Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies.
Mary Armanios
Title and authors | Publication | Year |
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Loss of Ten1 in mice induces telomere shortening and phenotypic changes resembling human dyskeratosis congenita
Adrián Sanz-Moreno, Lore Becker, Kan Xie, Patricia Silva-Buttkus, Nathalia Dragano, Antonio Aguilar-Pimentel, Oana Amarie, Julia Calzada-Wack, Markus Kraiger, Stefanie Leuchtenberger, Claudia Seisenberger, Susan Marschall, Birgit Rathkolb, Enzo Scifo, Ting Liu, Anoja Thanabalasingam, Sharon Savage, Helmut Fuchs, Dan Ehninger, Valérie Gailus-Durner, Martin Angelis |
Science advances | 2025 |
Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice.
Jiang H, Inoue S, Hatakeyama J, Liu P, Zhao T, Zhang Y, Liu B, He C, Moriyama H |
Biogerontology | 2025 |
Telomere attrition alters extracellular vesicles conferring adverse impacts on neuronal viability and inflammatory response
Gong Y, Wang Y, Delgado-Peraza F, Nogueras-Ortiz C, Noren Hooten N, Croteau DL, Temre M, Molnar AE, Bodogai M, Zou A, Abdelmohsen K, Zhu W, Zhang Y, Gorospe M, Weng NP, Evans MK, Kapogiannis D, Liu Y |
iScience | 2025 |
Association of life’s essential 8 with leukocyte telomere length and mitochondrial DNA copy number: Findings from the population-based UK Biobank study
Tian Y, Kong S, Mao L, Wang G, He J, Lei F, Lin L, Li J |
The Journal of Nutrition, Health & Aging | 2025 |
Human telomere length is chromosome specific and conserved across individuals
Karimian K, Groot A, Huso V, Kahidi R, Tan KT, Sholes S, Keener R, McDyer JF, Alder JK, Li H, Rechtsteiner A, Greider CW |
2024 | |
Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders.
Pennington KM, Simonetto D, Taner T, Mangaonkar AA |
Current Hematologic Malignancy Reports | 2024 |
Simultaneous Liver and Kidney Transplantation in a Patient With Telomere Biology Disorder: A Case Study.
Choudhary D, Lekshmon KS, Singh C, Subramani VN, Singh Y, Mitra S, Sekar A, Malik M, Bhagat N, Shiva Kumar SP, Taneja S, Gupta V, Ramachandran R, Singh S, Nada R, Kenwar D, Duseja AK, Yadav TD, Malhotra P, Sharma A |
Journal of Clinical and Experimental Hepatology | 2024 |
Telomere Biology Disorder: A Focus on Gastrointestinal and Hepatic Manifestations.
Warsame F, Simonetto DA |
Current Hematologic Malignancy Reports | 2024 |
A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells.
Li M, Liu JX, Ma B, Liu JY, Chen J, Jin F, Hu CH, Xu HK, Zheng CX, Hou R |
Stem Cell Reviews and Reports | 2024 |
Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications.
Liu WS, Wu BS, Yang L, Chen SD, Zhang YR, Deng YT, Wu XR, He XY, Yang J, Feng JF, Cheng W, Xu YM, Yu JT |
GeroScience | 2024 |
Telomere length exhibits inverse association with migraine among Americans aged 20–50 years, without implications beyond age 50: a cross-sectional study
Geng D, Liu H, Wang H, Wang H |
Scientific Reports | 2024 |
Effect of telomere shortening on disease progression in patients with inflammatory bowel disease: A systematic review and meta-analysis protocol.
