Developmental Biology 2020
p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators
CN Birts, A Banerjee, M Darley, CR Dunlop, S Nelson, SK Nijjar, R Parker, J West, A Tavassoli, MJ Rose-Zerilli, JP Blaydes
Science signaling 2020
Distinct Microbiota Dysbiosis in Patients with Non-Erosive Reflux Disease and Esophageal Adenocarcinoma
J Zhou, P Shrestha, Z Qiu, DG Harman, WC Teoh, S Al-Sohaily, H Liem, I Turner, V Ho
Journal of Clinical Medicine 2020
Activator of thyroid and retinoid receptor increases sorafenib resistance in hepatocellular carcinoma by facilitating the Warburg effect
L Ma, W Liu, A Xu, Q Ji, Y Ma, Y Tai, Y Wang, C Shen, Y Liu, T Wang, J Han, C Zhao
Cancer Science 2020
Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration
M Beloueche-Babari, TC Galobart, T Delgado-Goni, S Wantuch, HG Parkes, D Tandy, JA Harker, MO Leach
British Journal of Cancer 2020
Tongue Coating Bacteria as a Potential Stable Biomarker for Gastric Cancer Independent of Lifestyle
S Xu, C Xiang, J Wu, Y Teng, Z Wu, R Wang, B Lu, Z Zhan, H Wu, J Zhang
Digestive Diseases and Sciences 2020
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth
M Liu, Y Wang, C Yang, Y Ruan, C Bai, Q Chu, Y Cui, C Chen, G Ying, B Li
Journal of Experimental Medicine 2020
Molecular mechanisms and clinical implications of miRNAs in drug resistance of colorectal cancer
L Duan, W Yang, W Feng, L Cao, X Wang, L Niu, Y Li, W Zhou, Y Zhang, J Liu, H Zhang, Q Zhao, L Hong, D Fan
Therapeutic advances in medical oncology 2020

Serum Lactate Level Predicts Short-Term and Long-Term Mortality of HBV-ACLF Patients: A Prospective Study


Y Nie, Y Zhang, L Liu, X Zhu
Therapeutics and Clinical Risk Management 2020
Microfluidic Platform for the Isolation of Cancer-Cell Subpopulations Based on Single-Cell Glycolysis
C Zielke, CW Pan, AJ Ramirez, C Feit, C Dobson, C Davidson, B Sandel, P Abbyad
Analytical Chemistry 2020

Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy


L Gan, Y Ren, J Lu, J Ma, X Shen, Z Zhuang
OncoTargets and therapy 2020
Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite–Induced Allergic Airways Disease
C van de Wetering, R Aboushousha, AM Manuel, SB Chia, C Erickson, MB MacPherson, JL van der Velden, V Anathy, AE Dixon, CG Irvin, ME Poynter, A van der Vliet, EF Wouters, NL Reynaert, YM Janssen-Heininger
Journal of immunology (Baltimore, Md. : 1950) 2020
Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions
B Gantuya, HB Serag, T Matsumoto, NJ Ajami, T Uchida, K Oyuntsetseg, D Bolor, Y Yamaoka
Alimentary Pharmacology & Therapeutics 2020
Metabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture
S Acevedo-Acevedo, DC Millar, AD Simmons, P Favreau, PF Cobra, M Skala, SP Palecek
Scientific Reports 2020
SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis
M Shao, J Zhang, J Zhang, H Shi, Y Zhang, R Ji, F Mao, H Qian, W Xu, X Zhang
Cancer Cell International 2020
A Perspective on Expanding Our Understanding of Cancer Treatments by Integrating Approaches from the Biological and Physical Sciences
EJ Fong, C Strelez, SM Mumenthaler
SLAS Discovery 2020
Role of the oral microbiota in cancer evolution and progression
J Sun, Q Tang, S Yu, M Xie, Y Xie, G Chen, L Chen
Cancer Medicine 2020
Effects of a monocarboxylate transport 1 inhibitor, AZD3965, on retinal and visual function in the rat
AE Allen, EA Martin, K Greenwood, C Grant, P Vince, RJ Lucas, WS Redfern
British Journal of Pharmacology 2020
Combining 18F‐FDG PET/CT and Serum Lactate Dehydrogenase for Prognostic Evaluation of Small Cell Lung Cancer
X Lin, Z Xiao, Y Hu, X Zhang, W Fan
Frontiers in pharmacology 2020
Serum hydroxybutyrate dehydrogenase as an early predictive marker of the severity of acute pancreatitis: a retrospective study
W Xiao, W Liu, L Yin, Y Li, G Lu, X Liu, W Gong, Y Ding, M Wang, Z Yan
BMC Gastroenterology 2020
Gastrointestinal Microbiome – What We Need to Know in Clinical Practice
R Ortigão, P Pimentel-Nunes, M Dinis-Ribeiro, D Libânio
GE Portuguese Journal of Gastroenterology 2020
Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma
ME Roche, Z Lin, D Whitaker-Menezes, T Zhan, K Szuhai, JV Bovee, JA Abraham, W Jiang, U Martinez-Outschoorn, A Basu-Mallick
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2020
Synthesis and initial screening of lactate dehydrogenase inhibitor activity of 1,3-benzodioxole derivatives
Annas D, Cheon SY, Yusuf M, Bae SJ, Ha KT, Park KH
Scientific Reports 2020
LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1
Logotheti S, Marquardt S, Gupta SK, Richter C, Edelhäuser BA, Engelmann D, Brenmoehl J, Söhnchen C, Murr N, Alpers M, Singh KP, Wolkenhauer O, Heckl D, Spitschak A, Pützer BM
Theranostics 2020
HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma.
