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Citations to this article

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Jeffrey J. Iliff, … , Maiken Nedergaard, Helene Benveniste
Jeffrey J. Iliff, … , Maiken Nedergaard, Helene Benveniste
Published February 22, 2013
Citation Information: J Clin Invest. 2013;123(3):1299-1309. https://doi.org/10.1172/JCI67677.
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Technical Advance Article has an altmetric score of 137

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

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Abstract

The glymphatic system is a recently defined brain-wide paravascular pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates efficient clearance of solutes and waste from the brain. CSF enters the brain along para-arterial channels to exchange with ISF, which is in turn cleared from the brain along para-venous pathways. Because soluble amyloid β clearance depends on glymphatic pathway function, we proposed that failure of this clearance system contributes to amyloid plaque deposition and Alzheimer’s disease progression. Here we provide proof of concept that glymphatic pathway function can be measured using a clinically relevant imaging technique. Dynamic contrast-enhanced MRI was used to visualize CSF-ISF exchange across the rat brain following intrathecal paramagnetic contrast agent administration. Key features of glymphatic pathway function were confirmed, including visualization of para-arterial CSF influx and molecular size-dependent CSF-ISF exchange. Whole-brain imaging allowed the identification of two key influx nodes at the pituitary and pineal gland recesses, while dynamic MRI permitted the definition of simple kinetic parameters to characterize glymphatic CSF-ISF exchange and solute clearance from the brain. We propose that this MRI approach may provide the basis for a wholly new strategy to evaluate Alzheimer’s disease susceptibility and progression in the live human brain.

Authors

Jeffrey J. Iliff, Hedok Lee, Mei Yu, Tian Feng, Jean Logan, Maiken Nedergaard, Helene Benveniste

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
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Frontiers in physiology 2023
The Synucleins and the Astrocyte
Myers AJ, Brahimi A, Jenkins IJ, Koob AO
Biology 2023
Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer’s disease and related dementias
Uchida Y, Kan H, Sakurai K, Oishi K, Matsukawa N
Frontiers in aging neuroscience 2023
High pulse pressure impairs cerebral artery endothelial function in young, but not old, mice
Winder NR, Reeve EH, Kronquist EK, Khurana A, Lee B, Nguyen T, Henson GD, Walker AE
Experimental Gerontology 2023
Transport Pathways and Kinetics of Cerebrospinal Fluid Tracers in Mouse Brain Observed by Dynamic Contrast-Enhanced MRI.
Zhu Y, Wang G, Kolluru C, Gu Y, Gao H, Zhang J, Wang Y, Wilson DL, Zhu X, Flask CA, Yu X
Research square 2023
Remission of insomnia in older adults treated with cognitive behavioral therapy for insomnia (CBT-I) reduces p16(INK4a) gene expression in peripheral blood: secondary outcome analysis from a randomized clinical trial.
Carroll JE, Olmstead R, Cole SW, Breen EC, Arevalo JM, Irwin MR
GeroScience 2023
Neuroimaging uncovers distinct relationships of glymphatic dysfunction and motor symptoms in Parkinson's disease.
Qin Y, He R, Chen J, Zhou X, Zhou X, Liu Z, Xu Q, Guo JF, Yan XX, Jiang N, Liao W, Taoka T, Wang D, Tang B
Journal of Neurology 2023
Restoration of aquaporin-4 polarization in the spinal glymphatic system by metformin in rats with painful diabetic neuropathy
Xu C, Wang F, Su C, Guo X, Li J, Lin J
NeuroReport 2023
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Gomolka RS, Hablitz LM, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y
eLife 2023
Neuroinflammation with increased glymphatic flow in a murine model of decompression sickness
Thom SR, Bhopale VM, Bhat AR, Arya AK, Ruhela D, Qiao G, Li X, Tang S, Xu S
Journal of neurophysiology 2023
Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries
Raicevic N, Forer JM, Ladrón-de-Guevara A, Du T, Nedergaard M, Kelley DH, Boster K
Research square 2023
The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI.
Alghanimy A, Martin C, Gallagher L, Holmes WM
PloS one 2023
Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
St-Pierre MK, Carrier M, González Ibáñez F, Khakpour M, Wallman MJ, Parent M, Tremblay MÈ
Journal of Neuroinflammation 2023
Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease
Wijesinghe P, Whitmore CA, Campbell M, Li C, Tsuyuki M, To E, Haynes J, Pham W, Matsubara JA
Frontiers in neuroscience 2023
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm.
Reiter RJ, Sharma R, Cucielo MS, Tan DX, Rosales-Corral S, Gancitano G, de Almeida Chuffa LG
Cellular and molecular life sciences : CMLS 2023
Continuous positive airway pressure (CPAP) increases CSF flow speed and glymphatic transport
Burhan Ozturk, Sunil Koundal, Ehab Al Bizri, Xinan Chen, Zachary Gursky, Feng Dai, Andrew Lim, Paul Heerdt, Jonathan Kipnis, Allen Tannenbaum, Hedok Lee, Helene Benveniste
JCI Insight 2023
Multisite harmonization of diffusion tensor image analysis along the perivascular space using the COMBined Association Test.
Saito Y, Kamagata K, Andica C, Taoka T, Tuerxun R, Uchida W, Takabayashi K, Owaki M, Yoshida S, Yamazaki K, Naganawa S, Aoki S
Japanese Journal of Radiology 2023
Neuronal Ndst1 depletion accelerates prion protein clearance and enhances survival in prion-infected mice
Patricia Aguilar-Calvo, Adela Malik, Daniel Sandoval, Christopher Barback, Christina Orru, Heidi Standke, Olivia Thomas, Chrissa Dwyer, Donald Pizzo, Jaidev Bapat, Katrin Soldau, Ryotaro Ogawa, Mckenzie Riley, K. Nilsson, Allison Kraus, Byron Caughey, Jeffrey Iliff, David Vera, Jeffrey Esko, Christina Sigurdson
PLoS pathogens 2023
The consequences of sleep deprivation on cognitive performance.
Khan MA, Al-Jahdali H
2023
Reproducibility of automated calculation technique for diffusion tensor image analysis along the perivascular space.
Saito Y, Kamagata K, Andica C, Uchida W, Takabayashi K, Yoshida S, Nakaya M, Tanaka Y, Kamiyo S, Sato K, Nishizawa M, Akashi T, Shimoji K, Wada A, Aoki S
Japanese Journal of Radiology 2023
The glymphatic system's role in traumatic brain injury-related neurodegeneration.
Peters ME, Lyketsos CG
Molecular Psychiatry 2023
Single nucleotide polymorphisms in aquaporin-4 associate with cognitive impairment status in people with HIV.
Tice C, Zhao H, Langford D
Journal of Neurovirology 2023
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma neurofilament light, a biomarker of injury severity
Butler T, Zhou L, Ozsahin I, Wang XH, Garetti J, Zetterberg H, Blennow K, Jamison K, de Leon MJ, Li Y, Kuceyeski A, Shah SA
2023
The stress of losing sleep: Sex-specific neurobiological outcomes
Wright CJ, Milosavljevic S, Pocivavsek A
Neurobiology of Stress 2023
Cerebrospinal Fluid–Basic Concepts Review
Czarniak N, Kamińska J, Matowicka-Karna J, Koper-Lenkiewicz OM
Biomedicines 2023
Glymphatic influx and clearance are accelerated by neurovascular coupling.
Holstein-Rønsbo S, Gan Y, Giannetto MJ, Rasmussen MK, Sigurdsson B, Beinlich FRM, Rose L, Untiet V, Hablitz LM, Kelley DH, Nedergaard M
Nature Neuroscience 2023
Age- and time-of-day dependence of glymphatic function in the human brain measured via two diffusion MRI methods
Han G, Zhou Y, Zhang K, Jiao B, Hu J, Zhang Y, Wang Z, Lou M, Bai R
Frontiers in aging neuroscience 2023
Glymphatic system impairment in corticobasal syndrome: diffusion tensor image analysis along the perivascular space (DTI-ALPS).
Saito Y, Kamagata K, Andica C, Uchida W, Takabayashi K, Yoshida S, Nakaya M, Tanaka Y, Kamio S, Sato K, Nishizawa M, Akashi T, Shimoji K, Wada A, Aoki S
Japanese Journal of Radiology 2023
Perivascular network segmentations derived from high-field MRI and their implications for perivascular and parenchymal mass transport in the rat brain.
Rey JA, Farid UM, Najjoum CM, Brown A, Magdoom KN, Mareci TH, Sarntinoranont M
Scientific Reports 2023
AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies
Düchs M, Blazevic D, Rechtsteiner P, Kenny C, Lamla T, Low S, Savistchenko J, Neumann M, Melki R, Schönberger T, Stierstorfer B, Wyatt D, Igney F, Ciossek T
npj Parkinson's Disease 2023
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain.
Segeroth M, Wachsmuth L, Gagel M, Albers F, Hess A, Faber C
Fluids and barriers of the CNS 2023
Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation
Galea I, Bandyopadhyay S, Bulters D, Humar R, Hugelshofer M, Schaer DJ
Stroke; a journal of cerebral circulation 2023
A SPECT-based method for dynamic imaging of the glymphatic system in rats
Sigurdsson B, Hauglund NL, Lilius TO, Mogensen FL, Mortensen KN, Beschorner N, Klinger L, Bærentzen SL, Rosenholm MP, Shalgunov V, Herth M, Mori Y, Nedergaard M
Journal of Cerebral Blood Flow & Metabolism 2023
The glymphatic system: a new perspective on brain diseases
Ding Z, Fan X, Zhang Y, Yao M, Wang G, Dong Y, Liu J, Song W
Frontiers in aging neuroscience 2023
In Vivo Distribution of Cerebrospinal Fluid Tracer in Human Upper Spinal Cord and Brain Stem
Erik Melin, Are H Pripp, Per Eide, Geir Ringstad
JCI Insight 2023
Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage
Chai CZ, Ho UC, Kuo LT
International journal of molecular sciences 2023
rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage
Liu Y, Liu X, Sun P, Li J, Nie M, Gong J, He A, Zhao M, Yang C, Wang Z
Brain and Behavior 2023
Sizes and shapes of perivascular spaces surrounding murine pial arteries
Raicevic N, Forer JM, Ladrón-de-Guevara A, Du T, Nedergaard M, Kelley DH, Boster K
Fluids and barriers of the CNS 2023
Physiological alterations of pineal recess crowding in symptomatic non-hydrocephalic pineal cysts
Eide PK, Lindstrøm EK, Pripp AH, Valnes LM, Ringstad G
2023
New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery
Qi Y, Xiong W, Chen Q, Ye Z, Jiang C, He Y, Ye Q
Journal of nanobiotechnology 2023
Intrathecal [(64)Cu]Cu-albumin PET reveals age-related decline of lymphatic drainage of cerebrospinal fluid.
Sarker A, Suh M, Choi Y, Park JY, Lee YS, Lee DS
Scientific Reports 2023
Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease
Rego S, Sanchez G, Da Mesquita S
Molecular Neurodegeneration 2023
Evaluation of glymphatic system activity using diffusion tensor image analysis along the perivascular space and amyloid PET in older adults with objectively normal cognition: a preliminary study
Park CJ, Kim SY, Kim JH, Son NH, Park JY, Jeong YH, Kim HJ, Park J, Kim WJ
Frontiers in aging neuroscience 2023
Glymphatic transport is reduced in rats with spontaneous pituitary tumor.
Li L, Ding G, Zhang L, Luo H, Davoodi-Bojd E, Li Q, Chopp M, Zhang ZG, Jiang Q
Frontiers in Medicine 2023
Mapping the Glymphatic Pathway Using Imaging Advances.
Thakkar RN, Kioutchoukova IP, Griffin I, Foster DT, Sharma P, Valero EM, Lucke-Wold B
Journal of IMAB - Annual Proceeding (Scientific Papers) 2023
Transport pathways and kinetics of cerebrospinal fluid tracers in mouse brain observed by dynamic contrast-enhanced MRI
Zhu Y, Wang G, Kolluru C, Gu Y, Gao H, Zhang J, Wang Y, Wilson DL, Zhu X, Flask CA, Yu X
Scientific Reports 2023
A bibliometric and knowledge-map analysis of the glymphatic system from 2012 to 2022
Hou C, Ren W, Wang B, Fu X, Liu Q, Li J, Zhang H, Wang W, Yang X, Wei P, Zhao G
Frontiers in molecular neuroscience 2023
Preliminary cross-sectional investigations into the human glymphatic system using multiple novel non-contrast MRI methods
Levendovszky SR, Flores J, Peskind ER, Václavů L, van Osch MJ, Iliff J
2023
Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson's disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings.
