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Frauke Neff, … , Martin Hrabe de Angelis, Dan Ehninger
Published July 25, 2013
Citation Information: J Clin Invest. 2013;123(8):3272-3291. https://doi.org/10.1172/JCI67674.
Citation Information: J Clin Invest. 2013;123(8):3272-3291. https://doi.org/10.1172/JCI67674.
Abstract
Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an innovative strategy in the quest for novel and broadly effective treatments against age-related diseases. The recent report of lifespan extension in mice treated with the FDA-approved mTOR inhibitor rapamycin represented the first demonstration of pharmacological extension of maximal lifespan in mammals. Longevity effects of rapamycin may, however, be due to rapamycin’s effects on specific life-limiting pathologies, such as cancers, and it remains unclear if this compound actually slows the rate of aging in mammals. Here, we present results from a comprehensive, large-scale assessment of a wide range of structural and functional aging phenotypes, which we performed to determine whether rapamycin slows the rate of aging in male C57BL/6J mice. While rapamycin did extend lifespan, it ameliorated few studied aging phenotypes. A subset of aging traits appeared to be rescued by rapamycin. Rapamycin, however, had similar effects on many of these traits in young animals, indicating that these effects were not due to a modulation of aging, but rather related to aging-independent drug effects. Therefore, our data largely dissociate rapamycin’s longevity effects from effects on aging itself.
Authors
Frauke Neff, Diana Flores-Dominguez, Devon P. Ryan, Marion Horsch, Susanne Schröder, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Lillian Garrett, Wolfgang Hans, Moritz M. Hettich, Richard Holtmeier, Sabine M. Hölter, Kristin Moreth, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Birgit Rathkolb, Jan Rozman, Beatrix Naton, Rainer Ordemann, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Gerhard Ehninger, Jochen Graw, Heinz Höfler, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Jörg Stypmann, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Dan Ehninger
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Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins
CY Liao, SS Anderson, NH Chicoine, JR Mayfield, BJ Garrett, CS Kwok, EC Academia, YM Hsu, DM Miller, AM Bair, JA Wilson, G Tannady, EM Stewart, SS Adamson, J Wang, DJ Withers, BK Kennedy |
Cell Discovery | 2017 |
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Environmental Chemicals and Aging
BL Pearson, D Ehninger |
Current Environmental Health Reports | 2017 |
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Genome-wide DNA methylation analysis of senescence in repetitively infected memory cytotoxic T lymphocytes
J Shosaku |
Immunology | 2017 |
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GH and ageing: Pitfalls and new insights
A Bartke, J Darcy |
Best Practice & Research Clinical Endocrinology & Metabolism | 2017 |
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A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
SR Urfer, TL Kaeberlein, S Mailheau, PJ Bergman, KE Creevy, DE Promislow, M Kaeberlein |
GeroScience | 2017 |
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A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice
DP Ryan, KS Henzel, BL Pearson, ME Siwek, A Papazoglou, L Guo, K Paesler, M Yu, R Müller, K Xie, S Schröder, L Becker, L Garrett, SM Hölter, F Neff, I Rácz, B Rathkolb, J Rozman, G Ehninger, M Klingenspor, T Klopstock, E Wolf, W Wurst, A Zimmer, H Fuchs, V Gailus-Durner, MH de Angelis, K Sidiropoulou, M Weiergräber, Y Zhou, D Ehninger |
Molecular Psychiatry | 2017 |
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Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics
JL Barger, JM Vann, NL Cray, TD Pugh, A Mastaloudis, SN Hester, SM Wood, MA Newton, R Weindruch, TA Prolla |
Aging Cell | 2017 |
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A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae
MB Lee, DT Carr, MG Kiflezghi, YT Zhao, DB Kim, S Thon, MD Moore, MA Li, M Kaeberlein |
GeroScience | 2017 |
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Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
K Xie, F Neff, A Markert, J Rozman, JA Aguilar-Pimentel, OV Amarie, L Becker, R Brommage, L Garrett, KS Henzel, SM Hölter, D Janik, I Lehmann, K Moreth, BL Pearson, I Racz, B Rathkolb, DP Ryan, S Schröder, I Treise, R Bekeredjian, DH Busch, J Graw, G Ehninger, M Klingenspor, T Klopstock, M Ollert, M Sandholzer, C Schmidt-Weber, M Weiergräber, E Wolf, W Wurst, A Zimmer, V Gailus-Durner, H Fuchs, MH de Angelis, D Ehninger |
