The glymphatic system is a recently defined brain-wide paravascular pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates efficient clearance of solutes and waste from the brain. CSF enters the brain along para-arterial channels to exchange with ISF, which is in turn cleared from the brain along para-venous pathways. Because soluble amyloid β clearance depends on glymphatic pathway function, we proposed that failure of this clearance system contributes to amyloid plaque deposition and Alzheimer’s disease progression. Here we provide proof of concept that glymphatic pathway function can be measured using a clinically relevant imaging technique. Dynamic contrast-enhanced MRI was used to visualize CSF-ISF exchange across the rat brain following intrathecal paramagnetic contrast agent administration. Key features of glymphatic pathway function were confirmed, including visualization of para-arterial CSF influx and molecular size-dependent CSF-ISF exchange. Whole-brain imaging allowed the identification of two key influx nodes at the pituitary and pineal gland recesses, while dynamic MRI permitted the definition of simple kinetic parameters to characterize glymphatic CSF-ISF exchange and solute clearance from the brain. We propose that this MRI approach may provide the basis for a wholly new strategy to evaluate Alzheimer’s disease susceptibility and progression in the live human brain.
Jeffrey J. Iliff, Hedok Lee, Mei Yu, Tian Feng, Jean Logan, Maiken Nedergaard, Helene Benveniste
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Proceedings of the National Academy of Sciences | 2024 |
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2024 | |
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Aging and disease | 2024 |
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Journal of Cerebral Blood Flow & Metabolism | 2024 |
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medRxiv | 2024 |
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Brain sciences | 2024 |
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Perivascular Space Burden and Cerebrospinal Fluid Biomarkers in US Veterans With Blast-Related Mild Traumatic Brain Injury
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Journal of Neurotrauma | 2024 |
Clearance rate of contrast extravasation after endovascular therapy is associated with functional outcome and mediated by cerebral edema
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Journal of Cerebral Blood Flow & Metabolism | 2024 |
Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function.
Yang T, Tang Y, Liu X, Gong S, Yao E |
IUBMB life | 2024 |
Preliminary investigations into human neurofluid transport using multiple novel non-contrast MRI methods.
Rane Levendovszky S, Flores J, Peskind ER, Václavů L, van Osch MJ, Iliff J |
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism | 2024 |
The glymphatic system and cerebral small vessel disease.
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Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | 2024 |
Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease
Koundal S, Chen X, Gursky Z, Lee H, Xu K, Liang F, Xie Z, Xu F, Lin HM, Van Nostrand WE, Gu X, Elkin R, Tannenbaum A, Benveniste H |
iScience | 2024 |
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Han F, Lee J, Chen X, Ziontz J, Ward T, Landau SM, Baker SL, Harrison TM, Jagust WJ |
Alzheimer's & Dementia | 2024 |
The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease
Che Mohd Nassir CM, Che Ramli MD, Mohamad Ghazali M, Jaffer U, Abdul Hamid H, Mehat MZ, Hein ZM |
Life | 2024 |
Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer’s Disease
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International journal of molecular sciences | 2023 |
Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety
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Neoplasia (New York, N.Y.) | 2023 |
Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
Vasciaveo V, Iadarola A, Casile A, Dante D, Morello G, Minotta L, Tamagno E, Cicolin A, Guglielmotto M |
Acta Neuropathologica Communications | 2023 |
Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Ben-Nejma IR, Keliris AJ, Vanreusel V, Ponsaerts P, Van der Linden A, Keliris GA |
Alzheimer's research & therapy | 2023 |
Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain
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Nature Communications | 2023 |
Hypothermia impairs glymphatic drainage in traumatic brain injury as assessed by dynamic contrast-enhanced MRI with intrathecal contrast
Gu W, Bai Y, Cai J, Mi H, Bao Y, Zhao X, Lu C, Zhang F, Li YH, Lu Q |
Frontiers in neuroscience | 2023 |
Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium
Singhal D, Börner K, Chaikof EL, Detmar M, Hollmén M, Iliff JJ, Itkin M, Makinen T, Oliver G, Padera TP, Quardokus EM, Radtke AJ, Suami H, Weber GM, Rovira II, Muratoglu SC, Galis ZS |
Frontiers in physiology | 2023 |
The Synucleins and the Astrocyte
Myers AJ, Brahimi A, Jenkins IJ, Koob AO |
Biology | 2023 |
Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer’s disease and related dementias
Uchida Y, Kan H, Sakurai K, Oishi K, Matsukawa N |
Frontiers in aging neuroscience | 2023 |
High pulse pressure impairs cerebral artery endothelial function in young, but not old, mice
Winder NR, Reeve EH, Kronquist EK, Khurana A, Lee B, Nguyen T, Henson GD, Walker AE |
Experimental Gerontology | 2023 |
Transport Pathways and Kinetics of Cerebrospinal Fluid Tracers in Mouse Brain Observed by Dynamic Contrast-Enhanced MRI.
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Research square | 2023 |
Remission of insomnia in older adults treated with cognitive behavioral therapy for insomnia (CBT-I) reduces p16(INK4a) gene expression in peripheral blood: secondary outcome analysis from a randomized clinical trial.
Carroll JE, Olmstead R, Cole SW, Breen EC, Arevalo JM, Irwin MR |
GeroScience | 2023 |
Neuroimaging uncovers distinct relationships of glymphatic dysfunction and motor symptoms in Parkinson's disease.
Qin Y, He R, Chen J, Zhou X, Zhou X, Liu Z, Xu Q, Guo JF, Yan XX, Jiang N, Liao W, Taoka T, Wang D, Tang B |
Journal of Neurology | 2023 |
Restoration of aquaporin-4 polarization in the spinal glymphatic system by metformin in rats with painful diabetic neuropathy
Xu C, Wang F, Su C, Guo X, Li J, Lin J |
NeuroReport | 2023 |
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Gomolka RS, Hablitz LM, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y |
eLife | 2023 |
Neuroinflammation with increased glymphatic flow in a murine model of decompression sickness
Thom SR, Bhopale VM, Bhat AR, Arya AK, Ruhela D, Qiao G, Li X, Tang S, Xu S |
Journal of neurophysiology | 2023 |
Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries
Raicevic N, Forer JM, Ladrón-de-Guevara A, Du T, Nedergaard M, Kelley DH, Boster K |
Research square | 2023 |
The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI.
Alghanimy A, Martin C, Gallagher L, Holmes WM |
PloS one | 2023 |
Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
St-Pierre MK, Carrier M, González Ibáñez F, Khakpour M, Wallman MJ, Parent M, Tremblay MÈ |
Journal of Neuroinflammation | 2023 |
Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease
Wijesinghe P, Whitmore CA, Campbell M, Li C, Tsuyuki M, To E, Haynes J, Pham W, Matsubara JA |
Frontiers in neuroscience | 2023 |
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm.
Reiter RJ, Sharma R, Cucielo MS, Tan DX, Rosales-Corral S, Gancitano G, de Almeida Chuffa LG |
Cellular and molecular life sciences : CMLS | 2023 |
Continuous positive airway pressure (CPAP) increases CSF flow speed and glymphatic transport
Burhan Ozturk, Sunil Koundal, Ehab Al Bizri, Xinan Chen, Zachary Gursky, Feng Dai, Andrew Lim, Paul Heerdt, Jonathan Kipnis, Allen Tannenbaum, Hedok Lee, Helene Benveniste |
JCI Insight | 2023 |
Multisite harmonization of diffusion tensor image analysis along the perivascular space using the COMBined Association Test.
Saito Y, Kamagata K, Andica C, Taoka T, Tuerxun R, Uchida W, Takabayashi K, Owaki M, Yoshida S, Yamazaki K, Naganawa S, Aoki S |
Japanese Journal of Radiology | 2023 |
Neuronal Ndst1 depletion accelerates prion protein clearance and enhances survival in prion-infected mice
Patricia Aguilar-Calvo, Adela Malik, Daniel Sandoval, Christopher Barback, Christina Orru, Heidi Standke, Olivia Thomas, Chrissa Dwyer, Donald Pizzo, Jaidev Bapat, Katrin Soldau, Ryotaro Ogawa, Mckenzie Riley, K. Nilsson, Allison Kraus, Byron Caughey, Jeffrey Iliff, David Vera, Jeffrey Esko, Christina Sigurdson |
PLoS pathogens | 2023 |
The consequences of sleep deprivation on cognitive performance.
Khan MA, Al-Jahdali H |
2023 | |
Reproducibility of automated calculation technique for diffusion tensor image analysis along the perivascular space.
Saito Y, Kamagata K, Andica C, Uchida W, Takabayashi K, Yoshida S, Nakaya M, Tanaka Y, Kamiyo S, Sato K, Nishizawa M, Akashi T, Shimoji K, Wada A, Aoki S |
Japanese Journal of Radiology | 2023 |
The glymphatic system's role in traumatic brain injury-related neurodegeneration.
Peters ME, Lyketsos CG |
Molecular Psychiatry | 2023 |
Single nucleotide polymorphisms in aquaporin-4 associate with cognitive impairment status in people with HIV.
Tice C, Zhao H, Langford D |
Journal of Neurovirology | 2023 |
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma neurofilament light, a biomarker of injury severity
Butler T, Zhou L, Ozsahin I, Wang XH, Garetti J, Zetterberg H, Blennow K, Jamison K, de Leon MJ, Li Y, Kuceyeski A, Shah SA |
2023 | |
The stress of losing sleep: Sex-specific neurobiological outcomes
Wright CJ, Milosavljevic S, Pocivavsek A |
Neurobiology of Stress | 2023 |
Cerebrospinal Fluid–Basic Concepts Review
Czarniak N, Kamińska J, Matowicka-Karna J, Koper-Lenkiewicz OM |
Biomedicines | 2023 |
Glymphatic influx and clearance are accelerated by neurovascular coupling.
Holstein-Rønsbo S, Gan Y, Giannetto MJ, Rasmussen MK, Sigurdsson B, Beinlich FRM, Rose L, Untiet V, Hablitz LM, Kelley DH, Nedergaard M |
Nature Neuroscience | 2023 |
Age- and time-of-day dependence of glymphatic function in the human brain measured via two diffusion MRI methods
Han G, Zhou Y, Zhang K, Jiao B, Hu J, Zhang Y, Wang Z, Lou M, Bai R |
Frontiers in aging neuroscience | 2023 |
Glymphatic system impairment in corticobasal syndrome: diffusion tensor image analysis along the perivascular space (DTI-ALPS).
Saito Y, Kamagata K, Andica C, Uchida W, Takabayashi K, Yoshida S, Nakaya M, Tanaka Y, Kamio S, Sato K, Nishizawa M, Akashi T, Shimoji K, Wada A, Aoki S |
Japanese Journal of Radiology | 2023 |
Perivascular network segmentations derived from high-field MRI and their implications for perivascular and parenchymal mass transport in the rat brain.
Rey JA, Farid UM, Najjoum CM, Brown A, Magdoom KN, Mareci TH, Sarntinoranont M |
Scientific Reports | 2023 |
AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies
Düchs M, Blazevic D, Rechtsteiner P, Kenny C, Lamla T, Low S, Savistchenko J, Neumann M, Melki R, Schönberger T, Stierstorfer B, Wyatt D, Igney F, Ciossek T |
npj Parkinson's Disease | 2023 |
Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain.
Segeroth M, Wachsmuth L, Gagel M, Albers F, Hess A, Faber C |
Fluids and barriers of the CNS | 2023 |
Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation
Galea I, Bandyopadhyay S, Bulters D, Humar R, Hugelshofer M, Schaer DJ |
Stroke; a journal of cerebral circulation | 2023 |
A SPECT-based method for dynamic imaging of the glymphatic system in rats
Sigurdsson B, Hauglund NL, Lilius TO, Mogensen FL, Mortensen KN, Beschorner N, Klinger L, Bærentzen SL, Rosenholm MP, Shalgunov V, Herth M, Mori Y, Nedergaard M |
Journal of Cerebral Blood Flow & Metabolism | 2023 |
The glymphatic system: a new perspective on brain diseases
Ding Z, Fan X, Zhang Y, Yao M, Wang G, Dong Y, Liu J, Song W |
Frontiers in aging neuroscience | 2023 |
In Vivo Distribution of Cerebrospinal Fluid Tracer in Human Upper Spinal Cord and Brain Stem
Erik Melin, Are H Pripp, Per Eide, Geir Ringstad |
JCI Insight | 2023 |
Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage
Chai CZ, Ho UC, Kuo LT |
International journal of molecular sciences | 2023 |
rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage
Liu Y, Liu X, Sun P, Li J, Nie M, Gong J, He A, Zhao M, Yang C, Wang Z |
Brain and Behavior | 2023 |
Sizes and shapes of perivascular spaces surrounding murine pial arteries
Raicevic N, Forer JM, Ladrón-de-Guevara A, Du T, Nedergaard M, Kelley DH, Boster K |
Fluids and barriers of the CNS | 2023 |
Physiological alterations of pineal recess crowding in symptomatic non-hydrocephalic pineal cysts
Eide PK, Lindstrøm EK, Pripp AH, Valnes LM, Ringstad G |
2023 | |
New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery
Qi Y, Xiong W, Chen Q, Ye Z, Jiang C, He Y, Ye Q |
Journal of nanobiotechnology | 2023 |
Intrathecal [(64)Cu]Cu-albumin PET reveals age-related decline of lymphatic drainage of cerebrospinal fluid.
