Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Telomeres and age-related disease: how telomere biology informs clinical paradigms
Mary Armanios
Mary Armanios
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):996-1002. https://doi.org/10.1172/JCI66370.
View: Text | PDF
Review Series Article has an altmetric score of 18

Telomeres and age-related disease: how telomere biology informs clinical paradigms

  • Text
  • PDF
Abstract

Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies.

Authors

Mary Armanios

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 4 9 13 16 15 11 20 12 15 14 17 12 6 1 165
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (165)

Title and authors Publication Year
Loss of Ten1 in mice induces telomere shortening and phenotypic changes resembling human dyskeratosis congenita
Adrián Sanz-Moreno, Lore Becker, Kan Xie, Patricia Silva-Buttkus, Nathalia Dragano, Antonio Aguilar-Pimentel, Oana Amarie, Julia Calzada-Wack, Markus Kraiger, Stefanie Leuchtenberger, Claudia Seisenberger, Susan Marschall, Birgit Rathkolb, Enzo Scifo, Ting Liu, Anoja Thanabalasingam, Sharon Savage, Helmut Fuchs, Dan Ehninger, Valérie Gailus-Durner, Martin Angelis
Science advances 2025
Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice.
Jiang H, Inoue S, Hatakeyama J, Liu P, Zhao T, Zhang Y, Liu B, He C, Moriyama H
Biogerontology 2025
Telomere attrition alters extracellular vesicles conferring adverse impacts on neuronal viability and inflammatory response
Gong Y, Wang Y, Delgado-Peraza F, Nogueras-Ortiz C, Noren Hooten N, Croteau DL, Temre M, Molnar AE, Bodogai M, Zou A, Abdelmohsen K, Zhu W, Zhang Y, Gorospe M, Weng NP, Evans MK, Kapogiannis D, Liu Y
iScience 2025
Association of life’s essential 8 with leukocyte telomere length and mitochondrial DNA copy number: Findings from the population-based UK Biobank study
Tian Y, Kong S, Mao L, Wang G, He J, Lei F, Lin L, Li J
The Journal of Nutrition, Health & Aging 2025
Human telomere length is chromosome specific and conserved across individuals
Karimian K, Groot A, Huso V, Kahidi R, Tan KT, Sholes S, Keener R, McDyer JF, Alder JK, Li H, Rechtsteiner A, Greider CW
2024
Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders.
Pennington KM, Simonetto D, Taner T, Mangaonkar AA
Current Hematologic Malignancy Reports 2024
Simultaneous Liver and Kidney Transplantation in a Patient With Telomere Biology Disorder: A Case Study.
Choudhary D, Lekshmon KS, Singh C, Subramani VN, Singh Y, Mitra S, Sekar A, Malik M, Bhagat N, Shiva Kumar SP, Taneja S, Gupta V, Ramachandran R, Singh S, Nada R, Kenwar D, Duseja AK, Yadav TD, Malhotra P, Sharma A
Journal of Clinical and Experimental Hepatology 2024
Telomere Biology Disorder: A Focus on Gastrointestinal and Hepatic Manifestations.
Warsame F, Simonetto DA
Current Hematologic Malignancy Reports 2024
A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells.
Li M, Liu JX, Ma B, Liu JY, Chen J, Jin F, Hu CH, Xu HK, Zheng CX, Hou R
Stem Cell Reviews and Reports 2024
Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications.
Liu WS, Wu BS, Yang L, Chen SD, Zhang YR, Deng YT, Wu XR, He XY, Yang J, Feng JF, Cheng W, Xu YM, Yu JT
GeroScience 2024
Telomere length exhibits inverse association with migraine among Americans aged 20–50 years, without implications beyond age 50: a cross-sectional study
Geng D, Liu H, Wang H, Wang H
Scientific Reports 2024
Effect of telomere shortening on disease progression in patients with inflammatory bowel disease: A systematic review and meta-analysis protocol.
