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Jean-Pierre Issa
Published January 2, 2014
Citation Information: J Clin Invest. 2014;124(1):24-29. https://doi.org/10.1172/JCI69735.
Citation Information: J Clin Invest. 2014;124(1):24-29. https://doi.org/10.1172/JCI69735.
Abstract
The term epigenetics refers to stable patterns of gene expression that are seen during differentiation or X chromosome inactivation and are not dependent on dynamic changes in coding DNA. These gene expression states are encoded in the epigenome — a collection of marks on DNA or on histone tails that are established during embryogenesis. Genome-wide studies in aging cells and tissues have uncovered stochastic DNA methylation drift (gradual increases or decreases at specific loci) that reflects imperfect maintenance of epigenetic marks. Drift creates epigenetic mosaicism in aging stem cells that could potentially restrict their plasticity and worsen phenotypes such as stem cell exhaustion and focal proliferative defects that can lead to cancer.
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Jean-Pierre Issa
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Correlation between 5-α reductase type 2 protein expression and methylation of 5-α reductase type 2 promotor gene of benign prostatic hyperplasia
PM Kang, YJ Kim, WT Seo, SH Kang, TS Kim, BK Chun, WI Seo, JY Jeong, JI Chung |
World Journal of Urology | 2018 |
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Gene-environment interactions and predictors of breast cancer in family-based multi-ethnic groups
MC Gonzales, J Grayson, A Lie, CH Yu, SY Shiao |
Oncotarget | 2018 |
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Age prediction of children and adolescents aged 6-17 years: an epigenome-wide analysis of DNA methylation
C Li, W Gao, Y Gao, C Yu, J Lv, R Lv, J Duan, Y Sun, X Guo, W Cao, L Li |
Aging | 2018 |
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DNA Methylation Clocks in Aging: Categories, Causes, and Consequences
AE Field, NA Robertson, T Wang, A Havas, T Ideker, PD Adams |
Molecular Cell | 2018 |
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Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism
K Soda |
International journal of molecular sciences | 2018 |
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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
H Zhang, S Pandey, M Travers, H Sun, G Morton, J Madzo, W Chung, J Khowsathit, O Perez-Leal, CA Barrero, C Merali, Y Okamoto, T Sato, J Pan, J Garriga, NV Bhanu, J Simithy, B Patel, J Huang, NJ Raynal, BA Garcia, MA Jacobson, C Kadoch, S Merali, Y Zhang, W Childers, M Abou-Gharbia, J Karanicolas, SB Baylin, CA Zahnow, J Jelinek, X Graña, JP Issa |
Cell | 2018 |
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Astrocytes and Aging
AL Palmer, SS Ousman |
Frontiers in aging neuroscience | 2018 |
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DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort: DNA methylation markers as triage test in hrHPV-positive women
RW van Leeuwen, A Oštrbenk, M Poljak, AG van der Zee, E Schuuring, GB Wisman |
International Journal of Cancer | 2018 |
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LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells
A Grigoryan, N Guidi, K Senger, T Liehr, K Soller, G Marka, A Vollmer, Y Markaki, H Leonhardt, C Buske, DB Lipka, C Plass, Y Zheng, MA Mulaw, H Geiger, MC Florian |
Genome biology | 2018 |
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The proto CpG island methylator phenotype of sessile serrated adenomas/polyps
HR Parker, S Orjuela, AM Oliveira, F Cereatti, M Sauter, H Heinrich, G Tanzi, A Weber, P Komminoth, S Vavricka, L Albanese, F Buffoli, MD Robinson, G Marra |
Epigenetics : official journal of the DNA Methylation Society | 2018 |
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Zinc Finger Readers of Methylated DNA
NO Hudson, BA Buck-Koehntop |
Molecules (Basel, Switzerland) | 2018 |
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Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations
M Vaz, SY Hwang, I Kagiampakis, J Phallen, A Patil, HM O'Hagan, L Murphy, CA Zahnow, E Gabrielson, VE Velculescu, HP Easwaran, SB Baylin |
Cancer Cell | 2017 |
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Roadmap for investigating epigenome deregulation and environmental origins of cancer: Epigenetics and cancer
Z Herceg, A Ghantous, CP Wild, A Sklias, L Casati, SJ Duthie, R Fry, JP Issa, R Kellermayer, I Koturbash, Y Kondo, J Lepeule, SC Lima, CJ Marsit, V Rakyan, R Saffery, JA Taylor, AE Teschendorff, T Ushijima, P Vineis, CL Walker, RA Waterland, J Wiemels, S Ambatipudi, DD Esposti, H Hernandez-Vargas |
International Journal of Cancer | 2017 |
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The performance of the mSEPT9 assay is influenced by algorithm, cancer stage and age, but not sex and cancer location