Sarker A, Suh M, Choi Y, Park JY, Lee YS, Lee DS |
Scientific Reports | 2023 |
Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease
Rego S, Sanchez G, Da Mesquita S |
Molecular Neurodegeneration | 2023 |
Evaluation of glymphatic system activity using diffusion tensor image analysis along the perivascular space and amyloid PET in older adults with objectively normal cognition: a preliminary study
Park CJ, Kim SY, Kim JH, Son NH, Park JY, Jeong YH, Kim HJ, Park J, Kim WJ |
Frontiers in aging neuroscience | 2023 |
Glymphatic transport is reduced in rats with spontaneous pituitary tumor.
Li L, Ding G, Zhang L, Luo H, Davoodi-Bojd E, Li Q, Chopp M, Zhang ZG, Jiang Q |
Frontiers in Medicine | 2023 |
Mapping the Glymphatic Pathway Using Imaging Advances.
Thakkar RN, Kioutchoukova IP, Griffin I, Foster DT, Sharma P, Valero EM, Lucke-Wold B |
Journal of IMAB - Annual Proceeding (Scientific Papers) | 2023 |
Transport pathways and kinetics of cerebrospinal fluid tracers in mouse brain observed by dynamic contrast-enhanced MRI
Zhu Y, Wang G, Kolluru C, Gu Y, Gao H, Zhang J, Wang Y, Wilson DL, Zhu X, Flask CA, Yu X |
Scientific Reports | 2023 |
A bibliometric and knowledge-map analysis of the glymphatic system from 2012 to 2022
Hou C, Ren W, Wang B, Fu X, Liu Q, Li J, Zhang H, Wang W, Yang X, Wei P, Zhao G |
Frontiers in molecular neuroscience | 2023 |
Preliminary cross-sectional investigations into the human glymphatic system using multiple novel non-contrast MRI methods
Levendovszky SR, Flores J, Peskind ER, Václavů L, van Osch MJ, Iliff J |
2023 | |
Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson's disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings.
Mays GP, Hett K, Eisma J, McKnight CD, Elenberger J, Song AK, Considine C, Han C, Stark A, Claassen DO, Donahue MJ |
Research square | 2023 |
Assessment of factors influencing glymphatic activity and implications for clinical medicine
Gędek A, Koziorowski D, Szlufik S |
Frontiers in neurology | 2023 |
Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease
Lee YJ, Park KM, Heo CM, Park S, Kim YW, Lee D, Kim Y, Oh JS, Shin HS, Park BS |
Renal Failure | 2023 |
Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents
Kim E, Van Reet J, Yoo SS |
Scientific Reports | 2023 |
Spontaneous vasomotion propagates along pial arterioles in the awake mouse brain like stimulus-evoked vascular reactivity
Munting LP, Bonnar O, Kozberg MG, Auger CA, Hirschler L, Hou SS, Greenberg SM, Bacskai BJ, van Veluw SJ |
Journal of Cerebral Blood Flow & Metabolism | 2023 |
Neurofluids and the glymphatic system: anatomy, physiology, and imaging
Wang DJ, Hua J, Cao D, Ho ML |
British Journal of Radiology | 2023 |
Imaging glymphatic response to glioblastoma
Kaur J, Ding G, Zhang L, Lu Y, Luo H, Li L, Boyd E, Li Q, Wei M, Zhang Z, Chopp M, Jiang Q |
Cancer imaging : the official publication of the International Cancer Imaging Society | 2023 |
The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance
Kaur J, Boyd E, Ding G, Zhang L, Luo H, Li Q, Li L, Wei M, Landschoot-Ward J, Chopp M, Zhang Z, Jiang Q |
Research square | 2023 |
Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome
Agarwal N, Lewis LD, Hirschler L, Rivera LR, Naganawa S, Levendovszky SR, Ringstad G, Klarica M, Wardlaw J, Iadecola C, Hawkes C, Octavia Carare R, Wells J, Bakker EN, Kurtcuoglu V, Bilston L, Nedergaard M, Mori Y, Stoodley M, Alperin N, de Leon M, van Osch MJ |
Journal of magnetic resonance imaging : JMRI | 2023 |
Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
Larrea A, Elexpe A, Díez-Martín E, Torrecilla M, Astigarraga E, Barreda-Gómez G |
Current issues in molecular biology | 2023 |
Real-time Quantification of in vivo cerebrospinal fluid velocity using fMRI inflow effect
Diorio TC, Nair VV, Patel NM, Hedges LE, Rayz VL, Tong Y |
2023 | |
Quantification of T1 and T2 of subarachnoid CSF: implications for water exchange between CSF and brain tissues
Jiang D, Gou Y, Wei Z, Hou X, Yedavalli V, Lu H |
Magnetic Resonance in Medicine | 2023 |
The Haptoglobin Response after Aneurysmal Subarachnoid Haemorrhage.
Bandyopadhyay S, Garland P, Gaastra B, Zolnourian A, Bulters D, Galea I |
International journal of molecular sciences | 2023 |
Impaired glymphatic system revealed by DTI-ALPS in cerebral palsy due to periventricular leukomalacia: relation with brain lesion burden and hand dysfunction.
Yin Y, Peng Y, Nie L, Li X, Xiao Y, Jiang H, Gao L, Liu H |
Neuroradiology | 2023 |
Dysfunction of the glymphatic system in childhood absence epilepsy
Pu W, Wei S, Qiu M, Chen X, Zou W, Ge Y, Qiu W |
Frontiers in neuroscience | 2023 |
Interplay between the Glymphatic System and the Endocannabinoid System: Implications for Brain Health and Disease
Osuna-Ramos JF, Camberos-Barraza J, Torres-Mondragón LE, Rábago-Monzón ÁR, Camacho-Zamora A, Valdez-Flores MA, Angulo-Rojo CE, Guadrón-Llanos AM, Picos-Cárdenas VJ, Calderón-Zamora L, Magaña-Gómez JA, Norzagaray-Valenzuela CD, Cárdenas-Torres FI, De la Herrán-Arita AK |
International journal of molecular sciences | 2023 |
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases.
Zhang J, Liu S, Wu Y, Tang Z, Wu Y, Qi Y, Dong F, Wang Y |
Cellular and Molecular Neurobiology | 2023 |
Impaired cerebral interstitial fluid dynamics in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy
Hsu SL, Liao YC, Wu CH, Chang FC, Chen YL, Lai KL, Chung CP, Chen SP, Lee YC |
2023 | |
Imaging of brain clearance pathways via MRI assessment of the glymphatic system
He Y, Guan J, Lai L, Zhang X, Chen B, Wang X, Wu R |
Aging | 2023 |
Concurrent measurement of perfusion parameters related to small blood vessels and CSF circulation in the human brain using dynamic dual-spin-echo perfusion (DDSEP) MRI
Cao D, Sun Y, Li Y, Su P, Pillai JJ, Qiao Y, Lu H, Van Zijl PC, Knutsson L, Hua J |
NMR in Biomedicine | 2023 |
Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
Carrero L, Antequera D, Municio C, Carro E |
Neural Regeneration Research | 2023 |
Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for treatment of metastatic medulloblastoma
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM |
Science Translational Medicine | 2023 |
Effects of clamping end-tidal CO2 on neurofluidic low-frequency oscillations
Kish B, Jean Chen J, Tong Y |
NMR in Biomedicine | 2023 |
Blockage of CSF Outflow in Rats after Deep Cervical Lymph Node Ligation Observed Using Gd-based MR Imaging
Kinota N, Kameda H, Xiawei B, Fujii T, Kato D, Takahashi B, Morita R, Abo D, Majima R, Ishii H, Minowa K, Kudo K |
Magnetic Resonance in Medical Sciences | 2023 |
Gray matter reserve determines glymphatic system function in young-onset Alzheimer's disease: Evidenced by DTI-ALPS and compared with age-matched controls.
Chang HI, Huang CW, Hsu SW, Huang SH, Lin KJ, Ho TY, Ma MC, Hsiao WC, Chang CC |
Psychiatry and clinical neurosciences | 2023 |
Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice
Yann Decker, Jonas Krämer, Li Xin, Andreas Müller, Anja Scheller, Klaus Fassbender, Steven T Proulx |
JCI Insight | 2022 |
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline
Tuomas Lilius, Marko Rosenholm, Laura Klinger, Kristian Mortensen, Björn Sigurdsson, Frida Mogensen, Natalie Hauglund, Malthe Nielsen, Tomi Rantamäki, Maiken Nedergaard |
iScience | 2022 |
Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
E Candelario-Jalil, R Dijkhuizen, T Magnus |
Stroke; a journal of cerebral circulation | 2022 |
Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases
C Rickenbach, C Gericke |
Frontiers in neuroscience | 2022 |
Military traumatic brain injury: a challenge straddling neurology and psychiatry
L Kong, R Zhang, S Hu, J Lai |
Military Medical Research | 2022 |
Impediment of Cerebrospinal Fluid Drainage Through Glymphatic System in Glioma
D Xu, J Zhou, H Mei, H Li, W Sun, H Xu |
Frontiers in Oncology | 2022 |
The glymphatic hypothesis: the theory and the evidence
S Hladky, M Barrand |
Fluids and barriers of the CNS | 2022 |
Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment
M Li, A Kitamura, J Beverley, J Koudelka, J Duncombe, R Lennen, M Jansen, I Marshall, B Platt, U Wiegand, R Carare, R Kalaria, J Iliff, K Horsburgh |
Frontiers in aging neuroscience | 2022 |
Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review
P Chong, D Garic, M Shen, I Lundgaard, A Schwichtenberg |
Sleep Medicine Reviews | 2022 |
Immune dynamics in the CNS and its barriers during homeostasis and disease*
M Buckley, D McGavern |
Immunological Reviews | 2022 |
Interstitial Fluid Behavior and Diseases
W Liu, Y Cao, X Zhou, D Han |
Advanced Science | 2022 |
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
Y Li, H Rusinek, T Butler, L Glodzik, E Pirraglia, J Babich, P Mozley, S Nehmeh, S Pahlajani, X Wang, E Tanzi, L Zhou, S Strauss, R Carare, N Theise, N Okamura, M de Leon |
Fluids and barriers of the CNS | 2022 |
Gadolinium retention after contrast-enhanced magnetic resonance imaging: A narrative review
A Al-Muhanna |
2022 | |
Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis
A Zamani, A Walker, B Rollo, K Ayers, R Farah, T OBrien, D Wright |
Translational Neurodegeneration | 2022 |
Impaired Glymphatic Transport Kinetics Following Induced Acute Ischemic Brain Edema in a Mouse pMCAO Model
J Zhang, H Zhao, Y Xue, Y Liu, G Fan, H Wang, Q Dong, W Cao |
Frontiers in neurology | 2022 |
Aging-Related Alterations of Glymphatic Transport in Rat: In vivo Magnetic Resonance Imaging and Kinetic Study
L Li, G Ding, L Zhang, E Davoodi-Bojd, M Chopp, Q Li, Z Zhang, Q Jiang |
Frontiers in aging neuroscience | 2022 |
The Effects of Peripheral Inflammation on the Brain—A Neuroimaging Perspective
C Millett, K Burdick, M Kubicki |
Harvard Review of Psychiatry | 2022 |
Pulsatility Index in the Basal Ganglia Arteries Increases with Age in Elderly with and without Cerebral Small Vessel Disease
V Perosa, T Arts, A Assmann, H Mattern, O Speck, J Oltmer, H Heinze, E Düzel, S Schreiber, J Zwanenburg |
American Journal of Neuroradiology | 2022 |
TAT-HSP27 Peptide Improves Neurologic Deficits via Reducing Apoptosis After Experimental Subarachnoid Hemorrhage
X Zhou, J Sun, W Wang, S Li, H Li, H Yang, M Yang, H Yuan, Z Zhang, B Sun, J Han |
Frontiers in cellular neuroscience | 2022 |
Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model
R Kedarasetti, P Drew, F Costanzo |
Fluids and barriers of the CNS | 2022 |
Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders
D Zhang, X Li, B Li |
Frontiers in aging neuroscience | 2022 |
Periodontitis: Advances in Experimental Research
J Santi-Rocca |
2022 | |
Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain
S Keil, M Braun, R OBoyle, M Sevao, T Pedersen, S Agarwal, D Jansson, J Iliff |
Neurophotonics | 2022 |
Impaired Glymphatic System Actions in Obstructive Sleep Apnea Adults
B Roy, A Nunez, R Aysola, D Kang, S Vacas, R Kumar |
Frontiers in neuroscience | 2022 |
Perivascular Spaces, Glymphatic System and MR
L Yu, X Hu, H Li, Y Zhao |
Frontiers in neurology | 2022 |
[64Cu]Cu-Albumin Clearance Imaging to Evaluate Lymphatic Efflux of Cerebrospinal Space Fluid in Mouse Model
Sarker A, Suh M, Choi Y, Park JY, Kwon S, Kim H, Lee E, Seo H, Lee YS, Lee DS |
Nuclear Medicine and Molecular Imaging | 2022 |
Mesenchymal Stem Cells Improve Cognitive Impairment and Reduce Aβ Deposition via Promoting AQP4 Polarity and Relieving Neuroinflammation in Rats With Chronic Hypertension-Induced Cerebral Small-Vessel Disease
Liu XL, Ouyang FB, Hu LT, Sun P, Yang J, Sun YJ, Liao MS, Lan LF, Pei Z, Fan YH |
Frontiers in aging neuroscience | 2022 |
Meningeal and Visual Pathway Magnetic Resonance Imaging Analysis after Single and Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA)-Induced Disruption in Male and Female Mice
McNamara EH, Knutsen A, Korotcov A, Bosomtwi A, Liu J, Fu AH, Kostelnik C, Grillakis AA, Spencer H, Dardzinski B, McCabe JT |
Journal of Neurotrauma | 2022 |
Imaging perivascular space structure and function using brain MRI
Barisano G, Lynch KM, Sibilia F, Lan H, Shih NC, Sepehrband F, Choupan J |
NeuroImage | 2022 |
Aquaporin 4 Depolarization-Enhanced Transferrin Infiltration Leads to Neuronal Ferroptosis after Subarachnoid Hemorrhage in Mice
Liu Y, Wang Z, Cao C, Xu Z, Lu J, Shen H, Li X, Li H, Wu J, Chen G |
Oxidative medicine and cellular longevity | 2022 |
Brain Distribution of Drugs: Brain Morphology, Delivery Routes, and Species Differences.