Zhang Y, Ma Z, Kang L, Yang L |
PloS one | 2024 |
Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell
Dong Z, Wang X, Wang P, Bai M, Wang T, Chu Y, Qin Y |
Advanced Biology | 2024 |
Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
Amanda Stock, Saipriya Ayyar, Amogh Kashyap, Hagai Yanai, Mayuri Tanaka-Yano, Monica Bodogai, Matthew Starost, Chongkui Sun, Yajun Wang, Yunong Wang, Yi Gong, Chandrakala Puligilla, Evandro Fang, Vilhelm Bohr, Yie Liu, Isabel Beerman |
GeroScience | 2023 |
La sénescence cellulaire, nouvelle cible des infections virales respiratoires : du virus influenza au SARS-CoV-2
Adnot S, Bernard D, Lipskaia L, Trottein F |
2023 | |
The association between sleep quality and telomere length: A systematic literature review
Sabot D, Lovegrove R, Stapleton P |
2023 | |
Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian
Dhillon VS, Deo P, Thomas P, Fenech M |
International journal of molecular sciences | 2023 |
Genomic Fingerprint Associated with Familial Idiopathic Pulmonary Fibrosis: A Review
Ding D, Gao R, Xue Q, Luan R, Yang J |
International journal of medical sciences | 2023 |
Advances in cellular senescence in idiopathic pulmonary fibrosis (Review)
Han S, Lu Q, Liu X |
Experimental and therapeutic medicine | 2023 |
Telomere biology: from disorders to hematological diseases
Roka K, Solomou EE, Kattamis A |
Frontiers in Oncology | 2023 |
Dyskeratosis Congenita: A Case Report of a Patient With Coronary Artery Disease
Ghaly M, Ghaly M, Harris S |
Cureus | 2023 |
Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length.
Tichy ED, Lee JH, Li G, Estep KN, Brad Johnson F, Mourkioti F |
npj Microgravity | 2023 |
Protective Effects of Micronutrient Supplements, Phytochemicals and Phytochemical-Rich Beverages and Foods Against DNA Damage in Humans: A Systematic Review of Randomized Controlled Trials and Prospective Studies
Fenech MF, Bull CF, Van Klinken BJ |
Advances in Nutrition | 2023 |
Genetically determined telomere length and its association with chronic obstructive pulmonary disease and interstitial lung disease in biobank Japan: A Mendelian randomization study
Zhu Y, Meng Y, Zhang Y, Karlsson IK, Hägg S, Zhan Y |
Heliyon | 2023 |
Biological aging in multiple sclerosis
Zhang Y, Atkinson J, Burd CE, Graves J, Segal BM |
Multiple sclerosis (Houndmills, Basingstoke, England) | 2023 |
Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors
Gold NM, Okeke MN, He Y |
Aging and Disease | 2023 |
Leukocyte telomere length as a compensatory mechanism in vitamin D metabolism
D Agirbasli, M Kalyoncu, M Muftuoglu, F Aksungar, M Agirbasli, G Saretzki |
PloS one | 2022 |
Genetic and Epigenetic Inheritance at Telomeres
E Lister-Shimauchi, B McCarthy, M Lippincott, S Ahmed |
Epigenomes | 2022 |
The Role of Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases
J Jeong, Y Choi, H Lee |
Frontiers in pharmacology | 2022 |
The Controversial Role of HCY and Vitamin B Deficiency in Cardiovascular Diseases
W Herrmann, M Herrmann |
Nutrients | 2022 |
Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging
J Jung, D McCartney, J Wagner, D Rosoff, M Schwandt, H Sun, C Wiers, L de Carvalho, N Volkow, R Walker, A Campbell, D Porteous, A McIntosh, R Marioni, S Horvath, K Evans, F Lohoff |
Molecular Psychiatry | 2022 |
Nutrition Interventions of Herbal Compounds on Cellular Senescence
Chen Z, Wu Y, Lin Q, Cai J, Liu X, Liang Y |
Oxidative medicine and cellular longevity | 2022 |
Leukocyte Telomere Length as a Molecular Biomarker of Coronary Heart Disease
Zimnitskaya OV, Petrova MM, Lareva NV, Cherniaeva MS, Al-Zamil M, Ivanova AE, Shnayder NA |
Genes & development | 2022 |
BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact.