Nature Communications | 2017 |
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TOR-mediated regulation of metabolism in aging
H Antikainen, M Driscoll, G Haspel, R Dobrowolski |
Aging Cell | 2017 |
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Rapamycin treatment attenuates age-associated periodontitis in mice
JY An, EK Quarles, S Mekvanich, A Kang, A Liu, D Santos, RA Miller, PS Rabinovitch, TC Cox, M Kaeberlein |
GeroScience | 2017 |
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Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency
TK Ito, C Lu, J Khan, Q Nguyen, HZ Huang, D Kim, J Phillips, J Tan, Y Lee, T Nguyen, S Khessib, N Lim, S Mekvanich, J Oh, VV Pineda, W Wang, A Bitto, JY An, JF Morton, M Setou, WC Ladiges, M Kaeberlein |
Frontiers in Genetics | 2017 |
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Spermidine Promotes Cardioprotective Autophagy
D Tong, JA Hill |
Circulation research | 2017 |
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Translational geroscience: A new paradigm for 21st century medicine
M Kaeberlein |
Translational Medicine of Aging | 2017 |
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Activation of mTORC1 is Essential for β-Adrenergic Stimulation of Adipose 'Browning'
Dianxin Liu, Marica Bordicchia, Chaoying Zhang, Huafeng Fang, Wan Wei, Jian-Liang Li, Adilson Guilherme, Kalyani Guntur, Michael Czech, Sheila Collins |
Journal of Clinical Investigation | 2016 |
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Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L
Q Wang, S Wu, H Zhu, Y Ding, X Dai, C Ouyang, Y Han, Z Xie, MH Zou |
Autophagy | 2016 |
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Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease
V Galvan, MJ Hart |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 |
|
Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
S Kumar, DB Lombard |
F1000Research | 2016 |
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Energetic interventions for healthspan and resiliency with aging
DM Huffman, MJ Schafer, NK LeBrasseur |
Experimental Gerontology | 2016 |
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Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice
CY Liao, SS Anderson, NH Chicoine, JR Mayfield, EC Academia, JA Wilson, C Pongkietisak, MA Thompson, EP Lagmay, DM Miller, YM Hsu, MA McCormick, MN O'Leary, BK Kennedy |
Cell Reports | 2016 |
|
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond
DW Lamming |
Cold Spring Harbor Perspectives in Medicine | 2016 |
|
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways
NE Cummings, DW Lamming |
Molecular and Cellular Endocrinology | 2016 |
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Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction
M Xu, T Tchkonia, JL Kirkland |
Pharmacological Research | 2016 |
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mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation
J Yang, X Zhou, X Fan, M Xiao, D Yang, B Liang, M Dai, L Shan, J Lu, Z Lin, R Liu, J Liu, L Wang, M Zhong, Y Jiang, X Bai |
Blood | 2016 |
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Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice
SI Apelo, CP Pumper, EL Baar, NE Cummings, DW Lamming |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
|
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island
SI Apelo, DW Lamming |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
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Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats
QL Xue, H Yang, HF Li, PM Abadir, TN Burks, LG Koch, SL Britton, J Carlson, L Chen, JD Walston, SX Leng |
Aging | 2016 |
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A synopsis on aging—Theories, mechanisms and future prospects
JP da Costa, R Vitorino, GM Silva, C Vogel, AC Duarte, T Rocha-Santos |
Ageing Research Reviews | 2016 |
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Nutrition and energetics in rodent longevity research
VK Gibbs, DL Smith |
Experimental Gerontology | 2016 |
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Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease
CV Cauwenberghe, C Vandendriessche, C Libert, RE Vandenbroucke |
Mammalian Genome | 2016 |
|
Does Longer Lifespan Mean Longer Healthspan?