Bourasset F, Auvity S, Thorne RG, Scherrmann JM |
Handbook of experimental pharmacology | 2022 |
Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight
Hupfeld KE, Richmond SB, McGregor HR, Schwartz DL, Luther MN, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Wood SJ, Bloomberg JJ, Mulavara AP, Silbert LC, Iliff JJ, Seidler RD, Piantino J |
Scientific Reports | 2022 |
Sensitivity analysis on a network model of glymphatic flow
Boster KA, Tithof J, Cook DD, Thomas JH, Kelley DH |
Journal of The Royal Society Interface | 2022 |
Glymphatic system dysfunction in temporal lobe epilepsy patients with hippocampal sclerosis
Lee DA, Park BS, Ko J, Park SH, Lee YJ, Kim IH, Park JH, Park KM |
Epilepsia Open | 2022 |
Sleep and Alzheimer: The Link
GAUR A, KALIAPPAN A, BALAN Y, SAKTHIVADIVEL V, MEDALA K, UMESH M |
Mædica | 2022 |
MRI-Based Demonstration of the Normal Glymphatic System in a Human Population: A Systematic Review
Lee MK, Cho SJ, Bae YJ, Kim JM |
Frontiers in neurology | 2022 |
The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
Tang J, Zhang M, Liu N, Xue Y, Ren X, Huang Q, Shi L, Fu J |
Frontiers in aging neuroscience | 2022 |
Evaluation of the Glymphatic System Using the DTI-ALPS Index in Patients with Spontaneous Intracerebral Haemorrhage
Zhang C, Sha J, Cai L, Xia Y, Li D, Zhao H, Meng C, Xu K |
Oxidative medicine and cellular longevity | 2022 |
Immediate impact of yogic breathing on pulsatile cerebrospinal fluid dynamics.
Yildiz S, Grinstead J, Hildebrand A, Oshinski J, Rooney WD, Lim MM, Oken B |
Scientific Reports | 2022 |
The glymphatic system: implications for drugs for central nervous system diseases.
Lohela TJ, Lilius TO, Nedergaard M |
Nature reviews. Drug discovery | 2022 |
Glymphatic system dysfunction in patients with cluster headache.
Kim J, Lee DA, Lee HJ, Park BS, Ko J, Park SH, Lee YJ, Kim IH, Park JH, Park KM |
Brain and Behavior | 2022 |
Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques.
Meseck EK, Guibinga G, Wang S, McElroy C, Hudry E, Mansfield K |
Toxicologic pathology | 2022 |
Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy.
Szu JI, Binder DK |
Frontiers in cellular neuroscience | 2022 |
The role of the parenchymal vascular system in cerebrospinal fluid tracer clearance.
Hu J, Shen Y, Fahmy LM, Krishnamurthy S, Li J, Zhang L, Chen Y, Haacke EM, Jiang Q |
European Radiology | 2022 |
Effects of Hippocampal Sparing Radiotherapy on Brain Microstructure-A Diffusion Tensor Imaging Analysis.
Dinkel JG, Lahmer G, Mennecke A, Hock SW, Richter-Schmidinger T, Fietkau R, Distel L, Putz F, Dörfler A, Schmidt MA |
Brain Sciences | 2022 |
Biodistribution Analysis of an Anti-EGFR Antibody in the Rat Brain: Validation of CSF Microcirculation as a Viable Pathway to Circumvent the Blood-Brain Barrier for Drug Delivery.
Naseri Kouzehgarani G, Kumar P, Bolin SE, Reilly EB, Lefebvre DR |
Pharmaceutics | 2022 |
Glymphatic system dysfunction in patients with early chronic kidney disease.
Heo CM, Lee DA, Park KM, Lee YJ, Park S, Kim YW, Ko J, Yoo BC, Park BS |
Frontiers in neurology | 2022 |
Assessing pulsatile waveforms of paravascular cerebrospinal fluid dynamics using dynamic diffusion-weighted imaging (dDWI)
Wen Q, Tong Y, Zhou X, Dzemidzic M, Ho CY, Wu YC |
NeuroImage | 2022 |
Human CSF movement influenced by vascular low frequency oscillations and respiration
Vijayakrishnan Nair V, Kish BR, Inglis B, Yang HC, Wright AM, Wu YC, Zhou X, Schwichtenberg AJ, Tong Y |
Frontiers in physiology | 2022 |
Ocular Lymphatic and Glymphatic Systems: Implications for Retinal Health and Disease.
Uddin N, Rutar M |
International journal of molecular sciences | 2022 |
The glymphatic system: Current understanding and modeling.
Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M |
iScience | 2022 |
Effect of cerebral small vessel disease on cognitive impairment in Parkinson's disease.
Shen Y, Dong Z, Zhong J, Pan P, Xu G, Zhang Z, Zhang X, Shi H |
Acta Neurologica Belgica | 2022 |
The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis
Buccellato FR, D\u2019Anca M, Serpente M, Arighi A, Galimberti D |
Biomedicines | 2022 |
The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
Zhao Z, He J, Chen Y, Wang Y, Wang C, Tan C, Liao J, Xiao G |
Frontiers in molecular neuroscience | 2022 |
Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand WE, Benveniste H |
2022 | |
Plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy induced by type 2 diabetes mellitus
Wang G, Wang F, He Y, Lin J |
Journal of Neuroscience Research | 2022 |
Gadolinium Retention in the Brain of Mother and Pup Mouse: Effect of Pregnancy and Repeated Administration of Gadolinium‐Based Contrast Agents
Yao X, Zhang H, Shi D, Li Y, Guo Q, Yu Z, Wang S, Ren K |
Journal of Magnetic Resonance Imaging | 2022 |
Editorial: Natural products and brain energy metabolism: Astrocytes in neurodegenerative diseases
Wang F, Xu S, Pan F, Verkhratsky A, Huang JH |
Frontiers in pharmacology | 2022 |
High-resolution 3D demonstration of regional heterogeneity in the glymphatic system
He XZ, Li X, Li ZH, Meng JC, Mao RT, Zhang XK, Zhang RT, Huang HL, Gui Q, Xu GY, Wang LH |
Journal of Cerebral Blood Flow & Metabolism | 2022 |
Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders.
Jiang Y, Zou D, Li Y, Gu S, Dong J, Ma X, Xu S, Wang F, Huang JH |
Pharmaceuticals (Basel, Switzerland) | 2022 |
Perivascular spaces as a potential biomarker of Alzheimer's disease.
Lynch M, Pham W, Sinclair B, O'Brien TJ, Law M, Vivash L |
Frontiers in neuroscience | 2022 |
Technical feasibility of using auditory phase-targeted stimulation after pediatric severe traumatic brain injury in an intensive care setting.
Albrecht JN, Jaramillo V, Huber R, Karlen W, Baumann CR, Brotschi B |
BMC Pediatrics | 2022 |
Transport in the Brain Extracellular Space: Diffusion, but Which Kind?
Postnikov EB, Lavrova AI, Postnov DE |
International journal of molecular sciences | 2022 |
Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults
Blackman J, Stankeviciute L, Arenaza-Urquijo EM, Suárez-Calvet M, Sánchez-Benavides G, Vilor-Tejedor N, Iranzo A, Molinuevo JL, Gispert JD, Coulthard E, Grau-Rivera O |
2022 | |
Hypothermia reduces glymphatic transportation in traumatic edematous brain assessed by intrathecal dynamic contrast-enhanced MRI
Bai Y, Yuan M, Mi H, Zhang F, Liu X, Lu C, Bao Y, Li Y, Lu Q |
Frontiers in neurology | 2022 |
Neural Stem Cells in Adult Mammals are not Astrocytes
Velloso FJ, Shankar S, Parpura V, Rakic P, Levison SW |
ASN NEURO | 2022 |
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease
Scott-Massey A, Boag MK, Magnier A, Bispo DP, Khoo TK, Pountney DL |
International journal of molecular sciences | 2022 |
Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition
Princiotta Cariddi L, Mauri M, Cosentino M, Versino M, Marino F |
International journal of molecular sciences | 2022 |
Glymphatic system impairment in patients with status epilepticus.
Lee DA, Lee J, Park KM |
Neuroradiology | 2022 |
An Alzheimer’s Disease Mechanism Based on Early Pathology, Anatomy, Vascular-Induced Flow, and Migration of Maximum Flow Stress Energy Location with Increasing Vascular Disease
Trumbore CN, Raghunandan A |
Journal of Alzheimer's disease : JAD | 2022 |
Management of Sleep Disturbances in Parkinson’s Disease
Schütz L, Sixel-Döring F, Hermann W |
Journal of Parkinson's disease | 2022 |
The lymphatic drainage systems in the brain: a novel target for ischemic stroke?
Wang YJ, Sun YR, Pei YH, Ma HW, Mu YK, Qin LH, Yan JH |
Neural Regeneration Research | 2022 |
Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease
Saavedra J, Nascimento M, Liz MA, Cardoso I |
Frontiers in Cell and Developmental Biology | 2022 |
A critical guide to the automated quantification of perivascular spaces in magnetic resonance imaging
Pham W, Lynch M, Spitz G, O\u2019Brien T, Vivash L, Sinclair B, Law M |
Frontiers in neuroscience | 2022 |
Variances of quantifying of Virchow–Robin spaces detecting the different functional status of glymphatic system in simple febrile seizures affected by seizures duration
Li X, Ruan C, Wu Y, Musa M, Zibrila AI, Zhang Z, Salimeen M |
Medicine | 2022 |
Cisternostomy for malignant middle cerebral artery infarction: proposed pathophysiological mechanisms and preliminary results
Cardali SM, Caffo M, Caruso G, Scalia G, Gorgoglione N, Conti A, Vinci SL, Barresi V, Granata F, Ricciardo G, Garufi G, Raffa G, Germanò A |
2022 | |
CSF Dynamics: Implications for Hydrocephalus and Glymphatic Clearance
Bissenas A, Fleeting C, Patel D, Al-Bahou R, Patel A, Nguyen A, Woolridge M, Angelle C, Lucke-Wold B |
2022 | |
Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
Riba M, del Valle J, Molina-Porcel L, Pelegrí C, Vilaplana J |
Proceedings of the National Academy of Sciences | 2022 |
The Lymphatic System in Neurological Disease and Alzheimer's Disease. A Brief Editorial.
Pappolla MA, Carare RO, Poeggeler B, Wisniewski T, Sambamurti K |
Current Alzheimer research | 2022 |
Enlarged perivascular spaces are associated with decreased brain tau deposition
Kang KM, Byun MS, Yi D, Lee KH, Kim MJ, Ahn H, Jung G, Lee J, Kim YK, Lee Y, Sohn C, Lee DY |
CNS Neuroscience & Therapeutics | 2022 |
Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease.
Mehta NH, Suss RA, Dyke JP, Theise ND, Chiang GC, Strauss S, Saint-Louis L, Li Y, Pahlajani S, Babaria V, Glodzik L, Carare RO, de Leon MJ |
Neurobiology of Disease | 2022 |
Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI
Moses J, Sinclair B, Law M, O'Brien TJ, Vivash L |
Journal of Magnetic Resonance Imaging | 2022 |
Radiological biomarkers of idiopathic normal pressure hydrocephalus: new approaches for detecting concomitant Alzheimer's disease and predicting prognosis.