Mays GP, Hett K, Eisma J, McKnight CD, Elenberger J, Song AK, Considine C, Han C, Stark A, Claassen DO, Donahue MJ
Research square 2023
Assessment of factors influencing glymphatic activity and implications for clinical medicine
Gędek A, Koziorowski D, Szlufik S
Frontiers in neurology 2023
Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
Lee YJ, Park KM, Heo CM, Park S, Kim YW, Lee D, Kim Y, Oh JS, Shin HS, Park BS
Renal Failure 2023
Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents
Kim E, Van Reet J, Yoo SS
Scientific Reports 2023
Spontaneous vasomotion propagates along pial arterioles in the awake mouse brain like stimulus-evoked vascular reactivity
Munting LP, Bonnar O, Kozberg MG, Auger CA, Hirschler L, Hou SS, Greenberg SM, Bacskai BJ, van Veluw SJ
Journal of Cerebral Blood Flow & Metabolism 2023
Neurofluids and the glymphatic system: anatomy, physiology, and imaging
Wang DJ, Hua J, Cao D, Ho ML
British Journal of Radiology 2023
Imaging glymphatic response to glioblastoma
Kaur J, Ding G, Zhang L, Lu Y, Luo H, Li L, Boyd E, Li Q, Wei M, Zhang Z, Chopp M, Jiang Q
Cancer imaging : the official publication of the International Cancer Imaging Society 2023
The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance
Kaur J, Boyd E, Ding G, Zhang L, Luo H, Li Q, Li L, Wei M, Landschoot-Ward J, Chopp M, Zhang Z, Jiang Q
Research square 2023
Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome
Agarwal N, Lewis LD, Hirschler L, Rivera LR, Naganawa S, Levendovszky SR, Ringstad G, Klarica M, Wardlaw J, Iadecola C, Hawkes C, Octavia Carare R, Wells J, Bakker EN, Kurtcuoglu V, Bilston L, Nedergaard M, Mori Y, Stoodley M, Alperin N, de Leon M, van Osch MJ
Journal of magnetic resonance imaging : JMRI 2023
Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
Larrea A, Elexpe A, Díez-Martín E, Torrecilla M, Astigarraga E, Barreda-Gómez G
Current issues in molecular biology 2023
Real-time Quantification of in vivo cerebrospinal fluid velocity using fMRI inflow effect
Diorio TC, Nair VV, Patel NM, Hedges LE, Rayz VL, Tong Y
2023
Quantification of T1 and T2 of subarachnoid CSF: implications for water exchange between CSF and brain tissues
Jiang D, Gou Y, Wei Z, Hou X, Yedavalli V, Lu H
Magnetic Resonance in Medicine 2023
The Haptoglobin Response after Aneurysmal Subarachnoid Haemorrhage.
Bandyopadhyay S, Garland P, Gaastra B, Zolnourian A, Bulters D, Galea I
International journal of molecular sciences 2023
Impaired glymphatic system revealed by DTI-ALPS in cerebral palsy due to periventricular leukomalacia: relation with brain lesion burden and hand dysfunction.
Yin Y, Peng Y, Nie L, Li X, Xiao Y, Jiang H, Gao L, Liu H
Neuroradiology 2023
Dysfunction of the glymphatic system in childhood absence epilepsy
Pu W, Wei S, Qiu M, Chen X, Zou W, Ge Y, Qiu W
Frontiers in neuroscience 2023
Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease
Osuna-Ramos JF, Camberos-Barraza J, Torres-Mondragón LE, Rábago-Monzón ÁR, Camacho-Zamora A, Valdez-Flores MA, Angulo-Rojo CE, Guadrón-Llanos AM, Picos-Cárdenas VJ, Calderón-Zamora L, Magaña-Gómez JA, Norzagaray-Valenzuela CD, Cárdenas-Torres FI, De la Herrán-Arita AK
International journal of molecular sciences 2023
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases.
Zhang J, Liu S, Wu Y, Tang Z, Wu Y, Qi Y, Dong F, Wang Y
Cellular and Molecular Neurobiology 2023
Impaired cerebral interstitial fluid dynamics in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy
Hsu SL, Liao YC, Wu CH, Chang FC, Chen YL, Lai KL, Chung CP, Chen SP, Lee YC
2023
Imaging of brain clearance pathways via MRI assessment of the glymphatic system
He Y, Guan J, Lai L, Zhang X, Chen B, Wang X, Wu R
Aging 2023
Concurrent measurement of perfusion parameters related to small blood vessels and CSF circulation in the human brain using dynamic dual-spin-echo perfusion (DDSEP) MRI
Cao D, Sun Y, Li Y, Su P, Pillai JJ, Qiao Y, Lu H, Van Zijl PC, Knutsson L, Hua J
NMR in Biomedicine 2023
Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
Carrero L, Antequera D, Municio C, Carro E
Neural Regeneration Research 2023
Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for treatment of metastatic medulloblastoma
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM
Science Translational Medicine 2023
Effects of clamping end-tidal CO2 on neurofluidic low-frequency oscillations
Kish B, Jean Chen J, Tong Y
NMR in Biomedicine 2023
Blockage of CSF Outflow in Rats after Deep Cervical Lymph Node Ligation Observed Using Gd-based MR Imaging
Kinota N, Kameda H, Xiawei B, Fujii T, Kato D, Takahashi B, Morita R, Abo D, Majima R, Ishii H, Minowa K, Kudo K
Magnetic Resonance in Medical Sciences 2023
Gray matter reserve determines glymphatic system function in young-onset Alzheimer's disease: Evidenced by DTI-ALPS and compared with age-matched controls.
Chang HI, Huang CW, Hsu SW, Huang SH, Lin KJ, Ho TY, Ma MC, Hsiao WC, Chang CC
Psychiatry and clinical neurosciences 2023
Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice
Yann Decker, Jonas Krämer, Li Xin, Andreas Müller, Anja Scheller, Klaus Fassbender, Steven T Proulx
JCI Insight 2022
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline
Tuomas Lilius, Marko Rosenholm, Laura Klinger, Kristian Mortensen, Björn Sigurdsson, Frida Mogensen, Natalie Hauglund, Malthe Nielsen, Tomi Rantamäki, Maiken Nedergaard
iScience 2022
Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
E Candelario-Jalil, R Dijkhuizen, T Magnus
Stroke; a journal of cerebral circulation 2022
Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases
C Rickenbach, C Gericke
Frontiers in neuroscience 2022
Military traumatic brain injury: a challenge straddling neurology and psychiatry
L Kong, R Zhang, S Hu, J Lai
Military Medical Research 2022
Impediment of Cerebrospinal Fluid Drainage Through Glymphatic System in Glioma
D Xu, J Zhou, H Mei, H Li, W Sun, H Xu
Frontiers in Oncology 2022
The glymphatic hypothesis: the theory and the evidence
S Hladky, M Barrand
Fluids and barriers of the CNS 2022
Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment
M Li, A Kitamura, J Beverley, J Koudelka, J Duncombe, R Lennen, M Jansen, I Marshall, B Platt, U Wiegand, R Carare, R Kalaria, J Iliff, K Horsburgh
Frontiers in aging neuroscience 2022
Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review
P Chong, D Garic, M Shen, I Lundgaard, A Schwichtenberg
Sleep Medicine Reviews 2022
Immune dynamics in the CNS and its barriers during homeostasis and disease*
M Buckley, D McGavern
Immunological Reviews 2022
Interstitial Fluid Behavior and Diseases
W Liu, Y Cao, X Zhou, D Han
Advanced Science 2022
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
Y Li, H Rusinek, T Butler, L Glodzik, E Pirraglia, J Babich, P Mozley, S Nehmeh, S Pahlajani, X Wang, E Tanzi, L Zhou, S Strauss, R Carare, N Theise, N Okamura, M de Leon
Fluids and barriers of the CNS 2022
Gadolinium retention after contrast-enhanced magnetic resonance imaging: A narrative review
A Al-Muhanna
2022
Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis
A Zamani, A Walker, B Rollo, K Ayers, R Farah, T OBrien, D Wright
Translational Neurodegeneration 2022
Impaired Glymphatic Transport Kinetics Following Induced Acute Ischemic Brain Edema in a Mouse pMCAO Model
J Zhang, H Zhao, Y Xue, Y Liu, G Fan, H Wang, Q Dong, W Cao
Frontiers in neurology 2022
Aging-Related Alterations of Glymphatic Transport in Rat: In vivo Magnetic Resonance Imaging and Kinetic Study
L Li, G Ding, L Zhang, E Davoodi-Bojd, M Chopp, Q Li, Z Zhang, Q Jiang
Frontiers in aging neuroscience 2022
The Effects of Peripheral Inflammation on the Brain—A Neuroimaging Perspective
C Millett, K Burdick, M Kubicki
Harvard Review of Psychiatry 2022
Pulsatility Index in the Basal Ganglia Arteries Increases with Age in Elderly with and without Cerebral Small Vessel Disease
V Perosa, T Arts, A Assmann, H Mattern, O Speck, J Oltmer, H Heinze, E Düzel, S Schreiber, J Zwanenburg
American Journal of Neuroradiology 2022
TAT-HSP27 Peptide Improves Neurologic Deficits via Reducing Apoptosis After Experimental Subarachnoid Hemorrhage
X Zhou, J Sun, W Wang, S Li, H Li, H Yang, M Yang, H Yuan, Z Zhang, B Sun, J Han
Frontiers in cellular neuroscience 2022
Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model
R Kedarasetti, P Drew, F Costanzo
Fluids and barriers of the CNS 2022
Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders
D Zhang, X Li, B Li
Frontiers in aging neuroscience 2022
Periodontitis: Advances in Experimental Research
J Santi-Rocca
2022
Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain
S Keil, M Braun, R OBoyle, M Sevao, T Pedersen, S Agarwal, D Jansson, J Iliff
Neurophotonics 2022
Impaired Glymphatic System Actions in Obstructive Sleep Apnea Adults
B Roy, A Nunez, R Aysola, D Kang, S Vacas, R Kumar
Frontiers in neuroscience 2022
Perivascular Spaces, Glymphatic System and MR
L Yu, X Hu, H Li, Y Zhao
Frontiers in neurology 2022
[64Cu]Cu-Albumin Clearance Imaging to Evaluate Lymphatic Efflux of Cerebrospinal Space Fluid in Mouse Model
Sarker A, Suh M, Choi Y, Park JY, Kwon S, Kim H, Lee E, Seo H, Lee YS, Lee DS
Nuclear Medicine and Molecular Imaging 2022
Mesenchymal Stem Cells Improve Cognitive Impairment and Reduce Aβ Deposition via Promoting AQP4 Polarity and Relieving Neuroinflammation in Rats With Chronic Hypertension-Induced Cerebral Small-Vessel Disease
Liu XL, Ouyang FB, Hu LT, Sun P, Yang J, Sun YJ, Liao MS, Lan LF, Pei Z, Fan YH
Frontiers in aging neuroscience 2022
Meningeal and Visual Pathway Magnetic Resonance Imaging Analysis after Single and Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA)-Induced Disruption in Male and Female Mice
McNamara EH, Knutsen A, Korotcov A, Bosomtwi A, Liu J, Fu AH, Kostelnik C, Grillakis AA, Spencer H, Dardzinski B, McCabe JT
Journal of Neurotrauma 2022
Imaging perivascular space structure and function using brain MRI
Barisano G, Lynch KM, Sibilia F, Lan H, Shih NC, Sepehrband F, Choupan J
NeuroImage 2022
Aquaporin 4 Depolarization-Enhanced Transferrin Infiltration Leads to Neuronal Ferroptosis after Subarachnoid Hemorrhage in Mice
Liu Y, Wang Z, Cao C, Xu Z, Lu J, Shen H, Li X, Li H, Wu J, Chen G
Oxidative medicine and cellular longevity 2022
Brain Distribution of Drugs: Brain Morphology, Delivery Routes, and Species Differences.