Min X, Zhang X, Li Y, Cao X, Cheng H, Li Y, Li C, Kong Q, Mao Q, Peng P, Ni Y, Li J, Duan Y, Liu L, Ding Z
Theranostics 2020
Lactate: Fueling the fire starter
M Certo, G Marone, A Paulis, C Mauro, V Pucino
Wiley interdisciplinary reviews. Systems biology and medicine 2019
Prostate Cancer: Cellular and Genetic Mechanisms of Disease Development and Progression
SM Dehm, DJ Tindall
2019
Metastasis and cachexia: alongside in clinics, but not so in animal models
R Tomasin, AC Martin, MR Cominetti
Journal of Cachexia, Sarcopenia and Muscle 2019
Next-generation characterization of the Cancer Cell Line Encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ER McDonald, J Barretina, ET Gelfand, CM Bielski, H Li, K Hu, AY Andreev-Drakhlin, J Kim, JM Hess, BJ Haas, F Aguet, BA Weir, MV Rothberg, BR Paolella, MS Lawrence, R Akbani, Y Lu, HL Tiv, PC Gokhale, A de Weck, AA Mansour, C Oh, J Shih, K Hadi, Y Rosen, J Bistline, K Venkatesan, A Reddy, D Sonkin, M Liu, J Lehar, JM Korn, DA Porter, MD Jones, J Golji, G Caponigro, JE Taylor, CM Dunning, AL Creech, AC Warren, JM McFarland, M Zamanighomi, A Kauffmann, N Stransky, M Imielinski, YE Maruvka, AD Cherniack, A Tsherniak, F Vazquez, JD Jaffe, AA Lane, DM Weinstock, CM Johannessen, MP Morrissey, F Stegmeier, R Schlegel, WC Hahn, G Getz, GB Mills, JS Boehm, TR Golub, LA Garraway, WR Sellers
Nature 2019
Membrane protein-regulated networks across human cancers
CY Lin, CH Lee, YH Chuang, JY Lee, YY Chiu, YH Lee, YJ Jong, JK Hwang, SH Huang, LC Chen, CH Wu, SH Tu, YS Ho, JM Yang
Nature Communications 2019
Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling
K Sun, S Tang, Y Hou, , Y Chen, J Yin, M Peng, M Zhao, X Cui, M Liu
EBioMedicine 2019
Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer
Y Hayashi, A Yokota, H Harada, G Huang
Cancer Science 2019
Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment
D Yang, J Kim
Cells 2019
Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate
S Yadav, SK Pandey, Y Goel, MK Temre, SM Singh
Frontiers in pharmacology 2019
Impairment of HIF-1α-mediated metabolic adaption by NRF2-silencing in breast cancer cells
S Lee, SP Hallis, KA Jung, D Ryu, MK Kwak
Redox Biology 2019
Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)–PDH kinase axis
SM Hong, YK Lee, I Park, SM Kwon, S Min, G Yoon
The Journal of biological chemistry 2019
Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid
TW Chung, EY Kim, CW Han, SY Park, MS Jeong, D Yoon, HJ Choi, L Jin, MJ Park, YJ Kwon, H Lee, KJ Kim, KH Park, S Kim, SB Jang, KT Ha
Cancers 2019
Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
A Flores, S Sandoval-Gonzalez, R Takahashi, A Krall, L Sathe, L Wei, C Radu, J Jolly, N Graham, HR Christofk, WE Lowry
Nature Communications 2019
HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma
JC Fleming, J Woo, K Moutasim, M Mellone, SJ Frampton, A Mead, W Ahmed, O Wood, H Robinson, M Ward, CH Woelk, CH Ottensmeier, E King, D Kim, JP Blaydes, GJ Thomas
British Journal of Cancer 2019
Sorting by interfacial tension (SIFT): label-free selection of live cells based on single-cell metabolism
CW Pan, DG Horvath, S Braza, T Moore, A Lynch, C Feit, P Abbyad
Lab on a Chip 2019
A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death
EY Kim, TW Chung, CW Han, SY Park, KH Park, SB Jang, KT Ha
Scientific Reports 2019
Control of glucose metabolism is important in tenogenic differentiation of progenitors derived from human injured tendons
S Izumi, S Otsuru, N Adachi, N Akabudike, M Enomoto-Iwamoto, Y Dong
PloS one 2019
Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis?
E Sanchez-Lopez, A Cheng, M Guma
Journal of Clinical Medicine 2019
miR-140-5p induces cell apoptosis and decreases Warburg effect in chronic myeloid leukemia by targeting SIX1
ZY Nie, XJ Liu, Y Zhan, MH Liu, XY Zhang, ZY Li, YQ Lu, JM Luo, L Yang
Bioscience Reports 2019
Curcumin Treatment in Combination with Glucose Restriction Inhibits Intracellular Alkalinization and Tumor Growth in Hepatoma Cells
SW Kim, MJ Cha, SK Lee, BW Song, X Jin, JM Lee, JH Park, JD Lee
International journal of molecular sciences 2019
Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells
K Urbańska, A Orzechowski
International journal of molecular sciences 2019
Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment
D Mishra, D Banerjee
Cancers 2019
Multiplexed Single-Cell Measurements of FDG Uptake and Lactate Release Using Droplet Microfluidics
D Sengupta, A Mongersun, TJ Kim, K Mongersun, R von Eyben, P Abbyad, G Pratx
Technology in cancer research & treatment 2019

Oncogenic role of ABHD5 in endometrial cancer


Q Zhou, F Wang, K Zhou, K Huang, Q Zhu, X Luo, J Yu, Z Shi
Cancer management and research 2019
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells
P Ullmann, M Nurmik, R Begaj, S Haan, E Letellier
Cells 2019
LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc
J Tang, T Yan, Y Bao, C Shen, C Yu, X Zhu, X Tian, F Guo, Q Liang, Q Liu, M Zhong, J Chen, Z Ge, X Li, X Chen, Y Cui, Y Chen, W Zou, H Chen, J Hong, JY Fang
Nature Communications 2019
1H HR-MAS NMR-Based Metabolomics of Cancer Cells in Response to Treatment with the Diruthenium Trithiolato Complex [(p-MeC6H4iPr)2Ru2(SC6H4-p-But)3]+ (DiRu-1)
Primasová, Paul, Diserens, Primasová, Vermathen, Vermathen, Furrer
Metabolites 2019
MCT4 promotes cell proliferation and invasion of castration-resistant prostate cancer PC-3 cell line
Qing Sun, Liang-Liang Hu, Qiang Fu
EXCLI J 2019
LINC00184 silencing inhibits glycolysis and restores mitochondrial oxidative phosphorylation in esophageal cancer through demethylation of PTEN
W Li, K Huang, F Wen, G Cui, H Guo, Z He, S Zhao
EBioMedicine 2019
YIPF2 is a novel Rab-GDF that enhances HCC malignant phenotypes by facilitating CD147 endocytic recycle