L Song, J Jia, H Yu, X Peng, W Xiao, Y Gong, G Zhou, X Han, Y Li |
Journal of Cancer Research and Clinical Oncology | 2017 |
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DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
S Ambatipudi, S Horvath, F Perrier, C Cuenin, H Hernandez-Vargas, FL Calvez-Kelm, G Durand, G Byrnes, P Ferrari, L Bouaoun, A Sklias, V Chajes, K Overvad, G Severi, L Baglietto, F Clavel-Chapelon, R Kaaks, M Barrdahl, H Boeing, A Trichopoulou, P Lagiou, A Naska, G Masala, C Agnoli, S Polidoro, R Tumino, S Panico, M Dollé, PH Peeters, NC Onland-Moret, TM Sandanger, TH Nøst, E Weiderpass, JR Quirós, A Agudo, M Rodriguez-Barranco, JM Castaño, A Barricarte, AM Fernández, RC Travis, P Vineis, DC Muller, E Riboli, M Gunter, I Romieu, Z Herceg |
European Journal of Cancer | 2017 |
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Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
O Hahn, S Grönke, TM Stubbs, G Ficz, O Hendrich, F Krueger, S Andrews, Q Zhang, MJ Wakelam, A Beyer, W Reik, L Partridge |
Genome biology | 2017 |
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Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer’s Disease Subjects
EM Ellison, MA Bradley-Whitman, MA Lovell |
Journal of Molecular Neuroscience | 2017 |
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Caloric restriction delays age-related methylation drift
S Maegawa, Y Lu, T Tahara, JT Lee, J Madzo, S Liang, J Jelinek, RJ Colman, JP Issa |
Nature Communications | 2017 |
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Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma
EG Luebeck, K Curtius, WD Hazelton, S Maden, M Yu, PN Thota, DT Patil, A Chak, JE Willis, WM Grady |
Clinical Epigenetics | 2017 |
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Morphologic characterization of residual DNA methylation in the gastric mucosa after Helicobacter pylori eradication
S Tahara, T Tahara, T Tuskamoto, N Horiguchi, T Kawamura, M Okubo, T Ishizuka, M Nagasaka, Y Nakagawa, T Shibata, M Kuroda, N Ohmiya |
Cancer Medicine | 2017 |
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Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children’s Environmental Health Studies: The Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group
CV Breton, CJ Marsit, E Faustman, K Nadeau, JM Goodrich, DC Dolinoy, J Herbstman, N Holland, JM LaSalle, R Schmidt, P Yousefi, F Perera, BR Joubert, J Wiemels, M Taylor, IV Yang, R Chen, KM Hew, DM Freeland, R Miller, SK Murphy |
Environmental Health Perspectives | 2017 |
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Intercellular competition and the inevitability of multicellular aging
P Nelson, J Masel |
Proceedings of the National Academy of Sciences | 2017 |
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Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data
C Robins, AF McRae, JE Powell, HW Wiener, S Aslibekyan, EM Kennedy, DM Absher, DK Arnett, GW Montgomery, PM Visscher, DJ Cutler, KN Conneely |
Genetics | 2017 |
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Transcriptome-wide association study of inflammatory biologic age
H Lin, KL Lunetta, Q Zhao, J Rong, EJ Benjamin, MM Mendelson, R Joehanes, D Levy, MG Larson, JM Murabito |
Aging | 2017 |
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Environmental Deflection: The Impact of Toxicant Exposures on the Aging Epigenome
J Kochmanski, L Montrose, JM Goodrich, DC Dolinoy |
Toxicological Sciences | 2017 |
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Novel associations between blood DNA methylation and body mass index in middle-aged and older adults
YM Geurts, PA Dugué, JE Joo, E Makalic, CH Jung, W Guan, S Nguyen, ML Grove, EM Wong, AM Hodge, JK Bassett, LM FitzGerald, H Tsimiklis, L Baglietto, G Severi, DF Schmidt, DD Buchanan, RJ MacInnis, JL Hopper, JS Pankow, EW Demerath, MC Southey, GG Giles, DR English, RL Milne |
International Journal of Obesity | 2017 |
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The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment
Yoshioka H, Yoshiko Y |
International journal of molecular sciences | 2017 |
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Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice
J Kochmanski, EH Marchlewicz, M Savidge, L Montrose, C Faulk, DC Dolinoy |
Reproductive Toxicology | 2016 |
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Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study
F Ciccarone, M Malavolta, R Calabrese, T Guastafierro, MG Bacalini, A Reale, C Franceschi, M Capri, A Hervonen, M Hurme, B Grubeck-Loebenstein, B Koller, J Bernhardt, C Schӧn, PE Slagboom, O Toussaint, E Sikora, ES Gonos, N Breusing, T Grune, E Jansen, M Dollé, M Moreno-Villanueva, T Sindlinger, A Bürkle, M Zampieri, P Caiafa |
Aging Cell | 2016 |
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Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis
Y Okuchi, M Imajo, R Mizuno, Y Kamioka, H Miyoshi, MM Taketo, S Nagayama, Y Sakai, M Matsuda, M Plateroti |
PloS one | 2016 |
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Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
F Mirzamohammadi, G Papaioannou, JB Inloes, EB Rankin, H Xie, E Schipani, SH Orkin, T Kobayashi |
Nature Communications | 2016 |
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Novel regional age-associated DNA methylation changes within human common disease-associated loci
CG Bell, Y Xia, W Yuan, F Gao, K Ward, L Roos, M Mangino, PG Hysi, J Bell, J Wang, TD Spector |
Genome biology | 2016 |
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Longitudinal study of DNA methylation during the first 5 years of life
RG Urdinguio, MI Torró, GF Bayón, J Álvarez-Pitti, AF Fernández, P Redon, MF Fraga, E Lurbe |
Journal of Translational Medicine | 2016 |
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Reliability of DNA methylation measures from dried blood spots and mononuclear cells using the HumanMethylation450k BeadArray
PA Dugué, DR English, RJ MacInnis, CH Jung, JK Bassett, LM FitzGerald, EM Wong, JE Joo, JL Hopper, MC Southey, GG Giles, RL Milne |
Scientific Reports | 2016 |
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sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
A Kaur, MR Webster, K Marchbank, R Behera, A Ndoye, CH Kugel, VM Dang, J Appleton, MP OConnell, P Cheng, AA Valiga, R Morissette, NB McDonnell, L Ferrucci, AV Kossenkov, K Meeth, HY Tang, X Yin, WH Wood, E Lehrmann, KG Becker, KT Flaherty, DT Frederick, JA Wargo, ZA Cooper, MT Tetzlaff, C Hudgens, KM Aird, R Zhang, X Xu, Q Liu, E Bartlett, G Karakousis, Z Eroglu, RS Lo, M Chan, AM Menzies, GV Long, DB Johnson, J Sosman, B Schilling, D Schadendorf, DW Speicher, M Bosenberg, A Ribas, AT Weeraratna |
Nature | 2016 |
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Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
L Perna, Y Zhang, U Mons, B Holleczek, KU Saum, H Brenner |
Clinical Epigenetics | 2016 |
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Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
FA Choudry, M Frontini |
Stem Cells International | 2016 |
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The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences
S Sarkar, A Willbanks, M Greenshields, C Tyminski, S Heerboth, K Lapinska, K Haskins, M Leary |
Genetics & Epigenetics | 2016 |
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A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett’s Esophagus
K Curtius, CJ Wong, WD Hazelton, AM Kaz, A Chak, JE Willis, WM Grady, EG Luebeck, R Karchin |
PLoS computational biology | 2016 |
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Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis
H Tezval, N Dubrowinskaja, I Peters, C Reese, K Serth, F Atschekzei, J Hennenlotter, A Stenzl, MA Kuczyk, J Serth, JS Castresana |
PloS one | 2016 |
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Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases
Y Li, TO Tollefsbol |
Epigenomics | 2016 |
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Correlation of an epigenetic mitotic clock with cancer risk
Z Yang, A Wong, D Kuh, DS Paul, VK Rakyan, RD Leslie, SC Zheng, M Widschwendter, S Beck, AE Teschendorff |
Genome biology | 2016 |
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Phenotypic characteristics of aged CD4 + CD28 null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern
B Suarez-Álvarez, RM Rodríguez, K Schlangen, AB Raneros, L Márquez-Kisinousky, AF Fernández, C Díaz-Corte, AM Aransay, C López-Larrea |
Aging Cell | 2016 |
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Epigenetic Determinants of Cancer
SB Baylin, PA Jones |
Cold Spring Harbor perspectives in biology | 2016 |
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Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
D Avrahami, C Li, J Zhang, J Schug, R Avrahami, S Rao, MB Stadler, L Burger, D Schübeler, B Glaser, KH Kaestner |
Cell Metabolism | 2015 |
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Epigenetics in lung fibrosis: from pathobiology to treatment perspective
BA Helling, IV Yang |
Current Opinion in Pulmonary Medicine | 2015 |
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Lessons Learned About Prostatic Transformation from the Age-Related Methylation of 5α-Reductase Type 2 Gene
JT Isaacs |
The American Journal of Pathology | 2015 |
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Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes
N Acevedo, LE Reinius, M Vitezic, V Fortino, C Söderhäll, H Honkanen, R Veijola, O Simell, J Toppari, J Ilonen, M Knip, A Scheynius, H Hyöty, D Greco, J Kere |
Clinical Epigenetics | 2015 |
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DNA methylation dynamics in muscle development and disease
E Carrió |
Frontiers in aging neuroscience | 2015 |