De Sadeleer LJ, Verleden SE, Schupp JC, McDonough JE, Goos T, Yserbyt J, Bargagli E, Rottoli P, Kaminski N, Prasse A, Wuyts WA |
Chest | 2022 |
Alveolar Epithelial Type 2 Cell Dysfunction in Idiopathic Pulmonary Fibrosis.
Zhu W, Tan C, Zhang J |
Lung | 2022 |
Tieing together loose ends: telomere instability in cancer and aging
Borges G, Criqui M, Harrington L |
Molecular Oncology | 2022 |
Functional interaction between compound heterozygous TERT mutations causes severe telomere biology disorder.
Niaz A, Truong J, Manoleras A, Fox LC, Blombery P, Vasireddy RS, Pickett HA, Curtin JA, Barbaro PM, Rodgers J, Roy J, Riley LG, Holien JK, Cohen SB, Bryan TM |
Blood Advances | 2022 |
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes
Stock AJ, McDevitt RA, Puligilla C, Wang Y, Zhang Y, Wang K, Sun C, Becker KG, Lehrmann E, Wood WH 3rd, Gong Y, Aqdas M, Sung MH, Hoffmann V, Liu C, Gorospe M, Harrington L, Ferrucci L, Liu Y |
PLoS genetics | 2022 |
Telomeres and Psychological Stress: Perspective on Psychopathologies
Akay GG |
2022 | |
Association between Rheumatic Disease Comorbidity Index and factors of poor prognosis in a cohort of 280 patients with rheumatoid arthritis.
Ben Tekaya A, Hannech E, Saidane O, Rouached L, Bouden S, Tekaya R, Mahmoud I, Abdelmoula L |
BMC Rheumatology | 2022 |
Interstitial lung abnormalities are associated with decreased mean telomere length
Putman RK, Axelsson GT, Ash SY, Sanders JL, Menon AA, Araki T, Nishino M, Yanagawa M, Gudmundsson EF, Qiao D, Estépar RS, Dupuis J, O\u2019Connor GT, Rosas IO, Washko GR, El-Chemaly S, Raby BA, Gudnason V, DeMeo DL, Silverman EK, Hatabu H, DeVivo I, Cho MH, Gudmundsson G, Hunninghake GM |
European Respiratory Journal | 2022 |
The Role of Telomeres in Human Disease.
Armanios M |
Annual Review of Genomics and Human Genetics | 2022 |
TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis
Sherilyn Grill, Shilpa Padmanaban, Ann Friedman, Eric Perkey, Frederick Allen, Valerie Tesmer, Jennifer Chase, Rami Khoriaty, Catherine E. Keegan, Ivan Maillard, Jayakrishnan Nandakumar |
JCI Insight | 2021 |
Telomeres in Interstitial Lung Disease
CJ Stock, EA Renzoni |
Journal of Clinical Medicine | 2021 |
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining
S Abbasi, G Parmar, RD Kelly, N Balasuriya, C Schild-Poulter |
Cellular and Molecular Life Sciences | 2021 |
Liver transplant recipient with respiratory failure due to pulmonary fibrosis related to telomere disease requiring lung transplantation
M Singh, SK Merwat, JH Fair, AG Duarte |
Respiratory Medicine Case Reports | 2021 |
Correlation between Telomere Length and Chronic Obstructive Pulmonary Disease–Related Phenotypes: Results from the Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) Cohort
DH Moon, J Kim, MN Lim, SH Bak, WJ Kim |
Tuberculosis and Respiratory Diseases | 2021 |
Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers
LW Diebel, K Rockwood |
Current Oncology Reports | 2021 |
Lung Transplant Improves Survival and Quality of Life Regardless of Telomere Dysfunction
L Planas-Cerezales, EG Arias-Salgado, C Berastegui, A Montes-Worboys, R González-Montelongo, JM Lorenzo-Salazar, V Vicens-Zygmunt, M Garcia-Moyano, J Dorca, C Flores, R Perona, A Román, M Molina-Molina |
Frontiers in Medicine | 2021 |
Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort
R Guillén, F Otero, A Mosquera, M Vázquez-Mosquera, I Rego-Pérez, FJ Blanco, JL Fernández |
Scientific Reports | 2021 |
TAZ maintains telomere length in TNBC cells by mediating Rad51C expression
L Yang, B Wang, X Jiao, C Zhou, S Chen, X Gao, W Sun, S Song, J Li, J Liu, Y Wang, P Liu |
Breast Cancer Research | 2021 |
Telomere Length and Regulatory Genes as Novel Stress Biomarkers and Their Diversities in Broiler Chickens (Gallus gallus domesticus) Subjected to Corticosterone Feeding
KA Badmus, Z Idrus, GY Meng, AQ Sazili, K Mamat-Hamidi |
Animals | 2021 |
Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study
VB Ribeiro, DC Pedroso, GS Kogure, IP Lopes, BA Santana, HC de Souza, RA Ferriani, RT Calado, CL Furtado, RM dos Reis |
International journal of environmental research and public health | 2021 |
Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (Gallus gallus domesticus)
KA Badmus, Z Idrus, GY Meng, K Mamat-Hamidi |
Animals | 2021 |
Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing
S Sholes, K Karimian, A Gershman, T Kelly, W Timp, C Greider |
Genome research | 2021 |
NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction
Stock AJ, Liu Y |
2021 | |
Lung transplantation for interstitial lung disease.
Kapnadak SG, Raghu G |
2021 | |
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis
Jeremy Katzen, Michael F. Beers |
Journal of Clinical Investigation | 2020 |
Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging
S Piñeiro-Hermida, C Autilio, P Martínez, F Bosch, J Pérez-Gil, MA Blasco |
The Journal of Cell Biology | 2020 |
Leukocyte telomere length as a diagnostic biomarker for anti-tuberculosis drug-induced liver injury
W Udomsinprasert, N Chanhom, S Suvichapanich, S Wattanapokayakit, S Mahasirimongkol, W Chantratita, J Jittikoon |
Scientific Reports | 2020 |
Cancer and myeloid clonal evolution in the short telomere syndromes
KE Schratz, M Armanios |
Current Opinion in Genetics & Development | 2020 |
Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling
DE Ebeid, FG Khalafalla, KM Broughton, MM Monsanto, CY Esquer, V Sacchi, N Hariharan, KI Korski, M Moshref, J Emathinger, CT Cottage, PJ Quijada, JH Nguyen, R Alvarez, M Völkers, MH Konstandin, BJ Wang, F Firouzi, JM Navarrete, NA Gude, MJ Goumans, MA Sussman |
Cardiovascular Research | 2020 |
Role of telomere shortening in anticipation of inflammatory bowel disease
B Truta, E Wohler, N Sobreira, LW Datta, SR Brant |
World journal of gastrointestinal pharmacology and therapeutics | 2020 |
Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction
C Sun, K Wang, AJ Stock, Y Gong, TG Demarest, B Yang, N Giri, L Harrington, BP Alter, SA Savage, VA Bohr, Y Liu |
The EMBO Journal | 2020 |
Alterations in telomere length and mitochondrial DNA copy number in human lymphocytes on short-term exposure to moderate hypoxia
MR Alam, DK Kim |
Toxicology Reports | 2020 |
The role of extracellular DNA in COVID-19: clues from inflamm-aging
G Storci, F Bonifazi, P Garagnani, F Olivieri, M Bonafè |
Ageing Research Reviews | 2020 |
From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
AA van Batenburg, KM Kazemier, MF van Oosterhout, JJ van der Vis, HW van Es, JC Grutters, R Goldschmeding, CH van Moorsel, G Saretzki |
PloS one | 2020 |
Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial
Y Hachmo, A Hadanny, RA Hamed, M Daniel-Kotovsky, M Catalogna, G Fishlev, E Lang, N Polak, K Doenyas, M Friedman, Y Zemel, Y Bechor, S Efrati |
Aging | 2020 |
A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis
A Takezaki, S Tsukumo, Y Setoguchi, JG Ledford, H Goto, K Hosomichi, H Uehara, Y Nishioka, K Yasutomo |
Journal of Experimental Medicine | 2019 |
The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications
N Arish, D Petukhov, SB Wallach-Dayan |
International journal of molecular sciences | 2019 |
TERT gene polymorphisms are associated with chronic obstructive pulmonary disease risk in the Chinese Li population
Y Ding, Q Li, C Wu, W Wang, J Zhao, Q Feng, X Zhou, Y Xie, M Lin, P He, P Xie |
Molecular Genetics & Genomic Medicine | 2019 |
Telomere Biology and Human Phenotype
K Turner, V Vasu, D Griffin |
Cells | 2019 |
LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung
A Mammoto, M Muyleart, T Mammoto |
Aging | 2019 |
Heterozygous TERT gene mutation associated with familial idiopathic pulmonary fibrosis
SR Sousa, PC Mota, N Melo, HN Bastos, E Padrão, JM Pereira, R Cunha, CS Moura, S Guimarães, A Morais |
Respiratory Medicine Case Reports | 2019 |
Initiation of Pulmonary Fibrosis after Silica Inhalation in Rats is linked with Dysfunctional Shelterin Complex and DNA Damage Response
M Shoeb, GM Mustafa, P Joseph, C Umbright, V Kodali, KA Roach, T Meighan, JR Roberts, A Erdely, JM Antonini |
Scientific Reports | 2019 |
Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis
Y Yan, D Qin, B Hu, C Zhang, S Liu, D Wu, W Huang, X Huang, L Wang, X Chen, L Zhang |
Molecular Therapy — Nucleic Acids | 2019 |
Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study
I Pusceddu, W Herrmann, ME Kleber, H Scharnagl, MM Hoffmann, BM Winklhofer-Roob, W März, M Herrmann |
European Journal of Nutrition | 2019 |
The Spectrum of Hepatic Involvement in Patients With Telomere Disease
D Kapuria, G BenYakov, R Ortolano, MH Cho, O KalchiemDekel, V Takyar, S Lingala, N Gara, M Tana, YJ Kim, DE Kleiner, NS Young, DM Townsley, C Koh, T Heller |
Hepatology | 2019 |
Association of nutraceutical supplements with longer telomere length
D Tsoukalas, P Fragkiadaki, A Docea, A Alegakis, E Sarandi, E Vakonaki, E Salataj, E Kouvidi, D Nikitovic, L Kovatsi, D Spandidos, A Tsatsakis, D Calina |
International journal of molecular medicine | 2019 |
Telomere Abnormalities in the Pathobiology of Idiopathic Pulmonary Fibrosis
H Bilgili, AJ Białas, P Górski, WJ Piotrowski |
Journal of Clinical Medicine | 2019 |
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives
D Tsoukalas, P Fragkiadaki, A Docea, A Alegakis, E Sarandi, M Thanasoula, D Spandidos, A Tsatsakis, M Razgonova, D Calina |
Molecular medicine reports | 2019 |
Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice
K Whittemore, A Derevyanko, P Martinez, R Serrano, M Pumarola, F Bosch, MA Blasco |
Aging | 2019 |
Prognostic significance of pulmonary function tests in dyskeratosis congenita, a telomere biology disorder
N Giri, S Ravichandran, Y Wang, SM Gadalla, BP Alter, J Fontana, SA Savage |
ERJ Open Research | 2019 |
Heritability of telomere length across three generations of Korean families
JH Kim, CM Nam, D Lee, H Bang, JH Ko, I Lim, GJ Kim, BW Koes, DC Lee |