S Qi, L Su, J Li, P Zhao, Q Zhang, X Niu, J Liu, G Jia, X Wei, J Tavernier, J Jiang, Z Chen, S Zhang
Cell Death and Disease 2019
Connections between metabolism and epigenetics in cancers
C Thakur, F Chen
Seminars in Cancer Biology 2019
NMR-Based Metabolomics in Metal-Based Drug Research
FD Castro, M Benedetti, LD Coco, FP Fanizzi
Molecules (Basel, Switzerland) 2019
Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus
TR McGuire, DW Coulter, D Bai, JA Sughroue, J Li, Z Yang, Z Qiao, Y Liu, DJ Murry, YS Chhonker, EM McIntyre, G Alexander, JG Sharp, R Li
BMC Cancer 2019
New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota
B Agrawal
Clinical and Translational Medicine 2019
Myelopoiesis, metabolism and therapy: a crucial crossroads in cancer progression
A Sica, V Guarneri, A Gennari
2019
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma
C Yeung, AE Gibson, SH Issaq, N Oshima, JT Baumgart, LD Edessa, G Rai, DJ Urban, MS Johnson, GA Benavides, GL Squadrito, ME Yohe, H Lei, S Eldridge, J Hamre, T Dowdy, V Ruiz-Rodado, A Lita, A Mendoza, JF Shern, M Larion, LJ Helman, GM Stott, MC Krishna, MD Hall, V Darley-Usmar, LM Neckers, CM Heske
Cancer research 2019
Relating the gut metagenome and metatranscriptome to immunotherapy responses in melanoma patients
BA Peters, M Wilson, U Moran, A Pavlick, A Izsak, T Wechter, JS Weber, I Osman, J Ahn
Genome Medicine 2019
Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
W Zhou, DR Wahl
Cancers 2019
Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer
GH Mohammad, V Vassileva, P Acedo, SW Damink, M Malago, DK Dhar, SP Pereira
Cancers 2019
Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells
A Reda, A Refaat, AA Abd-Rabou, AM Mahmoud, M Adel, S Sabet, SS Ali
Scientific Reports 2019
Targeting L-Lactate Metabolism to Overcome Resistance to Immune Therapy of Melanoma and Other Tumor Entities
RG Feichtinger, R Lang
Journal of Oncology 2019
Lipid accumulation and oxidation in glioblastoma multiforme
B Taïb, AM Aboussalah, M Moniruzzaman, S Chen, NJ Haughey, SF Kim, RS Ahima
Scientific Reports 2019
Glucose Transporter 3 Is Essential for the Survival of Breast Cancer Cells in the Brain
MH Kuo, WW Chang, BW Yeh, YS Chu, YC Lee, HT Lee
Cells 2019
Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
A Cheng, P Zhang, B Wang, D Yang, X Duan, Y Jiang, T Xu, Y Jiang, J Shi, C Ding, G Wu, Z Sang, Q Wu, H Wang, M Wu, Z Zhang, X Pan, Y Pan, P Gao, H Zhang, C Zhou, J Guo, Z Yang
Nature Communications 2019
Citrobacter rodentium induces rapid and unique metabolic and inflammatory responses in mice suffering from severe disease
D Carson, R Barry, EG Hopkins, TI Roumeliotis, D GarcíaWeber, C MullineauxSanders, E Elinav, C Arrieumerlou, JS Choudhary, G Frankel
Cellular Microbiology 2019
Role of purines in regulation of metabolic reprogramming
Z Tang, W Ye, H Chen, X Kuang, J Guo, M Xiang, C Peng, X Chen, H Liu
Purinergic Signalling 2019
Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment
DA Annan, N Maishi, T Soga, R Dawood, C Li, H Kikuchi, T Hojo, M Morimoto, T Kitamura, MT Alam, K Minowa, N Shinohara, JM Nam, Y Hida, K Hida
Cell Communication and Signaling 2019
Reverse Warburg Effect-Related Mitochondrial Activity and 18F-FDG Uptake in Invasive Ductal Carcinoma
BW Choi, YJ Jeong, SH Park, HK Oh, S Kang
Nuclear Medicine and Molecular Imaging 2019
TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
W Hua, P ten Dijke, S Kostidis, M Giera, M Hornsveld
Cellular and Molecular Life Sciences 2019
Tumor‐derived exosomes (TDEs): How to avoid the sting in the tail
MH Wan, B Ning, S Spiegel, CJ Lyon, TY Hu
Medicinal Research Reviews 2019
Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma
H Zhao, C Hu, W Chen, P Huang
2019
Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming
B Ha, S Jung, Y Jang, B Jeon, Y Shon
Marine drugs 2019
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma.
Afonso J, Pinto T, Simões-Sousa S, Schmitt F, Longatto-Filho A, Pinheiro C, Marques H, Baltazar F
Cellular oncology (Dordrecht) 2019
Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy
AJ Wolpaw, CV Dang
Trends in Cell Biology 2018
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
A Muir, LV Danai, MG Heiden
Disease models & mechanisms 2018
A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment
S Bamji-Stocke, V van Berkel, DM Miller, HB Frieboes
Metabolomics 2018
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies
R Zappasodi, T Merghoub, JD Wolchok
Cancer Cell 2018
The Adaptive Complexity of Cancer
Y Derbal
BioMed Research International 2018
Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
A D'Alessandro, KC Kasmi, L Plecitá-Hlavatá, P Ježek, M Li, H Zhang, SA Gupte, KR Stenmark
Antioxidants & Redox Signaling 2018
Hypoxia and acidosis: immune suppressors and therapeutic targets
S Damgaci, A Ibrahim-Hashim, PM Enriquez-Navas, S Pilon-Thomas, A Guvenis, RJ Gillies
Immunology 2018
The Heterogeneity of Cancer Metabolism
A Le
2018
Actionable Metabolic Pathways in Heart Failure and Cancer—Lessons From Cancer Cell Metabolism
A Karlstaedt, W Schiffer, H Taegtmeyer
Frontiers in Cardiovascular Medicine 2018
Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses
A Morrot, LM da Fonseca, EJ Salustiano, LB Gentile, L Conde, AA Filardy, TN Franklim, KM da Costa, CG Freire-de-Lima, L Freire-de-Lima
Frontiers in Oncology 2018
Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer
SL Romero-Cordoba, S Rodriguez-Cuevas, V Bautista-Pina, A Maffuz-Aziz, E DIppolito, G Cosentino, S Baroni, MV Iorio, A Hidalgo-Miranda
Scientific Reports 2018
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
C Corbet, E Bastien, N Draoui, B Doix, L Mignion, BF Jordan, A Marchand, JC Vanherck, P Chaltin, O Schakman, HM Becker, O Riant, O Feron