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Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites
A Bellacosa, AC Drohat |
DNA repair | 2015 |
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Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging
M Jung, SG Jin, X Zhang, W Xiong, G Gogoshin, AS Rodin, GP Pfeifer |
Nucleic Acids Research | 2015 |
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Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis
KD Rasmussen, G Jia, JV Johansen, MT Pedersen, N Rapin, FO Bagger, BT Porse, OA Bernard, J Christensen, K Helin |
Genes & development | 2015 |
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Identification of Differentially Methylated Markers among Cytogenetic Risk Groups of Acute Myeloid Leukemia
X Qu, J Davison, L Du, B Storer, DL Stirewalt, S Heimfeld, E Estey, FR Appelbaum, M Fang |
Epigenetics : official journal of the DNA Methylation Society | 2015 |
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The Biology of Aging and Lymphoma: a Complex Interplay
C Sarkozy, G Salles, C Falandry |
Current Oncology Reports | 2015 |
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How the genome got a life span
M Lappé, H Landecker |
New Genetics and Society | 2015 |
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Impacts of Chromatin States and Long-Range Genomic Segments on Aging and DNA Methylation
D Sun, SV Yi, Y Zhang |
PloS one | 2015 |
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Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
Y Okugawa, WM Grady, A Goel |
Gastroenterology | 2015 |
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Patterns of gene expression and DNA methylation in human fetal and adult liver
SM Huse, PA Gruppuso, K Boekelheide, JA Sanders |
BMC Genomics | 2015 |
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Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors
AJ Levine, AI Phipps, JA Baron, DD Buchanan, DJ Ahnen, SA Cohen, NM Lindor, PA Newcomb, C Rosty, RW Haile, PW Laird, DJ Weisenberger |
Cancer epidemiology, biomarkers & prevention | 2015 |
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The cerebellum ages slowly according to the epigenetic clock
Horvath S, Mah V, Lu AT, Woo JS, Choi OW, Jasinska AJ, Riancho JA, Tung S, Coles NS, Braun J, Vinters HV, Coles LS |
Aging | 2015 |
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Age cutoff in lymphoma diagnosis
Ok CY, Young KH |
Aging | 2015 |
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At the Tipping Point for Epigenetic Therapies in Cancer
Peter A. Jones |
Journal of Clinical Investigation | 2014 |
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Epigenetics of hematopoietic stem cell aging and disease
M Oshima, A Iwama |
International Journal of Hematology | 2014 |
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Epigenetics of idiopathic pulmonary fibrosis
IV Yang, DA Schwartz |
Translational Research | 2014 |
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Longitudinal epigenetic drift in mice perinatally exposed to lead
C Faulk, K Liu, A Barks, JM Goodrich, DC Dolinoy |
Epigenetics : official journal of the DNA Methylation Society | 2014 |
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No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women: Effect of Weight Loss on LINE-1 Methylation
C Duggan, L Xiao, MB Terry, A McTiernan |
Obesity | 2014 |
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Linking the genetic architecture of cytosine modifications with human complex traits
X Zhang, EL Moen, C Liu, W Mu, ER Gamazon, SM Delaney, C Wing, LA Godley, ME Dolan, W Zhang |
Human Molecular Genetics | 2014 |
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Nutrition, the brain and cognitive decline: insights from epigenetics
MJ Dauncey |
European Journal of Clinical Nutrition | 2014 |
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Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery
RJ Felling, H Song |
Experimental Neurology | 2014 |
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The Molecular Pathogenesis of Colorectal Cancer and Its Potential Application to Colorectal Cancer Screening
WM Grady, SD Markowitz |
Digestive Diseases and Sciences | 2014 |
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Does epigenetic drift contribute to age-related increases in breast cancer risk?
SM Langevin, SM Pinney, YK Leung, SM Ho |
Epigenomics | 2014 |
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H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells
AF Fernández, GF Bayón, RG Urdinguio, EG Toraño, MG García, A Carella, S Petrus-Reurer, C Ferrero, P Martinez-Camblor, I Cubillo, J García-Castro, J Delgado-Calle, FM Pérez-Campo, JA Riancho, C Bueno, P Menéndez, A Mentink, K Mareschi, F Claire, C Fagnani, E Medda, V Toccaceli, S Brescianini, S Moran, M Esteller, A Stolzing, J Boer, L Nisticò, MA Stazi, MF Fraga |
Genome research | 2014 |
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