Pediatric Research | 2019 |
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis
DH Kim, JD Beckett, V Nagpal, MA Seman-Senderos, RA Gould, TJ Creamer, EG MacFarlane, Y Chen, D Bedja, JT Butcher, W Mitzner, R Rouf, S Hata, DS Warren, HC Dietz |
Science Translational Medicine | 2019 |
Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings
JR PetersHall, J Min, E Tedone, S Sho, S Siteni, I Mender, JW Shay |
The FASEB Journal | 2019 |
Genetically Increased Telomere Length and Aging-Related Traits in the U.K. Biobank
K Demanelis, L Tong, BL Pierce, DL Couteur |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2019 |
Telomeres and telomerase: three decades of progress
J Shay, W Wright |
Nature Reviews Genetics | 2019 |
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-López, M Bobadilla, JM Flores, F Bosch, MA Blasco |
eLife | 2018 |
Trade-offs in aging lung diseases: a review on shared but opposite genetic risk variants in idiopathic pulmonary fibrosis, lung cancer and chronic obstructive pulmonary disease
CH van Moorsel |
Current Opinion in Pulmonary Medicine | 2018 |
The aging lung: tissue telomere shortening in health and disease
S Everaerts, EJ Lammertyn, DS Martens, LJ Sadeleer, K Maes, AA van Batenburg, R Goldschmeding, CH van Moorsel, LJ Dupont, WA Wuyts, R Vos, G Gayan-Ramirez, N Kaminski, JC Hogg, W Janssens, GM Verleden, TS Nawrot, SE Verleden, JE McDonough, BM Vanaudenaerde |
Respiratory Research | 2018 |
Idiopathic Pulmonary Fibrosis (IPF): An Overview
S Barratt, A Creamer, C Hayton, N Chaudhuri |
Journal of Clinical Medicine | 2018 |
Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis
R Snetselaar, MF van Oosterhout, JC Grutters, CH van Moorsel |
Frontiers in Medicine | 2018 |
Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study
A Dressen, AR Abbas, C Cabanski, J Reeder, TR Ramalingam, M Neighbors, TR Bhangale, MJ Brauer, J Hunkapiller, J Reeder, K Mukhyala, K Cuenco, J Tom, A Cowgill, J Vogel, WF Forrest, HR Collard, PJ Wolters, JA Kropski, LH Lancaster, TS Blackwell, JR Arron, BL Yaspan |
The lancet. Respiratory medicine | 2018 |
Genetic Determinants of Telomere Length in African American Youth
AM Zeiger, MJ White, C Eng, SS Oh, J Witonsky, PC Goddard, MG Contreras, JR Elhawary, D Hu, AC Mak, EY Lee, KL Keys, LA Samedy, O Risse-Adams, J Magaña, S Huntsman, S Salazar, A Davis, K Meade, E Brigino-Buenaventura, MA LeNoir, HJ Farber, K Bibbins-Domingo, LN Borrell, EG Burchard |
Scientific Reports | 2018 |
TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast
JJ Wanat, GA Logsdon, JH Driskill, Z Deng, PM Lieberman, FB Johnson, S Ahmed |
PloS one | 2018 |
Dysfunctional telomeres and hematological disorders
E Fiorini, A Santoni, S Colla |
Differentiation; research in biological diversity | 2018 |
Risk factors for primary Sjögren syndrome-associated interstitial lung disease
Y Wang, Z Hou, M Qiu, Q Ye |
Journal of Thoracic Disease | 2018 |
Significance of TERT and ATRX mutations in glioma
J Liu, X Zhang, X Yan, M Sun, Y Fan, Y Huang |
Oncology Letters | 2018 |
Telomere length and early trauma in schizophrenia
Riley G, Perrin M, Vaez-Azizi LM, Ruby E, Goetz RR, Dracxler R, Walsh-Messinger J, Keefe DL, Buckley PF, Szeszko PR, Malaspina D |
Schizophrenia Research | 2018 |
SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34 + Progenitor CellsClinical Perspective
L Zhang, A Jambusaria, Z Hong, G Marsboom, PT Toth, BS Herbert, AB Malik, J Rehman |
Circulation | 2017 |
Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
TL Yang, Q Chen, JT Deng, G Jagannathan, JW Tobias, DC Schultz, S Wang, CJ Lengner, AK Rustgi, JP Lynch, FB Johnson |
Nature Communications | 2017 |
IPF lung fibroblasts have a senescent phenotype
D Álvarez, N Cárdenes, J Sellarés, M Bueno, C Corey, VS Hanumanthu, Y Peng, H DCunha, J Sembrat, M Nouraie, S Shanker, C Caufield, S Shiva, M Armanios, AL Mora, M Rojas |
American journal of physiology. Lung cellular and molecular physiology | 2017 |
Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy
Y Cai, V Kandula, R Kosuru, X Ye, MG Irwin, Z Xia |
Cell cycle (Georgetown, Tex.) | 2017 |
The FTO rs9939609 polymorphism is associated with short leukocyte telomere length in nonobese individuals:
JH Yu, I Baik, HJ Cho, JA Seo, SG Kim, KM Choi, SH Baik, DS Choi, C Shin, NH Kim |
Medicine | 2017 |
Telomere Length and CCL11 Levels are Associated With Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging
LS Czepielewski, R Massuda, B Panizzutti, LK Grun, FM Barbé-Tuana, AL Teixeira, DM Barch, CS Gama |
Schizophrenia Bulletin | 2017 |
Leukocyte telomere length is linked to vascular risk factors not to Alzheimer’s disease in the VITA study
M Hinterberger, P Fischer, K Huber, W Krugluger, S Zehetmayer |
Journal of Neural Transmission | 2017 |
Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
CL Elizabeth, CR Sara, EJ Adriana, JP de-Torres, P María-José, AJ Armando, C Bartolomé, C Ciro |
Respiratory Research | 2017 |
Telomere Biology—Insights into an Intriguing Phenomenon
S Venkatesan, A Khaw, M Hande |
Cells | 2017 |
BRD4 inhibitors block telomere elongation
S Wang, AM Pike, SS Lee, MA Strong, CJ Connelly, CW Greider |
Nucleic Acids Research | 2017 |
Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles
ED Tichy, DK Sidibe, MT Tierney, MJ Stec, M Sharifi-Sanjani, H Hosalkar, S Mubarak, FB Johnson, A Sacco, F Mourkioti |
Stem Cell Reports | 2017 |
Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion
JM Leung, N Fishbane, M Jones, A Morin, S Xu, JC Liu, J MacIsaac, MJ Milloy, K Hayashi, J Montaner, S Horvath, M Kobor, DD Sin, PR Harrigan, SF Man |
Aging | 2017 |
Long Telomeres Do Not Affect Cellular Fitness in Yeast
Y Harari, S Zadok-Laviel, M Kupiec, FM Winston |
mBio | 2017 |
Telomeres in health and disease
S Chatterjee |
Journal of Oral and Maxillofacial Pathology : JOMFP | 2017 |
37 kDa LRP::FLAG enhances telomerase activity and reduces senescent markers in vitro
TC Otgaar, E Ferreira, S Malindisa, M Bernert, BT Letsolo, SF Weiss |
Oncotarget | 2017 |
Telomere Dysfunction In Alveolar Epithelial Cells Causes Lung Remodeling and Fibrosis
Ram Naikawadi, Supparerk Disayabutr, Benat Mallavia, Matthew Donne, Gary Green, Janet La, Jason Rock, Mark Looney, Paul Wolters |
JCI Insight | 2016 |
Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD
CA Lerner, IK Sundar, I Rahman |
The International Journal of Biochemistry & Cell Biology | 2016 |
Candidate genes of idiopathic pulmonary fibrosis: current evidence and research
Y Wang, W Zhou |
The Application of Clinical Genetics | 2016 |
The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?