M Hansen, BK Kennedy |
Trends in Cell Biology | 2016 |
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INFRAFRONTIER: a European resource for studying the functional basis of human disease
M Raess, AA de Castro, V Gailus-Durner, S Fessele, MH de Angelis |
Mammalian Genome | 2016 |
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Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model
EJ Chung, A Sowers, A Thetford, G McKay-Corkum, SI Chung, JB Mitchell, DE Citrin |
International journal of radiation oncology, biology, physics | 2016 |
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Rapamycin Attenuates Age-associated Changes in Tibialis Anterior Tendon Viscoelastic Properties
LW Zaseck, RA Miller, SV Brooks |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
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Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways
LA Lesniewski, DR Seals, AE Walker, GD Henson, MW Blimline, DW Trott, GC Bosshardt, TJ LaRocca, BR Lawson, MC Zigler, AJ Donato |
Aging Cell | 2016 |
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The dog aging project: translational geroscience in companion animals
M Kaeberlein, KE Creevy, DE Promislow |
Mammalian Genome | 2016 |
|
Geroscience approaches to increase healthspan and slow aging
S Melov |
F1000Research | 2016 |
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The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents
PM Treuting, JM Snyder, Y Ikeno, PN Schofield, JM Ward, JP Sundberg |
Veterinary pathology | 2016 |
|
Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype
D Gabriel, LB Gordon, K Djabali, V Trajkovic |
PloS one | 2016 |
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Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders: mTOR inhibitors in progeria and related disorders
C Evangelisti, V Cenni, G Lattanzi |
British Journal of Clinical Pharmacology | 2016 |
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Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate
Lelegren M, Liu Y, Ross C, Tardif S, Salmon AB |
Pathobiology of Aging & Age Related Diseases | 2016 |
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Adaptations to chronic rapamycin in mice
Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD |
Pathobiology of Aging & Age Related Diseases | 2016 |
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Essential role of autophagy in lifespan extension
Frank Madeo, Andreas Zimmerman, Maria Chiara Maiuri, Guido Kroemer |
Journal of Clinical Investigation | 2015 |
|
Prevention of Carcinogen and Inflammation-Induced Dermal Cancer by Oral Rapamycin Includes Reducing Genetic Damage
V Dao, S Pandeswara, Y Liu, V Hurez, S Dodds, D Callaway, A Liu, P Hasty, ZD Sharp, TJ Curiel |
Cancer prevention research (Philadelphia, Pa.) | 2015 |
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Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
SM Ebert, MC Dyle, SA Bullard, JM Dierdorff, DJ Murry, DK Fox, KS Bongers, VA Lira, DK Meyerholz, JJ Talley, CM Adams |
The Journal of biological chemistry | 2015 |
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Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake
AP Sharples, DC Hughes, CS Deane, A Saini, C Selman, CE Stewart |
Aging Cell | 2015 |
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Deficiency in mTORC1-controlled C/EBP -mRNA translation improves metabolic health in mice
LM Zidek, T Ackermann, G Hartleben, S Eichwald, G Kortman, M Kiehntopf, A Leutz, N Sonenberg, ZQ Wang, J Maltzahn, C Muller, CF Calkhoven |
EMBO reports | 2015 |
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17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling
A Kusch, M Schmidt, D Gürgen, D Postpieszala, R Catar, B Hegner, MM Davidson, S Mahmoodzadeh, D Dragun, MA Sussman |
PloS one | 2015 |
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Do altered energy metabolism or spontaneous locomotion ‘mediate’ decelerated senescence?
O Arum, JA Dawson, DL Smith, JJ Kopchick, DB Allison, A Bartke |
Aging Cell | 2015 |
|
The Aging Heart: Figure 1
YA Chiao, PS Rabinovitch |
Cold Spring Harbor Perspectives in Medicine | 2015 |
|
MYC, Metabolism, and Cancer
ZE Stine, ZE Walton, BJ Altman, AL Hsieh, CV Dang |
Cancer Discovery | 2015 |
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Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice
V Hurez, V Dao, A Liu, S Pandeswara, J Gelfond, L Sun, M Bergman, CJ Orihuela, V Galvan, Á Padrón, J Drerup, Y Liu, P Hasty, ZD Sharp, TJ Curiel |
Aging Cell | 2015 |
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Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity: Translational physiology of ageing
DR Seals, JN Justice, TJ LaRocca |
The Journal of Physiology | 2015 |
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Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society
J Nikolich-Žugich, DP Goldman, PR Cohen, D Cortese, L Fontana, BK Kennedy, MJ Mohler, SJ Olshansky, T Perls, D Perry, A Richardson, C Ritchie, AM Wertheimer, RG Faragher, MJ Fain |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2015 |
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Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life
CS Carter, D Khamiss, M Matheny, HZ Toklu, N Kirichenko, KY Strehler, N Tumer, PJ Scarpace, D Morgan |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2015 |
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Reduced Expression of MYC Increases Longevity and Enhances Healthspan
JW Hofmann, X Zhao, M De Cecco, AL Peterson, L Pagliaroli, J Manivannan, GB Hubbard, Y Ikeno, Y Zhang, B Feng, X Li, T Serre, W Qi, H Van Remmen, RA Miller, KG Bath, R de Cabo, H Xu, N Neretti, JM Sedivy |
Cell | 2015 |
|
Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors
Y Luo, J Zhou, MX Li, PF Wu, ZL Hu, L Ni, Y Jin, JG Chen, F Wang |
Aging Cell | 2015 |
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10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling
Y Honda, Y Araki, T Hata, K Ichihara, M Ito, M Tanaka, S Honda |
Journal of Aging Research | 2015 |
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When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?