Cai H, Zou Y, Gao H, Huang K, Liu Y, Cheng Y, Liu Y, Zhou L, Zhou D, Chen Q |
2022 | |
Direct imaging of glymphatic transport using H2O17 MRI
Mohammed Alshuhri, Lindsay Gallagher, Lorraine M. Work, William M Holmes |
JCI Insight | 2021 |
Glymphatic System in the Central Nervous System, a Novel Therapeutic Direction Against Brain Edema After Stroke
X Zhou, Y Li, C Lenahan, Y Ou, M Wang, Y He |
Frontiers in aging neuroscience | 2021 |
CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
SP das Neves, N Delivanoglou, SD Mesquita |
Frontiers in pharmacology | 2021 |
Basal lamina changes in neurodegenerative disorders
B Nguyen, G Bix, Y Yao |
Molecular Neurodegeneration | 2021 |
Waste Clearance in the Brain
J Kaur, LM Fahmy, E Davoodi-Bojd, L Zhang, G Ding, J Hu, Z Zhang, M Chopp, Q Jiang |
Frontiers in neuroanatomy | 2021 |
Localized Modification of Water Molecule Transport After Focused Ultrasound-Induced Blood–Brain Barrier Disruption in Rat Brain
M Han, H Seo, H Choi, EH Lee, J Park |
Frontiers in neuroscience | 2021 |
Water exchange rate across the blood‐brain barrier is associated with CSF amyloid‐β 42 in healthy older adults
BT Gold, X Shao, TL Sudduth, GA Jicha, DM Wilcock, ER Seago, DJ Wang |
Alzheimer's & dementia : the journal of the Alzheimer's Association | 2021 |
Contrasting Metabolic Insufficiency in Aging and Dementia
DA Turner |
Aging and disease | 2021 |
A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms
K Segawa, Y Blumenthal, Y Yamawaki, Ohtsuki |
Biology : open access journal | 2021 |
Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia
K Albert, J Niskanen, S Kälvälä, Š Lehtonen |
International journal of molecular sciences | 2021 |
Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans
V Fleischer, G Gonzalez-Escamilla, D Ciolac, P Albrecht, P Küry, J Gruchot, M Dietrich, C Hecker, T Müntefering, S Bock, M Oshaghi, A Radetz, M Cerina, J Krämer, L Wachsmuth, C Faber, H Lassmann, T Ruck, SG Meuth, M Muthuraman, S Groppa |
Proceedings of the National Academy of Sciences | 2021 |
Imaging Extracellular Acidification and Immune Activation in Cancer
F Hyder, D Coman |
Current Opinion in Biomedical Engineering | 2021 |
Mapping Solute Clearance From the Mouse Hippocampus Using a 3D Imaging Cryomicrotome
DM Naessens, JG Dobbe, J de Vos, E VanBavel, EN Bakker |
Frontiers in neuroscience | 2021 |
Transient changes in white matter microstructure during general anesthesia
CY Tang, VX Wang, MY Lun, JS Mincer, JC Ng, JW Brallier, AE Schwartz, H Ahn, PJ McCormick, T Nir, B Delman, M Sano, SG Deiner, MG Baxter, Q Jiang |
PloS one | 2021 |
Woes with flows under pressure
DJ Jansson, JJ Iliff |
2021 | |
No Arachnoid Granulations—No Problems: Number, Size, and Distribution of Arachnoid Granulations From Birth to 80 Years of Age
M Radoš, M Živko, A Periša, D Orešković, M Klarica |
Frontiers in aging neuroscience | 2021 |
Electroacupuncture Improves Clearance of Amyloid-β through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer’s Disease
P Liang, L Li, Y Zhang, Y Shen, L Zhang, J Zhou, Z Wang, S Wang, S Yang, F Zhang |
Neural plasticity | 2021 |
Modeling Pharmacokinetics and Pharmacodynamics of Therapeutic Antibodies: Progress, Challenges, and Future Directions
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Pharmaceutics | 2021 |
Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study
T Taoka, R Ito, R Nakamichi, K Kamagata, M Sakai, H Kawai, T Nakane, T Abe, K Ichikawa, J Kikuta, S Aoki, S Naganawa |
Japanese Journal of Radiology | 2021 |
All Central Nervous System Neuro- and Vascular-Communication Channels Are Surrounded With Cerebrospinal Fluid
LM Fahmy, Y Chen, S Xuan, EM Haacke, J Hu, Q Jiang |
Frontiers in neurology | 2021 |
Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
H Benveniste, H Lee, B Ozturk, X Chen, S Koundal, P Vaska, A Tannenbaum, ND Volkow |
Neuroscience | 2021 |
Case report: Manual therapies promote resolution of persistent post-concussion symptoms in a 24-year-old athlete
SV Kratz |
SAGE Open Medical Case Reports | 2021 |
A proposed framework for cerebral venous congestion
A Arun, MR Amans, N Higgins, W Brinjikji, M Sattur, SR Satti, P Nakaji, M Luciano, TA Huisman, A Moghekar, VM Pereira, R Meng, K Fargen, FK Hui |
The neuroradiology journal | 2021 |
Link between Mild Traumatic Brain Injury, Poor Sleep, and Magnetic Resonance Imaging: Visible Perivascular Spaces in Veterans
J Piantino, DL Schwartz, M Luther, C Newgard, L Silbert, M Raskind, K Pagulayan, N Kleinhans, J Iliff, E Peskind |
Journal of Neurotrauma | 2021 |
Accumulation of Macromolecules in Idiopathic Normal Pressure Hydrocephalus
Y AKIYAMA, R YOKOYAMA, H TAKASHIMA, Y KAWATA, M ARIHARA, R CHIBA, Y KIMURA, T MIKAMI, N MIKUNI |
Neurologia medico-chirurgica | 2021 |
Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics
BO Ozturk, B Monte, S Koundal, F Dai, H Benveniste, H Lee |
Fluids and barriers of the CNS | 2021 |
Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline
F Han, GL Brown, Y Zhu, AE BelkinRosen, MM Lewis, G Du, Y Gu, PJ Eslinger, RB Mailman, X Huang, X Liu |
Movement disorders : official journal of the Movement Disorder Society | 2021 |
Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting
S Naganawa, R Ito, Y Kato, H Kawai, T Taoka, T Yoshida, K Maruyama, K Murata, G Körzdörfer, J Pfeuffer, M Nittka, M Sone |
Magnetic Resonance in Medical Sciences | 2021 |
Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration
S Naganawa, R Ito, R Nakamichi, M Kawamura, H Kawai, T Taoka, T Yoshida, M Sone |
Magnetic Resonance in Medical Sciences | 2021 |
The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage
E Liu, X Peng, H Ma, Y Zhang, X Yang, Y Zhang, L Sun, J Yan |
Frontiers in aging neuroscience | 2021 |
Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer’s Disease
D Reimers, M Vallejo-Muñoz, MJ Casarejos, A Jimenez-Escrig, R Gonzalo-Gobernado, E Bazan |
International journal of molecular sciences | 2021 |
Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients
K Chatterjee, N Atay, D Abler, S Bhargava, P Sahoo, RC Rockne, JM Munson |
Pharmaceutics | 2021 |
Research on the Glial–Lymphatic System and Its Relationship With Alzheimer’s Disease
D Ding, X Wang, Q Li, L Li, J Wu |
Frontiers in neuroscience | 2021 |
Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration
Y Hatakawa, A Tanaka, T Furubayashi, R Nakamura, M Konishi, T Akizawa, T Sakane |
Pharmaceutics | 2021 |
Extracellular fluid, cerebrospinal fluid and plasma biomarkers of axonal and neuronal injury following intracerebral hemorrhage
L Tobieson, H Zetterberg, K Blennow, N Marklund |
Scientific Reports | 2021 |
Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion
NW Churchill, AP Battista, SG Rhind, D Richards, TA Schweizer, MG Hutchison, MA Deli |
PloS one | 2021 |
Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit
A Gilbert, X Elorza-Vidal, A Rancillac, A Chagnot, M Yetim, V Hingot, T Deffieux, AC Boulay, R Alvear-Perez, S Cisternino, S Martin, S Taïb, A Gelot, V Mignon, M Favier, I Brunet, X Declèves, M Tanter, R Estevez, D Vivien, B Saubaméa, M Cohen-Salmon |
eLife | 2021 |
The Glymphatic System: A Novel Component of Fundamental Neurobiology
LM Hablitz, M Nedergaard |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2021 |
Quantitative analysis of macroscopic solute transport in the murine brain
LA Ray, M Pike, M Simon, JJ Iliff, JJ Heys |
Fluids and barriers of the CNS | 2021 |
Diffusion Tensor Imaging Along the Perivascular Space Index in Different Stages of Parkinson’s Disease
X Ma, S Li, C Li, R Wang, M Chen, H Chen, W Su |
Frontiers in aging neuroscience | 2021 |
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
L Zhang, H Xu, N Ding, X Li, X Chen, Z Chen |
Frontiers in physiology | 2021 |
Magnetic Resonance Imaging in Animal Models of Alzheimer’s Disease Amyloidosis
R Ni |
International journal of molecular sciences | 2021 |
Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex
V Perosa, J Oltmer, LP Munting, WM Freeze, CA Auger, AA Scherlek, AJ van der Kouwe, JE Iglesias, A Atzeni, BJ Bacskai, A Viswanathan, MP Frosch, SM Greenberg, SJ van Veluw |
Acta Neuropathologica | 2021 |
An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension
J Kikuta, K Kamagata, K Takabayashi, T Taoka, H Yokota, C Andica, A Wada, Y Someya, Y Tamura, R Kawamori, H Watada, S Naganawa, S Aoki |
American Journal of Neuroradiology | 2021 |
The bidirectional link between sleep disturbances and traumatic brain injury symptoms: A role for glymphatic dysfunction?
J Piantino, J Iliff, M Lim |
Biological Psychiatry | 2021 |
Cerebrospinal fluid‐tissue exchange revealed by phase alternate labeling with null recovery MRI
A Li, J Xu |
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 2021 |
Age‐dependent cerebrospinal fluid‐tissue water exchange detected by magnetization transfer indirect spin labeling MRI
A Li, L Chen, H Liu, Y Li, W Duan, J Xu |
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 2021 |
Fluid Transport in the Brain
M Rasmussen, H Mestre, M Nedergaard |
Physiological reviews | 2021 |
A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes
Y Fang, L Huang, X Wang, X Si, C Lenahan, H Shi, A Shao, J Tang, S Chen, J Zhang, J Zhang |
Journal of Cerebral Blood Flow & Metabolism | 2021 |
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
M Salman, P Kitchen, A Halsey, M Wang, S Törnroth-Horsefield, A Conner, J Badaut, J Iliff, R Bill |
Brain | 2021 |
The blood cerebrospinal fluid barrier orchestrates immunosurveillance, immunoprotection, and immunopathology in the central nervous system
Ayub M, Jin HK, Bae JS |
BMB Reports | 2021 |
Contrast Enhancement of the Normal Infundibular Recess Using Heavily T2-weighted 3D FLAIR.
Osawa I, Kozawa E, Yamamoto Y, Tanaka S, Shiratori T, Kaizu A, Inoue K, Niitsu M |
2021 | |
Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis
Jason Millward, Paula Ramos Delgado, Alina Smorodchenko, Laura Boehmert, Joao S. Periquito, Henning M. Reimann, Christian Prinz, Antje Els, Michael Scheel, Judith Bellmann-Strobl, Helmar Waiczies, Jens Wuerfel, Carmen Infante-Duarte, Claudia Chien, Joseph Kuchling, Andreas Pohlmann, Frauke Zipp, Friedemann Paul, Thoralf Niendorf, Sonia Waiczies |
JCI Insight | 2020 |
Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model
IF Harrison, O Ismail, A Machhada, N Colgan, Y Ohene, P Nahavandi, Z Ahmed, A Fisher, S Meftah, TK Murray, OP Ottersen, EA Nagelhus, MJ ONeill, JA Wells, MF Lythgoe |
Brain | 2020 |
Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels
GC Rosu, B Catalin, TA Balseanu, M Laurentiu, M Claudiu, S Kumar-Singh, P Daniel |
Molecular Neurobiology | 2020 |
Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system
NB Bèchet, TM Kylkilahti, B Mattsson, M Petrasova, NC Shanbhag, I Lundgaard |
Journal of Cerebral Blood Flow & Metabolism | 2020 |
Androgens’ effects on cerebrovascular function in health and disease
C Abi-Ghanem, LS Robison, KL Zuloaga |
Biology of sex differences | 2020 |
Perivascular spaces in the brain: anatomy, physiology and pathology
JM Wardlaw, H Benveniste, M Nedergaard, BV Zlokovic, H Mestre, H Lee, FN Doubal, R Brown, J Ramirez, BJ MacIntosh, A Tannenbaum, L Ballerini, RL Rungta, D Boido, M Sweeney, A Montagne, S Charpak, A Joutel, KJ Smith, SE Black |
Nature Reviews Neurology | 2020 |
A Review of Hematoma Components Clearance Mechanism After Subarachnoid Hemorrhage
P Pan, L Xu, H Zhang, Y Liu, X Lu, G Chen, H Tang, J Wu |
Frontiers in neuroscience | 2020 |
A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
MS Stringer, H Lee, MT Huuskonen, BJ MacIntosh, R Brown, A Montagne, S Atwi, J Ramirez, MA Jansen, I Marshall, SE Black, BV Zlokovic, H Benveniste, JM Wardlaw |
Translational Stroke Research | 2020 |
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
J Machhi, BD Kevadiya, IK Muhammad, J Herskovitz, KE Olson, RL Mosley, HE Gendelman |
Molecular Neurodegeneration | 2020 |
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects
T Kiss, Á Nyúl-Tóth, P Balasubramanian, S Tarantini, C Ahire, A Yabluchanskiy, T Csipo, E Farkas, JD Wren, L Garman, A Csiszar, Z Ungvari |
GeroScience | 2020 |
Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats
S Bussi, A Coppo, R Celeste, A Fanizzi, AF Mingo, A Ferraris, C Botteron, MA Kirchin, F Tedoldi, F Maisano |
Insights into Imaging | 2020 |
Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor
C Debaker, B Djemai, L Ciobanu, T Tsurugizawa, DL Bihan, Q Jiang |
PloS one | 2020 |
Magnetic Resonance Imaging and Modeling of the Glymphatic System
J Kaur, E Davoodi-Bojd, LM Fahmy, L Zhang, G Ding, J Hu, Z Zhang, M Chopp, Q Jiang |
Diagnostics | 2020 |
Methods to measure, model and manipulate fluid flow in brain
K Chatterjee, CM Carman-Esparza, JM Munson |
Journal of Neuroscience Methods | 2020 |
Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy
H Lee, F Xu, X Liu, S Koundal, X Zhu, J Davis, D Yanez, J Schrader, A Stanisavljevic, DL Rothman, J Wardlaw, WE Nostrand, H Benveniste |
Journal of Cerebral Blood Flow & Metabolism | 2020 |
Brain Glymphatic/Lymphatic Imaging by MRI and PET
DS Lee, M Suh, A Sarker, Y Choi |
Nuclear Medicine and Molecular Imaging | 2020 |
In vivo T1 mapping for quantifying glymphatic system transport and cervical lymph node drainage
Y Xue, X Liu, S Koundal, S Constantinou, F Dai, L Santambrogio, H Lee, H Benveniste |
Scientific Reports | 2020 |
MRI detection of impairment of glymphatic function in rat after mild traumatic brain injury
L Li, M Chopp, G Ding, E Davoodi-Bojd, L Zhang, Q Li, Y Zhang, Y Xiong, Q Jiang |
Brain Research | 2020 |
In vivo assessment of cerebrospinal fluid efflux to nasal mucosa in humans
E Melin, PK Eide, G Ringstad |
Scientific Reports | 2020 |
Characterization of focused ultrasound-mediated brainstem delivery of intranasally administered agents
D Ye, J Luan, H Pang, Y Yang, A Nazeri, JB Rubin, H Chen |
Journal of Controlled Release | 2020 |
CSF Surfactant Protein Changes in Preterm Infants After Intraventricular Hemorrhage
M Krause, W Härtig, CV Mahr, C Richter, J Schob, J Puchta, KT Hoffmann, U Nestler, U Thome, M Knüpfer, C Gebauer, S Schob |
Frontiers in Pediatrics | 2020 |
Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance
W Feng, Y Zhang, Z Wang, H Xu, T Wu, C Marshall, J Gao, M Xiao |
Alzheimer's research & therapy | 2020 |
Current Techniques for Investigating the Brain Extracellular Space
FN Soria, C Miguelez, O Peñagarikano, J Tønnesen |
Frontiers in neuroscience | 2020 |
Apolipoprotein A‐I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high‐density lipoproteins assembled by ABCA1 and LCAT
M Tsujita, B Vaisman, L Chengyu, KC Vickers, K Okuhira, S BraeschAndersen, AT Remaley |
FEBS Letters | 2020 |
Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?
C Tice, J McDevitt, D Langford |
Frontiers in Cellular and Infection Microbiology | 2020 |
The Role of Basement Membranes in Cerebral Amyloid Angiopathy
MD Howe, LD McCullough, A Urayama |
Frontiers in physiology | 2020 |
Regional Differences in Penetration of the Protein Stabilizer Trimethoprim (TMP) in the Rat Central Nervous System
BV Ineichen, SD Palma, E Laczko, SA Liddelow, S Neumann, ME Schwab, AC Mosberger |
Frontiers in molecular neuroscience | 2020 |
Intrathecal 99m Tc‐DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans
A Verma, JY Hesterman, JL Chazen, R Holt, P Connolly, L Horky, S Vallabhajosula, PD Mozley |
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | 2020 |
Apparent diffusion coefficient estimates based on 24 hours tracer movement support glymphatic transport in human cerebral cortex
LM Valnes, SK Mitusch, G Ringstad, PK Eide, SW Funke, KA Mardal |
Scientific Reports | 2020 |
Physiology of Astroglial Excitability
A Verkhratsky, A Semyanov, R Zorec |
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Medical Image Computing and Computer Assisted Intervention – MICCAI 2020: 23rd International Conference, Lima, Peru, October 4–8, 2020, Proceedings, Part VII
AL Martel, P Abolmaesumi, D Stoyanov, D Mateus, MA Zuluaga, SK Zhou, D Racoceanu, L Joskowicz |
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Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
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Neuroradiology | 2020 |
Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry
Y Zhang, J Song, XZ He, J Xiong, R Xue, JH Ge, SY Lu, D Hu, GX Zhang, GY Xu, LH Wang |
Neuroscience Bulletin | 2020 |
The anterior eye chamber: entry of the natural excretion pathway of gadolinium contrast agents?
K Deike-Hofmann, P von Lampe, HP Schlemmer, N Bechrakis, C Kleinschnitz, M Forsting, A Radbruch |
European Radiology | 2020 |
Guide to preclinical models used to study the pathophysiology of idiopathic intracranial hypertension
Z Alimajstorovic, CS Westgate, RH Jensen, S Eftekhari, J Mitchell, V Vijay, SY Seneviratne, SP Mollan, AJ Sinclair |
Eye | 2020 |
The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices
OC Reddy, YD van der Werf |
Brain Sciences | 2020 |
Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System
S Koundal, R Elkin, S Nadeem, Y Xue, S Constantinou, S Sanggaard, X Liu, B Monte, F Xu, WV Nostrand, M Nedergaard, H Lee, J Wardlaw, H Benveniste, A Tannenbaum |
Scientific Reports | 2020 |
Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective
T Taoka, S Naganawa |
Korean Journal of Radiology | 2020 |
Cerebrospinal fluid influx drives acute ischemic tissue swelling
H Mestre, T Du, AM Sweeney, G Liu, AJ Samson, W Peng, KN Mortensen, FF Stæger, PA Bork, L Bashford, ER Toro, J Tithof, DH Kelley, JH Thomas, PG Hjorth, EA Martens, RI Mehta, O Solis, P Blinder, D Kleinfeld, H Hirase, Y Mori, M Nedergaard |
Science | 2020 |
Role of aquaporins in hydrocephalus: what do we know and where do we stand? A systematic review
C de Laurentis, P Cristaldi, A Arighi, C Cavandoli, A Trezza, EP Sganzerla, CG Giussani, AD Cristofori |
Journal of Neurology | 2020 |
The glymphatic system and its role in cerebral homeostasis
H Benveniste, R Elkin, PM Heerdt, S Koundal, Y Xue, H Lee, J Wardlaw, A Tannenbaum |
Journal of applied physiology | 2020 |
The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation
Y Li, H Han, K Shi, D Cui, J Yang, IL Alberts, L Yuan, G Zhao, R Wang, X Cai, Z Teng |
Aging and disease | 2020 |
Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging
M Brady, A Rahman, A Combs, C Venkatraman, RT Kasper, C McQuaid, WC Kwok, RW Wood, R Deane |
Fluids and barriers of the CNS | 2020 |
A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by 18F-positron emitting tomography and fluorescence
H Guo, H Kommidi, CC Lekaye, J Koutcher, MS Judenhofer, SR Cherry, AP Wu, O Akin, MM Souweidane, O Aras, Z Zhu, R Ting |
EJNMMI Research | 2020 |
In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus
HH Jacobsen, T Sandell, ØK Jørstad, MC Moe, G Ringstad, PK Eide |
Investigative ophthalmology & visual science | 2020 |
Determinants of Intraparenchymal Infusion Distributions: Modeling and Analyses of Human Glioblastoma Trials
M Brady, R Raghavan, J Sampson |
Pharmaceutics | 2020 |
Neurons, Glia, Extracellular Matrix and Neurovascular Unit: A Systems Biology Approach to the Complexity of Synaptic Plasticity in Health and Disease
CD Luca, AM Colangelo, A Virtuoso, L Alberghina, M Papa |
International journal of molecular sciences | 2020 |
Fast whole brain MR imaging of dynamic susceptibility contrast changes in the cerebrospinal fluid (cDSC MRI)
D Cao, N Kang, JJ Pillai, X Miao, A Paez, X Xu, J Xu, X Li, Q Qin, PC Zijl, P Barker, J Hua |
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 2020 |
Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases
G Yang, N Deng, Y Liu, Y Gu, X Yao |
Frontiers in human neuroscience | 2020 |
Retention of Gadolinium in Brain Parenchyma: Pathways for Speciation, Access, and Distribution. A Critical Review
M Rasschaert, RO Weller, JA Schroeder, C Brochhausen, JM Idée |
Journal of magnetic resonance imaging : JMRI | 2020 |
Molecular Magnetic Resonance Imaging of Nitric Oxide in Biological Systems
A Barandov, S Ghosh, N Li, BB Bartelle, JI Daher, ML Pegis, H Collins, A Jasanoff |
ACS Sensors | 2020 |
Hippocampal vascular reserve associated with cognitive performance and hippocampal volume
V Perosa, A Priester, G Ziegler, A Cardenas-Blanco, L Dobisch, M Spallazzi, A Assmann, A Maass, O Speck, J Oltmer, HJ Heinze, S Schreiber, E Düzel |
Brain | 2020 |
Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent
S Naganawa, R Ito, H Kawai, T Taoka, T Yoshida, M Sone |
Magnetic Resonance in Medical Sciences | 2020 |
Quantitative imaging of the clearance systems in the eye and the brain
W Deng, C Liu, C Parra, JR Sims, MA Faiq, A Sainulabdeen, H Song, KC Chan |
Quantitative imaging in medicine and surgery | 2020 |
When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow
BA Plog, N Lou, CA Pierre, A Cove, HM Kenney, E Hitomi, H Kang, JJ Iliff, DM Zeppenfeld, M Nedergaard, GE Vates |
Journal of Neurosurgery | 2020 |
Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson’s Disease
AA Tran, MD Smet, GD Grant, TK Khoo, DL Pountney |
2020 | |
The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging.
Naganawa S, Taoka T |
2020 | |
Dural lymphatics regulate clearance of extracellular tau from the CNS
TK Patel, LM Habimana-Griffin, X Gao, B Xu, S Achilefu, K Alitalo, CA McKee, PW Sheehan, ES Musiek, C Xiong, D Coble, DM Holtzman |
Molecular Neurodegeneration | 2019 |
Transcranial Impedance Changes during Sleep: A Rheoencephalography Study
AH Meghdadi, D Popovic, G Rupp, S Smith, C Berka, A Verma |
IEEE Journal of Translational Engineering in Health and Medicine | 2019 |
Development of a Multicomponent Intervention to Prevent Alzheimer's Disease
S Saito, Y Yamamoto, M Ihara |
Frontiers in neurology | 2019 |
Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease
S Sundaram, RL Hughes, E Peterson, EM Müller-Oehring, HM Brontë-Stewart, KL Poston, A Faerman, C Bhowmick, T Schulte |
Neuroscience and biobehavioral reviews | 2019 |
Neuroimaging of traumatic brain injury in military personnel: An overview
A Bhattrai, A Irimia, JD Horn |
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | 2019 |
Gadolinium Deposition in the Brain: Current Updates
JW Choi, WJ Moon |
Korean Journal of Radiology | 2019 |
Modeling glymphatic system of the brain using MRI
E Davoodi-Bojd, G Ding, L Zhang, Q Li, L Li, M Chopp, ZG Zhang, Q Jiang |
NeuroImage | 2019 |
Gadolinium retention in gliomas and adjacent normal brain tissue: association with tumor contrast enhancement and linear/macrocyclic agents
A Kiviniemi, M Gardberg, P Ek, J Frantzén, J Bobacka, H Minn |
Neuroradiology | 2019 |
Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
R Watts, JM Steinklein, L Waldman, X Zhou, CG Filippi |
American Journal of Neuroradiology | 2019 |
Don't forget astrocytes when targeting Alzheimer's disease
JS Sadick, SA Liddelow |
British Journal of Pharmacology | 2019 |
Analysis of convective and diffusive transport in the brain interstitium
L Ray, JJ Iliff, JJ Heys |
Fluids and barriers of the CNS | 2019 |
Increased signal intensity of low-concentration gadolinium contrast agent by longer repetition time in heavily T2-weighted-3D-FLAIR
Y Kato, K Bokura, T Taoka, S Naganawa |
Japanese Journal of Radiology | 2019 |
Increased cerebral blood volume in small arterial vessels is a correlate of Amyloid-β related cognitive decline
J Hua, SW Lee, NI Blair, M Wyss, JM van Bergen, SJ Schreiner, SM Kagerer, SE Leh, AF Gietl, V Treyer, A Buck, RM Nitsch, KP Pruessmann, H Lu, PC Zijl, M Albert, C Hock, PG Unschuld |
Neurobiology of Aging | 2019 |
Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure
AJ Smith, T Duan, AS Verkman |
Acta Neuropathologica Communications | 2019 |
Effect of extradural constriction on CSF flow in rat spinal cord
JA Berliner, T Woodcock, E Najafi, SJ Hemley, M Lam, S Cheng, LE Bilston, MA Stoodley |
Fluids and barriers of the CNS | 2019 |
Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis
JE Carroll, MR Irwin, TE Seeman, AV Diez-Roux, AA Prather, R Olmstead, E Epel, J Lin, S Redline |
Sleep | 2019 |
Gadolinium Retention and Clearance in the Diabetic Brain after Administrations of Gadodiamide, Gadopentetate Dimeglumine, and Gadoterate Meglumine in a Rat Model
S Wang, Z Hua, D Fan, X Zhang, K Ren |
BioMed Research International | 2019 |
Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience
W Deng, MA Faiq, C Liu, V Adi, KC Chan |
Frontiers in neural circuits | 2019 |
MRI of Whole Rat Brain Perivascular Network Reveals Role for Ventricles in Brain Waste Clearance
KN Magdoom, A Brown, J Rey, TH Mareci, MA King, M Sarntinoranont |
Scientific Reports | 2019 |
MRI and glymphatic system
Q Jiang |
BMJ (Clinical research ed.) | 2019 |
Quantitative analysis of Gd in the protein content of the brain following single injection of gadolinium-based contrast agents (GBCAs) by size exclusion chromatography
AA Kartamihardja, H Hanaoka, P Andriana, S Kameo, A Takahashi, H Koyama, Y Tsushima |
British Journal of Radiology | 2019 |
Impaired Glymphatic Transport in Spontaneously Hypertensive Rats
KN Mortensen, S Sanggaard, H Mestre, H Lee, S Kostrikov, AL Xavier, A Gjedde, H Benveniste, M Nedergaard |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2019 |
Sleep as a Therapeutic Target in the Aging Brain
TM Bah, J Goodman, JJ Iliff |
Neurotherapeutics | 2019 |
Imaging of cerebrospinal fluid flow: fundamentals, techniques, and clinical applications of phase-contrast magnetic resonance imaging
A Korbecki, A Zimny, P Podgórski, M Sąsiadek, J Bladowska |
Polish journal of radiology / Polish Medical Society of Radiology | 2019 |
In Reply: Optic Disc Swelling in Astronauts
AS Huang, MB Stenger, BR Macias |
Journal of Glaucoma | 2019 |
Two-Point Dynamic Observation of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus
N Jingami, K Uemura, M Asada-Utsugi, A Kuzuya, S Yamada, M Ishikawa, T Kawahara, T Iwasaki, M Atsuchi, R Takahashi, A Kinoshita |