Bourasset F, Auvity S, Thorne RG, Scherrmann JM
Handbook of experimental pharmacology 2022
Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight
Hupfeld KE, Richmond SB, McGregor HR, Schwartz DL, Luther MN, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Wood SJ, Bloomberg JJ, Mulavara AP, Silbert LC, Iliff JJ, Seidler RD, Piantino J
Scientific Reports 2022
Sensitivity analysis on a network model of glymphatic flow
Boster KA, Tithof J, Cook DD, Thomas JH, Kelley DH
Journal of The Royal Society Interface 2022
Glymphatic system dysfunction in temporal lobe epilepsy patients with hippocampal sclerosis
Lee DA, Park BS, Ko J, Park SH, Lee YJ, Kim IH, Park JH, Park KM
Epilepsia Open 2022
Sleep and Alzheimer: The Link
GAUR A, KALIAPPAN A, BALAN Y, SAKTHIVADIVEL V, MEDALA K, UMESH M
Mædica 2022
MRI-Based Demonstration of the Normal Glymphatic System in a Human Population: A Systematic Review
Lee MK, Cho SJ, Bae YJ, Kim JM
Frontiers in neurology 2022
The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
Tang J, Zhang M, Liu N, Xue Y, Ren X, Huang Q, Shi L, Fu J
Frontiers in aging neuroscience 2022
Evaluation of the Glymphatic System Using the DTI-ALPS Index in Patients with Spontaneous Intracerebral Haemorrhage
Zhang C, Sha J, Cai L, Xia Y, Li D, Zhao H, Meng C, Xu K
Oxidative medicine and cellular longevity 2022
Immediate impact of yogic breathing on pulsatile cerebrospinal fluid dynamics.
Yildiz S, Grinstead J, Hildebrand A, Oshinski J, Rooney WD, Lim MM, Oken B
Scientific Reports 2022
The glymphatic system: implications for drugs for central nervous system diseases.
Lohela TJ, Lilius TO, Nedergaard M
Nature reviews. Drug discovery 2022
Glymphatic system dysfunction in patients with cluster headache.
Kim J, Lee DA, Lee HJ, Park BS, Ko J, Park SH, Lee YJ, Kim IH, Park JH, Park KM
Brain and Behavior 2022
Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques.
Meseck EK, Guibinga G, Wang S, McElroy C, Hudry E, Mansfield K
Toxicologic pathology 2022
Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy.
Szu JI, Binder DK
Frontiers in cellular neuroscience 2022
The role of the parenchymal vascular system in cerebrospinal fluid tracer clearance.
Hu J, Shen Y, Fahmy LM, Krishnamurthy S, Li J, Zhang L, Chen Y, Haacke EM, Jiang Q
European Radiology 2022
Effects of Hippocampal Sparing Radiotherapy on Brain Microstructure-A Diffusion Tensor Imaging Analysis.
Dinkel JG, Lahmer G, Mennecke A, Hock SW, Richter-Schmidinger T, Fietkau R, Distel L, Putz F, Dörfler A, Schmidt MA
Brain Sciences 2022
Biodistribution Analysis of an Anti-EGFR Antibody in the Rat Brain: Validation of CSF Microcirculation as a Viable Pathway to Circumvent the Blood-Brain Barrier for Drug Delivery.
Naseri Kouzehgarani G, Kumar P, Bolin SE, Reilly EB, Lefebvre DR
Pharmaceutics 2022
Glymphatic system dysfunction in patients with early chronic kidney disease.
Heo CM, Lee DA, Park KM, Lee YJ, Park S, Kim YW, Ko J, Yoo BC, Park BS
Frontiers in neurology 2022
Assessing pulsatile waveforms of paravascular cerebrospinal fluid dynamics using dynamic diffusion-weighted imaging (dDWI)
Wen Q, Tong Y, Zhou X, Dzemidzic M, Ho CY, Wu YC
NeuroImage 2022
Human CSF movement influenced by vascular low frequency oscillations and respiration
Vijayakrishnan Nair V, Kish BR, Inglis B, Yang HC, Wright AM, Wu YC, Zhou X, Schwichtenberg AJ, Tong Y
Frontiers in physiology 2022
Ocular Lymphatic and Glymphatic Systems: Implications for Retinal Health and Disease.
Uddin N, Rutar M
International journal of molecular sciences 2022
The glymphatic system: Current understanding and modeling.
Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M
iScience 2022
Effect of cerebral small vessel disease on cognitive impairment in Parkinson's disease.
Shen Y, Dong Z, Zhong J, Pan P, Xu G, Zhang Z, Zhang X, Shi H
Acta Neurologica Belgica 2022
The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis
Buccellato FR, D\u2019Anca M, Serpente M, Arighi A, Galimberti D
Biomedicines 2022
The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
Zhao Z, He J, Chen Y, Wang Y, Wang C, Tan C, Liao J, Xiao G
Frontiers in molecular neuroscience 2022
Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand WE, Benveniste H
2022
Plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy induced by type 2 diabetes mellitus
Wang G, Wang F, He Y, Lin J
Journal of Neuroscience Research 2022
Gadolinium Retention in the Brain of Mother and Pup Mouse: Effect of Pregnancy and Repeated Administration of Gadolinium‐Based Contrast Agents
Yao X, Zhang H, Shi D, Li Y, Guo Q, Yu Z, Wang S, Ren K
Journal of Magnetic Resonance Imaging 2022
Editorial: Natural products and brain energy metabolism: Astrocytes in neurodegenerative diseases
Wang F, Xu S, Pan F, Verkhratsky A, Huang JH
Frontiers in pharmacology 2022
High-resolution 3D demonstration of regional heterogeneity in the glymphatic system
He XZ, Li X, Li ZH, Meng JC, Mao RT, Zhang XK, Zhang RT, Huang HL, Gui Q, Xu GY, Wang LH
Journal of Cerebral Blood Flow & Metabolism 2022
Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders.
Jiang Y, Zou D, Li Y, Gu S, Dong J, Ma X, Xu S, Wang F, Huang JH
Pharmaceuticals (Basel, Switzerland) 2022
Perivascular spaces as a potential biomarker of Alzheimer's disease.
Lynch M, Pham W, Sinclair B, O'Brien TJ, Law M, Vivash L
Frontiers in neuroscience 2022
Technical feasibility of using auditory phase-targeted stimulation after pediatric severe traumatic brain injury in an intensive care setting.
Albrecht JN, Jaramillo V, Huber R, Karlen W, Baumann CR, Brotschi B
BMC Pediatrics 2022
Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
Postnikov EB, Lavrova AI, Postnov DE
International journal of molecular sciences 2022
Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults
Blackman J, Stankeviciute L, Arenaza-Urquijo EM, Suárez-Calvet M, Sánchez-Benavides G, Vilor-Tejedor N, Iranzo A, Molinuevo JL, Gispert JD, Coulthard E, Grau-Rivera O
2022
Hypothermia reduces glymphatic transportation in traumatic edematous brain assessed by intrathecal dynamic contrast-enhanced MRI
Bai Y, Yuan M, Mi H, Zhang F, Liu X, Lu C, Bao Y, Li Y, Lu Q
Frontiers in neurology 2022
Neural Stem Cells in Adult Mammals are not Astrocytes
Velloso FJ, Shankar S, Parpura V, Rakic P, Levison SW
ASN NEURO 2022
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease
Scott-Massey A, Boag MK, Magnier A, Bispo DP, Khoo TK, Pountney DL
International journal of molecular sciences 2022
Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition
Princiotta Cariddi L, Mauri M, Cosentino M, Versino M, Marino F
International journal of molecular sciences 2022
Glymphatic system impairment in patients with status epilepticus.
Lee DA, Lee J, Park KM
Neuroradiology 2022
An Alzheimer’s Disease Mechanism Based on Early Pathology, Anatomy, Vascular-Induced Flow, and Migration of Maximum Flow Stress Energy Location with Increasing Vascular Disease
Trumbore CN, Raghunandan A
Journal of Alzheimer's disease : JAD 2022
Management of Sleep Disturbances in Parkinson’s Disease
Schütz L, Sixel-Döring F, Hermann W
Journal of Parkinson's disease 2022
The lymphatic drainage systems in the brain: a novel target for ischemic stroke?
Wang YJ, Sun YR, Pei YH, Ma HW, Mu YK, Qin LH, Yan JH
Neural Regeneration Research 2022
Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease
Saavedra J, Nascimento M, Liz MA, Cardoso I
Frontiers in Cell and Developmental Biology 2022
A critical guide to the automated quantification of perivascular spaces in magnetic resonance imaging
Pham W, Lynch M, Spitz G, O\u2019Brien T, Vivash L, Sinclair B, Law M
Frontiers in neuroscience 2022
Variances of quantifying of Virchow–Robin spaces detecting the different functional status of glymphatic system in simple febrile seizures affected by seizures duration
Li X, Ruan C, Wu Y, Musa M, Zibrila AI, Zhang Z, Salimeen M
Medicine 2022
Cisternostomy for malignant middle cerebral artery infarction: proposed pathophysiological mechanisms and preliminary results
Cardali SM, Caffo M, Caruso G, Scalia G, Gorgoglione N, Conti A, Vinci SL, Barresi V, Granata F, Ricciardo G, Garufi G, Raffa G, Germanò A
2022
CSF Dynamics: Implications for Hydrocephalus and Glymphatic Clearance
Bissenas A, Fleeting C, Patel D, Al-Bahou R, Patel A, Nguyen A, Woolridge M, Angelle C, Lucke-Wold B
2022
Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
Riba M, del Valle J, Molina-Porcel L, Pelegrí C, Vilaplana J
Proceedings of the National Academy of Sciences 2022
The Lymphatic System in Neurological Disease and Alzheimer's Disease. A Brief Editorial.
Pappolla MA, Carare RO, Poeggeler B, Wisniewski T, Sambamurti K
Current Alzheimer research 2022
Enlarged perivascular spaces are associated with decreased brain tau deposition
Kang KM, Byun MS, Yi D, Lee KH, Kim MJ, Ahn H, Jung G, Lee J, Kim YK, Lee Y, Sohn C, Lee DY
CNS Neuroscience & Therapeutics 2022
Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease.
Mehta NH, Suss RA, Dyke JP, Theise ND, Chiang GC, Strauss S, Saint-Louis L, Li Y, Pahlajani S, Babaria V, Glodzik L, Carare RO, de Leon MJ
Neurobiology of Disease 2022
Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI
Moses J, Sinclair B, Law M, O'Brien TJ, Vivash L
Journal of Magnetic Resonance Imaging 2022
Radiological biomarkers of idiopathic normal pressure hydrocephalus: new approaches for detecting concomitant Alzheimer's disease and predicting prognosis.