NN Yokoyama, AP Denmon, EM Uchio, M Jordan, D Mercola, X Zi |
Current Pharmacology Reports | 2015 |
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Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice
SC Johnson, ME Yanos, A Bitto, A Castanza, A Gagnidze, B Gonzalez, K Gupta, J Hui, C Jarvie, BM Johnson, N Letexier, L McCanta, M Sangesland, O Tamis, L Uhde, AV Ende, PS Rabinovitch, Y Suh, M Kaeberlein |
Frontiers in Genetics | 2015 |
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Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways
KY Salas-Ramirez, C Bagnall, L Frias, SA Abdali, TA Ahles, K Hubbard |
Behavioural Brain Research | 2015 |
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Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life
KE Fischer, JA Gelfond, VY Soto, C Han, S Someya, A Richardson, SN Austad, C Englert |
PloS one | 2015 |
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Mathematical Modelling of Metabolic Regulation in Aging
M Auley, K Mooney, P Angell, S Wilkinson |
Metabolites | 2015 |
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Effect of Chronic Administration of Low Dose Rapamycin on Development and Immunity in Young Rats
Z Lu, F Liu, L Chen, H Zhang, Y Ding, J Liu, M Wong, LH Zeng, BO Williams |
PloS one | 2015 |
|
Measures of Healthspan as Indices of Aging in Mice—A Recommendation
A Richardson, KE Fischer, JR Speakman, R Cabo, SJ Mitchell, CA Peterson, P Rabinovitch, YA Chiao, G Taffet, RA Miller, RC Rentería, J Bower, DK Ingram, WC Ladiges, Y Ikeno, F Sierra, SN Austad |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2015 |
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Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1
A Bitto, AM Wang, CF Bennett, M Kaeberlein |
Cold Spring Harbor Perspectives in Medicine | 2015 |
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Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models
BA Neel, H Zong, JM Backer, JE Pessin |
Frontiers in physiology | 2015 |
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Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production
ZE Gillespie, K MacKay, M Sander, B Trost, W Dawicki, A Wickramarathna, J Gordon, M Eramian, IR Kill, JM Bridger, A Kusalik, JA Mitchell, CH Eskiw |
Nucleus | 2015 |
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Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling
Wei Yang, Britta Burkhardt, Luise Fischer, Maja Beirow, Nadja Bork, Eva C. Wönne, Cornelia Wagner, Bettina Husen, Katrin Zeilinger, Liegang Liu, Andreas K. Nussler |
EXCLI J | 2015 |
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The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects
M Kaeberlein |
Veterinary pathology | 2015 |
|
Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes
K Sataranatarajan, Y Ikeno, A Bokov, D Feliers, H Yalamanchili, HJ Lee, MM Mariappan, H Tabatabai-Mir, V Diaz, S Prasad, MA Javors, GG Choudhury, GB Hubbard, JL Barnes, A Richardson, BS Kasinath |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2015 |
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Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions
Jahrling JB, Laberge RM |
Current topics in medicinal chemistry | 2015 |
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p53 and rapamycin are additive
Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P |
Oncotarget | 2015 |
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Alive and well? Exploring disease by studying lifespan
JO Brett, TA Rando |
Current Opinion in Genetics & Development | 2014 |
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mTOR signaling in tumorigenesis
K Xu, P Liu, W Wei |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 |
|
Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span
CB Newgard, JE Pessin |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2014 |
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Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in Mice
