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2012 Association of American Physicians George M. Kober Medal
Introduction of Arthur H. Rubenstein
Kenneth S. Polonsky
Kenneth S. Polonsky
Published November 1, 2012
Citation Information: J Clin Invest. 2012;122(11):4283-4288. https://doi.org/10.1172/JCI66849.
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AAP Kober Medal

2012 Association of American Physicians George M. Kober Medal
Introduction of Arthur H. Rubenstein

  • Text
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Abstract

Authors

Kenneth S. Polonsky

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Figure 4

Measurement of C-peptide to define the natural history of changes in insulin secretion in a patient with diabetes.

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Measurement of C-peptide to define the natural history of changes in ins...
In 1969, significant C-peptide immunoreactivity is detectable in this patient’s plasma, indicating that endogenous insulin secretion is present. As a result, diet therapy is effective. Over time, C-peptide concentrations fall and become undetectable, and this loss of endogenous insulin secretion corresponds with the need to use exogenous insulin injections to control blood glucose. Reproduced with permission from the New England Journal of Medicine (3).

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