Cai H, Zou Y, Gao H, Huang K, Liu Y, Cheng Y, Liu Y, Zhou L, Zhou D, Chen Q
2022
Direct imaging of glymphatic transport using H2O17 MRI
Mohammed Alshuhri, Lindsay Gallagher, Lorraine M. Work, William M Holmes
JCI Insight 2021
Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke
X Zhou, Y Li, C Lenahan, Y Ou, M Wang, Y He
Frontiers in aging neuroscience 2021
CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
SP das Neves, N Delivanoglou, SD Mesquita
Frontiers in pharmacology 2021
Basal lamina changes in neurodegenerative disorders
B Nguyen, G Bix, Y Yao
Molecular Neurodegeneration 2021
Waste Clearance in the Brain
J Kaur, LM Fahmy, E Davoodi-Bojd, L Zhang, G Ding, J Hu, Z Zhang, M Chopp, Q Jiang
Frontiers in neuroanatomy 2021
Localized Modification of Water Molecule Transport After Focused Ultrasound-Induced Blood–Brain Barrier Disruption in Rat Brain
M Han, H Seo, H Choi, EH Lee, J Park
Frontiers in neuroscience 2021
Water exchange rate across the blood‐brain barrier is associated with CSF amyloid‐β 42 in healthy older adults
BT Gold, X Shao, TL Sudduth, GA Jicha, DM Wilcock, ER Seago, DJ Wang
Alzheimer's & dementia : the journal of the Alzheimer's Association 2021
Contrasting Metabolic Insufficiency in Aging and Dementia
DA Turner
Aging and disease 2021
A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms
K Segawa, Y Blumenthal, Y Yamawaki, Ohtsuki
Biology : open access journal 2021
Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
K Albert, J Niskanen, S Kälvälä, Š Lehtonen
International journal of molecular sciences 2021
Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans
V Fleischer, G Gonzalez-Escamilla, D Ciolac, P Albrecht, P Küry, J Gruchot, M Dietrich, C Hecker, T Müntefering, S Bock, M Oshaghi, A Radetz, M Cerina, J Krämer, L Wachsmuth, C Faber, H Lassmann, T Ruck, SG Meuth, M Muthuraman, S Groppa
Proceedings of the National Academy of Sciences 2021
Imaging Extracellular Acidification and Immune Activation in Cancer
F Hyder, D Coman
Current Opinion in Biomedical Engineering 2021
Mapping Solute Clearance From the Mouse Hippocampus Using a 3D Imaging Cryomicrotome
DM Naessens, JG Dobbe, J de Vos, E VanBavel, EN Bakker
Frontiers in neuroscience 2021
Transient changes in white matter microstructure during general anesthesia
CY Tang, VX Wang, MY Lun, JS Mincer, JC Ng, JW Brallier, AE Schwartz, H Ahn, PJ McCormick, T Nir, B Delman, M Sano, SG Deiner, MG Baxter, Q Jiang
PloS one 2021
Woes with flows under pressure
DJ Jansson, JJ Iliff
2021
No Arachnoid Granulations—No Problems: Number, Size, and Distribution of Arachnoid Granulations From Birth to 80 Years of Age
M Radoš, M Živko, A Periša, D Orešković, M Klarica
Frontiers in aging neuroscience 2021
Electroacupuncture Improves Clearance of Amyloid-β through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer’s Disease
P Liang, L Li, Y Zhang, Y Shen, L Zhang, J Zhou, Z Wang, S Wang, S Yang, F Zhang
Neural plasticity 2021
Modeling Pharmacokinetics and Pharmacodynamics of Therapeutic Antibodies: Progress, Challenges, and Future Directions
Y Tang, Y Cao
Pharmaceutics 2021
Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study
T Taoka, R Ito, R Nakamichi, K Kamagata, M Sakai, H Kawai, T Nakane, T Abe, K Ichikawa, J Kikuta, S Aoki, S Naganawa
Japanese Journal of Radiology 2021
All Central Nervous System Neuro- and Vascular-Communication Channels Are Surrounded With Cerebrospinal Fluid
LM Fahmy, Y Chen, S Xuan, EM Haacke, J Hu, Q Jiang
Frontiers in neurology 2021
Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
H Benveniste, H Lee, B Ozturk, X Chen, S Koundal, P Vaska, A Tannenbaum, ND Volkow
Neuroscience 2021
Case report: Manual therapies promote resolution of persistent post-concussion symptoms in a 24-year-old athlete
SV Kratz
SAGE Open Medical Case Reports 2021
A proposed framework for cerebral venous congestion
A Arun, MR Amans, N Higgins, W Brinjikji, M Sattur, SR Satti, P Nakaji, M Luciano, TA Huisman, A Moghekar, VM Pereira, R Meng, K Fargen, FK Hui
The neuroradiology journal 2021
Link between Mild Traumatic Brain Injury, Poor Sleep, and Magnetic Resonance Imaging: Visible Perivascular Spaces in Veterans
J Piantino, DL Schwartz, M Luther, C Newgard, L Silbert, M Raskind, K Pagulayan, N Kleinhans, J Iliff, E Peskind
Journal of Neurotrauma 2021
Accumulation of Macromolecules in Idiopathic Normal Pressure Hydrocephalus
Y AKIYAMA, R YOKOYAMA, H TAKASHIMA, Y KAWATA, M ARIHARA, R CHIBA, Y KIMURA, T MIKAMI, N MIKUNI
Neurologia medico-chirurgica 2021
Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics
BO Ozturk, B Monte, S Koundal, F Dai, H Benveniste, H Lee
Fluids and barriers of the CNS 2021
Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline
F Han, GL Brown, Y Zhu, AE BelkinRosen, MM Lewis, G Du, Y Gu, PJ Eslinger, RB Mailman, X Huang, X Liu
Movement disorders : official journal of the Movement Disorder Society 2021
Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting
S Naganawa, R Ito, Y Kato, H Kawai, T Taoka, T Yoshida, K Maruyama, K Murata, G Körzdörfer, J Pfeuffer, M Nittka, M Sone
Magnetic Resonance in Medical Sciences 2021
Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration
S Naganawa, R Ito, R Nakamichi, M Kawamura, H Kawai, T Taoka, T Yoshida, M Sone
Magnetic Resonance in Medical Sciences 2021
The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage
E Liu, X Peng, H Ma, Y Zhang, X Yang, Y Zhang, L Sun, J Yan
Frontiers in aging neuroscience 2021
Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer’s Disease
D Reimers, M Vallejo-Muñoz, MJ Casarejos, A Jimenez-Escrig, R Gonzalo-Gobernado, E Bazan
International journal of molecular sciences 2021
Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients
K Chatterjee, N Atay, D Abler, S Bhargava, P Sahoo, RC Rockne, JM Munson
Pharmaceutics 2021
Research on the Glial–Lymphatic System and Its Relationship With Alzheimer’s Disease
D Ding, X Wang, Q Li, L Li, J Wu
Frontiers in neuroscience 2021
Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration
Y Hatakawa, A Tanaka, T Furubayashi, R Nakamura, M Konishi, T Akizawa, T Sakane
Pharmaceutics 2021
Extracellular fluid, cerebrospinal fluid and plasma biomarkers of axonal and neuronal injury following intracerebral hemorrhage
L Tobieson, H Zetterberg, K Blennow, N Marklund
Scientific Reports 2021
Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion
NW Churchill, AP Battista, SG Rhind, D Richards, TA Schweizer, MG Hutchison, MA Deli
PloS one 2021
Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit
A Gilbert, X Elorza-Vidal, A Rancillac, A Chagnot, M Yetim, V Hingot, T Deffieux, AC Boulay, R Alvear-Perez, S Cisternino, S Martin, S Taïb, A Gelot, V Mignon, M Favier, I Brunet, X Declèves, M Tanter, R Estevez, D Vivien, B Saubaméa, M Cohen-Salmon
eLife 2021
The Glymphatic System: A Novel Component of Fundamental Neurobiology
LM Hablitz, M Nedergaard
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021
Quantitative analysis of macroscopic solute transport in the murine brain
LA Ray, M Pike, M Simon, JJ Iliff, JJ Heys
Fluids and barriers of the CNS 2021
Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
X Ma, S Li, C Li, R Wang, M Chen, H Chen, W Su
Frontiers in aging neuroscience 2021
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
L Zhang, H Xu, N Ding, X Li, X Chen, Z Chen
Frontiers in physiology 2021
Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis
R Ni
International journal of molecular sciences 2021
Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex
V Perosa, J Oltmer, LP Munting, WM Freeze, CA Auger, AA Scherlek, AJ van der Kouwe, JE Iglesias, A Atzeni, BJ Bacskai, A Viswanathan, MP Frosch, SM Greenberg, SJ van Veluw
Acta Neuropathologica 2021
An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension
J Kikuta, K Kamagata, K Takabayashi, T Taoka, H Yokota, C Andica, A Wada, Y Someya, Y Tamura, R Kawamori, H Watada, S Naganawa, S Aoki
American Journal of Neuroradiology 2021
The bidirectional link between sleep disturbances and traumatic brain injury symptoms: A role for glymphatic dysfunction?
J Piantino, J Iliff, M Lim
Biological Psychiatry 2021
Cerebrospinal fluid‐tissue exchange revealed by phase alternate labeling with null recovery MRI
A Li, J Xu
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2021
Age‐dependent cerebrospinal fluid‐tissue water exchange detected by magnetization transfer indirect spin labeling MRI
A Li, L Chen, H Liu, Y Li, W Duan, J Xu
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2021
Fluid Transport in the Brain
M Rasmussen, H Mestre, M Nedergaard
Physiological reviews 2021
A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes
Y Fang, L Huang, X Wang, X Si, C Lenahan, H Shi, A Shao, J Tang, S Chen, J Zhang, J Zhang
Journal of Cerebral Blood Flow & Metabolism 2021
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
M Salman, P Kitchen, A Halsey, M Wang, S Törnroth-Horsefield, A Conner, J Badaut, J Iliff, R Bill
Brain 2021
The blood cerebrospinal fluid barrier orchestrates immunosurveillance, immunoprotection, and immunopathology in the central nervous system
Ayub M, Jin HK, Bae JS
BMB Reports 2021
Contrast Enhancement of the Normal Infundibular Recess Using Heavily T2-weighted 3D FLAIR.
Osawa I, Kozawa E, Yamamoto Y, Tanaka S, Shiratori T, Kaizu A, Inoue K, Niitsu M
2021
Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis
Jason Millward, Paula Ramos Delgado, Alina Smorodchenko, Laura Boehmert, Joao S. Periquito, Henning M. Reimann, Christian Prinz, Antje Els, Michael Scheel, Judith Bellmann-Strobl, Helmar Waiczies, Jens Wuerfel, Carmen Infante-Duarte, Claudia Chien, Joseph Kuchling, Andreas Pohlmann, Frauke Zipp, Friedemann Paul, Thoralf Niendorf, Sonia Waiczies
JCI Insight 2020
Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model
IF Harrison, O Ismail, A Machhada, N Colgan, Y Ohene, P Nahavandi, Z Ahmed, A Fisher, S Meftah, TK Murray, OP Ottersen, EA Nagelhus, MJ ONeill, JA Wells, MF Lythgoe
Brain 2020
Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels
GC Rosu, B Catalin, TA Balseanu, M Laurentiu, M Claudiu, S Kumar-Singh, P Daniel
Molecular Neurobiology 2020
Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system
NB Bèchet, TM Kylkilahti, B Mattsson, M Petrasova, NC Shanbhag, I Lundgaard
Journal of Cerebral Blood Flow & Metabolism 2020
Androgens’ effects on cerebrovascular function in health and disease
C Abi-Ghanem, LS Robison, KL Zuloaga
Biology of sex differences 2020
Perivascular spaces in the brain: anatomy, physiology and pathology
JM Wardlaw, H Benveniste, M Nedergaard, BV Zlokovic, H Mestre, H Lee, FN Doubal, R Brown, J Ramirez, BJ MacIntosh, A Tannenbaum, L Ballerini, RL Rungta, D Boido, M Sweeney, A Montagne, S Charpak, A Joutel, KJ Smith, SE Black
Nature Reviews Neurology 2020
A Review of Hematoma Components Clearance Mechanism After Subarachnoid Hemorrhage
P Pan, L Xu, H Zhang, Y Liu, X Lu, G Chen, H Tang, J Wu
Frontiers in neuroscience 2020
A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
MS Stringer, H Lee, MT Huuskonen, BJ MacIntosh, R Brown, A Montagne, S Atwi, J Ramirez, MA Jansen, I Marshall, SE Black, BV Zlokovic, H Benveniste, JM Wardlaw
Translational Stroke Research 2020
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
J Machhi, BD Kevadiya, IK Muhammad, J Herskovitz, KE Olson, RL Mosley, HE Gendelman
Molecular Neurodegeneration 2020
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects
T Kiss, Á Nyúl-Tóth, P Balasubramanian, S Tarantini, C Ahire, A Yabluchanskiy, T Csipo, E Farkas, JD Wren, L Garman, A Csiszar, Z Ungvari
GeroScience 2020
Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats
S Bussi, A Coppo, R Celeste, A Fanizzi, AF Mingo, A Ferraris, C Botteron, MA Kirchin, F Tedoldi, F Maisano
Insights into Imaging 2020
Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor
C Debaker, B Djemai, L Ciobanu, T Tsurugizawa, DL Bihan, Q Jiang
PloS one 2020
Magnetic Resonance Imaging and Modeling of the Glymphatic System
J Kaur, E Davoodi-Bojd, LM Fahmy, L Zhang, G Ding, J Hu, Z Zhang, M Chopp, Q Jiang
Diagnostics 2020
Methods to measure, model and manipulate fluid flow in brain
K Chatterjee, CM Carman-Esparza, JM Munson
Journal of Neuroscience Methods 2020
Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy
H Lee, F Xu, X Liu, S Koundal, X Zhu, J Davis, D Yanez, J Schrader, A Stanisavljevic, DL Rothman, J Wardlaw, WE Nostrand, H Benveniste
Journal of Cerebral Blood Flow & Metabolism 2020
Brain Glymphatic/Lymphatic Imaging by MRI and PET
DS Lee, M Suh, A Sarker, Y Choi
Nuclear Medicine and Molecular Imaging 2020
In vivo T1 mapping for quantifying glymphatic system transport and cervical lymph node drainage
Y Xue, X Liu, S Koundal, S Constantinou, F Dai, L Santambrogio, H Lee, H Benveniste
Scientific Reports 2020
MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury
L Li, M Chopp, G Ding, E Davoodi-Bojd, L Zhang, Q Li, Y Zhang, Y Xiong, Q Jiang
Brain Research 2020
In vivo assessment of cerebrospinal fluid efflux to nasal mucosa in humans
E Melin, PK Eide, G Ringstad
Scientific Reports 2020
Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents
D Ye, J Luan, H Pang, Y Yang, A Nazeri, JB Rubin, H Chen
Journal of Controlled Release 2020
CSF Surfactant Protein Changes in Preterm Infants After Intraventricular Hemorrhage
M Krause, W Härtig, CV Mahr, C Richter, J Schob, J Puchta, KT Hoffmann, U Nestler, U Thome, M Knüpfer, C Gebauer, S Schob
Frontiers in Pediatrics 2020
Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance
W Feng, Y Zhang, Z Wang, H Xu, T Wu, C Marshall, J Gao, M Xiao
Alzheimer's research & therapy 2020
Current Techniques for Investigating the Brain Extracellular Space
FN Soria, C Miguelez, O Peñagarikano, J Tønnesen
Frontiers in neuroscience 2020
Apolipoprotein A‐I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high‐density lipoproteins assembled by ABCA1 and LCAT
M Tsujita, B Vaisman, L Chengyu, KC Vickers, K Okuhira, S BraeschAndersen, AT Remaley
FEBS Letters 2020
Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?