Zhang Y, Ma Z, Kang L, Yang L
PloS one 2024
Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell
Dong Z, Wang X, Wang P, Bai M, Wang T, Chu Y, Qin Y
Advanced Biology 2024
Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
Amanda Stock, Saipriya Ayyar, Amogh Kashyap, Hagai Yanai, Mayuri Tanaka-Yano, Monica Bodogai, Matthew Starost, Chongkui Sun, Yajun Wang, Yunong Wang, Yi Gong, Chandrakala Puligilla, Evandro Fang, Vilhelm Bohr, Yie Liu, Isabel Beerman
GeroScience 2023
La sénescence cellulaire, nouvelle cible des infections virales respiratoires : du virus influenza au SARS-CoV-2
Adnot S, Bernard D, Lipskaia L, Trottein F
2023
The association between sleep quality and telomere length: A systematic literature review
Sabot D, Lovegrove R, Stapleton P
2023
Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian
Dhillon VS, Deo P, Thomas P, Fenech M
International journal of molecular sciences 2023
Genomic Fingerprint Associated with Familial Idiopathic Pulmonary Fibrosis: A Review
Ding D, Gao R, Xue Q, Luan R, Yang J
International journal of medical sciences 2023
Advances in cellular senescence in idiopathic pulmonary fibrosis (Review)
Han S, Lu Q, Liu X
Experimental and therapeutic medicine 2023
Telomere biology: from disorders to hematological diseases
Roka K, Solomou EE, Kattamis A
Frontiers in Oncology 2023
Dyskeratosis Congenita: A Case Report of a Patient With Coronary Artery Disease
Ghaly M, Ghaly M, Harris S
Cureus 2023
Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length.
Tichy ED, Lee JH, Li G, Estep KN, Brad Johnson F, Mourkioti F
npj Microgravity 2023
Protective Effects of Micronutrient Supplements, Phytochemicals and Phytochemical-Rich Beverages and Foods Against DNA Damage in Humans: A Systematic Review of Randomized Controlled Trials and Prospective Studies
Fenech MF, Bull CF, Van Klinken BJ
Advances in Nutrition 2023
Genetically determined telomere length and its association with chronic obstructive pulmonary disease and interstitial lung disease in biobank Japan: A Mendelian randomization study
Zhu Y, Meng Y, Zhang Y, Karlsson IK, Hägg S, Zhan Y
Heliyon 2023
Biological aging in multiple sclerosis
Zhang Y, Atkinson J, Burd CE, Graves J, Segal BM
Multiple sclerosis (Houndmills, Basingstoke, England) 2023
Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors
Gold NM, Okeke MN, He Y
Aging and Disease 2023
Leukocyte telomere length as a compensatory mechanism in vitamin D metabolism
D Agirbasli, M Kalyoncu, M Muftuoglu, F Aksungar, M Agirbasli, G Saretzki
PloS one 2022
Genetic and Epigenetic Inheritance at Telomeres
E Lister-Shimauchi, B McCarthy, M Lippincott, S Ahmed
Epigenomes 2022
The Role of Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases
J Jeong, Y Choi, H Lee
Frontiers in pharmacology 2022
The Controversial Role of HCY and Vitamin B Deficiency in Cardiovascular Diseases
W Herrmann, M Herrmann
Nutrients 2022
Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging
J Jung, D McCartney, J Wagner, D Rosoff, M Schwandt, H Sun, C Wiers, L de Carvalho, N Volkow, R Walker, A Campbell, D Porteous, A McIntosh, R Marioni, S Horvath, K Evans, F Lohoff
Molecular Psychiatry 2022
Nutrition Interventions of Herbal Compounds on Cellular Senescence
Chen Z, Wu Y, Lin Q, Cai J, Liu X, Liang Y
Oxidative medicine and cellular longevity 2022
Leukocyte Telomere Length as a Molecular Biomarker of Coronary Heart Disease
Zimnitskaya OV, Petrova MM, Lareva NV, Cherniaeva MS, Al-Zamil M, Ivanova AE, Shnayder NA
Genes & development 2022
BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact.
De Sadeleer LJ, Verleden SE, Schupp JC, McDonough JE, Goos T, Yserbyt J, Bargagli E, Rottoli P, Kaminski N, Prasse A, Wuyts WA
Chest 2022
Alveolar Epithelial Type 2 Cell Dysfunction in Idiopathic Pulmonary Fibrosis.
Zhu W, Tan C, Zhang J
Lung 2022
Tieing together loose ends: telomere instability in cancer and aging
Borges G, Criqui M, Harrington L
Molecular Oncology 2022
Functional interaction between compound heterozygous TERT mutations causes severe telomere biology disorder.
Niaz A, Truong J, Manoleras A, Fox LC, Blombery P, Vasireddy RS, Pickett HA, Curtin JA, Barbaro PM, Rodgers J, Roy J, Riley LG, Holien JK, Cohen SB, Bryan TM
Blood Advances 2022
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes
Stock AJ, McDevitt RA, Puligilla C, Wang Y, Zhang Y, Wang K, Sun C, Becker KG, Lehrmann E, Wood WH 3rd, Gong Y, Aqdas M, Sung MH, Hoffmann V, Liu C, Gorospe M, Harrington L, Ferrucci L, Liu Y
PLoS genetics 2022
Telomeres and Psychological Stress: Perspective on Psychopathologies
Akay GG
2022
Association between Rheumatic Disease Comorbidity Index and factors of poor prognosis in a cohort of 280 patients with rheumatoid arthritis.
