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Usage Information

Predicting response to epigenetic therapy
Marianne B. Treppendahl, … , Lasse S. Kristensen, Kirsten Grønbæk
Marianne B. Treppendahl, … , Lasse S. Kristensen, Kirsten Grønbæk
Published January 2, 2014
Citation Information: J Clin Invest. 2014;124(1):47-55. https://doi.org/10.1172/JCI69737.
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Predicting response to epigenetic therapy

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Abstract

Drugs targeting the epigenome are new promising cancer treatment modalities; however, not all patients receive the same benefit from these drugs. In contrast to conventional chemotherapy, responses may take several months after the initiation of treatment to occur. Accordingly, identification of good pretreatment predictors of response is of great value. Many clinical parameters and molecular targets have been tested in preclinical and clinical studies with varying results, leaving room for optimization. Here we provide an overview of markers that may predict the efficacy of FDA- and EMA-approved epigenetic drugs.

Authors

Marianne B. Treppendahl, Lasse S. Kristensen, Kirsten Grønbæk

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 973 36
PDF 65 12
Figure 117 0
Table 298 0
Citation downloads 70 0
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Total Views 1,571
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