Nature Communications 2018
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
D Benjamin, D Robay, SK Hindupur, J Pohlmann, M Colombi, MY El-Shemerly, SM Maira, C Moroni, HA Lane, MN Hall
Cell Reports 2018
VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation
Diana Fang, Eduardo N Maldonado
Advances in cancer research 2018
An integrative theory for cancer (Review)
G Luo, N Liu
International journal of molecular medicine 2018
Metabolic reprogramming in the pathogenesis of chronic lung diseases, including BPD, COPD, and pulmonary fibrosis
H Zhao, PA Dennery, H Yao
American journal of physiology. Lung cellular and molecular physiology 2018
Shikonin, vitamin K3 and vitamin K5 inhibit multiple glycolytic enzymes in MCF-7 cells
J Chen, X Hu, J Cui
Oncology Letters 2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
HM Feyter, KL Behar, ZA Corbin, RK Fulbright, PB Brown, S McIntyre, TW Nixon, DL Rothman, RA de Graaf
Science Advances 2018
Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension
KR Stenmark, MG Frid, BB Graham, RM Tuder
Cardiovascular Research 2018
Dual IFN-γ/hypoxia priming enhances immunosuppression of mesenchymal stromal cells through regulatory proteins and metabolic mechanisms
HM Wobma, M Kanai, SP Ma, Y Shih, HW Li, R Duran-Struuck, R Winchester, S Goeta, LM Brown, G Vunjak-Novakovic
2018
Multiomics Integration Reveals the Landscape of Prometastasis Metabolism in Hepatocellular Carcinoma
Y Li, H Zhuang, X Zhang, Y Li, Y Liu, X Yi, G Qin, W Wei, R Chen
Molecular & cellular proteomics : MCP 2018
Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy
S Kouidhi, FB Ayed, AB Elgaaied
Frontiers in immunology 2018
Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy: Relevance of the monocarboxylate transporter family in disease and therapy
P Fisel, E Schaeffeler, M Schwab
Clinical and Translational Science 2018
Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer
S Bisetto, D Whitaker-Menezes, NA Wilski, M Tuluc, J Curry, T Zhan, CM Snyder, UE Martinez-Outschoorn, NJ Philp
Frontiers in Oncology 2018
Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing
K Zhang, MW Hast, S Izumi, Y Usami, S Shetye, N Akabudike, NJ Philp, M Iwamoto, I Nissim, LJ Soslowsky, M Enomoto-Iwamoto
The American journal of sports medicine 2018
Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria
C Lai, N Pursell, J Gierut, U Saxena, W Zhou, M Dills, R Diwanji, C Dutta, M Koser, N Nazef, R Storr, B Kim, C Martin-Higueras, E Salido, W Wang, M Abrams, H Dudek, BD Brown
Molecular Therapy 2018
Colorectal Cancer Cells Increase the Production of Short Chain Fatty Acids by Propionibacterium freudenreichii Impacting on Cancer Cells Survival
MR Casanova, J Azevedo-Silva, LR Rodrigues, A Preto
Frontiers in Nutrition 2018
Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism
W Yu, Y Chen, J Dubrulle, F Stossi, V Putluri, A Sreekumar, N Putluri, D Baluya, SY Lai, VC Sandulache
Scientific Reports 2018
Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells
CA Sommer, A Capilla, FJ Molina-Estevez, A Gianotti-Sommer, N Skvir, I Caballero, S Chowdhury, G Mostoslavsky, J Dulak
PloS one 2018
Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
D Kumar, J New, V Vishwakarma, R Joshi, J Enders, F Lin, S Dasari, WR Gutierrez, G Leef, S Ponnurangam, H Chavan, L Ganaden, MM Thornton, H Dai, O Tawfik, J Straub, Y Shnayder, K Kakarala, TT Tsue, DA Girod, BV Houten, S Anant, P Krishnamurthy, SM Thomas
Cancer research 2018
11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation
M Verma, TM Kipari, Z Zhang, TY Man, T Forster, NZ Homer, JR Seckl, MC Holmes, KE Chapman
Brain, Behavior, and Immunity 2018
Constraint based modeling of metabolism allows finding metabolic cancer hallmarks and identifying personalized therapeutic windows
S Bordel
Oncotarget 2018
Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells
DN DeHart, D Fang, K Heslop, L Li, JJ Lemasters, EN Maldonado
Biochemical Pharmacology 2018
Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms
AR Penheiter, DK Deelchand, E Kittelson, SE Damgard, SJ Murphy, DR O'Brien, WR Bamlet, MR Passow, TC Smyrk, FJ Couch, G Vasmatzis, JD Port, M Marjańska, SK Carlson
Pancreatology 2018
CARM1 suppresses de novo serine synthesis by promoting PKM2 activity
T Abeywardana, M Oh, L Jiang, Y Yang, M Kong, J Song, Y Yang
The Journal of biological chemistry 2018
Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13 C-MRSI
C Hundshammer, M Braeuer, CA Müller, AE Hansen, M Schillmaier, S Düwel, B Feuerecker, SJ Glaser, A Haase, W Weichert, K Steiger, J Cabello, F Schilling, JB Hövener, A Kjær, SG Nekolla, M Schwaiger
Theranostics 2018
Prognostic Factors and Decision Tree for Long-Term Survival in Metastatic Uveal Melanoma
D Lorenzo, M Ochoa, JM Piulats, C Gutiérrez, L Arias, J Català, M Grau, J Peñafiel, E Cobos, P Garcia-Bru, MJ Rubio, N Padrón-Pérez, B Dias, J Pera, JM Caminal
Cancer Research and Treatment 2018
Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis
C Chinopoulos, TN Seyfried
ASN NEURO 2018
Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect
Scroggins BT, Matsuo M, White AO, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Takakusagi Y, Ichikawa K, Mitchell JB, Krishna MC, Citrin DE
Clinical cancer research 2018
Metabolic Features of Multiple Myeloma
El Arfani C, De Veirman K, Maes K, De Bruyne E, Menu E
International journal of molecular sciences 2018
Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells.
Coverdale JPC, Romero-Canelón I, Sanchez-Cano C, Clarkson GJ, Habtemariam A, Wills M, Sadler PJ
Nature Chemistry 2018
Induction of Pyruvate Dehydrogenase Kinase 1 by Hypoxia Alters Cellular Metabolism and Inhibits Apoptosis in Endometriotic Stromal Cells.
Lee HC, Lin SC, Wu MH, Tsai SJ
Reproductive sciences (Thousand Oaks, Calif.) 2018
Metabolism shapes the tumor microenvironment
M Reina-Campos, J Moscat, M Diaz-Meco
Current Opinion in Cell Biology 2017
Targeting Metabolism for Cancer Therapy
A Luengo, DY Gui, MG Heiden
Cell Chemical Biology 2017
Metabolic Interactions in the Tumor Microenvironment
CA Lyssiotis, AC Kimmelman
Trends in Cell Biology 2017
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
A Angelin, L Gil-de-Gómez, S Dahiya, J Jiao, L Guo, MH Levine, Z Wang, WJ Quinn, PK Kopinski, L Wang, T Akimova, Y Liu, TR Bhatti, R Han, BL Laskin, JA Baur, IA Blair, DC Wallace, WW Hancock, UH Beier
Cell Metabolism 2017
Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells
Y Sunami, A Rebelo, J Kleeff
Cancers 2017
VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch
EN Maldonado
Frontiers in Oncology 2017
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
S Gupta, A Roy, BS Dwarakanath
Frontiers in Oncology 2017
Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
H Chen, DC Chan
Cell Metabolism 2017
Metabolic Coupling and the Reverse Warburg Effect in Cancer, implications for novel biomarker and anticancer agent development
L Wilde, M Roche, M Domingo-Vidal, K Tanson, N Philp, J Curry, U Martinez-Outschoorn
Seminars in Oncology 2017
Dysbiosis of the microbiome in gastric carcinogenesis
N Castaño-Rodríguez, KL Goh, KM Fock, HM Mitchell, NO Kaakoush
Scientific Reports 2017
Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy
M Tomasetti, W Lee, L Santarelli, J Neuzil
Experimental & molecular medicine 2017
Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
L Jin, J Chun, C Pan, GN Alesi, D Li, KR Magliocca, Y Kang, ZG Chen, DM Shin, FR Khuri, J Fan, S Kang
Oncogene 2017
HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
P Miikkulainen, H Högel, K Rantanen, T Suomi, P Kouvonen, LL Elo, PM Jaakkola
Cancer & Metabolism 2017
Metabolic Alterations of Thyroid Cancer as Potential Therapeutic Targets
D Ciavardelli, M Bellomo, A Consalvo, C Crescimanno, V Vella
BioMed Research International 2017
FX11 inhibits aerobic glycolysis and growth of neuroblastoma cells
EJ Rellinger, BT Craig, AL Alvarez, HL Dusek, KW Kim, J Qiao, DH Chung
Surgery 2017
Composite Hydrogels with Engineered Microdomains for Optical Glucose Sensing at Low Oxygen Conditions
L Bornhoeft, A Biswas, M McShane
Biosensors 2017
Peroxisomal Dysfunction in Age-Related Diseases
CM Cipolla, IJ Lodhi
Trends in Endocrinology & Metabolism 2017
pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma
JP Caruso, BJ Koch, PD Benson, E Varughese, MD Monterey, AE Lee, AM Dave, S Kiousis, AE Sloan, SP Mathupala
Neoplasia (New York, N.Y.) 2017
M2-like macrophage polarization in high lactic acid-producing head and neck cancer
T Ohashi, M Aoki, H Tomita, T Akazawa, K Sato, B Kuze, K Mizuta, A Hara, H Nagaoka, N Inoue, Y Ito
Cancer Science 2017
Targeting MYC Dependence by Metabolic Inhibitors in Cancer
HS Sabnis, RR Somasagara, KD Bunting
Genes & development 2017
MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect
N Shtraizent, C DeRossi, S Nayar, R Sachidanandam, LS Katz, A Prince, AP Koh, A Vincek, Y Hadas, Y Hoshida, DK Scott, E Eliyahu, HH Freeze, KC Sadler, J Chu
eLife 2017
Glycolytic reliance promotes anabolism in photoreceptors
Y Chinchore, T Begaj, D Wu, E Drokhlyansky, CL Cepko
eLife 2017
Perspective on the dynamics of cancer
Y Derbal
Theoretical Biology and Medical Modelling 2017
Tumour acidosis: from the passenger to the driver's seat
C Corbet, O Feron
Nature Reviews Cancer 2017
Mitochondrial and glycolytic metabolic compartmentalization in Diffuse Large B Cell Lymphoma
M Gooptu, D Whitaker-Menezes, J Sprandio, M Domingo-Vidal, Z Lin, G Uppal, J Gong, R Fratamico, B Leiby, A Dulau-Florea, J Caro, U Martinez-Outschoorn
Seminars in Oncology 2017
The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy
Y Fu, S Liu, S Yin, W Niu, W Xiong, M Tan, G Li, M Zhou
Oncotarget 2017
H 2 S-induced S -sulfhydration of lactate dehydrogenase A (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells
AA Untereiner, G Oláh, K Módis, MR Hellmich, C Szabo
Biochemical Pharmacology 2017
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
N Ilic, K Birsoy, AJ Aguirre, N Kory, ME Pacold, S Singh, SE Moody, JD DeAngelo, NA Spardy, E Freinkman, BA Weir, A Tsherniak, GS Cowley, DE Root, JM Asara, F Vazquez, HR Widlund, DM Sabatini, WC Hahn
Proceedings of the National Academy of Sciences 2017
Intratumoral lactate metabolism in barrett’s esophagus and adenocarcinoma
H Huhta, O Helminen, S Palomäki, JH Kauppila, J Saarnio, PP Lehenkari, TJ Karttunen
Oncotarget 2017
MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy
M Beloueche-Babari, S Wantuch, TC Galobart, M Koniordou, HG Parkes, V Arunan, YL Chung, TR Eykyn, PD Smith, MO Leach
Cancer research 2017
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism
MA Silvers, S Deja, N Singh, RA Egnatchik, J Sudderth, X Luo, MS Beg, SC Burgess, RJ DeBerardinis, DA Boothman, ME Merritt
The Journal of biological chemistry 2017
Drosophila as a Model to Study the Link between Metabolism and Cancer
H Herranz, S Cohen
Journal of Developmental Biology 2017
IL-1/inhibitory κB kinase ε–induced glycolysis augment epithelial effector function and promote allergic airways disease
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Journal of Allergy and Clinical Immunology 2017
Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor
GA Vitiello, BD Medina, S Zeng, TG Bowler, JQ Zhang, JK Loo, NJ Param, M Liu, AJ Moral, JN Zhao, F Rossi, CR Antonescu, VP Balachandran, JR Cross, RP DeMatteo
Clinical cancer research 2017
Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A
AM Altamimi, AM Alafeefy, A Balode, I Vozny, A Pustenko, ME Shikh, FA Alasmary, SA Abdel-Gawad, R Žalubovskis
Journal of Enzyme Inhibition and Medicinal Chemistry 2017
Exo-MFA - A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism.