Ben Tekaya A, Hannech E, Saidane O, Rouached L, Bouden S, Tekaya R, Mahmoud I, Abdelmoula L
BMC Rheumatology 2022
Interstitial lung abnormalities are associated with decreased mean telomere length
Putman RK, Axelsson GT, Ash SY, Sanders JL, Menon AA, Araki T, Nishino M, Yanagawa M, Gudmundsson EF, Qiao D, Estépar RS, Dupuis J, O\u2019Connor GT, Rosas IO, Washko GR, El-Chemaly S, Raby BA, Gudnason V, DeMeo DL, Silverman EK, Hatabu H, DeVivo I, Cho MH, Gudmundsson G, Hunninghake GM
European Respiratory Journal 2022
The Role of Telomeres in Human Disease.
Armanios M
Annual Review of Genomics and Human Genetics 2022
TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis
Sherilyn Grill, Shilpa Padmanaban, Ann Friedman, Eric Perkey, Frederick Allen, Valerie Tesmer, Jennifer Chase, Rami Khoriaty, Catherine E. Keegan, Ivan Maillard, Jayakrishnan Nandakumar
JCI Insight 2021
Telomeres in Interstitial Lung Disease
CJ Stock, EA Renzoni
Journal of Clinical Medicine 2021
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining
S Abbasi, G Parmar, RD Kelly, N Balasuriya, C Schild-Poulter
Cellular and Molecular Life Sciences 2021
Liver transplant recipient with respiratory failure due to pulmonary fibrosis related to telomere disease requiring lung transplantation
M Singh, SK Merwat, JH Fair, AG Duarte
Respiratory Medicine Case Reports 2021
Correlation between Telomere Length and Chronic Obstructive Pulmonary Disease–Related Phenotypes: Results from the Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) Cohort
DH Moon, J Kim, MN Lim, SH Bak, WJ Kim
Tuberculosis and Respiratory Diseases 2021
Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers
LW Diebel, K Rockwood
Current Oncology Reports 2021
Lung Transplant Improves Survival and Quality of Life Regardless of Telomere Dysfunction
L Planas-Cerezales, EG Arias-Salgado, C Berastegui, A Montes-Worboys, R González-Montelongo, JM Lorenzo-Salazar, V Vicens-Zygmunt, M Garcia-Moyano, J Dorca, C Flores, R Perona, A Román, M Molina-Molina
Frontiers in Medicine 2021
Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort
R Guillén, F Otero, A Mosquera, M Vázquez-Mosquera, I Rego-Pérez, FJ Blanco, JL Fernández
Scientific Reports 2021
TAZ maintains telomere length in TNBC cells by mediating Rad51C expression
L Yang, B Wang, X Jiao, C Zhou, S Chen, X Gao, W Sun, S Song, J Li, J Liu, Y Wang, P Liu
Breast Cancer Research 2021
Telomere Length and Regulatory Genes as Novel Stress Biomarkers and Their Diversities in Broiler Chickens (Gallus gallus domesticus) Subjected to Corticosterone Feeding
KA Badmus, Z Idrus, GY Meng, AQ Sazili, K Mamat-Hamidi
Animals 2021
Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study
VB Ribeiro, DC Pedroso, GS Kogure, IP Lopes, BA Santana, HC de Souza, RA Ferriani, RT Calado, CL Furtado, RM dos Reis
International journal of environmental research and public health 2021
Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (Gallus gallus domesticus)
KA Badmus, Z Idrus, GY Meng, K Mamat-Hamidi
Animals 2021
Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing
S Sholes, K Karimian, A Gershman, T Kelly, W Timp, C Greider
Genome research 2021
NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction
Stock AJ, Liu Y
2021
Lung transplantation for interstitial lung disease.