Journal of Alzheimer's disease : JAD | 2019 |
Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system
JR Goodman, JJ Iliff |
Journal of Cerebral Blood Flow & Metabolism | 2019 |
Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats
X Cai, J Qiao, P Kulkarni, IC Harding, E Ebong, CF Ferris |
Proceedings of the National Academy of Sciences | 2019 |
Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction
J Piantino, MM Lim, CD Newgard, J Iliff |
Current Pain and Headache Reports | 2019 |
Spatiotemporal Distribution of Agrin after Intrathecal Injection and Its Protective Role in Cerebral Ischemia/Reperfusion Injury
S Li, Y Wang, D Jiang, D Ni, CJ Kutyreff, TE Barnhart, JW Engle, W Cai |
Advanced Science | 2019 |
CrossTalk proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin‐4
J Iliff, M Simon |
The Journal of Physiology | 2019 |
Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma
GL Iverson, AJ Gardner, SR Shultz, GS Solomon, P McCrory, R Zafonte, G Perry, LN Hazrati, CD Keene, RJ Castellani |
Brain | 2019 |
Origins of Beta Amyloid Differ Between Vascular Amyloid Deposition and Parenchymal Amyloid Plaques in the Spinal Cord of a Mouse Model of Alzheimer’s Disease
Q Yuan, X Liu, YF Xian, Y Tang, J Zou, X Zhang, P Huang, W Wu, Y Song, ZX Lin |
Molecular Neurobiology | 2019 |
Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients
CS Edeklev, M Halvorsen, G Løvland, SA Vatnehol, Ø Gjertsen, B Nedregaard, R Sletteberg, G Ringstad, PK Eide |
American Journal of Neuroradiology | 2019 |
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
RH Earls, KB Menees, J Chung, J Barber, CA Gutekunst, MG Hazim, JK Lee |
Journal of Neuroinflammation | 2019 |
Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype
JE Carroll, BJ Small, DB Tometich, W Zhai, X Zhou, G Luta, TA Ahles, AJ Saykin, KN Nudelman, JD Clapp, HS Jim, PB Jacobsen, A Hurria, D Graham, BC McDonald, N Denduluri, M Extermann, C Isaacs, AA Dilawari, J Root, RA Stern, JS Mandelblatt |
Cancer | 2019 |
Modulation of O-GlcNAcylation Regulates Autophagy in Cortical Astrocytes
A Rahman, H Hwang, Y Cho, H Rhim |
Oxidative medicine and cellular longevity | 2019 |
Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial
P Zamboni, R Galeotti, F Salvi, A Giaquinta, C Setacci, S Alborino, G Guzzardi, SJ Sclafani, E Maietti, P Veroux, E Barbarossa, I Bartolomei, S Ceruti, P Conforti, AM Malagoni, E Menegatti, M Tessari, L Pellegrino, F Pancaldi, ME Vanini, MG Piscaglia, P Cenni, F Rasi, M Babini, A Drea, E Guerrini, EM Lotti, A Morelli, M Peroni, V Zalambani, S Zecchini, C Chisari, I Chiaramonte, V Cimino, LD Pino, G Failla, R Cantello, M Leone, L Coppo, O Raymkulova, S Ruggerone, A Stecco, D Vecchio, PA Confalonieri, E Ciceri, M Danni, C Belleggia, G Luccioni, L Oncini, C Quatrini |
Journal of Endovascular Therapy | 2019 |
Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome‐autophagosome‐lysosome pathway dysfunction and microglia‐mediated neuroinflammation
Y Xie, L Ba, M Wang, SY Deng, SM Chen, LF Huang, M Zhang, W Wang, FF Ding |
CNS Neuroscience & Therapeutics | 2019 |
An [ 18 F]-Positron Emitting Fluorophore Allows Safe Evaluation of Small Molecule Distribution in the CSF, CSF Fistulas, and CNS Device Placement
H Guo, H Kommidi, UB Maachani, JC Voronina, W Zhang, RS Magge, J Ivanidze, AP Wu, MM Souweidane, O Aras, R Ting |
Molecular Pharmaceutics | 2019 |
Decreased Vascular Pulsatility in Alzheimer’s Disease Dementia Measured by Transcranial Color-Coded Duplex Sonography M Ortner, C Hauser, C Schmaderer, C Muggenthaler, A Hapfelmeier, C Sorg, J Diehl-Schmid, A Kurz, H Förstl, B Ikenberg, K Kotliar, H Poppert, T Grimmer |
Neuropsychiatric Disease and Treatment | 2019 |
In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
AM Sweeney, V Plá, T Du, G Liu, Q Sun, S Peng, BA Plog, BT Kress, X Wang, H Mestre, M Nedergaard |
Journal of visualized experiments : JoVE | 2019 |
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
Geir Ringstad, Lars Magnus Valnes, Anders Dale, Are H Pripp, Sven A Vatnehol, Kyrre E Emblem, Kent A Mardal, Per Eide |
JCI Insight | 2018 |
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain
Benjamin A Plog, Humberto Mestre, Genaro E Olveda, Amanda M. Sweeney, H. Mark Kenney, Alexander Cove, Kosha Dholakia, Jeffrey R Tithof, Thomas D Nevins, Iben Lundgaard, Ting Du, Douglas H. Kelley, Maiken Nedergaard |
JCI Insight | 2018 |
General Anesthesia Inhibits the Activity of the “Glymphatic System”
C Gakuba, T Gaberel, S Goursaud, J Bourges, CD Palma, A Quenault, SM de Lizarrondo, D Vivien, M Gauberti |
Theranostics | 2018 |
The Meningeal Lymphatic System: A New Player in Neurophysiology
SD Mesquita, Z Fu, J Kipnis |
Neuron | 2018 |
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
SB Hladky, MA Barrand |
Fluids and barriers of the CNS | 2018 |
Tissue-specific immunopathology during malaria infection
C Coban, MS Lee, KJ Ishii |
Nature Reviews Immunology | 2018 |
The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?
AJ Smith, AS Verkman |
The FASEB Journal | 2018 |
The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep
EL Boespflug, JJ Iliff |
Biological Psychiatry | 2018 |
Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma
BG Harder, MR Blomquist, J Wang, AJ Kim, GF Woodworth, JA Winkles, JC Loftus, NL Tran |
Frontiers in Oncology | 2018 |
Physiology of Astroglia
A Verkhratsky, M Nedergaard |
Physiological reviews | 2018 |
Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
R Hussain, H Zubair, S Pursell, M Shahab |
Brain Sciences | 2018 |
Insulin transport into the brain
SM Gray, EJ Barrett |
American journal of physiology. Cell physiology | 2018 |
Reactive Astrocytes as Drug Target in Alzheimer’s Disease
BT Assefa, AK Gebre, BM Altaye |
BioMed Research International | 2018 |
Cannula Implantation into the Cisterna Magna of Rodents
AL Xavier, NL Hauglund, S von Holstein-Rathlou, Q Li, S Sanggaard, N Lou, I Lundgaard, M Nedergaard |
Journal of visualized experiments : JoVE | 2018 |
Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum: Differences Between Gd Chelates, Presence in the Virchow-Robin Space, Association With Lipofuscin, and Hypotheses About Distribution Pathway
M Rasschaert, JA Schroeder, TD Wu, S Marco, A Emerit, H Siegmund, C Fischer, N Fretellier, JM Idée, C Corot, C Brochhausen, JL Guerquin-Kern |
Investigative Radiology | 2018 |
Shear-induced amyloid formation in the brain: IV. Effects on synapses surrounding senile plaque and in plaque-free regions
CN Trumbore |
Journal of Alzheimer's disease : JAD | 2018 |
Reduced spinal cord parenchymal cerebrospinal fluid circulation in experimental autoimmune encephalomyelitis
AP Fournier, M Gauberti, A Quenault, D Vivien, R Macrez, F Docagne |
Journal of Cerebral Blood Flow & Metabolism | 2018 |
A Review of the Current Evidence on Gadolinium Deposition in the Brain
R Pullicino, M Radon, S Biswas, M Bhojak, K Das |
Clinical Neuroradiology | 2018 |
The Aging of Iron Man
A Ashraf, M Clark, PW So |
Frontiers in aging neuroscience | 2018 |
Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter
S Naganawa, T Nakane, H Kawai, T Taoka |
Magnetic Resonance in Medical Sciences | 2018 |
Gadolinium-based contrast agents in children
MN Rozenfeld, DJ Podberesky |
Pediatric Radiology | 2018 |
Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
DO Borroto-Escuela, S Hinz, G Navarro, R Franco, CE Müller, K Fuxe |
Frontiers in neuroscience | 2018 |
The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system
K Messlinger |
The Journal of Headache and Pain | 2018 |
Pseudotumor Cerebri and Glymphatic Dysfunction
ML de Souza Bezerra, AC de Freitas Ferreira, R de Oliveira-Souza |
Frontiers in neurology | 2018 |
Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study
PK Eide, G Ringstad |
Journal of Cerebral Blood Flow & Metabolism | 2018 |
A Molecular Neurobiological Approach to Understanding the Aetiology of Chronic Fatigue Syndrome (Myalgic Encephalomyelitis or Systemic Exertion Intolerance Disease) with Treatment Implications
JA Monro, BK Puri |
Molecular Neurobiology | 2018 |
Localization, Occurrence, and CSF Changes of SP-G, a New Surface Active Protein with Assumable Immunoregulatory Functions in the CNS
M Krause, N Peukert, W Härtig, A Emmer, CV Mahr, C Richter, J Dieckow, J Puchta, M Pirlich, KT Hoffmann, U Nestler, S Schob |
Molecular Neurobiology | 2018 |
MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain
DS Hersh, P Anastasiadis, A Mohammadabadi, BA Nguyen, S Guo, JA Winkles, AJ Kim, R Gullapalli, A Keller, V Frenkel, GF Woodworth, V Ceña |
PloS one | 2018 |
Brain drains: new insights into brain clearance pathways from lymphatic biology
NI Bower, BM Hogan |
Journal of Molecular Medicine | 2018 |
Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities
Y Xiong, A Mahmood, M Chopp |
Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association | 2018 |
Shear-Induced Amyloid Formation in the Brain: III. The Roles of Shear Energy and Seeding in a Proposed Shear Model
CN Trumbore |
Journal of Alzheimer's disease : JAD | 2018 |
The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future
BA Plog, M Nedergaard |
Annual review of pathology | 2018 |
Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes
PK Eide, SA Vatnehol, KE Emblem, G Ringstad |
Scientific Reports | 2018 |
Methodological Aspects for Preclinical Evaluation of Gadolinium Presence in Brain Tissue: Critical Appraisal and Suggestions for Harmonization—A Joint Initiative
P Robert, T Frenzel, C Factor, G Jost, M Rasschaert, G Schuetz, N Fretellier, J Boyken, JM Idée, H Pietsch |
Investigative Radiology | 2018 |
Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
IF Harrison, B Siow, AB Akilo, PG Evans, O Ismail, Y Ohene, P Nahavandi, DL Thomas, MF Lythgoe, JA Wells |
eLife | 2018 |
Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy
SH Xin, L Tan, X Cao, JT Yu, L Tan |
Neurotoxicity Research | 2018 |
MRI investigation of glymphatic responses to Gd-DTPA infusion rates
G Ding, M Chopp, L Li, L Zhang, E Davoodi-Bojd, Q Li, Z Zhang, Q Jiang |
Journal of Neuroscience Research | 2018 |
Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain
G Li, X He, H Li, Y Wu, Y Guan, S Liu, H Jia, Y Li, L Wang, R Huang, Z Pei, Y Lan, Y Zhang |
International journal of molecular medicine | 2018 |
Efficacy and Safety of Extracranial Vein Angioplasty in Multiple Sclerosis: A Randomized Clinical Trial
P Zamboni, L Tesio, S Galimberti, L Massacesi, F Salvi, R DAlessandro, P Cenni, R Galeotti, D Papini, R DAmico, S Simi, MG Valsecchi, G Filippini |
JAMA NEUROL | 2018 |
Appearance of the Organum Vasculosum of the Lamina Terminalis on Contrast-enhanced MR Imaging
S Naganawa, T Taoka, H Kawai, M Yamazaki, K Suzuki |
Magnetic Resonance in Medical Sciences | 2018 |
Cerebral small vessel disease: neuroimaging markers and clinical implication
X Chen, J Wang, Y Shan, W Cai, S Liu, M Hu, S Liao, X Huang, B Zhang, Y Wang, Z Lu |
Journal of Neurology | 2018 |
The glymphatic pathway in neurological disorders
MK Rasmussen, H Mestre, M Nedergaard |
Lancet neurology | 2018 |
Apparent diffusion coefficient changes in human brain during sleep – Does it inform on the existence of a glymphatic system?
