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Abstract
Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-β and prostaglandin E2. Here they discuss the evolving relationship among apoptosis, phagocytosis, and inflammation.
Authors
Peter M. Henson, Donna L. Bratton
Figure 1
Responses of macrophages to recognition of apoptotic cells.
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(A ) The antiinflammatory effects outlined in the 1998 JCI paper (7 ). (B ) An outline of the broader concepts of such responses as seen 15 years later.
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