Kapnadak SG, Raghu G
2021
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis
Jeremy Katzen, Michael F. Beers
Journal of Clinical Investigation 2020
Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging
S Piñeiro-Hermida, C Autilio, P Martínez, F Bosch, J Pérez-Gil, MA Blasco
The Journal of Cell Biology 2020
Leukocyte telomere length as a diagnostic biomarker for anti-tuberculosis drug-induced liver injury
W Udomsinprasert, N Chanhom, S Suvichapanich, S Wattanapokayakit, S Mahasirimongkol, W Chantratita, J Jittikoon
Scientific Reports 2020
Cancer and myeloid clonal evolution in the short telomere syndromes
KE Schratz, M Armanios
Current Opinion in Genetics & Development 2020
Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling
DE Ebeid, FG Khalafalla, KM Broughton, MM Monsanto, CY Esquer, V Sacchi, N Hariharan, KI Korski, M Moshref, J Emathinger, CT Cottage, PJ Quijada, JH Nguyen, R Alvarez, M Völkers, MH Konstandin, BJ Wang, F Firouzi, JM Navarrete, NA Gude, MJ Goumans, MA Sussman
Cardiovascular Research 2020
Role of telomere shortening in anticipation of inflammatory bowel disease
B Truta, E Wohler, N Sobreira, LW Datta, SR Brant
World journal of gastrointestinal pharmacology and therapeutics 2020
Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction
C Sun, K Wang, AJ Stock, Y Gong, TG Demarest, B Yang, N Giri, L Harrington, BP Alter, SA Savage, VA Bohr, Y Liu
The EMBO Journal 2020
Alterations in telomere length and mitochondrial DNA copy number in human lymphocytes on short-term exposure to moderate hypoxia
MR Alam, DK Kim
Toxicology Reports 2020
The role of extracellular DNA in COVID-19: clues from inflamm-aging
G Storci, F Bonifazi, P Garagnani, F Olivieri, M Bonafè
Ageing Research Reviews 2020
From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
AA van Batenburg, KM Kazemier, MF van Oosterhout, JJ van der Vis, HW van Es, JC Grutters, R Goldschmeding, CH van Moorsel, G Saretzki
PloS one 2020
Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial
Y Hachmo, A Hadanny, RA Hamed, M Daniel-Kotovsky, M Catalogna, G Fishlev, E Lang, N Polak, K Doenyas, M Friedman, Y Zemel, Y Bechor, S Efrati
Aging 2020
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis
A Takezaki, S Tsukumo, Y Setoguchi, JG Ledford, H Goto, K Hosomichi, H Uehara, Y Nishioka, K Yasutomo
Journal of Experimental Medicine 2019
The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications
N Arish, D Petukhov, SB Wallach-Dayan
International journal of molecular sciences 2019
TERT gene polymorphisms are associated with chronic obstructive pulmonary disease risk in the Chinese Li population
Y Ding, Q Li, C Wu, W Wang, J Zhao, Q Feng, X Zhou, Y Xie, M Lin, P He, P Xie
Molecular Genetics & Genomic Medicine 2019
Telomere Biology and Human Phenotype
K Turner, V Vasu, D Griffin
Cells 2019
LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung
A Mammoto, M Muyleart, T Mammoto
Aging 2019
Heterozygous TERT gene mutation associated with familial idiopathic pulmonary fibrosis
SR Sousa, PC Mota, N Melo, HN Bastos, E Padrão, JM Pereira, R Cunha, CS Moura, S Guimarães, A Morais
Respiratory Medicine Case Reports 2019
Initiation of Pulmonary Fibrosis after Silica Inhalation in Rats is linked with Dysfunctional Shelterin Complex and DNA Damage Response
M Shoeb, GM Mustafa, P Joseph, C Umbright, V Kodali, KA Roach, T Meighan, JR Roberts, A Erdely, JM Antonini
Scientific Reports 2019
Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis
Y Yan, D Qin, B Hu, C Zhang, S Liu, D Wu, W Huang, X Huang, L Wang, X Chen, L Zhang
Molecular Therapy — Nucleic Acids 2019
Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study
I Pusceddu, W Herrmann, ME Kleber, H Scharnagl, MM Hoffmann, BM Winklhofer-Roob, W März, M Herrmann
European Journal of Nutrition 2019