Achreja A, Zhao H, Yang L, Yun TH, Marini J, Nagrath D
Metabolic Engineering 2017
Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming
S Selleri, P Bifsha, S Civini, C Pacelli, MM Dieng, W Lemieux, P Jin, R Bazin, N Patey, FM Marincola, F Moldovan, C Zaouter, LE Trudeau, B Benabdhalla, I Louis, C Beauséjour, D Stroncek, FL Deist, E Haddad
Oncotarget 2016
Cancer metabolism: a therapeutic perspective
UE Martinez-Outschoorn, M Peiris-Pagés, RG Pestell, F Sotgia, MP Lisanti
Nature Reviews Clinical Oncology 2016
Mitochondrial pyruvate carrier function and cancer metabolism
AJ Rauckhorst, EB Taylor
Current Opinion in Genetics & Development 2016
Attacking the supply wagons to starve cancer cells to death
EM Selwan, BT Finicle, SM Kim, AL Edinger
FEBS Letters 2016
NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy
Y Yang, AA Sauve
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 2016
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
C Vernieri, S Casola, M Foiani, F Pietrantonio, F Braud, V Longo
Cancer Discovery 2016
Tumor-derived factors modulating dendritic cell function
J Zong, AA Keskinov, GV Shurin, MR Shurin
Cancer Immunology, Immunotherapy 2016
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress
D Huang, T Li, L Wang, L Zhang, R Yan, K Li, S Xing, G Wu, L Hu, W Jia, SC Lin, CV Dang, L Song, P Gao, H Zhang
Cell Research 2016
Role of Intestinal HIF-2α in Health and Disease
SK Ramakrishnan, YM Shah
Annual Review of Physiology 2016
Oxygen availability and metabolic adaptations
MS Nakazawa, B Keith, MC Simon
Nature Reviews Cancer 2016
Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines
I Kovalenko, A Glasauer, L Schöckel, DR Sauter, A Ehrmann, F Sohler, A Hägebarth, I Novak, S Christian, J Santos
PloS one 2016
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis
S Masri, T Papagiannakopoulos, K Kinouchi, Y Liu, M Cervantes, P Baldi, T Jacks, P Sassone-Corsi
Cell 2016
Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
S Romero-Garcia, MM Moreno-Altamirano, H Prado-Garcia, FJ Sánchez-García
Frontiers in immunology 2016
Droplet Microfluidic Platform for the Determination of Single-Cell Lactate Release
A Mongersun, I Smeenk, G Pratx, P Asuri, P Abbyad
Analytical Chemistry 2016
Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction
PC McDonald, SC Chafe, S Dedhar
Frontiers in Cell and Developmental Biology 2016
Lactate, a Neglected Factor for Diabetes and Cancer Interaction
Y Wu, Y Dong, M Atefi, Y Liu, Y Elshimali, JV Vadgama
Mediators of Inflammation 2016
Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect
I San-Millán, GA Brooks
Carcinogenesis 2016
Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation
C Berrios, M Padi, MA Keibler, DE Park, V Molla, J Cheng, SM Lee, G Stephanopoulos, J Quackenbush, JA DeCaprio, RF Kalejta
PLoS pathogens 2016
ROS homeostasis and metabolism: a critical liaison for cancer therapy
J Kim, J Kim, JS Bae
Experimental & molecular medicine 2016
Combination of lactate calcium salt with 5‑indanesulfonamide and α‑cyano‑4‑hydroxycinnamic acid to enhance the antitumor effect on HCT116 cells via intracellular acidification
KY Jeong, P Mander, J Sim, H Kim
Oncology Letters 2016
Monitoring cancer prognosis, diagnosis and treatment efficacy using metabolomics and lipidomics
EG Armitage, AD Southam
Metabolomics 2016
EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
SO Lim, CW Li, W Xia, HH Lee, SS Chang, J Shen, JL Hsu, D Raftery, D Djukovic, H Gu, WC Chang, HL Wang, ML Chen, L Huo, CH Chen, Y Wu, A Sahin, SM Hanash, GN Hortobagyi, MC Hung
Cancer research 2016
Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression
CC Chang, C Zhang, Q Zhang, O Sahin, H Wang, J Xu, Y Xiao, J Zhang, SK Rehman, P Li, MC Hung, F Behbod, D Yu
Oncotarget 2016
Regulation of Monocarboxylic Acid Transporter 1 Trafficking by the Canonical Wnt/β-Catenin Pathway in Rat Brain Endothelial Cells Requires Cross-talk with Notch Signaling
Z Liu, M Sneve, TA Haroldson, JP Smith, LR Drewes
The Journal of biological chemistry 2016
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
N Hay
Nature Reviews Cancer 2016
MR Molecular Imaging of Brain Cancer Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy:
C Najac, SM Ronen
Topics in Magnetic Resonance Imaging 2016
Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
A Strickaert, M Saiselet, G Dom, XD Deken, JE Dumont, O Feron, P Sonveaux, C Maenhaut
Oncogene 2016
Role of multifaceted regulators in cancer glucose metabolism and their clinical significance
L Zhao, Y Mao, Y Zhao, Y Cao, X Chen
Oncotarget 2016
Measuring relative utilization of aerobic glycolysis in breast cancer cells by positional isotopic discrimination
DQ Yang, DM Freund, BR Harris, D Wang, MP Cleary, AD Hegeman
FEBS Letters 2016
Protein expression changes induced in a malignant melanoma cell line by the curcumin analogue compound D6
M Pisano, A Palomba, A Tanca, D Pagnozzi, S Uzzau, MF Addis, MA Dettori, D Fabbri, G Palmieri, C Rozzo
BMC Cancer 2016
Innate-like functions of natural killer T cell subsets result from highly divergent gene programs
I Engel, G Seumois, L Chavez, D Samaniego-Castruita, B White, A Chawla, D Mock, P Vijayanand, M Kronenberg
Nature Immunology 2016
Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo A Biomarker for LDH Activity
C DeBrosse, RP Nanga, P Bagga, K Nath, M Haris, F Marincola, MD Schnall, H Hariharan, R Reddy
Scientific Reports 2016
The metabolic interaction of cancer cells and fibroblasts – coupling between NAD(P)H and FAD, intracellular pH and hydrogen peroxide
IN Druzhkova, MV Shirmanova, MM Lukina, VV Dudenkova, NM Mishina, EV Zagaynova
Cell cycle (Georgetown, Tex.) 2016
Induction of triglyceride accumulation and mitochondrial maintenance in muscle cells by lactate
J Sun, X Ye, M Xie, J Ye
Scientific Reports 2016
Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years
S Blatt, N Voelxen, K Sagheb, AM Pabst, S Walenta, T Schroeder, W Mueller-Klieser, T Ziebart
Clinical Oral Investigations 2016
Autophagy protects ovarian cancer-associated fibroblasts against oxidative stress
Q Wang, L Xue, X Zhang, S Bu, X Zhu, D Lai
Cell cycle (Georgetown, Tex.) 2016
Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster
