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Clinical development of demethylating agents in hematology
Shyamala C. Navada, … , Michael Lübbert, Lewis R. Silverman
Shyamala C. Navada, … , Michael Lübbert, Lewis R. Silverman
Published January 2, 2014
Citation Information: J Clin Invest. 2014;124(1):40-46. https://doi.org/10.1172/JCI69739.
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Review Series Article has an altmetric score of 6

Clinical development of demethylating agents in hematology

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Abstract

The term epigenetics refers to the heritable changes in gene expression that are not associated with a change in the actual DNA sequence. Epigenetic dysregulation is linked to the pathogenesis of a number of malignancies and has been studied extensively in myelodysplastic syndromes and acute myeloid leukemia. DNA methylation is frequently altered in cancerous cells and likely results in transcriptional silencing of tumor suppressor genes. Re-expression of these genes by inhibition of the DNA methyltransferases has been successful in the treatment of benign and malignant disease. In this Review, we discuss the clinical development of demethylating agents in hematology, with a focus on azacitidine and decitabine.

Authors

Shyamala C. Navada, Juliane Steinmann, Michael Lübbert, Lewis R. Silverman

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Usage data is cumulative from May 2024 through May 2025.

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Text version 826 56
PDF 108 26
Figure 148 1
Table 179 0
Citation downloads 87 0
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Total Views 1,431
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Referenced in 4 patents
Referenced in 1 Wikipedia pages
139 readers on Mendeley
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