In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with
Qiuzhen Liu, Sara Tomei, Maria Libera Ascierto, Valeria De Giorgi, Davide Bedognetti, Cuilian Dai, Lorenzo Uccellini, Tara Spivey, Zoltan Pos, Jaime Thomas, Jennifer Reinboth, Daniela Murtas, Qianbing Zhang, Lotfi Chouchane, Geoffrey R. Weiss, Craig L. Slingluff Jr., Peter P. Lee, Steven A. Rosenberg, Harvey Alter, Kaitai Yao, Ena Wang, Francesco M. Marincola
Title and authors | Publication | Year |
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The role of nitric oxide in melanoma
K Yarlagadda, J Hassani, IP Foote, J Markowitz |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2017 |
The MAPK hypothesis: immune-regulatory effects of MAPK-pathway genetic dysregulations and implications for breast cancer immunotherapy
FM Marincola, D Bedognetti, J Roelands, J Decock, E Wang, W Hendrickx |
Emerging Topics in Life Sciences | 2017 |
Cancer immune resistance: can theories converge?
FM Marincola, R Lu, T Turan, J Samayoa, FM Marincola |
Emerging Topics in Life Sciences | 2017 |