C Tice, J McDevitt, D Langford
Frontiers in Cellular and Infection Microbiology 2020
The Role of Basement Membranes in Cerebral Amyloid Angiopathy
MD Howe, LD McCullough, A Urayama
Frontiers in physiology 2020
Regional Differences in Penetration of the Protein Stabilizer Trimethoprim (TMP) in the Rat Central Nervous System
BV Ineichen, SD Palma, E Laczko, SA Liddelow, S Neumann, ME Schwab, AC Mosberger
Frontiers in molecular neuroscience 2020
Intrathecal 99m Tc‐DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans
A Verma, JY Hesterman, JL Chazen, R Holt, P Connolly, L Horky, S Vallabhajosula, PD Mozley
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2020
Apparent diffusion coefficient estimates based on 24 hours tracer movement support glymphatic transport in human cerebral cortex
LM Valnes, SK Mitusch, G Ringstad, PK Eide, SW Funke, KA Mardal
Scientific Reports 2020
Physiology of Astroglial Excitability
A Verkhratsky, A Semyanov, R Zorec
2020
Medical Image Computing and Computer Assisted Intervention – MICCAI 2020: 23rd International Conference, Lima, Peru, October 4–8, 2020, Proceedings, Part VII
AL Martel, P Abolmaesumi, D Stoyanov, D Mateus, MA Zuluaga, SK Zhou, D Racoceanu, L Joskowicz
2020
Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
M Halvorsen, CS Edeklev, J Fraser-Green, G Løvland, SA Vatnehol, Ø Gjertsen, B Nedregaard, R Sletteberg, G Ringstad, PK Eide
Neuroradiology 2020
Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry
Y Zhang, J Song, XZ He, J Xiong, R Xue, JH Ge, SY Lu, D Hu, GX Zhang, GY Xu, LH Wang
Neuroscience Bulletin 2020
The anterior eye chamber: entry of the natural excretion pathway of gadolinium contrast agents?
K Deike-Hofmann, P von Lampe, HP Schlemmer, N Bechrakis, C Kleinschnitz, M Forsting, A Radbruch
European Radiology 2020
Guide to preclinical models used to study the pathophysiology of idiopathic intracranial hypertension
Z Alimajstorovic, CS Westgate, RH Jensen, S Eftekhari, J Mitchell, V Vijay, SY Seneviratne, SP Mollan, AJ Sinclair
Eye 2020
The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices
OC Reddy, YD van der Werf
Brain Sciences 2020
Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System
S Koundal, R Elkin, S Nadeem, Y Xue, S Constantinou, S Sanggaard, X Liu, B Monte, F Xu, WV Nostrand, M Nedergaard, H Lee, J Wardlaw, H Benveniste, A Tannenbaum
Scientific Reports 2020
Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective
T Taoka, S Naganawa
Korean Journal of Radiology 2020
Cerebrospinal fluid influx drives acute ischemic tissue swelling
H Mestre, T Du, AM Sweeney, G Liu, AJ Samson, W Peng, KN Mortensen, FF Stæger, PA Bork, L Bashford, ER Toro, J Tithof, DH Kelley, JH Thomas, PG Hjorth, EA Martens, RI Mehta, O Solis, P Blinder, D Kleinfeld, H Hirase, Y Mori, M Nedergaard
Science 2020
Role of aquaporins in hydrocephalus: what do we know and where do we stand? A systematic review
C de Laurentis, P Cristaldi, A Arighi, C Cavandoli, A Trezza, EP Sganzerla, CG Giussani, AD Cristofori
Journal of Neurology 2020
The glymphatic system and its role in cerebral homeostasis
H Benveniste, R Elkin, PM Heerdt, S Koundal, Y Xue, H Lee, J Wardlaw, A Tannenbaum
Journal of applied physiology 2020
The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation
Y Li, H Han, K Shi, D Cui, J Yang, IL Alberts, L Yuan, G Zhao, R Wang, X Cai, Z Teng
Aging and disease 2020
Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging
M Brady, A Rahman, A Combs, C Venkatraman, RT Kasper, C McQuaid, WC Kwok, RW Wood, R Deane
Fluids and barriers of the CNS 2020
A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by 18F-positron emitting tomography and fluorescence
H Guo, H Kommidi, CC Lekaye, J Koutcher, MS Judenhofer, SR Cherry, AP Wu, O Akin, MM Souweidane, O Aras, Z Zhu, R Ting
EJNMMI Research 2020
In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus
HH Jacobsen, T Sandell, ØK Jørstad, MC Moe, G Ringstad, PK Eide
Investigative ophthalmology & visual science 2020
Determinants of Intraparenchymal Infusion Distributions: Modeling and Analyses of Human Glioblastoma Trials
M Brady, R Raghavan, J Sampson
Pharmaceutics 2020
Neurons, Glia, Extracellular Matrix and Neurovascular Unit: A Systems Biology Approach to the Complexity of Synaptic Plasticity in Health and Disease
CD Luca, AM Colangelo, A Virtuoso, L Alberghina, M Papa
International journal of molecular sciences 2020
Fast whole brain MR imaging of dynamic susceptibility contrast changes in the cerebrospinal fluid (cDSC MRI)
D Cao, N Kang, JJ Pillai, X Miao, A Paez, X Xu, J Xu, X Li, Q Qin, PC Zijl, P Barker, J Hua
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2020
Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases
G Yang, N Deng, Y Liu, Y Gu, X Yao
Frontiers in human neuroscience 2020
Retention of Gadolinium in Brain Parenchyma: Pathways for Speciation, Access, and Distribution. A Critical Review
M Rasschaert, RO Weller, JA Schroeder, C Brochhausen, JM Idée
Journal of magnetic resonance imaging : JMRI 2020
Molecular Magnetic Resonance Imaging of Nitric Oxide in Biological Systems
A Barandov, S Ghosh, N Li, BB Bartelle, JI Daher, ML Pegis, H Collins, A Jasanoff
ACS Sensors 2020
Hippocampal vascular reserve associated with cognitive performance and hippocampal volume
V Perosa, A Priester, G Ziegler, A Cardenas-Blanco, L Dobisch, M Spallazzi, A Assmann, A Maass, O Speck, J Oltmer, HJ Heinze, S Schreiber, E Düzel
Brain 2020
Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent
S Naganawa, R Ito, H Kawai, T Taoka, T Yoshida, M Sone
Magnetic Resonance in Medical Sciences 2020
Quantitative imaging of the clearance systems in the eye and the brain
W Deng, C Liu, C Parra, JR Sims, MA Faiq, A Sainulabdeen, H Song, KC Chan
Quantitative imaging in medicine and surgery 2020
When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow
BA Plog, N Lou, CA Pierre, A Cove, HM Kenney, E Hitomi, H Kang, JJ Iliff, DM Zeppenfeld, M Nedergaard, GE Vates
Journal of Neurosurgery 2020
Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson’s Disease
AA Tran, MD Smet, GD Grant, TK Khoo, DL Pountney
2020
The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging.
Naganawa S, Taoka T
2020
Dural lymphatics regulate clearance of extracellular tau from the CNS
TK Patel, LM Habimana-Griffin, X Gao, B Xu, S Achilefu, K Alitalo, CA McKee, PW Sheehan, ES Musiek, C Xiong, D Coble, DM Holtzman
Molecular Neurodegeneration 2019
Transcranial Impedance Changes during Sleep: A Rheoencephalography Study
AH Meghdadi, D Popovic, G Rupp, S Smith, C Berka, A Verma
IEEE Journal of Translational Engineering in Health and Medicine 2019
Development of a Multicomponent Intervention to Prevent Alzheimer's Disease
S Saito, Y Yamamoto, M Ihara
Frontiers in neurology 2019
Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease
S Sundaram, RL Hughes, E Peterson, EM Müller-Oehring, HM Brontë-Stewart, KL Poston, A Faerman, C Bhowmick, T Schulte
Neuroscience and biobehavioral reviews 2019
Neuroimaging of traumatic brain injury in military personnel: An overview
A Bhattrai, A Irimia, JD Horn
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2019
Gadolinium Deposition in the Brain: Current Updates
JW Choi, WJ Moon
Korean Journal of Radiology 2019
Modeling glymphatic system of the brain using MRI
E Davoodi-Bojd, G Ding, L Zhang, Q Li, L Li, M Chopp, ZG Zhang, Q Jiang
NeuroImage 2019
Gadolinium retention in gliomas and adjacent normal brain tissue: association with tumor contrast enhancement and linear/macrocyclic agents
A Kiviniemi, M Gardberg, P Ek, J Frantzén, J Bobacka, H Minn
Neuroradiology 2019
Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
R Watts, JM Steinklein, L Waldman, X Zhou, CG Filippi
American Journal of Neuroradiology 2019
Don't forget astrocytes when targeting Alzheimer's disease
JS Sadick, SA Liddelow
British Journal of Pharmacology 2019
Analysis of convective and diffusive transport in the brain interstitium
L Ray, JJ Iliff, JJ Heys
Fluids and barriers of the CNS 2019
Increased signal intensity of low-concentration gadolinium contrast agent by longer repetition time in heavily T2-weighted-3D-FLAIR
Y Kato, K Bokura, T Taoka, S Naganawa
Japanese Journal of Radiology 2019
Increased cerebral blood volume in small arterial vessels is a correlate of Amyloid-β related cognitive decline
J Hua, SW Lee, NI Blair, M Wyss, JM van Bergen, SJ Schreiner, SM Kagerer, SE Leh, AF Gietl, V Treyer, A Buck, RM Nitsch, KP Pruessmann, H Lu, PC Zijl, M Albert, C Hock, PG Unschuld
Neurobiology of Aging 2019
Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure
AJ Smith, T Duan, AS Verkman
Acta Neuropathologica Communications 2019
Effect of extradural constriction on CSF flow in rat spinal cord
JA Berliner, T Woodcock, E Najafi, SJ Hemley, M Lam, S Cheng, LE Bilston, MA Stoodley
Fluids and barriers of the CNS 2019
Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis
JE Carroll, MR Irwin, TE Seeman, AV Diez-Roux, AA Prather, R Olmstead, E Epel, J Lin, S Redline
Sleep 2019
Gadolinium Retention and Clearance in the Diabetic Brain after Administrations of Gadodiamide, Gadopentetate Dimeglumine, and Gadoterate Meglumine in a Rat Model
S Wang, Z Hua, D Fan, X Zhang, K Ren
BioMed Research International 2019
Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience
W Deng, MA Faiq, C Liu, V Adi, KC Chan
Frontiers in neural circuits 2019
MRI of Whole Rat Brain Perivascular Network Reveals Role for Ventricles in Brain Waste Clearance
KN Magdoom, A Brown, J Rey, TH Mareci, MA King, M Sarntinoranont
Scientific Reports 2019
MRI and glymphatic system
Q Jiang
BMJ (Clinical research ed.) 2019
Quantitative analysis of Gd in the protein content of the brain following single injection of gadolinium-based contrast agents (GBCAs) by size exclusion chromatography
AA Kartamihardja, H Hanaoka, P Andriana, S Kameo, A Takahashi, H Koyama, Y Tsushima
British Journal of Radiology 2019
Impaired Glymphatic Transport in Spontaneously Hypertensive Rats
KN Mortensen, S Sanggaard, H Mestre, H Lee, S Kostrikov, AL Xavier, A Gjedde, H Benveniste, M Nedergaard
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019
Sleep as a Therapeutic Target in the Aging Brain
TM Bah, J Goodman, JJ Iliff
Neurotherapeutics 2019
Imaging of cerebrospinal fluid flow: fundamentals, techniques, and clinical applications of phase-contrast magnetic resonance imaging
A Korbecki, A Zimny, P Podgórski, M Sąsiadek, J Bladowska
Polish journal of radiology / Polish Medical Society of Radiology 2019
In Reply: Optic Disc Swelling in Astronauts
AS Huang, MB Stenger, BR Macias
Journal of Glaucoma 2019
Two-Point Dynamic Observation of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus
N Jingami, K Uemura, M Asada-Utsugi, A Kuzuya, S Yamada, M Ishikawa, T Kawahara, T Iwasaki, M Atsuchi, R Takahashi, A Kinoshita
