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Citations to this article

Coming of age: molecular drivers of aging and therapeutic opportunities
Christopher B. Newgard, Norman E. Sharpless
Christopher B. Newgard, Norman E. Sharpless
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):946-950. https://doi.org/10.1172/JCI68833.
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Review Series Article has an altmetric score of 2

Coming of age: molecular drivers of aging and therapeutic opportunities

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Abstract

Aging is like the weather: everyone talks about it, but no one seems to do anything about it. We believe this may soon change, as an improved understanding of the molecular and genetic pathways underlying aging suggests it is possible to therapeutically target the aging process and increase health span. This Review series focuses on fundamental cellular mechanisms of aging and their relationship to human disease. These pathways include telomere dysfunction in cellular senescence and induction of the senescence-associated secretory phenotype (SASP) in systemic aging, sirtuin family regulation of metabolism and aging-associated diseases, mitochondrial metabolism in aging, the mechanistic target of rapamycin (mTOR) signaling pathway and the use of mTOR inhibitors to increase longevity, the progressive decline of the immune system with age, and aging-associated changes to pancreatic islet β cells that may contribute to diabetes. Together, these articles explore pathways affecting aging and possible interventional targets to slow or delay the onset of age-related pathologies.

Authors

Christopher B. Newgard, Norman E. Sharpless

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Total
Citations: 4 8 8 6 7 12 4 8 2 7 6 7 4 83
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

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