The Spectrum of Hepatic Involvement in Patients With Telomere Disease
D Kapuria, G BenYakov, R Ortolano, MH Cho, O KalchiemDekel, V Takyar, S Lingala, N Gara, M Tana, YJ Kim, DE Kleiner, NS Young, DM Townsley, C Koh, T Heller
Hepatology 2019
Association of nutraceutical supplements with longer telomere length
D Tsoukalas, P Fragkiadaki, A Docea, A Alegakis, E Sarandi, E Vakonaki, E Salataj, E Kouvidi, D Nikitovic, L Kovatsi, D Spandidos, A Tsatsakis, D Calina
International journal of molecular medicine 2019
Telomere Abnormalities in the Pathobiology of Idiopathic Pulmonary Fibrosis
H Bilgili, AJ Białas, P Górski, WJ Piotrowski
Journal of Clinical Medicine 2019
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
D Tsoukalas, P Fragkiadaki, A Docea, A Alegakis, E Sarandi, M Thanasoula, D Spandidos, A Tsatsakis, M Razgonova, D Calina
Molecular medicine reports 2019
Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice
K Whittemore, A Derevyanko, P Martinez, R Serrano, M Pumarola, F Bosch, MA Blasco
Aging 2019
Prognostic significance of pulmonary function tests in dyskeratosis congenita, a telomere biology disorder
N Giri, S Ravichandran, Y Wang, SM Gadalla, BP Alter, J Fontana, SA Savage
ERJ Open Research 2019
Heritability of telomere length across three generations of Korean families
JH Kim, CM Nam, D Lee, H Bang, JH Ko, I Lim, GJ Kim, BW Koes, DC Lee
Pediatric Research 2019
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis
DH Kim, JD Beckett, V Nagpal, MA Seman-Senderos, RA Gould, TJ Creamer, EG MacFarlane, Y Chen, D Bedja, JT Butcher, W Mitzner, R Rouf, S Hata, DS Warren, HC Dietz
Science Translational Medicine 2019
Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings
JR PetersHall, J Min, E Tedone, S Sho, S Siteni, I Mender, JW Shay
The FASEB Journal 2019
Genetically Increased Telomere Length and Aging-Related Traits in the U.K. Biobank
K Demanelis, L Tong, BL Pierce, DL Couteur
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2019
Telomeres and telomerase: three decades of progress
J Shay, W Wright
Nature Reviews Genetics 2019
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-López, M Bobadilla, JM Flores, F Bosch, MA Blasco
eLife 2018
Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease
CH van Moorsel
Current Opinion in Pulmonary Medicine 2018
The aging lung: tissue telomere shortening in health and disease
S Everaerts, EJ Lammertyn, DS Martens, LJ Sadeleer, K Maes, AA van Batenburg, R Goldschmeding, CH van Moorsel, LJ Dupont, WA Wuyts, R Vos, G Gayan-Ramirez, N Kaminski, JC Hogg, W Janssens, GM Verleden, TS Nawrot, SE Verleden, JE McDonough, BM Vanaudenaerde
Respiratory Research 2018
Idiopathic Pulmonary Fibrosis (IPF): An Overview
S Barratt, A Creamer, C Hayton, N Chaudhuri
Journal of Clinical Medicine 2018
Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis
R Snetselaar, MF van Oosterhout, JC Grutters, CH van Moorsel
Frontiers in Medicine 2018
Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study
A Dressen, AR Abbas, C Cabanski, J Reeder, TR Ramalingam, M Neighbors, TR Bhangale, MJ Brauer, J Hunkapiller, J Reeder, K Mukhyala, K Cuenco, J Tom, A Cowgill, J Vogel, WF Forrest, HR Collard, PJ Wolters, JA Kropski, LH Lancaster, TS Blackwell, JR Arron, BL Yaspan
The lancet. Respiratory medicine 2018
Genetic Determinants of Telomere Length in African American Youth
AM Zeiger, MJ White, C Eng, SS Oh, J Witonsky, PC Goddard, MG Contreras, JR Elhawary, D Hu, AC Mak, EY Lee, KL Keys, LA Samedy, O Risse-Adams, J Magaña, S Huntsman, S Salazar, A Davis, K Meade, E Brigino-Buenaventura, MA LeNoir, HJ Farber, K Bibbins-Domingo, LN Borrell, EG Burchard
Scientific Reports 2018
TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast
JJ Wanat, GA Logsdon, JH Driskill, Z Deng, PM Lieberman, FB Johnson, S Ahmed
PloS one 2018