Journal of Alzheimer's disease : JAD 2019
Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system
JR Goodman, JJ Iliff
Journal of Cerebral Blood Flow & Metabolism 2019
Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats
X Cai, J Qiao, P Kulkarni, IC Harding, E Ebong, CF Ferris
Proceedings of the National Academy of Sciences 2019
Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction
J Piantino, MM Lim, CD Newgard, J Iliff
Current Pain and Headache Reports 2019
Spatiotemporal Distribution of Agrin after Intrathecal Injection and Its Protective Role in Cerebral Ischemia/Reperfusion Injury
S Li, Y Wang, D Jiang, D Ni, CJ Kutyreff, TE Barnhart, JW Engle, W Cai
Advanced Science 2019
CrossTalk proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin‐4
J Iliff, M Simon
The Journal of Physiology 2019
Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma
GL Iverson, AJ Gardner, SR Shultz, GS Solomon, P McCrory, R Zafonte, G Perry, LN Hazrati, CD Keene, RJ Castellani
Brain 2019
Origins of Beta Amyloid Differ Between Vascular Amyloid Deposition and Parenchymal Amyloid Plaques in the Spinal Cord of a Mouse Model of Alzheimer’s Disease
Q Yuan, X Liu, YF Xian, Y Tang, J Zou, X Zhang, P Huang, W Wu, Y Song, ZX Lin
Molecular Neurobiology 2019
Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients
CS Edeklev, M Halvorsen, G Løvland, SA Vatnehol, Ø Gjertsen, B Nedregaard, R Sletteberg, G Ringstad, PK Eide
American Journal of Neuroradiology 2019
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
RH Earls, KB Menees, J Chung, J Barber, CA Gutekunst, MG Hazim, JK Lee
Journal of Neuroinflammation 2019
Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype
JE Carroll, BJ Small, DB Tometich, W Zhai, X Zhou, G Luta, TA Ahles, AJ Saykin, KN Nudelman, JD Clapp, HS Jim, PB Jacobsen, A Hurria, D Graham, BC McDonald, N Denduluri, M Extermann, C Isaacs, AA Dilawari, J Root, RA Stern, JS Mandelblatt
Cancer 2019
Modulation of O-GlcNAcylation Regulates Autophagy in Cortical Astrocytes
A Rahman, H Hwang, Y Cho, H Rhim
Oxidative medicine and cellular longevity 2019
Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial
P Zamboni, R Galeotti, F Salvi, A Giaquinta, C Setacci, S Alborino, G Guzzardi, SJ Sclafani, E Maietti, P Veroux, E Barbarossa, I Bartolomei, S Ceruti, P Conforti, AM Malagoni, E Menegatti, M Tessari, L Pellegrino, F Pancaldi, ME Vanini, MG Piscaglia, P Cenni, F Rasi, M Babini, A Drea, E Guerrini, EM Lotti, A Morelli, M Peroni, V Zalambani, S Zecchini, C Chisari, I Chiaramonte, V Cimino, LD Pino, G Failla, R Cantello, M Leone, L Coppo, O Raymkulova, S Ruggerone, A Stecco, D Vecchio, PA Confalonieri, E Ciceri, M Danni, C Belleggia, G Luccioni, L Oncini, C Quatrini
Journal of Endovascular Therapy 2019
Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome‐autophagosome‐lysosome pathway dysfunction and microglia‐mediated neuroinflammation
Y Xie, L Ba, M Wang, SY Deng, SM Chen, LF Huang, M Zhang, W Wang, FF Ding
CNS Neuroscience & Therapeutics 2019
An [ 18 F]-Positron Emitting Fluorophore Allows Safe Evaluation of Small Molecule Distribution in the CSF, CSF Fistulas, and CNS Device Placement
H Guo, H Kommidi, UB Maachani, JC Voronina, W Zhang, RS Magge, J Ivanidze, AP Wu, MM Souweidane, O Aras, R Ting
Molecular Pharmaceutics 2019

Decreased Vascular Pulsatility in Alzheimer’s Disease Dementia Measured by Transcranial Color-Coded Duplex Sonography


M Ortner, C Hauser, C Schmaderer, C Muggenthaler, A Hapfelmeier, C Sorg, J Diehl-Schmid, A Kurz, H Förstl, B Ikenberg, K Kotliar, H Poppert, T Grimmer
Neuropsychiatric Disease and Treatment 2019
In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
AM Sweeney, V Plá, T Du, G Liu, Q Sun, S Peng, BA Plog, BT Kress, X Wang, H Mestre, M Nedergaard
Journal of visualized experiments : JoVE 2019
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
Geir Ringstad, Lars Magnus Valnes, Anders Dale, Are H Pripp, Sven A Vatnehol, Kyrre E Emblem, Kent A Mardal, Per Eide
JCI Insight 2018
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain
Benjamin A Plog, Humberto Mestre, Genaro E Olveda, Amanda M. Sweeney, H. Mark Kenney, Alexander Cove, Kosha Dholakia, Jeffrey R Tithof, Thomas D Nevins, Iben Lundgaard, Ting Du, Douglas H. Kelley, Maiken Nedergaard
JCI Insight 2018
General Anesthesia Inhibits the Activity of the “Glymphatic System”
C Gakuba, T Gaberel, S Goursaud, J Bourges, CD Palma, A Quenault, SM de Lizarrondo, D Vivien, M Gauberti
Theranostics 2018
The Meningeal Lymphatic System: A New Player in Neurophysiology
SD Mesquita, Z Fu, J Kipnis
Neuron 2018
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
SB Hladky, MA Barrand
Fluids and barriers of the CNS 2018
Tissue-specific immunopathology during malaria infection
C Coban, MS Lee, KJ Ishii
Nature Reviews Immunology 2018
The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?
AJ Smith, AS Verkman
The FASEB Journal 2018
The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep
EL Boespflug, JJ Iliff
Biological Psychiatry 2018
Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma
BG Harder, MR Blomquist, J Wang, AJ Kim, GF Woodworth, JA Winkles, JC Loftus, NL Tran
Frontiers in Oncology 2018
Physiology of Astroglia
A Verkhratsky, M Nedergaard
Physiological reviews 2018
Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
R Hussain, H Zubair, S Pursell, M Shahab
Brain Sciences 2018
Insulin transport into the brain
SM Gray, EJ Barrett
American journal of physiology. Cell physiology 2018
Reactive Astrocytes as Drug Target in Alzheimer’s Disease
BT Assefa, AK Gebre, BM Altaye
BioMed Research International 2018
Cannula Implantation into the Cisterna Magna of Rodents
AL Xavier, NL Hauglund, S von Holstein-Rathlou, Q Li, S Sanggaard, N Lou, I Lundgaard, M Nedergaard
Journal of visualized experiments : JoVE 2018
Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum: Differences Between Gd Chelates, Presence in the Virchow-Robin Space, Association With Lipofuscin, and Hypotheses About Distribution Pathway
M Rasschaert, JA Schroeder, TD Wu, S Marco, A Emerit, H Siegmund, C Fischer, N Fretellier, JM Idée, C Corot, C Brochhausen, JL Guerquin-Kern
Investigative Radiology 2018
Shear-induced amyloid formation in the brain: IV. Effects on synapses surrounding senile plaque and in plaque-free regions
CN Trumbore
Journal of Alzheimer's disease : JAD 2018
Reduced spinal cord parenchymal cerebrospinal fluid circulation in experimental autoimmune encephalomyelitis
AP Fournier, M Gauberti, A Quenault, D Vivien, R Macrez, F Docagne
Journal of Cerebral Blood Flow & Metabolism 2018
A Review of the Current Evidence on Gadolinium Deposition in the Brain
R Pullicino, M Radon, S Biswas, M Bhojak, K Das
Clinical Neuroradiology 2018
The Aging of Iron Man
A Ashraf, M Clark, PW So
Frontiers in aging neuroscience 2018
Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter
S Naganawa, T Nakane, H Kawai, T Taoka
Magnetic Resonance in Medical Sciences 2018
Gadolinium-based contrast agents in children
MN Rozenfeld, DJ Podberesky
Pediatric Radiology 2018
Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
DO Borroto-Escuela, S Hinz, G Navarro, R Franco, CE Müller, K Fuxe
Frontiers in neuroscience 2018
The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system
K Messlinger
The Journal of Headache and Pain 2018
Pseudotumor Cerebri and Glymphatic Dysfunction
ML de Souza Bezerra, AC de Freitas Ferreira, R de Oliveira-Souza
Frontiers in neurology 2018
Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study
PK Eide, G Ringstad
Journal of Cerebral Blood Flow & Metabolism 2018
A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications
JA Monro, BK Puri
Molecular Neurobiology 2018
Localization, Occurrence, and CSF Changes of SP-G, a New Surface Active Protein with Assumable Immunoregulatory Functions in the CNS
M Krause, N Peukert, W Härtig, A Emmer, CV Mahr, C Richter, J Dieckow, J Puchta, M Pirlich, KT Hoffmann, U Nestler, S Schob
Molecular Neurobiology 2018
MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain
DS Hersh, P Anastasiadis, A Mohammadabadi, BA Nguyen, S Guo, JA Winkles, AJ Kim, R Gullapalli, A Keller, V Frenkel, GF Woodworth, V Ceña
PloS one 2018
Brain drains: new insights into brain clearance pathways from lymphatic biology
NI Bower, BM Hogan
Journal of Molecular Medicine 2018
Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities
Y Xiong, A Mahmood, M Chopp
Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association 2018
Shear-Induced Amyloid Formation in the Brain: III. The Roles of Shear Energy and Seeding in a Proposed Shear Model
CN Trumbore
Journal of Alzheimer's disease : JAD 2018
The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future
BA Plog, M Nedergaard
Annual review of pathology 2018
Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes
PK Eide, SA Vatnehol, KE Emblem, G Ringstad
Scientific Reports 2018
Methodological Aspects for Preclinical Evaluation of Gadolinium Presence in Brain Tissue: Critical Appraisal and Suggestions for Harmonization—A Joint Initiative
P Robert, T Frenzel, C Factor, G Jost, M Rasschaert, G Schuetz, N Fretellier, J Boyken, JM Idée, H Pietsch
Investigative Radiology 2018
Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
IF Harrison, B Siow, AB Akilo, PG Evans, O Ismail, Y Ohene, P Nahavandi, DL Thomas, MF Lythgoe, JA Wells
eLife 2018
Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy
SH Xin, L Tan, X Cao, JT Yu, L Tan
Neurotoxicity Research 2018
MRI investigation of glymphatic responses to Gd-DTPA infusion rates
G Ding, M Chopp, L Li, L Zhang, E Davoodi-Bojd, Q Li, Z Zhang, Q Jiang
Journal of Neuroscience Research 2018
Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain
G Li, X He, H Li, Y Wu, Y Guan, S Liu, H Jia, Y Li, L Wang, R Huang, Z Pei, Y Lan, Y Zhang
International journal of molecular medicine 2018
Efficacy and Safety of Extracranial Vein Angioplasty in Multiple Sclerosis: A Randomized Clinical Trial
P Zamboni, L Tesio, S Galimberti, L Massacesi, F Salvi, R DAlessandro, P Cenni, R Galeotti, D Papini, R DAmico, S Simi, MG Valsecchi, G Filippini
JAMA NEUROL 2018
Appearance of the Organum Vasculosum of the Lamina Terminalis on Contrast-enhanced MR Imaging
S Naganawa, T Taoka, H Kawai, M Yamazaki, K Suzuki
Magnetic Resonance in Medical Sciences 2018
Cerebral small vessel disease: neuroimaging markers and clinical implication
X Chen, J Wang, Y Shan, W Cai, S Liu, M Hu, S Liao, X Huang, B Zhang, Y Wang, Z Lu
Journal of Neurology 2018
The glymphatic pathway in neurological disorders
MK Rasmussen, H Mestre, M Nedergaard
Lancet neurology 2018
Apparent diffusion coefficient changes in human brain during sleep – Does it inform on the existence of a glymphatic system?
