Why stress is BAD for cancer patients
Archana S. Nagaraja, … , Susan K. Lutgendorf, Anil K. Sood
Archana S. Nagaraja, … , Susan K. Lutgendorf, Anil K. Sood
Published January 25, 2013
Citation Information: J Clin Invest. 2013;123(2):558-560. https://doi.org/10.1172/JCI67887.
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Commentary

Why stress is BAD for cancer patients

Abstract

Behavioral stress is known to promote tumor progression in experimental models, but the role of behavioral stress in cancer initiation is less clear. In this issue, Hassan et al. focus on the signaling and biological effects induced by stress hormones that lead to tumor cell evasion from apoptosis, resulting in prostate cancer progression.

Authors

Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Susan K. Lutgendorf, Anil K. Sood

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Figure 1

Hassan et al. explored the role of stress in two models of prostate cancer (9).

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Hassan et al. explored the role of stress in two models of prostate canc...
(A) In an androgen-independent Pten mutant model, signaling through the adrenergic receptor led to phosphorylation (and inactivation) of the proapoptotic molecule BAD, promoting survival of prostate cancer cells. (B) In an androgen-dependent model, stress signaling blocked apoptosis by the PKA/BAD pathway and contributed to androgen therapy resistance.