Top panel: Insulin secretion rates were measured in subjects with type 2 diabetes (solid lines) and matched non-diabetic controls (shaded lines) over a 24-hour period that included 3 meals (breakfast, lunch, and dinner). Bottom panel: The insulin secretion rates are expressed as a percent changes from basal. In subjects with type 2 diabetes, the insulin secretory responses to meals are delayed and blunted. Reproduced with permission from the New England Journal of Medicine (5).