Acute kidney injury (AKI) often results from ischemia reperfusion, sepsis, or exposure to nephrotoxins and is associated with a high rate of mortality and morbidity. Advances in understanding the pathophysiology of AKI may lead to the development of specific therapies. Although there is evidence of an important role for immune cells in AKI, the specific relevant populations and the mechanisms of their actions are unclear. In this issue of the JCI, Li et al. demonstrate that adenosine manipulates DC responses to kidney injury, raising hope that immunotherapy could be a tangible approach to AKI.
Hamid Rabb
Title and authors | Publication | Year |
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Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1α and NF-κB (p65)/Smad7 Pathways
Tang L, Zhu M, Che X, Yang X, Xu Y, Ma Q, Zhang M, Ni Z, Shao X, Mou S |
Journal of Personalized Medicine | 2022 |
The role of the immune system in kidney disease: The immune system in kidney disease
J Tecklenborg, D Clayton, S Siebert, SM Coley |
Clinical & Experimental Immunology | 2018 |
Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk
F Husain-Syed, Z Ricci, D Brodie, JL Vincent, VM Ranieri, AS Slutsky, FS Taccone, L Gattinoni, C Ronco |
Intensive Care Medicine | 2018 |
Acute kidney injury in HCT: an update
JA Lopes, S Jorge, M Neves |
Bone Marrow Transplantation | 2016 |
Research Progress on Regulatory T Cells in Acute Kidney Injury
Y Wang, Y Tao |
Journal of Immunology Research | 2015 |
A Brief Journey through the Immune System
KM Yatim, FG Lakkis |
Clinical journal of the American Society of Nephrology : CJASN | 2015 |
Therapeutic Translation in Acute Kidney Injury: The Epithelial-Endothelial Axis
Bruce A Molitoris |
Journal of Clinical Investigation | 2014 |
T Lymphocytes and Acute Kidney Injury: Update
MN Martina, S Noel, S Bandapalle, AR Hamad, H Rabb |
2014 | |
Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report
R Bassi, A Vergani, F D’Addio, MB Nasr, A Mocci, MP Rastaldi, T Ichimura, JV Bonventre, P Fiorina |
SpringerPlus | 2014 |
Mouse adult renal progenitor cells in combination with erythropoietin or suramin - a potential new strategy for the treatment of acute kidney injury
PR Wang |
Stem Cell Research & Therapy | 2013 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |