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Sudden death in epilepsy: of mice and men
Daniel Friedman, … , Janice Chyou, Orrin Devinsky
Daniel Friedman, … , Janice Chyou, Orrin Devinsky
Published March 25, 2013
Citation Information: J Clin Invest. 2013;123(4):1415-1416. https://doi.org/10.1172/JCI67759.
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The Attending Physician

Sudden death in epilepsy: of mice and men

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Abstract

A 20-year-old man with intellectual disability and intractable multifocal epilepsy presented to a neurologist for further evaluation and management. His seizures began at 4 months, the night after his first DPT vaccine, and he continued to have frequent tonic-clonic seizures throughout his life. Several weeks after his visit, he was found facedown on the floor, dead, by his family. His autopsy was unremarkable, but genetic testing revealed a frame shift mutation in SCN1A, consistent with severe myoclonic epilepsy of infancy (Dravet syndrome).

Authors

Daniel Friedman, Janice Chyou, Orrin Devinsky

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Figure 1

Schematic of proposed mechanisms of seizure-associated death in SUDEP.

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Schematic of proposed mechanisms of seizure-associated death in SUDEP.
S...
Seizures originate in cortical structures and can propagate to brainstem nuclei involved in the regulation of arousal (e.g., periaqueductal gray area), cardioregulatory reflexes (e.g., nucleus of the solitary tract), and respiratory nuclei in the ventromedial medulla and caudal raphe. Seizure-related activation and postictal suppression of these regions can lead to the following: (a) postictal coma, which can lead to loss of protective airway reflexes; (b) increased sympathetic activation of the heart and associated increased risk of arrhythmia or parasympathetic activation and associated risk of asystole; (c) decreased respiration drive and hypoventilation. Severe seizure-related derangements (indicated in red), either alone or in combination, would lead to death under the right environmental circumstances. HR, heart rate.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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