AM Kaynar, V Bakalov, SM Laverde, AI Cambriel, BH Lee, A Towheed, AD Gregory, SA Webb, MJ Palladino, FA Bozza, SD Shapiro, DC Angus
Intensive Care Medicine Experimental 2016
The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis
G Li, Z Wang, J Xu, H Wu, S Cai, Y He
BMC Cancer 2016
Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors
RN Nair, JK Mishra, F Li, M Tortosa, C Yang, JR Doherty, M Cameron, JL Cleveland, WR Roush, TD Bannister
MedChemComm 2016
Lactate metabolism is associated with mammalian mitochondria
YJ Chen, NG Mahieu, X Huang, M Singh, PA Crawford, SL Johnson, RW Gross, J Schaefer, GJ Patti
Nature Chemical Biology 2016
Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
GH Mohammad, SW Damink, M Malago, DK Dhar, SP Pereira, M Muders
PloS one 2016
Glucose metabolism in gastric cancer: The cutting-edge
LW Yuan
World journal of gastroenterology : WJG 2016
DGCA: A comprehensive R package for Differential Gene Correlation Analysis
AT McKenzie, I Katsyv, WM Song, M Wang, B Zhang
BMC Systems Biology 2016
Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling
NA Malinovskaya, YK Komleva, VV Salmin, AV Morgun, AN Shuvaev, YA Panina, EB Boitsova, AB Salmina
Frontiers in physiology 2016
PKM2 and other key regulators of Warburg effect positively correlate with CD147 (EMMPRIN) gene expression and predict survival in multiple myeloma
S Panchabhai, I Schlam, S Sebastian, R Fonseca
Leukemia 2016
Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513
DW Coulter, TR McGuire, JG Sharp, EM McIntyre, Y Dong, X Wang, S Gray, GR Alexander, NK Chatuverdi, SS Joshi, X Chen, JL Vennerstrom
BMC Cancer 2016
The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
P Lis, M Dyląg, K Niedźwiecka, Y Ko, P Pedersen, A Goffeau, S Ułaszewski
Molecules (Basel, Switzerland) 2016
Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential
WL Chen, YY Wang, A Zhao, L Xia, G Xie, M Su, L Zhao, J Liu, C Qu, R Wei, C Rajani, Y Ni, Z Cheng, Z Chen, SJ Chen, W Jia
Cancer Cell 2016
The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas
CP Cheng, LC Huang, YL Chang, CH Hsieh, SM Huang, DY Hueng
Oncotarget 2016
Glucose Metabolism Reprogrammed by Overexpression of IKKε Promotes Pancreatic Tumor Growth
H Zubair, S Azim, SK Srivastava, A Ahmad, A Bhardwaj, MA Khan, GK Patel, S Arora, JE Carter, S Singh, AP Singh
Cancer research 2016
Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters
P Viswanath, C Najac, JL Izquierdo-Garcia, A Pankov, C Hong, P Eriksson, JF Costello, RO Pieper, SM Ronen
Oncotarget 2016
Lactate, a useful marker for disease mortality and severity but an unreliable marker of tissue hypoxia/hypoperfusion in critically ill patients
S Kushimoto, S Akaishi, T Sato, R Nomura, M Fujita, D Kudo, Y Kawazoe, Y Yoshida, N Miyagawa
Acute Medicine & Surgery 2016
Cancer metabolism at a glance
A Vazquez, JJ Kamphorst, EK Markert, ZT Schug, S Tardito, E Gottlieb
Journal of cell science 2016
Non-metabolic functions of glycolytic enzymes in tumorigenesis.
Yu X, Li S
Oncogene 2016
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis
N Xie, Z Tan, S Banerjee, H Cui, J Ge, RM Liu, K Bernard, VJ Thannickal, G Liu
American journal of respiratory and critical care medicine 2015
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
S Lovisa, VS LeBleu, B Tampe, H Sugimoto, K Vadnagara, JL Carstens, CC Wu, Y Hagos, BC Burckhardt, T Pentcheva-Hoang, H Nischal, JP Allison, M Zeisberg, R Kalluri
Nature Medicine 2015
Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment
IL Romero, A Mukherjee, HA Kenny, LM Litchfield, E Lengyel
Clinical cancer research 2015
Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1
S Fujiwara, N Wada, Y Kawano, Y Okuno, Y Kikukawa, S Endo, N Nishimura, N Ueno, H Mitsuya, H Hata
Experimental Hematology and Oncology 2015
Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle
F Capuani, DD Martino, E Marinari, AD Martino
Scientific Reports 2015
PTHrP-linked Hypercalcemia in a Melanoma Patient Treated with Ipilimumab: Hormone source and Clinical and Metabolic Correlates
TA Mills, M Orloff, M Domingo-Vidal, P Cotzia, R Birbe, R Draganova-Tacheva, MP Martinez-Cantarin, M Tuluc, U Martinez-Outschoorn
Seminars in Oncology 2015
Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy
RJ Zuo, XW Gu, QR Qi, TS Wang, XY Zhao, JL Liu, ZM Yang
The Journal of biological chemistry 2015
Novel Therapeutic Targets of Tumor Metabolism:
RJ Kishton, JC Rathmell
The Cancer Journal 2015
Uncovering metabolism in rhabdomyosarcoma
E Monti, A Fanzani
Cell cycle (Georgetown, Tex.) 2015
Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death
S Daniele, C Giacomelli, E Zappelli, C Granchi, ML Trincavelli, F Minutolo, C Martini
Scientific Reports 2015
Metabolic Signatures of Human Breast Cancer
P Mishra, S Ambs
Molecular & Cellular Oncology 2015
Targeting cancer cell metabolism in pancreatic adenocarcinoma
R Cohen, C Neuzillet, A Tijeras-Raballand, S Faivre, A Gramont, E Raymond
Oncotarget 2015
Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain
T Yoneda, M Hiasa, Y Nagata, T Okui, F White
Biochimica et Biophysica Acta (BBA) - Biomembranes 2015
Modulation of Intracellular Calcium Levels by Calcium Lactate Affects Colon Cancer Cell Motility through Calcium-Dependent Calpain
P Sundaramoorthy, JJ Sim, YS Jang, SK Mishra, KY Jeong, P Mander, OB Chul, WS Shim, SH Oh, KY Nam, HM Kim, NA Hotchin
PloS one 2015
Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells
NS Madhukar, MO Warmoes, JW Locasale, VD Appanna
PloS one 2015
Glucose, lactate, and shuttling of metabolites in vertebrate retinas: Lactate Shuttle in the Retina
JB Hurley, KJ Lindsay, J Du
Journal of Neuroscience Research 2015
Melanoma brain metastasis is independent of lactate dehydrogenase A expression
T Sundstrom, H Espedal, PN Harter, KE Fasmer, KO Skaftnesmo, S Horn, E Hodneland, M Mittelbronn, B Weide, R Beschorner, B Bender, CB Rygh, M Lund-Johansen, R Bjerkvig, F Thorsen
Neuro-Oncology 2015
Acidic microenvironment and bone pain in cancer-colonized bone
T Yoneda, M Hiasa, Y Nagata, T Okui, FA White
BoneKEy Reports 2015
Metabolic reprogramming in glioblastoma: The influence of cancer metabolism on epigenetics and unanswered questions
S Agnihotri, G Zadeh
Neuro-Oncology 2015
Does aberrant membrane transport contribute to poor outcome in adult acute myeloid leukemia?