Dysfunctional telomeres and hematological disorders
E Fiorini, A Santoni, S Colla
Differentiation; research in biological diversity 2018
Risk factors for primary Sjögren syndrome-associated interstitial lung disease
Y Wang, Z Hou, M Qiu, Q Ye
Journal of Thoracic Disease 2018
Significance of TERT and ATRX mutations in glioma
J Liu, X Zhang, X Yan, M Sun, Y Fan, Y Huang
Oncology Letters 2018
Telomere length and early trauma in schizophrenia
Riley G, Perrin M, Vaez-Azizi LM, Ruby E, Goetz RR, Dracxler R, Walsh-Messinger J, Keefe DL, Buckley PF, Szeszko PR, Malaspina D
Schizophrenia Research 2018
SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34 + Progenitor CellsClinical Perspective
L Zhang, A Jambusaria, Z Hong, G Marsboom, PT Toth, BS Herbert, AB Malik, J Rehman
Circulation 2017
Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
TL Yang, Q Chen, JT Deng, G Jagannathan, JW Tobias, DC Schultz, S Wang, CJ Lengner, AK Rustgi, JP Lynch, FB Johnson
Nature Communications 2017
IPF lung fibroblasts have a senescent phenotype
D Álvarez, N Cárdenes, J Sellarés, M Bueno, C Corey, VS Hanumanthu, Y Peng, H DCunha, J Sembrat, M Nouraie, S Shanker, C Caufield, S Shiva, M Armanios, AL Mora, M Rojas
American journal of physiology. Lung cellular and molecular physiology 2017
Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy
Y Cai, V Kandula, R Kosuru, X Ye, MG Irwin, Z Xia
Cell cycle (Georgetown, Tex.) 2017
The FTO rs9939609 polymorphism is associated with short leukocyte telomere length in nonobese individuals:
JH Yu, I Baik, HJ Cho, JA Seo, SG Kim, KM Choi, SH Baik, DS Choi, C Shin, NH Kim
Medicine 2017
Telomere Length and CCL11 Levels are Associated With Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging
LS Czepielewski, R Massuda, B Panizzutti, LK Grun, FM Barbé-Tuana, AL Teixeira, DM Barch, CS Gama
Schizophrenia Bulletin 2017
Leukocyte telomere length is linked to vascular risk factors not to Alzheimer’s disease in the VITA study
M Hinterberger, P Fischer, K Huber, W Krugluger, S Zehetmayer
Journal of Neural Transmission 2017
Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
CL Elizabeth, CR Sara, EJ Adriana, JP de-Torres, P María-José, AJ Armando, C Bartolomé, C Ciro
Respiratory Research 2017
Telomere Biology—Insights into an Intriguing Phenomenon
S Venkatesan, A Khaw, M Hande
Cells 2017
BRD4 inhibitors block telomere elongation
S Wang, AM Pike, SS Lee, MA Strong, CJ Connelly, CW Greider
Nucleic Acids Research 2017
Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles
ED Tichy, DK Sidibe, MT Tierney, MJ Stec, M Sharifi-Sanjani, H Hosalkar, S Mubarak, FB Johnson, A Sacco, F Mourkioti
Stem Cell Reports 2017
Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion
JM Leung, N Fishbane, M Jones, A Morin, S Xu, JC Liu, J MacIsaac, MJ Milloy, K Hayashi, J Montaner, S Horvath, M Kobor, DD Sin, PR Harrigan, SF Man
Aging 2017
Long Telomeres Do Not Affect Cellular Fitness in Yeast
Y Harari, S Zadok-Laviel, M Kupiec, FM Winston
mBio 2017
Telomeres in health and disease
S Chatterjee
Journal of Oral and Maxillofacial Pathology : JOMFP 2017
37 kDa LRP::FLAG enhances telomerase activity and reduces senescent markers in vitro
TC Otgaar, E Ferreira, S Malindisa, M Bernert, BT Letsolo, SF Weiss
Oncotarget 2017
Telomere Dysfunction In Alveolar Epithelial Cells Causes Lung Remodeling and Fibrosis
Ram Naikawadi, Supparerk Disayabutr, Benat Mallavia, Matthew Donne, Gary Green, Janet La, Jason Rock, Mark Looney, Paul Wolters
JCI Insight 2016
Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD
CA Lerner, IK Sundar, I Rahman
The International Journal of Biochemistry & Cell Biology 2016
Candidate genes of idiopathic pulmonary fibrosis: current evidence and research
Y Wang, W Zhou
The Application of Clinical Genetics 2016
The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?