ŞB Demiral, D Tomasi, J Sarlls, H Lee, CE Wiers, A Zehra, T Srivastava, K Ke, E Shokri-Kojori, CR Freeman, E Lindgren, V Ramirez, G Miller, P Bandettini, S Horovitz, GJ Wang, H Benveniste, ND Volkow
NeuroImage 2018
The Glymphatic System in Diabetes-Induced Dementia
YK Kim, KI Nam, J Song
Frontiers in neurology 2018
Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging
S Naganawa, T Nakane, H Kawai, T Taoka
Magnetic Resonance in Medical Sciences 2018
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
H Mestre, LM Hablitz, AL Xavier, W Feng, W Zou, T Pu, H Monai, G Murlidharan, RM Rivera, MJ Simon, MM Pike, V Plá, T Du, BT Kress, X Wang, BA Plog, AS Thrane, I Lundgaard, Y Abe, M Yasui, JH Thomas, M Xiao, H Hirase, A Asokan, JJ Iliff, M Nedergaard
eLife 2018
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
H Mestre, J Tithof, T Du, W Song, W Peng, AM Sweeney, G Olveda, JH Thomas, M Nedergaard, DH Kelley
Nature Communications 2018
Controversies and Misconceptions Related to Cerebrospinal Fluid Circulation: A Review of the Literature from the Historical Pioneers’ Theories to Current Models
G Mantovani, M Menegatti, A Scerrati, MA Cavallo, PD Bonis
BioMed Research International 2018
Neuroglia: Realising their true potential
A Butt, A Verkhratsky
2018
Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease
EL Boespflug, MJ Simon, E Leonard, M Grafe, R Woltjer, LC Silbert, JA Kaye, JJ Iliff, A Hatami
Journal of Alzheimer's disease : JAD 2018
Aortic stiffness, pressure and flow pulsatility, and target organ damage
GF Mitchell
Journal of applied physiology 2018
The Glymphatic System and Waste Clearance with Brain Aging: A Review
H Benveniste, X Liu, S Koundal, S Sanggaard, H Lee, J Wardlaw
Gerontology 2018
Augmented astrocyte microdomain Ca 2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice
JR Diaz, KJ Kim, MW Brands, JA Filosa
Glia 2018
Cell Volume Control in Healthy Brain and Neuropathologies
Wilson CS, Mongin AA
Current topics in membranes 2018
Impaired brain glymphatic flow in experimental hepatic encephalopathy
Hadjihambi A, Harrison IF, Costas-Rodríguez M, Vanhaecke F, Arias N, Gallego-Durán R, Mastitskaya S, Hosford PS, Olde Damink SW, Davies N, Habtesion A, Lythgoe MF, Gourine AV, Jalan R
Journal of Hepatology 2018
A novel MRI phantom to study interstitial fluid transport in the glymphatic system.
Komlosh ME, Benjamini D, Williamson NW, Horkay F, Hutchinson EB, Basser PJ
Magnetic Resonance Imaging 2018
Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI
M Absinta, SK Ha, G Nair, P Sati, NJ Luciano, M Palisoc, A Louveau, KA Zaghloul, S Pittaluga, J Kipnis, DS Reich
eLife 2017
Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation
ZA Zhao, P Li, SY Ye, YL Ning, H Wang, Y Peng, N Yang, Y Zhao, ZH Zhang, JF Chen, YG Zhou
Scientific Reports 2017
The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid
MA Lam, SJ Hemley, E Najafi, NG Vella, LE Bilston, MA Stoodley
Scientific Reports 2017
Perivascular spaces, glymphatic dysfunction, and small vessel disease
H Mestre, S Kostrikov, RI Mehta, M Nedergaard
Clinical Science 2017
The diabetic brain and cognition
P Riederer, AD Korczyn, SS Ali, O Bajenaru, MS Choi, M Chopp, V Dermanovic-Dobrota, E Grünblatt, KA Jellinger, MA Kamal, W Kamal, J Leszek, TM Sheldrick-Michel, G Mushtaq, B Meglic, R Natovich, Z Pirtosek, M Rakusa, M Salkovic-Petrisic, R Schmidt, A Schmitt, GR Sridhar, L Vécsei, ZB Wojszel, H Yaman, ZG Zhang, T Cukierman-Yaffe
Journal of Neural Transmission 2017
Clinical Correlation of Abnormal Findings on Magnetic Resonance Elastography in Idiopathic Normal Pressure Hydrocephalus
A Perry, CS Graffeo, N Fattahi, MM ElSheikh, N Cray, A Arani, RL Ehman, KJ Glaser, A Manduca, FB Meyer, J Huston
World Neurosurgery 2017
Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus
DD Limbrick, B Baksh, CD Morgan, G Habiyaremye, JP McAllister, TE Inder, D Mercer, DM Holtzman, J Strahle, MJ Wallendorf, DM Morales, Y Hoshi
PloS one 2017
Overview of Traumatic Brain Injury: An Immunological Context
D Nizamutdinov, L Shapiro
Brain Sciences 2017
Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases
T Taoka, Y Masutani, H Kawai, T Nakane, K Matsuoka, F Yasuno, T Kishimoto, S Naganawa
Japanese Journal of Radiology 2017
Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Mass Transport
V Ratner, Y Gao, H Lee, R Elkin, M Nedergaard, H Benveniste, A Tannenbaum
NeuroImage 2017
The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging
JA Coles, PJ Stewart-Hutchinson, E Myburgh, JM Brewer
Methods 2017
Subarachnoid hemorrhage – Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor)
EV Golanov, EI Bovshik, KK Wong, RG Pautler, CH Foster, RG Federley, JY Zhang, J Mancuso, ST Wong, GW Britz
Journal of Cerebral Blood Flow & Metabolism 2017
Long-Lasting Cerebral Vasospasm, Microthrombosis, Apoptosis and Paravascular Alterations Associated with Neurological Deficits in a Mouse Model of Subarachnoid Hemorrhage
ME Amki, M Dubois, A Lefevre-Scelles, N Magne, M Roussel, T Clavier, PO Guichet, E Gérardin, V Compère, H Castel
Molecular Neurobiology 2017
Circadian Rhythms in AD Pathogenesis: a Critical Appraisal
ES Musiek
Current Sleep Medicine Reports 2017
Histology and Gadolinium Distribution in the Rodent Brain After the Administration of Cumulative High Doses of Linear and Macrocyclic Gadolinium-Based Contrast Agents:
J Lohrke, AL Frisk, T Frenzel, L Schöckel, M Rosenbruch, G Jost, DC Lenhard, MA Sieber, V Nischwitz, A Küppers, H Pietsch
Investigative Radiology 2017
The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease
KG Burfeind, CF Murchison, SK Westaway, MJ Simon, D Erten-Lyons, JA Kaye, JF Quinn, JJ Iliff
Alzheimer's & Dementia: Translational Research & Clinical Interventions 2017
Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T: Quantitative Gd-DOTA Uptake from CSF into Rat Brain
H Lee, K Mortensen, S Sanggaard, P Koch, H Brunner, B Quistorff, M Nedergaard, H Benveniste
Magnetic Resonance in Medicine 2017
Stratification of astrocytes in healthy and diseased brain: Astroglia in health and disease
A Verkhratsky, R Zorec, V Parpura
Brain Pathology 2017
Glymphatic MRI in idiopathic normal pressure hydrocephalus
G Ringstad, SA Vatnehol, PK Eide
Brain 2017
Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis
B Gaastra, J Glazier, D Bulters, I Galea
Oxidative medicine and cellular longevity 2017
An [ 18 F]-Positron-Emitting, Fluorescent, Cerebrospinal Fluid Probe for Imaging Damage to the Brain and Spine
H Kommidi, H Guo, N Chen, D Kim, B He, AP Wu, O Aras, R Ting
Theranostics 2017
Magnetic Resonance Imaging of Cardiovascular Function and the Brain: Is Dementia a Cardiovascular-Driven Disease?
A Roos, J der Grond, G Mitchell, J Westenberg
Circulation 2017
Disruption of the leptomeningeal blood barrier in neuromyelitis optica spectrum disorder
N Asgari, EP Flanagan, K Fujihara, HJ Kim, HP Skejoe, J Wuerfel, H Kuroda, SH Kim, E Maillart, R Marignier, SJ Pittock, F Paul, BG Weinshenker
Neurology: Neuroimmunology & Neuroinflammation 2017
Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET
MJ de Leon, Y Li, N Okamura, WH Tsui, LA Saint-Louis, L Glodzik, RS Osorio, J Fortea, T Butler, E Pirraglia, S Fossati, HJ Kim, RO Carare, M Nedergaard, H Benveniste, H Rusinek
Journal of Nuclear Medicine 2017
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts
M Wang, F Ding, SY Deng, X Guo, W Wang, JJ Iliff, M Nedergaard
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy
A Bacyinski, M Xu, W Wang, J Hu
Frontiers in neuroanatomy 2017
Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane:
H Benveniste, H Lee, F Ding, Q Sun, E Al-Bizri, R Makaryus, S Probst, M Nedergaard, EA Stein, H Lu
Anesthesiology 2017
Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition
A Harding, U Gonder, SJ Robinson, SJ Crean, SK Singhrao
Frontiers in aging neuroscience 2017
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery: Mechanisms of intrathecal antibody transport
ME Pizzo, DJ Wolak, NN Kumar, E Brunette, CL Brunnquell, MJ Hannocks, NJ Abbott, ME Meyerand, L Sorokin, DB Stanimirovic, RG Thorne
The Journal of Physiology 2017
Elevated Surfactant Protein Levels and Increased Flow of Cerebrospinal Fluid in Cranial Magnetic Resonance Imaging
S Schob, A Weiß, A Surov, J Dieckow, C Richter, M Pirlich, D Horvath-Rizea, W Härtig, KT Hoffmann, M Krause, U Quäschling
Molecular Neurobiology 2017
Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow
B Bedussi, M Almasian, J de Vos, E VanBavel, EN Bakker
Journal of Cerebral Blood Flow & Metabolism 2017
Distribution and chemical forms of gadolinium in the brain: a review
T Kanda, Y Nakai, A Hagiwara, H Oba, K Toyoda, S Furui
British Journal of Radiology 2017
Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats: Differences in Gd Retention Between cGBCAs
S Bussi, A Coppo, C Botteron, V Fraimbault, A Fanizzi, ED Laurentiis, SC Serra, MA Kirchin, F Tedoldi, F Maisano
Journal of magnetic resonance imaging : JMRI 2017
Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System
S Dreha-Kulaczewski, AA Joseph, KD Merboldt, HC Ludwig, J Gärtner, J Frahm
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
Starling forces drive intracranial water exchange during normal and pathological states
Linninger AA, Xu C, Tangen K, Hartung G
Croatian medical journal 2017
Dynamic dual isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery
Daniel Wolf, Jacob Hesterman, Jenna M. Sullivan, Kelly Orcutt, Matt Silva, Merryl Lobo, Tyler Wellman, Jack Hoppin, Ajay Verma
JCI Insight 2016
Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases
EN Bakker, BJ Bacskai, M Arbel-Ornath, R Aldea, B Bedussi, AW Morris, RO Weller, RO Carare
Cellular and Molecular Neurobiology 2016
Blood biomarkers for brain injury: What are we measuring?
K Kawata, CY Liu, SF Merkel, SH Ramirez, RT Tierney, D Langford
Neuroscience & Biobehavioral Reviews 2016
Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis
M Thon, T Hosoi, K Ozawa
Frontiers in Endocrinology 2016
Pathways for insulin access to the brain: the role of the microvascular endothelial cell
RI Meijer, SM Gray, KW Aylor, EJ Barrett
American journal of physiology. Heart and circulatory physiology 2016
Central Nervous System: (Immunological) Ivory Tower or Not?