T Ito, N Yoshikawa, T Inui, N Miyazaki, SW Schaffer, J Azuma, AS Lewin |
PloS one | 2014 |
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Sirtuins: guardians of mammalian healthspan
W Giblin, ME Skinner, DB Lombard |
Trends in Genetics | 2014 |
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Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease
S Sciarretta, M Volpe, J Sadoshima |
Circulation research | 2014 |
|
Caloric restriction mimetics: towards a molecular definition
F Madeo, F Pietrocola, T Eisenberg, G Kroemer |
Nature Reviews Drug Discovery | 2014 |
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Interaction of growth hormone receptor/binding protein gene disruption and caloric restriction for insulin sensitivity and attenuated aging
O Arum, J Saleh, R Boparai, J Turner, J Kopchick, R Khardori, A Bartke |
F1000Research | 2014 |
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Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
DF Dai, PP Karunadharma, YA Chiao, N Basisty, D Crispin, EJ Hsieh, T Chen, H Gu, D Djukovic, D Raftery, RP Beyer, MJ MacCoss, PS Rabinovitch |
Aging Cell | 2014 |
|
ATF4 activity: a common feature shared by many kinds of slow-aging mice
W Li, X Li, RA Miller |
Aging Cell | 2014 |
|
Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms
EL Goldberg, MJ Romero-Aleshire, KR Renkema, MS Ventevogel, WM Chew, JL Uhrlaub, MJ Smithey, KH Limesand, GD Sempowski, HL Brooks, J Nikolich-Žugich |
Aging Cell | 2014 |
|
Rapamycin: One Drug, Many Effects
J Li, SG Kim, J Blenis |
Cell Metabolism | 2014 |
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Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition
A Umemura, EJ Park, K Taniguchi, JH Lee, S Shalapour, MA Valasek, M Aghajan, H Nakagawa, E Seki, MN Hall, M Karin |
Cell Metabolism | 2014 |
|
Lifespan Modulation in Mice and the Confounding Effects of Genetic Background
L Mulvey, A Sinclair, C Selman |
Journal of Genetics and Genomics | 2014 |
|
In search of antiaging modalities: Evaluation of mTOR- and ROS/DNA damage-signaling by cytometry: Cytometry in Search of Antiaging Modalities
Z Darzynkiewicz, H Zhao, HD Halicka, J Li, YS Lee, TC Hsieh, JM Wu |
Cytometry Part A | 2014 |
|
Rapamycin reduces Drosophila longevity under low nutrition
EV Cuesta, F Fan, DM Rand |
IOSR Journal of Pharmacy (IOSRPHR) | 2014 |
|
Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet
OV Leontieva, GM Paszkiewicz, MV Blagosklonny |
Aging Cell | 2014 |
|
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
RA Miller, DE Harrison, CM Astle, E Fernandez, K Flurkey, M Han, MA Javors, X Li, NL Nadon, JF Nelson, S Pletcher, AB Salmon, ZD Sharp, SV Roekel, L Winkleman, R Strong |
Aging Cell | 2014 |
|
Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver
Z Yu, R Wang, WC Fok, A Coles, AB Salmon, VI Perez |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2014 |
|
Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin
IG Popovich, VN Anisimov, MA Zabezhinski, AV Semenchenko, ML Tyndyk, MN Yurova, MV Blagosklonny |
Cancer biology & therapy | 2014 |
|
Longevity pathways and memory aging
I Gkikas, D Petratou, N Tavernarakis |
Frontiers in Genetics | 2014 |
|
Abnormal brain iron metabolism in irp2 deficient mice is associated with mild neurological and behavioral impairments
KB Zumbrennen-Bullough, L Becker, L Garrett, SM Hölter, J Calzada-Wack, I Mossbrugger, L Quintanilla-Fend, I Racz, B Rathkolb, T Klopstock, W Wurst, A Zimmer, E Wolf, H Fuchs, V Gailus-Durner, MH de Angelis, SJ Romney, EA Leibold |
PloS one | 2014 |
|
Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
M Kleinert, L Sylow, DJ Fazakerley, JR Krycer, KC Thomas, AJ Oxbøll, AB Jordy, TE Jensen, G Yang, P Schjerling, B Kiens, DE James, MA Ruegg, EA Richter |
Molecular Metabolism | 2014 |
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Rapamycin and Ageing: When, for How Long, and How Much?