V Kordinas, A Ioannidis, S Chatzipanagiotou
Genes & development 2016
Telomerase and the Genetics of Emphysema Susceptibility. Implications for Pathogenesis Paradigms and Patient Care
SE Stanley, SJ Merck, M Armanios
Annals of the American Thoracic Society 2016
Role of lncRNAs in Cellular Aging
U Degirmenci, S Lei
Frontiers in Endocrinology 2016
Role of PGC-1α in Vascular RegulationHighlights: Implications for Atherosclerosis
AO Kadlec, DS Chabowski, K Ait-Aissa, DD Gutterman
Arteriosclerosis, thrombosis, and vascular biology 2016
Telomere-associated aging disorders
PL Opresko, JW Shay
Ageing Research Reviews 2016
Age-related declines in immune response in a wild mammal are unrelated to immune cell telomere length
C Beirne, L Waring, RA McDonald, R Delahay, A Young
Proceedings of the Royal Society B: Biological Sciences 2016
Heart aging measured with coronary artery calcium scoring and cardiovascular risk assessment algorithms in HIV infected patients
P Raggi, C Corwin
Virulence 2016
Telomere Length and Coronary Atherosclerosis in Rheumatoid Arthritis
MJ Ormseth, JF Solus, AM Oeser, A Bian, T Gebretsadik, A Shintani, P Raggi, CM Stein
The Journal of rheumatology 2016
Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study
CT Dow, C Harley
Clinical ophthalmology (Auckland, N.Z.) 2016
Robust DNA Damage Response and Elevated Reactive Oxygen Species in TINF2-Mutated Dyskeratosis Congenita Cells
L Pereboeva, M Hubbard, FD Goldman, ER Westin, AJ Lustig
PloS one 2016
Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer
W Kim, AT Ludlow, J Min, JD Robin, G Stadler, I Mender, TP Lai, N Zhang, WE Wright, JW Shay, D Durocher
PLoS Biology 2016
What the Genetics “ RTEL ”ing Us about Telomeres and Pulmonary Fibrosis
SE Stanley, I Noth, M Armanios
American journal of respiratory and critical care medicine 2015
Telomere dysfunction causes alveolar stem cell failure
JK Alder, CE Barkauskas, N Limjunyawong, SE Stanley, F Kembou, RM Tuder, BL Hogan, W Mitzner, M Armanios
Proceedings of the National Academy of Sciences 2015
The short and long telomere syndromes: paired paradigms for molecular medicine
SE Stanley, M Armanios
Current Opinion in Genetics & Development 2015
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs
R Chen, K Zhang, H Chen, X Zhao, J Wang, L Li, Y Cong, Z Ju, D Xu, BR Williams, J Jia, JP Liu
The Journal of biological chemistry 2015
Forging a signature of in vivo senescence
NE Sharpless, CJ Sherr
Nature Reviews Cancer 2015
PML is required for telomere stability in non-neoplastic human cells
M Marchesini, R Matocci, L Tasselli, V Cambiaghi, A OrlethOrleth, L Furia, C Marinelli, S Lombardi, G Sammarelli, F Aversa, S Minucci, M Faretta, PG Pelicci, F Grignani
Oncogene 2015
Understanding Idiopathic Interstitial Pneumonia: A Gene-Based Review of Stressed Lungs
CH van Moorsel, TW Hoffman, AA van Batenburg, D Klay, JJ van der Vis, JC Grutters
BioMed Research International 2015
Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis
M Barczyk, M Schmidt, S Mattoli
Stem Cell Reviews and Reports 2015
Telomeric aging: mitotic clock or stress indicator?
AK Koliada, DS Krasnenkov, AM Vaiserman
Frontiers in Genetics 2015
Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells
H Vallabhaneni, F Zhou, RW Maul, J Sarkar, J Yin, M Lei, L Harrington, PJ Gearhart, Y Liu
The Journal of biological chemistry 2015
TERT gene harbors multiple variants associated with pancreatic cancer susceptibility: Telomerase SNPs and pancreatic cancer risk
D Campa, C Rizzato, R Stolzenberg-Solomon, P Pacetti, P Vodicka, SP Cleary, G Capurso, HB Bueno-de-Mesquita, J Werner, M Gazouli, K Butterbach, A Ivanauskas, N Giese, GM Petersen, P Fogar, Z Wang, C Bassi, M Ryska, GE Theodoropoulos, C Kooperberg, D Li, W Greenhalf, C Pasquali, T Hackert, CS Fuchs, B Mohelnikova-Duchonova, C Sperti, N Funel, AK Dieffenbach, NJ Wareham, J Buring, I Holcátová, E Costello, CF Zambon, J Kupcinskas, HA Risch, P Kraft, PM Bracci, R Pezzilli, SH Olson, HD Sesso, P Hartge, O Strobel, E Małecka-Panas, K Visvanathan, AA Arslan, S Pedrazzoli, P Souček, D Gioffreda, TJ Key, R Talar-Wojnarowska, A Scarpa, A Mambrini, EJ Jacobs, K Jamroziak, A Klein, F Tavano, F Bambi, S Landi, MA Austin, L Vodickova, H Brenner, SJ Chanock, GD Fave, A Piepoli, M Cantore, W Zheng, BM Wolpin, LT Amundadottir, F Canzian
International Journal of Cancer 2015