ŞB Demiral, D Tomasi, J Sarlls, H Lee, CE Wiers, A Zehra, T Srivastava, K Ke, E Shokri-Kojori, CR Freeman, E Lindgren, V Ramirez, G Miller, P Bandettini, S Horovitz, GJ Wang, H Benveniste, ND Volkow |
NeuroImage | 2018 |
The Glymphatic System in Diabetes-Induced Dementia
YK Kim, KI Nam, J Song |
Frontiers in neurology | 2018 |
Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging
S Naganawa, T Nakane, H Kawai, T Taoka |
Magnetic Resonance in Medical Sciences | 2018 |
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
H Mestre, LM Hablitz, AL Xavier, W Feng, W Zou, T Pu, H Monai, G Murlidharan, RM Rivera, MJ Simon, MM Pike, V Plá, T Du, BT Kress, X Wang, BA Plog, AS Thrane, I Lundgaard, Y Abe, M Yasui, JH Thomas, M Xiao, H Hirase, A Asokan, JJ Iliff, M Nedergaard |
eLife | 2018 |
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
H Mestre, J Tithof, T Du, W Song, W Peng, AM Sweeney, G Olveda, JH Thomas, M Nedergaard, DH Kelley |
Nature Communications | 2018 |
Controversies and Misconceptions Related to Cerebrospinal Fluid Circulation: A Review of the Literature from the Historical Pioneers’ Theories to Current Models
G Mantovani, M Menegatti, A Scerrati, MA Cavallo, PD Bonis |
BioMed Research International | 2018 |
Neuroglia: Realising their true potential
A Butt, A Verkhratsky |
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Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease
EL Boespflug, MJ Simon, E Leonard, M Grafe, R Woltjer, LC Silbert, JA Kaye, JJ Iliff, A Hatami |
Journal of Alzheimer's disease : JAD | 2018 |
Aortic stiffness, pressure and flow pulsatility, and target organ damage
GF Mitchell |
Journal of applied physiology | 2018 |
The Glymphatic System and Waste Clearance with Brain Aging: A Review
H Benveniste, X Liu, S Koundal, S Sanggaard, H Lee, J Wardlaw |
Gerontology | 2018 |
Augmented astrocyte microdomain Ca 2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice
JR Diaz, KJ Kim, MW Brands, JA Filosa |
Glia | 2018 |
Cell Volume Control in Healthy Brain and Neuropathologies
Wilson CS, Mongin AA |
Current topics in membranes | 2018 |
Impaired brain glymphatic flow in experimental hepatic encephalopathy
Hadjihambi A, Harrison IF, Costas-Rodríguez M, Vanhaecke F, Arias N, Gallego-Durán R, Mastitskaya S, Hosford PS, Olde Damink SW, Davies N, Habtesion A, Lythgoe MF, Gourine AV, Jalan R |
Journal of Hepatology | 2018 |
A novel MRI phantom to study interstitial fluid transport in the glymphatic system.
Komlosh ME, Benjamini D, Williamson NW, Horkay F, Hutchinson EB, Basser PJ |
Magnetic Resonance Imaging | 2018 |
Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI
M Absinta, SK Ha, G Nair, P Sati, NJ Luciano, M Palisoc, A Louveau, KA Zaghloul, S Pittaluga, J Kipnis, DS Reich |
eLife | 2017 |
Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation
ZA Zhao, P Li, SY Ye, YL Ning, H Wang, Y Peng, N Yang, Y Zhao, ZH Zhang, JF Chen, YG Zhou |
Scientific Reports | 2017 |
The ultrastructure of spinal cord perivascular spaces: Implications for the circulation of cerebrospinal fluid
MA Lam, SJ Hemley, E Najafi, NG Vella, LE Bilston, MA Stoodley |
Scientific Reports | 2017 |
Perivascular spaces, glymphatic dysfunction, and small vessel disease
H Mestre, S Kostrikov, RI Mehta, M Nedergaard |
Clinical Science | 2017 |
The diabetic brain and cognition
P Riederer, AD Korczyn, SS Ali, O Bajenaru, MS Choi, M Chopp, V Dermanovic-Dobrota, E Grünblatt, KA Jellinger, MA Kamal, W Kamal, J Leszek, TM Sheldrick-Michel, G Mushtaq, B Meglic, R Natovich, Z Pirtosek, M Rakusa, M Salkovic-Petrisic, R Schmidt, A Schmitt, GR Sridhar, L Vécsei, ZB Wojszel, H Yaman, ZG Zhang, T Cukierman-Yaffe |
Journal of Neural Transmission | 2017 |
Clinical Correlation of Abnormal Findings on Magnetic Resonance Elastography in Idiopathic Normal Pressure Hydrocephalus
A Perry, CS Graffeo, N Fattahi, MM ElSheikh, N Cray, A Arani, RL Ehman, KJ Glaser, A Manduca, FB Meyer, J Huston |
World Neurosurgery | 2017 |
Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus
DD Limbrick, B Baksh, CD Morgan, G Habiyaremye, JP McAllister, TE Inder, D Mercer, DM Holtzman, J Strahle, MJ Wallendorf, DM Morales, Y Hoshi |
PloS one | 2017 |
Overview of Traumatic Brain Injury: An Immunological Context
D Nizamutdinov, L Shapiro |
Brain Sciences | 2017 |
Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases
T Taoka, Y Masutani, H Kawai, T Nakane, K Matsuoka, F Yasuno, T Kishimoto, S Naganawa |
Japanese Journal of Radiology | 2017 |
Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Mass Transport
V Ratner, Y Gao, H Lee, R Elkin, M Nedergaard, H Benveniste, A Tannenbaum |
NeuroImage | 2017 |
The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging
JA Coles, PJ Stewart-Hutchinson, E Myburgh, JM Brewer |
Methods | 2017 |
Subarachnoid hemorrhage – Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor)
EV Golanov, EI Bovshik, KK Wong, RG Pautler, CH Foster, RG Federley, JY Zhang, J Mancuso, ST Wong, GW Britz |
Journal of Cerebral Blood Flow & Metabolism | 2017 |
Long-Lasting Cerebral Vasospasm, Microthrombosis, Apoptosis and Paravascular Alterations Associated with Neurological Deficits in a Mouse Model of Subarachnoid Hemorrhage
ME Amki, M Dubois, A Lefevre-Scelles, N Magne, M Roussel, T Clavier, PO Guichet, E Gérardin, V Compère, H Castel |
Molecular Neurobiology | 2017 |
Circadian Rhythms in AD Pathogenesis: a Critical Appraisal
ES Musiek |
Current Sleep Medicine Reports | 2017 |
Histology and Gadolinium Distribution in the Rodent Brain After the Administration of Cumulative High Doses of Linear and Macrocyclic Gadolinium-Based Contrast Agents:
J Lohrke, AL Frisk, T Frenzel, L Schöckel, M Rosenbruch, G Jost, DC Lenhard, MA Sieber, V Nischwitz, A Küppers, H Pietsch |
Investigative Radiology | 2017 |
The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease
KG Burfeind, CF Murchison, SK Westaway, MJ Simon, D Erten-Lyons, JA Kaye, JF Quinn, JJ Iliff |
Alzheimer's & Dementia: Translational Research & Clinical Interventions | 2017 |
Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T: Quantitative Gd-DOTA Uptake from CSF into Rat Brain
H Lee, K Mortensen, S Sanggaard, P Koch, H Brunner, B Quistorff, M Nedergaard, H Benveniste |
Magnetic Resonance in Medicine | 2017 |
Stratification of astrocytes in healthy and diseased brain: Astroglia in health and disease
A Verkhratsky, R Zorec, V Parpura |
Brain Pathology | 2017 |
Glymphatic MRI in idiopathic normal pressure hydrocephalus
G Ringstad, SA Vatnehol, PK Eide |
Brain | 2017 |
Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis
B Gaastra, J Glazier, D Bulters, I Galea |
Oxidative medicine and cellular longevity | 2017 |
An [ 18 F]-Positron-Emitting, Fluorescent, Cerebrospinal Fluid Probe for Imaging Damage to the Brain and Spine
H Kommidi, H Guo, N Chen, D Kim, B He, AP Wu, O Aras, R Ting |
Theranostics | 2017 |
Magnetic Resonance Imaging of Cardiovascular Function and the Brain: Is Dementia a Cardiovascular-Driven Disease?
A Roos, J der Grond, G Mitchell, J Westenberg |
Circulation | 2017 |
Disruption of the leptomeningeal blood barrier in neuromyelitis optica spectrum disorder
N Asgari, EP Flanagan, K Fujihara, HJ Kim, HP Skejoe, J Wuerfel, H Kuroda, SH Kim, E Maillart, R Marignier, SJ Pittock, F Paul, BG Weinshenker |
Neurology: Neuroimmunology & Neuroinflammation | 2017 |
Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET
MJ de Leon, Y Li, N Okamura, WH Tsui, LA Saint-Louis, L Glodzik, RS Osorio, J Fortea, T Butler, E Pirraglia, S Fossati, HJ Kim, RO Carare, M Nedergaard, H Benveniste, H Rusinek |
Journal of Nuclear Medicine | 2017 |
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts
M Wang, F Ding, SY Deng, X Guo, W Wang, JJ Iliff, M Nedergaard |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2017 |
The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy
A Bacyinski, M Xu, W Wang, J Hu |
Frontiers in neuroanatomy | 2017 |
Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane:
H Benveniste, H Lee, F Ding, Q Sun, E Al-Bizri, R Makaryus, S Probst, M Nedergaard, EA Stein, H Lu |
Anesthesiology | 2017 |
Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition
A Harding, U Gonder, SJ Robinson, SJ Crean, SK Singhrao |
Frontiers in aging neuroscience | 2017 |
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery: Mechanisms of intrathecal antibody transport
ME Pizzo, DJ Wolak, NN Kumar, E Brunette, CL Brunnquell, MJ Hannocks, NJ Abbott, ME Meyerand, L Sorokin, DB Stanimirovic, RG Thorne |
The Journal of Physiology | 2017 |
Elevated Surfactant Protein Levels and Increased Flow of Cerebrospinal Fluid in Cranial Magnetic Resonance Imaging
S Schob, A Weiß, A Surov, J Dieckow, C Richter, M Pirlich, D Horvath-Rizea, W Härtig, KT Hoffmann, M Krause, U Quäschling |
Molecular Neurobiology | 2017 |
Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow
B Bedussi, M Almasian, J de Vos, E VanBavel, EN Bakker |
Journal of Cerebral Blood Flow & Metabolism | 2017 |
Distribution and chemical forms of gadolinium in the brain: a review
T Kanda, Y Nakai, A Hagiwara, H Oba, K Toyoda, S Furui |
British Journal of Radiology | 2017 |
Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats: Differences in Gd Retention Between cGBCAs
S Bussi, A Coppo, C Botteron, V Fraimbault, A Fanizzi, ED Laurentiis, SC Serra, MA Kirchin, F Tedoldi, F Maisano |
Journal of magnetic resonance imaging : JMRI | 2017 |
Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System
S Dreha-Kulaczewski, AA Joseph, KD Merboldt, HC Ludwig, J Gärtner, J Frahm |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2017 |
Starling forces drive intracranial water exchange during normal and pathological states
Linninger AA, Xu C, Tangen K, Hartung G |
Croatian medical journal | 2017 |
Dynamic dual isotope molecular imaging elucidates principles for optimizing intrathecal drug delivery
Daniel Wolf, Jacob Hesterman, Jenna M. Sullivan, Kelly Orcutt, Matt Silva, Merryl Lobo, Tyler Wellman, Jack Hoppin, Ajay Verma |
JCI Insight | 2016 |
Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases
EN Bakker, BJ Bacskai, M Arbel-Ornath, R Aldea, B Bedussi, AW Morris, RO Weller, RO Carare |
Cellular and Molecular Neurobiology | 2016 |
Blood biomarkers for brain injury: What are we measuring?
K Kawata, CY Liu, SF Merkel, SH Ramirez, RT Tierney, D Langford |
Neuroscience & Biobehavioral Reviews | 2016 |
Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis
M Thon, T Hosoi, K Ozawa |
Frontiers in Endocrinology | 2016 |
Pathways for insulin access to the brain: the role of the microvascular endothelial cell
RI Meijer, SM Gray, KW Aylor, EJ Barrett |
American journal of physiology. Heart and circulatory physiology | 2016 |
Central Nervous System: (Immunological) Ivory Tower or Not?
IA Marin, J Kipnis |
Neuropsychopharmacology | 2016 |
Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review
BM Asken, MJ Sullan, AR Snyder, ZM Houck, VE Bryant, LP Hizel, ME McLaren, DE Dede, MS Jaffee, ST DeKosky, RM Bauer |
Neuropsychology Review | 2016 |
Distribution and clearance of retained gadolinium in the brain: differences between linear and macrocyclic gadolinium based contrast agents in a mouse model
AA Kartamihardja, T Nakajima, S Kameo, H Koyama, Y Tsushima |
British Journal of Radiology | 2016 |
Antigen Presentation After Stroke
F Miró-Mur, X Urra, M Gallizioli, A Chamorro, AM Planas |
Neurotherapeutics | 2016 |
Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia
S NAGANAWA, T NAKANE, H KAWAI, T TAOKA |
Magnetic Resonance in Medical Sciences | 2016 |
Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest
EL Fink, RP Berger, RS Clark, RS Watson, DC Angus, A Panigrahy, R Richichi, CW Callaway, MJ Bell, S Mondello, RL Hayes, PM Kochanek |
Resuscitation | 2016 |
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy
V Puvenna, M Engeler, M Banjara, C Brennan, P Schreiber, A Dadas, A Bahrami, J Solanki, A Bandyopadhyay, JK Morris, C Bernick, C Ghosh, E Rapp, JJ Bazarian, D Janigro |
Brain Research | 2016 |
The occurrence of individual slow waves in sleep is predicted by heart rate
A Mensen, Z Zhang, M Qi, R Khatami |
Scientific Reports | 2016 |
Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease
J Cedernaes, RS Osorio, AW Varga, K Kam, HB Schiöth, C Benedict |
Sleep Medicine Reviews | 2016 |
Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation
K Eom, C Im, S Hwang, S Eom, TS Kim, HS Jeong, KH Kim, KM Byun, SB Jun, SJ Kim |
Biomedical Optics Express | 2016 |
The homeostatic astroglia emerges from evolutionary specialization of neural cells
A Verkhratsky, M Nedergaard |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2016 |
Aquaporin-4 in Astroglial Cells in the CNS and Supporting Cells of Sensory Organs—A Comparative Perspective
C Gleiser, A Wagner, P Fallier-Becker, H Wolburg, B Hirt, A Mack |
International journal of molecular sciences | 2016 |
Pulsed ultrasound expands the extracellular and perivascular spaces of the brain
DS Hersh, BA Nguyen, JG Dancy, AR Adapa, JA Winkles, GF Woodworth, AJ Kim, V Frenkel |
Brain Research | 2016 |
Shear-Induced Amyloid Formation in the Brain: I. Potential Vascular and Parenchymal Processes
CN Trumbore |
Journal of Alzheimer's disease : JAD | 2016 |
Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease
F Pistollato, SS Cano, I Elio, MM Vergara, F Giampieri, M Battino |
Advances in nutrition (Bethesda, Md.) | 2016 |
Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream
A Hoffmann, J Pfeil, J Alfonso, FT Kurz, F Sahm, S Heiland, H Monyer, M Bendszus, AK Mueller, X Helluy, M Pham, KB Seydel |
PLoS pathogens | 2016 |
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis
IM Vincent, R Daly, B Courtioux, AM Cattanach, S Biéler, JM Ndungu, S Bisser, MP Barrett, DK Masiga |
PLoS neglected tropical diseases | 2016 |
Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system
M Xia, L Yang, G Sun, S Qi, B Li |
Psychopharmacology | 2016 |
Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning
CH Fung, MV Vitiello, CA Alessi, GA Kuchel |
Journal of the American Geriatrics Society | 2016 |
Patterned Fibers Embedded Microfluidic Chips Based on PLA and PDMS for Ag Nanoparticle Safety Testing
Y Liu, S Wang, Y Wang |
Polymers | 2016 |
Impairment of the glymphatic system after diabetes
Q Jiang, L Zhang, G Ding, E Davoodi-Bojd, Q Li, L Li, N Sadry, M Nedergaard, M Chopp, Z Zhang |
Journal of Cerebral Blood Flow & Metabolism | 2016 |
“Small Blood Vessels: Big Health Problems?”: Scientific Recommendations of the National Institutes of Health Workshop
F Bosetti, ZS Galis, MS Bynoe, M Charette, MJ Cipolla, GJ Zoppo, D Gould, TS Hatsukami, TL Jones, JI Koenig, GA Lutty, C MaricBilkan, T Stevens, HE Tolunay, W Koroshetz |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2016 |
Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System
BA Plog, ML Dashnaw, E Hitomi, W Peng, Y Liao, N Lou, R Deane, M Nedergaard |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2015 |
Interaction between therapeutic interventions for Alzheimer’s disease and physiological Aβ clearance mechanisms
CD Morrone, M Liu, SE Black, JA McLaurin |
Frontiers in aging neuroscience | 2015 |
Clearance systems in the brain—implications for Alzheimer disease
JM Tarasoff-Conway, RO Carare, RS Osorio, L Glodzik, T Butler, E Fieremans, L Axel, H Rusinek, C Nicholson, BV Zlokovic, B Frangione, K Blennow, J Ménard, H Zetterberg, T Wisniewski, MJ de Leon |
Nature Reviews Neurology | 2015 |
From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
NL Trevaskis, LM Kaminskas, CJ Porter |
Nature Reviews Drug Discovery | 2015 |
The role of the lymphatic system in cholesterol transport
LH Huang, A Elvington, GJ Randolph |
Frontiers in pharmacology | 2015 |
Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease
H Lian, H Zheng |
Journal of Neurochemistry | 2015 |
Lysosomal storage disease: Gene therapy on both sides of the blood–brain barrier
EL Aronovich, PB Hackett |
Molecular Genetics and Metabolism | 2015 |
The Glymphatic System: A Beginner’s Guide
NA Jessen, AS Munk, I Lundgaard, M Nedergaard |
Neurochemical Research | 2015 |
Remote ischemic conditioning: A treatment for vascular cognitive impairment
DC Hess, MB Khan, JC Morgan, N Hoda |
Brain Circulation | 2015 |
Ubiquitin-Proteasome System in Neurodegenerative Disorders
GR Croft |
Journal of Drug Metabolism & Toxicology | 2015 |
Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate rats
J Hordeaux, L Dubreil, J Deniaud, F Iacobelli, S Moreau, M Ledevin, CL Guiner, V Blouin, JL Duff, A Mendes-Madeira, F Rolling, Y Cherel, P Moullier, MA Colle |
Gene Therapy | 2015 |
A novel method to study cerebrospinal fluid dynamics in rats
JK Karimy, KT Kahle, DB Kurland, E Yu, V Gerzanich, JM Simard |
Journal of Neuroscience Methods | 2015 |
Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging
DJ Wolak, ME Pizzo, RG Thorne |
Journal of Controlled Release | 2015 |
A review of flux considerations for in vivo neurochemical measurements
DW Paul, JA Stenken |
The Analyst | 2015 |
Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease
A Gupta, C Iadecola |
Frontiers in aging neuroscience | 2015 |
Cerebrospinal fluid aquaporin-4-immunoglobulin G disrupts blood brain barrier
N Asgari, CT Berg, MT Mørch, R Khorooshi, T Owens |
Annals of Clinical and Translational Neurology | 2015 |
A new glaucoma hypothesis: a role of glymphatic system dysfunction
P Wostyn, DV Dam, K Audenaert, HE Killer, PP de Deyn, VD Groot |
Fluids and barriers of the CNS | 2015 |
Blood–brain barrier, bulk flow, and interstitial clearance in epilepsy
N Marchi, M Banjara, D Janigro |
Journal of Neuroscience Methods | 2015 |
Implications of the discovery of brain lymphatic pathways
JJ Iliff, SA Goldman, M Nedergaard |
The Lancet Neurology | 2015 |
The Effect of Body Posture on Brain Glymphatic Transport
H Lee, L Xie, M Yu, H Kang, T Feng, R Deane, J Logan, M Nedergaard, H Benveniste |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2015 |
Quinckes’ pioneering 19th centuries CSF studies may inform 21th centuries research
K Bechter, H Benveniste |
Neurology, Psychiatry and Brain Research | 2015 |
Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease
MJ Simon, JJ Iliff |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2015 |
The Role of the Craniocervical Junction in Craniospinal Hydrodynamics and Neurodegenerative Conditions
MF Flanagan |
Neurology Research International | 2015 |
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
Z Xu, N Xiao, Y Chen, H Huang, C Marshall, J Gao, Z Cai, T Wu, G Hu, M Xiao |
Molecular Neurodegeneration | 2015 |
Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment
F Deak, WM Freeman, Z Ungvari, A Csiszar, WE Sonntag |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2015 |
Optimal-mass-transfer-based estimation of glymphatic transport in living brain
Ratner V, Zhu L, Kolesov I, Nedergaard M, Benveniste H, Tannenbaum A |
Proceedings of SPIE--the International Society for Optical Engineering | 2015 |
Impairment of paravascular clearance pathways in the aging brain: Paravascular Clearance
BT Kress, JJ Iliff, M Xia, M Wang, HS Wei, D Zeppenfeld, L Xie, H Kang, Q Xu, JA Liew, BA Plog, F Ding, R Deane, M Nedergaard |
Annals of Neurology | 2014 |
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
JJ Iliff, MJ Chen, BA Plog, DM Zeppenfeld, M Soltero, L Yang, I Singh, R Deane, M Nedergaard |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2014 |
Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment
J Pahnke, O Langer, M Krohn |
Neurobiology of Disease | 2014 |
Insulin Regulates Brain Function, but How Does It Get There?
SM Gray, RI Meijer, EJ Barrett |
Diabetes | 2014 |
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment:
E Cassol, V Misra, A Dutta, S Morgello, D Gabuzda |
AIDS | 2014 |
Drowning stars: reassessing the role of astrocytes in brain edema
AS Thrane, VR Thrane, M Nedergaard |
Trends in Neurosciences | 2014 |
Water for Thought: Is There a Role for Aquaporin Channels in Delirium?
A Sfera, C Osorio |
Frontiers in Psychiatry | 2014 |
Normal pressure hydrocephalus as a failure of ICP homeostasis mechanism: the hidden role of Monro–Kellie doctrine in the genesis of NPH
A Salma |
Child's Nervous System | 2014 |
Open questions for Alzheimer’s disease immunotherapy
TE Golde |
Alzheimer's research & therapy | 2014 |
Inflammation-sleep interface in brain disease: TNF, insulin, orexin
IA Clark, B Vissel |
Journal of Neuroinflammation | 2014 |
A new look at cerebrospinal fluid circulation
T Brinker, E Stopa, J Morrison, P Klinge |
Fluids and barriers of the CNS | 2014 |
Why are Astrocytes Important?
A Verkhratsky, M Nedergaard, L Hertz |
Neurochemical Research | 2014 |
Cerebral vascular leak in a mouse model of amyloid neuropathology
EA Tanifum, ZA Starosolski, SW Fowler, JL Jankowsky, AV Annapragada |
Journal of Cerebral Blood Flow & Metabolism | 2014 |
A new look at cerebrospinal fluid movement
D Orešković, M Klarica |
Fluids and barriers of the CNS | 2014 |
Pathways of cerebrospinal fluid outflow: a deeper understanding of resorption
L Chen, G Elias, MP Yostos, B Stimec, J Fasel, K Murphy |
Neuroradiology | 2014 |
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration
JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne |
Journal of Cerebral Blood Flow & Metabolism | 2014 |
Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence
SB Hladky, MA Barrand |
Fluids and barriers of the CNS | 2014 |
Intranasal Administration as a Route for Drug Delivery to the Brain: Evidence for a Unique Pathway for Albumin
JA Falcone, TS Salameh, X Yi, BJ Cordy, WG Mortell, AV Kabanov, WA Banks |
The Journal of pharmacology and experimental therapeutics | 2014 |
CSF Flow in the Brain in the Context of Normal Pressure Hydrocephalus
WG Bradley |
American Journal of Neuroradiology | 2014 |
Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
Orešković D, Klarica M |
Croatian medical journal | 2014 |
A proposed role for efflux transporters in the pathogenesis of hydrocephalus.
Krishnamurthy S, Tichenor MD, Satish AG, Lehmann DB |
Croatian medical journal | 2014 |
A computational model of cerebrospinal fluid production and reabsorption driven by Starling forces.
Buishas J, Gould IG, Linninger AA |
Croatian medical journal | 2014 |
Bathing the Brain
Warren James Strittmatter |
Journal of Clinical Investigation | 2013 |
The Pathobiology of Vascular Dementia
C Iadecola |
Neuron | 2013 |
Sleep Drives Metabolite Clearance from the Adult Brain
L Xie, H Kang, Q Xu, MJ Chen, Y Liao, M Thiyagarajan, J O'Donnell, DJ Christensen, C Nicholson, JJ Iliff, T Takano, R Deane, M Nedergaard |
Science | 2013 |
White matter astrocytes in health and disease
I Lundgaard, MJ Osório, BT Kress, S Sanggaard, M Nedergaard |
Neuroscience | 2013 |
Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid
R Mokgokong, S Wang, CJ Taylor, MA Barrand, SB Hladky |
Pflügers Archiv - European Journal of Physiology | 2013 |
Exploring the efficacy of endoscopic ventriculostomy for hydrocephalus treatment via a multicompartmental poroelastic model of CSF transport: a computational perspective
JC Vardakis, BJ Tully, Y Ventikos |
PloS one | 2013 |
Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain
JJ Iliff, M Wang, DM Zeppenfeld, A Venkataraman, BA Plog, Y Liao, R Deane, M Nedergaard |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2013 |
Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature
GV Chaitanya, S Omura, F Sato, NE Martinez, A Minagar, M Ramanathan, BW Guttman, R Zivadinov, I Tsunoda, JS Alexander |
Journal of Neuroinflammation | 2013 |
Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
VR Thrane, AS Thrane, BA Plog, M Thiyagarajan, JJ Iliff, R Deane, EA Nagelhus, M Nedergaard |
Scientific Reports | 2013 |
Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer
L Yang, BT Kress, HJ Weber, M Thiyagarajan, B Wang, R Deane, H Benveniste, JJ Iliff, M Nedergaard |
Journal of Translational Medicine | 2013 |
Garbage Truck of the Brain
M Nedergaard |
Science | 2013 |
The Detection of Surfactant Proteins A, B, C and D in the Human Brain and Their Regulation in Cerebral Infarction, Autoimmune Conditions and Infections of the CNS
S Schob, M Schicht, S Sel, D Stiller, A Kekulé, F Paulsen, E Maronde, L Bräuer, JA Coles |
PloS one | 2013 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
New concepts in the pathogenesis of hydrocephalus
Satish Krishnamurthy, Jie Li |
Translational Pediatrics | |
MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain
PK Eide, G Ringstad |
Acta Radiologica Open | 2015 |
Adult Astrogenesis and the Etiology of Cortical Neurodegeneration
A Koob, T Mohn |
Journal of Experimental Neuroscience | 2015 |
Modern cerebrospinal fluid flow research and Heinrich Quincke's seminal 1872 article on the distribution of cinnabar in freely moving animals: Erratum
H Benveniste, PR Hof, M Nedergaard, K Bechter |
The Journal of Comparative Neurology | 2015 |