IA Marin, J Kipnis
Neuropsychopharmacology 2016
Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review
BM Asken, MJ Sullan, AR Snyder, ZM Houck, VE Bryant, LP Hizel, ME McLaren, DE Dede, MS Jaffee, ST DeKosky, RM Bauer
Neuropsychology Review 2016
Distribution and clearance of retained gadolinium in the brain: differences between linear and macrocyclic gadolinium based contrast agents in a mouse model
AA Kartamihardja, T Nakajima, S Kameo, H Koyama, Y Tsushima
British Journal of Radiology 2016
Antigen Presentation After Stroke
F Miró-Mur, X Urra, M Gallizioli, A Chamorro, AM Planas
Neurotherapeutics 2016
Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia
S NAGANAWA, T NAKANE, H KAWAI, T TAOKA
Magnetic Resonance in Medical Sciences 2016
Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest
EL Fink, RP Berger, RS Clark, RS Watson, DC Angus, A Panigrahy, R Richichi, CW Callaway, MJ Bell, S Mondello, RL Hayes, PM Kochanek
Resuscitation 2016
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy
V Puvenna, M Engeler, M Banjara, C Brennan, P Schreiber, A Dadas, A Bahrami, J Solanki, A Bandyopadhyay, JK Morris, C Bernick, C Ghosh, E Rapp, JJ Bazarian, D Janigro
Brain Research 2016
The occurrence of individual slow waves in sleep is predicted by heart rate
A Mensen, Z Zhang, M Qi, R Khatami
Scientific Reports 2016
Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease
J Cedernaes, RS Osorio, AW Varga, K Kam, HB Schiöth, C Benedict
Sleep Medicine Reviews 2016
Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation
K Eom, C Im, S Hwang, S Eom, TS Kim, HS Jeong, KH Kim, KM Byun, SB Jun, SJ Kim
Biomedical Optics Express 2016
The homeostatic astroglia emerges from evolutionary specialization of neural cells
A Verkhratsky, M Nedergaard
Philosophical Transactions of the Royal Society B: Biological Sciences 2016
Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs—A Comparative Perspective
C Gleiser, A Wagner, P Fallier-Becker, H Wolburg, B Hirt, A Mack
International journal of molecular sciences 2016
Pulsed ultrasound expands the extracellular and perivascular spaces of the brain
DS Hersh, BA Nguyen, JG Dancy, AR Adapa, JA Winkles, GF Woodworth, AJ Kim, V Frenkel
Brain Research 2016
Shear-Induced Amyloid Formation in the Brain: I. Potential Vascular and Parenchymal Processes
CN Trumbore
Journal of Alzheimer's disease : JAD 2016
Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease
F Pistollato, SS Cano, I Elio, MM Vergara, F Giampieri, M Battino
Advances in nutrition (Bethesda, Md.) 2016
Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream
A Hoffmann, J Pfeil, J Alfonso, FT Kurz, F Sahm, S Heiland, H Monyer, M Bendszus, AK Mueller, X Helluy, M Pham, KB Seydel
PLoS pathogens 2016
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis
IM Vincent, R Daly, B Courtioux, AM Cattanach, S Biéler, JM Ndungu, S Bisser, MP Barrett, DK Masiga
PLoS neglected tropical diseases 2016
Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system
M Xia, L Yang, G Sun, S Qi, B Li
Psychopharmacology 2016
Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning
CH Fung, MV Vitiello, CA Alessi, GA Kuchel
Journal of the American Geriatrics Society 2016
Patterned Fibers Embedded Microfluidic Chips Based on PLA and PDMS for Ag Nanoparticle Safety Testing
Y Liu, S Wang, Y Wang
Polymers 2016
Impairment of the glymphatic system after diabetes
Q Jiang, L Zhang, G Ding, E Davoodi-Bojd, Q Li, L Li, N Sadry, M Nedergaard, M Chopp, Z Zhang
Journal of Cerebral Blood Flow & Metabolism 2016
“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop
F Bosetti, ZS Galis, MS Bynoe, M Charette, MJ Cipolla, GJ Zoppo, D Gould, TS Hatsukami, TL Jones, JI Koenig, GA Lutty, C MaricBilkan, T Stevens, HE Tolunay, W Koroshetz
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2016
Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System
BA Plog, ML Dashnaw, E Hitomi, W Peng, Y Liao, N Lou, R Deane, M Nedergaard
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Interaction between therapeutic interventions for Alzheimer’s disease and physiological Aβ clearance mechanisms
CD Morrone, M Liu, SE Black, JA McLaurin
Frontiers in aging neuroscience 2015
Clearance systems in the brain—implications for Alzheimer disease
JM Tarasoff-Conway, RO Carare, RS Osorio, L Glodzik, T Butler, E Fieremans, L Axel, H Rusinek, C Nicholson, BV Zlokovic, B Frangione, K Blennow, J Ménard, H Zetterberg, T Wisniewski, MJ de Leon
Nature Reviews Neurology 2015
From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
NL Trevaskis, LM Kaminskas, CJ Porter
Nature Reviews Drug Discovery 2015
The role of the lymphatic system in cholesterol transport
LH Huang, A Elvington, GJ Randolph
Frontiers in pharmacology 2015
Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease
H Lian, H Zheng
Journal of Neurochemistry 2015
Lysosomal storage disease: Gene therapy on both sides of the blood–brain barrier
EL Aronovich, PB Hackett
Molecular Genetics and Metabolism 2015
The Glymphatic System: A Beginner’s Guide
NA Jessen, AS Munk, I Lundgaard, M Nedergaard
Neurochemical Research 2015
Remote ischemic conditioning: A treatment for vascular cognitive impairment
DC Hess, MB Khan, JC Morgan, N Hoda
Brain Circulation 2015
Ubiquitin-Proteasome System in Neurodegenerative Disorders
GR Croft
Journal of Drug Metabolism & Toxicology 2015
Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate rats
J Hordeaux, L Dubreil, J Deniaud, F Iacobelli, S Moreau, M Ledevin, CL Guiner, V Blouin, JL Duff, A Mendes-Madeira, F Rolling, Y Cherel, P Moullier, MA Colle
Gene Therapy 2015
A novel method to study cerebrospinal fluid dynamics in rats
JK Karimy, KT Kahle, DB Kurland, E Yu, V Gerzanich, JM Simard
Journal of Neuroscience Methods 2015
Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging
DJ Wolak, ME Pizzo, RG Thorne
Journal of Controlled Release 2015
A review of flux considerations for in vivo neurochemical measurements
DW Paul, JA Stenken
The Analyst 2015
Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease
A Gupta, C Iadecola
Frontiers in aging neuroscience 2015
Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier
N Asgari, CT Berg, MT Mørch, R Khorooshi, T Owens
Annals of Clinical and Translational Neurology 2015
A new glaucoma hypothesis: a role of glymphatic system dysfunction
P Wostyn, DV Dam, K Audenaert, HE Killer, PP de Deyn, VD Groot
Fluids and barriers of the CNS 2015
Blood–brain barrier, bulk flow, and interstitial clearance in epilepsy
N Marchi, M Banjara, D Janigro
Journal of Neuroscience Methods 2015
Implications of the discovery of brain lymphatic pathways
JJ Iliff, SA Goldman, M Nedergaard
The Lancet Neurology 2015
The Effect of Body Posture on Brain Glymphatic Transport
H Lee, L Xie, M Yu, H Kang, T Feng, R Deane, J Logan, M Nedergaard, H Benveniste
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Quinckes’ pioneering 19th centuries CSF studies may inform 21th centuries research
K Bechter, H Benveniste
Neurology, Psychiatry and Brain Research 2015
Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease
MJ Simon, JJ Iliff
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015
The Role of the Craniocervical Junction in Craniospinal Hydrodynamics and Neurodegenerative Conditions
MF Flanagan
Neurology Research International 2015
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
Z Xu, N Xiao, Y Chen, H Huang, C Marshall, J Gao, Z Cai, T Wu, G Hu, M Xiao
Molecular Neurodegeneration 2015
Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment
F Deak, WM Freeman, Z Ungvari, A Csiszar, WE Sonntag
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2015
Optimal-mass-transfer-based estimation of glymphatic transport in living brain
Ratner V, Zhu L, Kolesov I, Nedergaard M, Benveniste H, Tannenbaum A
Proceedings of SPIE--the International Society for Optical Engineering 2015
Impairment of paravascular clearance pathways in the aging brain: Paravascular Clearance
BT Kress, JJ Iliff, M Xia, M Wang, HS Wei, D Zeppenfeld, L Xie, H Kang, Q Xu, JA Liew, BA Plog, F Ding, R Deane, M Nedergaard
Annals of Neurology 2014
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
JJ Iliff, MJ Chen, BA Plog, DM Zeppenfeld, M Soltero, L Yang, I Singh, R Deane, M Nedergaard
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment
J Pahnke, O Langer, M Krohn
Neurobiology of Disease 2014
Insulin Regulates Brain Function, but How Does It Get There?
SM Gray, RI Meijer, EJ Barrett
Diabetes 2014
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment:
E Cassol, V Misra, A Dutta, S Morgello, D Gabuzda
AIDS 2014
Drowning stars: reassessing the role of astrocytes in brain edema
AS Thrane, VR Thrane, M Nedergaard
Trends in Neurosciences 2014
Water for Thought: Is There a Role for Aquaporin Channels in Delirium?
A Sfera, C Osorio
Frontiers in Psychiatry 2014
Normal pressure hydrocephalus as a failure of ICP homeostasis mechanism: the hidden role of Monro–Kellie doctrine in the genesis of NPH
A Salma
Child's Nervous System 2014
Open questions for Alzheimer’s disease immunotherapy
TE Golde
Alzheimer's research & therapy 2014
Inflammation-sleep interface in brain disease: TNF, insulin, orexin
IA Clark, B Vissel
Journal of Neuroinflammation 2014
A new look at cerebrospinal fluid circulation
T Brinker, E Stopa, J Morrison, P Klinge
Fluids and barriers of the CNS 2014
Why are Astrocytes Important?
A Verkhratsky, M Nedergaard, L Hertz
Neurochemical Research 2014
Cerebral vascular leak in a mouse model of amyloid neuropathology
EA Tanifum, ZA Starosolski, SW Fowler, JL Jankowsky, AV Annapragada
Journal of Cerebral Blood Flow & Metabolism 2014
A new look at cerebrospinal fluid movement
D Orešković, M Klarica
Fluids and barriers of the CNS 2014
Pathways of cerebrospinal fluid outflow: a deeper understanding of resorption
L Chen, G Elias, MP Yostos, B Stimec, J Fasel, K Murphy
Neuroradiology 2014
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration
JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne
Journal of Cerebral Blood Flow & Metabolism 2014
Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence
SB Hladky, MA Barrand
Fluids and barriers of the CNS 2014
Intranasal Administration as a Route for Drug Delivery to the Brain: Evidence for a Unique Pathway for Albumin
JA Falcone, TS Salameh, X Yi, BJ Cordy, WG Mortell, AV Kabanov, WA Banks
The Journal of pharmacology and experimental therapeutics 2014
CSF Flow in the Brain in the Context of Normal Pressure Hydrocephalus
WG Bradley
American Journal of Neuroradiology 2014
Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
Orešković D, Klarica M
Croatian medical journal 2014
A proposed role for efflux transporters in the pathogenesis of hydrocephalus.
Krishnamurthy S, Tichenor MD, Satish AG, Lehmann DB
Croatian medical journal 2014
A computational model of cerebrospinal fluid production and reabsorption driven by Starling forces.
Buishas J, Gould IG, Linninger AA
Croatian medical journal 2014
Bathing the Brain
Warren James Strittmatter
Journal of Clinical Investigation 2013
The Pathobiology of Vascular Dementia
C Iadecola
Neuron 2013
Sleep Drives Metabolite Clearance from the Adult Brain
L Xie, H Kang, Q Xu, MJ Chen, Y Liao, M Thiyagarajan, J O'Donnell, DJ Christensen, C Nicholson, JJ Iliff, T Takano, R Deane, M Nedergaard
Science 2013
White matter astrocytes in health and disease
I Lundgaard, MJ Osório, BT Kress, S Sanggaard, M Nedergaard
Neuroscience 2013
Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid
R Mokgokong, S Wang, CJ Taylor, MA Barrand, SB Hladky
Pflügers Archiv - European Journal of Physiology 2013
Exploring the efficacy of endoscopic ventriculostomy for hydrocephalus treatment via a multicompartmental poroelastic model of CSF transport: a computational perspective
JC Vardakis, BJ Tully, Y Ventikos
PloS one 2013
Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain
JJ Iliff, M Wang, DM Zeppenfeld, A Venkataraman, BA Plog, Y Liao, R Deane, M Nedergaard
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature
GV Chaitanya, S Omura, F Sato, NE Martinez, A Minagar, M Ramanathan, BW Guttman, R Zivadinov, I Tsunoda, JS Alexander
Journal of Neuroinflammation 2013
Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
VR Thrane, AS Thrane, BA Plog, M Thiyagarajan, JJ Iliff, R Deane, EA Nagelhus, M Nedergaard
Scientific Reports 2013
Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer
L Yang, BT Kress, HJ Weber, M Thiyagarajan, B Wang, R Deane, H Benveniste, JJ Iliff, M Nedergaard
Journal of Translational Medicine 2013
Garbage Truck of the Brain
M Nedergaard
Science 2013
The Detection of Surfactant Proteins A, B, C and D in the Human Brain and Their Regulation in Cerebral Infarction, Autoimmune Conditions and Infections of the CNS
S Schob, M Schicht, S Sel, D Stiller, A Kekulé, F Paulsen, E Maronde, L Bräuer, JA Coles
PloS one 2013
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
New concepts in the pathogenesis of hydrocephalus
Satish Krishnamurthy, Jie Li
Translational Pediatrics
MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain
PK Eide, G Ringstad
Acta Radiologica Open 2015
Adult Astrogenesis and the Etiology of Cortical Neurodegeneration
A Koob, T Mohn
Journal of Experimental Neuroscience 2015
Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals: Erratum
H Benveniste, PR Hof, M Nedergaard, K Bechter
The Journal of Comparative Neurology 2015

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