A Chigaev
Frontiers in pharmacology 2015
Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
M Reginato, S Karakashev
Cancer management and research 2015
The predictive value of alkaline phosphatase and lactate dehydrogenase for overall survival in patients with esophageal squamous cell carcinoma
X Wei, D Zhang, M He, Y Jin, D Wang, Y Zhou, L Bai, Z Li, H Luo, F Wang, R Xu
Tumor Biology 2015
Targeted Therapies in Adult B-Cell Malignancies
JF Rossi
BioMed Research International 2015
Severe hyperlactatemia, lactate clearance and mortality in unselected critically ill patients
SA Haas, T Lange, B Saugel, M Petzoldt, V Fuhrmann, M Metschke, S Kluge
Intensive Care Medicine 2015
Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis
R Rupaimoole, J Lee, M Haemmerle, H Ling, RA Previs, S Pradeep, SY Wu, C Ivan, M Ferracin, JB Dennison, NM Millward, AS Nagaraja, KM Gharpure, M McGuire, N Sam, GN Armaiz-Pena, NC Sadaoui, C Rodriguez-Aguayo, GA Calin, RI Drapkin, J Kovacs, GB Mills, W Zhang, G Lopez-Berestein, PK Bhattacharya, AK Sood
Cell Reports 2015
How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity
GD Grass, BP Toole
Bioscience Reports 2015
Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics
H Zhang, F Guo, G Zhu, LJ Knoll
PLoS pathogens 2015
A Pilot Proteogenomic Study with Data Integration Identifies MCT1 and GLUT1 as Prognostic Markers in Lung Adenocarcinoma
PA Stewart, K Parapatics, EA Welsh, AC Müller, H Cao, B Fang, JM Koomen, SA Eschrich, KL Bennett, EB Haura, JJ Chen
PloS one 2015
MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism
SK Shukla, V Gunda, J Abrego, D Haridas, A Mishra, J Souchek, NV Chaika, F Yu, AR Sasson, AJ Lazenby, SK Batra, PK Singh
Oncotarget 2015
Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension
KR Stenmark, RM Tuder, KC el Kasmi
Journal of applied physiology 2015
Clinical development of cancer therapeutics that target metabolism: Figure 1
BF Clem, J ONeal, AC Klarer, S Telang, J Chesney
QJM 2015
Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential
ES Knudsen, U Balaji, E Freinkman, P McCue, AK Witkiewicz
Oncotarget 2015
Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer
Pertega-Gomes N, Vizcaino JR, Felisbino S, Warren AY, Shaw G, Kay J, Whitaker H, Lynch AG, Fryer L, Neal DE, Massie CE
Oncotarget 2015
Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression
Chaube B, Malvi P, Singh SV, Mohammad N, Meena AS, Bhat MK
Oncotarget 2015
Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
Song K, Kwon H, Han C, Zhang J, Dash S, Lim K, Wu T
Oncotarget 2015
Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
Shukla SK, Dasgupta A, Mehla K, Gunda V, Vernucci E, Souchek J, Goode G, King R, Mishra A, Rai I, Nagarajan S, Chaika NV, Yu F, Singh PK
Oncotarget 2015
Enhanced tumorigenicity by mitochondrial DNA mild mutations.
Cruz-Bermúdez A, Vallejo CG, Vicente-Blanco RJ, Gallardo ME, Fernández-Moreno MÁ, Quintanilla M, Garesse R
Oncotarget 2015
KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.
Riz I, Hawley TS, Hawley RG
Oncotarget 2015
Fibroblast heterogeneity in the cancer wound
D Ohlund, E Elyada, D Tuveson
Journal of Experimental Medicine 2014
Heterogeneity of glycolysis in cancers and therapeutic opportunities
MO Warmoes, JW Locasale
Biochemical Pharmacology 2014
Restricting carbohydrates to fight head and neck cancer-is this realistic?
Rainer J Klement
Cancer biology & medicine 2014
Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?
M Grimm, M Cetindis, M Lehmann, T Biegner, A Munz, P Teriete, W Kraut, S Reinert
Journal of Translational Medicine 2014
Redox control of glutamine utilization in cancer
L Alberghina, D Gaglio
Cell Death and Disease 2014
NMR-based evaluation of the metabolic profile and response to dichloroacetate of human prostate cancer cells: METABOLIC PROFILE AND RESPONSE TO DCA OF HUMAN PROSTATE CANCER CELLS
M Kailavasan, I Rehman, S Reynolds, A Bucur, G Tozer, M Paley
NMR in Biomedicine 2014
MUC1: A novel metabolic master regulator
K Mehla, PK Singh
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2014
In vitro model suggests oxidative stress involved in keratoconus disease
D Karamichos, AE Hutcheon, CB Rich, V Trinkaus-Randall, JM Asara, JD Zieske
Scientific Reports 2014
Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work
DA Kane
Frontiers in neuroscience 2014
[Advances in the relationship between tumor cell metabolism and tumor metastasis]
Yalong Zhang, Nianzhen Fang, Jiacong You, Qinghua Zhou
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2014
Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells
Yang Y, Su D, Zhao L, Zhang D, Xu J, Wan J, Fan S, Chen M
Oncotarget 2014
Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma
Li C, Meng G, Su L, Chen A, Xia M, Xu C, Yu D, Jiang A, Wei J
Oncotarget 2014
Exploiting tumor metabolism: challenges for clinical translation
Matthew Vander Heiden
Journal of Clinical Investigation 2013
LUD, a new protein domain associated with lactate utilization
WC Hwang, C Bakolitsa, M Punta, PC Coggill, A Bateman, HL Axelrod, ND Rawlings, M Sedova, SN Peterson, RY Eberhardt, L Aravind, J Pascual, A Godzik
BMC bioinformatics 2013
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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