Telomere Length in Peripheral Blood Leukocytes Is Associated with Severity of Biliary Atresia
W Udomsinprasert, Y Poovorawan, V Chongsrisawat, P Vejchapipat, D Zhan, S Honsawek, G Saretzki
PloS one 2015
PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases
S Xiong, N Patrushev, F Forouzandeh, L Hilenski, RW Alexander
Cell Reports 2015
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation
I Pusceddu, M Herrmann, SH Kirsch, C Werner, U Hübner, M Bodis, U Laufs, S Wagenpfeil, J Geisel, W Herrmann
European Journal of Nutrition 2015
Telomere homeostasis in mammalian germ cells: a review
R Reig-Viader, M Garcia-Caldés, A Ruiz-Herrera
Chromosoma 2015
Associations of TERC Single Nucleotide Polymorphisms with Human Leukocyte Telomere Length and the Risk of Type 2 Diabetes Mellitus
RA Khaldi, O Mojiminiyi, F AlMulla, N Abdella, G Saretzki
PloS one 2015
Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quantification in Whole Blood
A Tolios, D Teupser, LM Holdt, G Saretzki
PloS one 2015
Telomerase mutations in smokers with emphysema
Susan Stanley, Julian Chen, Joshua Podlevsky, Jonathan K. Alder, Nadia Hansel, RAsika Mathias, Xiaodong Qi, Nicholas Rafaels, Robert Wise, Edwin Silverman, Kathleen Barnes, Mary Armanios
Journal of Clinical Investigation 2014
Adult Stem Cells and Diseases of Aging
L Boyette, R Tuan
Journal of Clinical Medicine 2014
Functional Role of Calstabin2 in Age-related Cardiac Alterations
Q Yuan, Z Chen, G Santulli, L Gu, ZG Yang, ZQ Yuan, YT Zhao, HB Xin, KY Deng, SQ Wang, G Ji
2014
APE1 Incision Activity at Abasic Sites in Tandem Repeat Sequences
M Li, J Völker, KJ Breslauer, DM Wilson
Journal of Molecular Biology 2014
Telomere length, family history, and paternal age in schizophrenia
D Malaspina, R Dracxler, J Walsh-Messinger, S Harlap, RR Goetz, D Keefe, MC Perrin
Molecular Genetics & Genomic Medicine 2014
Cell biology of disease: Telomeropathies: An emerging spectrum disorder
B Holohan, WE Wright, JW Shay
The Journal of Cell Biology 2014
Telomere Length Reprogramming in Embryos and Stem Cells
K Kalmbach, LR Robinson, F Wang, L Liu, D Keefe
BioMed Research International 2014
Lung transplantation in telomerase mutation carriers with pulmonary fibrosis
LL Silhan, PD Shah, DC Chambers, LD Snyder, GC Riise, CL Wagner, E Hellström-Lindberg, JB Orens, JF Mewton, SK Danoff, MO Arcasoy, M Armanios
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2014
Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study
L González-Guardia, EM Yubero-Serrano, O Rangel-Zuñiga, C Marin, A Camargo, P Pérez-Martínez, J Delgado-Lista, F Gómez-Delgado, A Garcia-Rios, FJ Tinahones, HM Roche, F Pérez-Jiménez, J López-Miranda
AGE 2014
Age-Related Declines and Disease-Associated Variation in Immune Cell Telomere Length in a Wild Mammal
C Beirne, R Delahay, M Hares, A Young, RJ Wellinger
PloS one 2014
Short telomeres, telomeropathy and subclinical extra-pulmonary organ damage in patients with interstitial lung disease
G George, IO Rosas, Y Cui, C McKane, GM Hunninghake, PC Camp, BA Raby, HJ Goldberg, S El-Chemaly
Chest 2014
Antiproliferative Effect of the Isoquinoline Alkaloid Papaverine in Hepatocarcinoma HepG-2 Cells — Inhibition of Telomerase and Induction of Senescence
S Noureini, M Wink
Molecules (Basel, Switzerland) 2014
Coming of age: molecular drivers of aging and therapeutic opportunities
Christopher Newgard, Norman Sharpless
Journal of Clinical Investigation 2013
Mechanistic links between aging and lung fibrosis
VJ Thannickal
Biogerontology 2013
The janus head of T cell aging - autoimmunity and immunodeficiency
JJ Goronzy, G Li, Z Yang, CM Weyand
Frontiers in immunology 2013
Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins
AT Ludlow, LW Ludlow, SM Roth
BioMed Research International 2013
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function
NK Kim, Q Zhang, J Feigon
Nucleic Acids Research 2013
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence
JM Platt, P Ryvkin, JJ Wanat, G Donahue, MD Ricketts, SP Barrett, HJ Waters, S Song, A Chavez, KO Abdallah, SR Master, LS Wang, FB Johnson
Genes & development 2013
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

← Previous 1 2 3 4 5 6 7 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 1 news outlets
Referenced in 1 policy sources
Posted by 3 X users
Referenced in 1 patents
On 1 Facebook pages
323 readers on Mendeley
1 readers on CiteULike
See more details