M Kaeberlein |
Journal of Genetics and Genomics | 2014 |
|
Longevity, aging and rapamycin
D Ehninger, F Neff, K Xie |
Cellular and Molecular Life Sciences | 2014 |
|
Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset
S Tardif, C Ross, P Bergman, E Fernandez, M Javors, A Salmon, J Spross, R Strong, A Richardson |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2014 |
|
Biotechnological Applications Derived from Microorganisms of the Atacama Desert
A Azua-Bustos, C González-Silva |
BioMed Research International | 2014 |
|
Pleiotropic functions for transcription factor zscan10
P Kraus, Sivakamasundari, HB Yu, X Xing, SL Lim, T Adler, JA Pimentel, L Becker, A Bohla, L Garrett, W Hans, SM Hölter, E Janas, K Moreth, C Prehn, O Puk, B Rathkolb, J Rozman, J Adamski, R Bekeredjian, DH Busch, J Graw, M Klingenspor, T Klopstock, F Neff, M Ollert, T Stoeger, AÖ Yildrim, O Eickelberg, E Wolf, W Wurst, H Fuchs, V Gailus-Durner, MH de Angelis, T Lufkin, LW Stanton |
PloS one | 2014 |
|
Interrelation between protein synthesis, proteostasis and life span
K Arnsburg, J Kirstein-Miles |
Current genomics | 2014 |
|
Comparison of rapamycin schedules in mice on high-fat diet
OV Leontieva, GM Paszkiewicz, MV Blagosklonny |
Cell cycle (Georgetown, Tex.) | 2014 |
|
How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story
A Richardson, V Galvan, AL Lin, S Oddo |
Experimental Gerontology | 2014 |
|
Immune Memory-Boosting Dose of Rapamycin Impairs Macrophage Vesicle Acidification and Curtails Glycolysis in Effector CD8 Cells, Impairing Defense against Acute Infections
EL Goldberg, MJ Smithey, LK Lutes, JL Uhrlaub, J Nikolich- ugich |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
|
Longevity Manipulations Differentially Affect Serotonin/Dopamine Level and Behavioral Deterioration in Aging Caenorhabditis elegans
JA Yin, XJ Liu, J Yuan, J Jiang, SQ Cai |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2014 |
|
Rapamycin-induced metabolic defects are reversible in both lean and obese mice
Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DW, Richardson A, Salmon AB |
Aging | 2014 |
|
Gerosuppression in confluent cells
Leontieva OV, Blagosklonny MV |
Aging | 2014 |
|
Rapamycin, anti-aging, and avoiding the fate of Tithonus
Arlan Richardson |
Journal of Clinical Investigation | 2013 |
|
Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
YH Youm, RW Grant, LR McCabe, DC Albarado, KY Nguyen, A Ravussin, P Pistell, S Newman, R Carter, A Laque, H Münzberg, CJ Rosen, DK Ingram, JM Salbaum, VD Dixit |
Cell Metabolism | 2013 |
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mTOR Inhibition: From Aging to Autism and Beyond
M Kaeberlein |
Scientifica | 2013 |
|
Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver
WC Fok, A Bokov, J Gelfond, Z Yu, Y Zhang, M Doderer, Y Chen, M Javors, WH Wood, Y Zhang, KG Becker, A Richardson, VI Pérez |
Aging Cell | 2013 |
|
Cardiac Hegemony of Senescence
S Siddiqi, MA Sussman |
Current Translational Geriatrics and Gerontology Reports | 2013 |
|
Preserving Youth: Does Rapamycin Deliver?
SC Johnson, GM Martin, PS Rabinovitch, M Kaeberlein |
Science Translational Medicine | 2013 |
|
eRapa Restores a Normal Life Span in a FAP Mouse Model
P Hasty, CB Livi, SG Dodds, D Jones, R Strong, M Javors, KE Fischer, L Sloane, K Murthy, G Hubbard, L Sun, V Hurez, TJ Curiel, ZD Sharp |
Cancer prevention research (Philadelphia, Pa.) | 2013 |
|
Increased Mammalian Target of Rapamycin Complex 2 Signaling Promotes Age-Related Decline in CD4 T Cell Signaling and Function
E Perkey, D Fingar, RA Miller, GG Garcia |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Rapamycin extends life- and health span because it slows aging
Blagosklonny MV |
Aging | 2013 |
|
Berberine suppresses gero-conversion from cell cycle arrest to senescence
Zhao H, Halicka HD, Li J, Darzynkiewicz Z |
Aging | 2013 |
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