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Citations to this article

Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension
Michal Pravenec, … , Elizabeth M. St. Lezin, Theodore W. Kurtz
Michal Pravenec, … , Elizabeth M. St. Lezin, Theodore W. Kurtz
Published June 15, 1999
Citation Information: J Clin Invest. 1999;103(12):1651-1657. https://doi.org/10.1172/JCI6691.
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Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension

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Abstract

Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic cardiovascular risk factors in SHRs is unknown. In the SHR.BN-Il6/Npy congenic strain, we have found that transfer of a segment of chromosome 4 (including Cd36) from the Brown Norway (BN) rat onto the SHR background induces reductions in blood pressure and ameliorates dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence a broad spectrum of cardiovascular risk factors involved in the hypertension metabolic syndrome. However, analysis of Cd36 genotypes in the SHR and stroke-prone SHR strains indicates that the deletion variant of Cd36 was not critical to the initial selection for hypertension in the SHR model. Thus, the ability of chromosome 4 to influence multiple cardiovascular risk factors, including hypertension, may depend on linkage of Cd36 to other genes trapped within the differential segment of the SHR.BN-Il6/Npy strain.

Authors

Michal Pravenec, Vaclav Zidek, Miroslava Simakova, Vladimir Kren, Drahomira Krenova, Karel Horky, Marie Jachymova, Blanka Mikova, Ludmila Kazdova, Timothy J. Aitman, Paul C. Churchill, R. Clinton Webb, Nilesh H. Hingarh, Ying Yang, Jia-Ming Wang, Elizabeth M. St. Lezin, Theodore W. Kurtz

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Total citations by year

Year: 2023 2022 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 Total
Citations: 1 3 1 1 1 4 1 2 1 3 4 2 8 2 4 4 3 3 5 11 9 7 1 1 82
Citation information
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Citations to this article in year 2012 (3)

Title and authors Publication Year
The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?
T Nabika, H Ohara, N Kato, M Isomura
Hypertension Research 2012
NPY and NPY receptors in airway structural and inflammatory cells in allergic asthma
TO Makinde, R Steininger, DK Agrawal
Experimental and Molecular Pathology 2012
CD36 as a therapeutic target for endothelial dysfunction in stroke
S Cho
Current pharmaceutical design 2012

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