V Kordinas, A Ioannidis, S Chatzipanagiotou |
Genes & development | 2016 |
Telomerase and the Genetics of Emphysema Susceptibility. Implications for Pathogenesis Paradigms and Patient Care
SE Stanley, SJ Merck, M Armanios |
Annals of the American Thoracic Society | 2016 |
Role of lncRNAs in Cellular Aging
U Degirmenci, S Lei |
Frontiers in Endocrinology | 2016 |
Role of PGC-1α in Vascular RegulationHighlights: Implications for Atherosclerosis
AO Kadlec, DS Chabowski, K Ait-Aissa, DD Gutterman |
Arteriosclerosis, thrombosis, and vascular biology | 2016 |
Telomere-associated aging disorders
PL Opresko, JW Shay |
Ageing Research Reviews | 2016 |
Age-related declines in immune response in a wild mammal are unrelated to immune cell telomere length
C Beirne, L Waring, RA McDonald, R Delahay, A Young |
Proceedings of the Royal Society B: Biological Sciences | 2016 |
Heart aging measured with coronary artery calcium scoring and cardiovascular risk assessment algorithms in HIV infected patients
P Raggi, C Corwin |
Virulence | 2016 |
Telomere Length and Coronary Atherosclerosis in Rheumatoid Arthritis
MJ Ormseth, JF Solus, AM Oeser, A Bian, T Gebretsadik, A Shintani, P Raggi, CM Stein |
The Journal of rheumatology | 2016 |
Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study
CT Dow, C Harley |
Clinical ophthalmology (Auckland, N.Z.) | 2016 |
Robust DNA Damage Response and Elevated Reactive Oxygen Species in TINF2-Mutated Dyskeratosis Congenita Cells
L Pereboeva, M Hubbard, FD Goldman, ER Westin, AJ Lustig |
PloS one | 2016 |
Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer
W Kim, AT Ludlow, J Min, JD Robin, G Stadler, I Mender, TP Lai, N Zhang, WE Wright, JW Shay, D Durocher |
PLoS Biology | 2016 |
What the Genetics “ RTEL ”ing Us about Telomeres and Pulmonary Fibrosis
SE Stanley, I Noth, M Armanios |
American journal of respiratory and critical care medicine | 2015 |
Telomere dysfunction causes alveolar stem cell failure
JK Alder, CE Barkauskas, N Limjunyawong, SE Stanley, F Kembou, RM Tuder, BL Hogan, W Mitzner, M Armanios |
Proceedings of the National Academy of Sciences | 2015 |
The short and long telomere syndromes: paired paradigms for molecular medicine
SE Stanley, M Armanios |
Current Opinion in Genetics & Development | 2015 |
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs
R Chen, K Zhang, H Chen, X Zhao, J Wang, L Li, Y Cong, Z Ju, D Xu, BR Williams, J Jia, JP Liu |
The Journal of biological chemistry | 2015 |
Forging a signature of in vivo senescence
NE Sharpless, CJ Sherr |
Nature Reviews Cancer | 2015 |
PML is required for telomere stability in non-neoplastic human cells
M Marchesini, R Matocci, L Tasselli, V Cambiaghi, A OrlethOrleth, L Furia, C Marinelli, S Lombardi, G Sammarelli, F Aversa, S Minucci, M Faretta, PG Pelicci, F Grignani |
Oncogene | 2015 |
Understanding Idiopathic Interstitial Pneumonia: A Gene-Based Review of Stressed Lungs
CH van Moorsel, TW Hoffman, AA van Batenburg, D Klay, JJ van der Vis, JC Grutters |
BioMed Research International | 2015 |
Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis
M Barczyk, M Schmidt, S Mattoli |
Stem Cell Reviews and Reports | 2015 |
Telomeric aging: mitotic clock or stress indicator?
AK Koliada, DS Krasnenkov, AM Vaiserman |
Frontiers in Genetics | 2015 |
Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells
H Vallabhaneni, F Zhou, RW Maul, J Sarkar, J Yin, M Lei, L Harrington, PJ Gearhart, Y Liu |
The Journal of biological chemistry | 2015 |
TERT gene harbors multiple variants associated with pancreatic cancer susceptibility: Telomerase SNPs and pancreatic cancer risk
D Campa, C Rizzato, R Stolzenberg-Solomon, P Pacetti, P Vodicka, SP Cleary, G Capurso, HB Bueno-de-Mesquita, J Werner, M Gazouli, K Butterbach, A Ivanauskas, N Giese, GM Petersen, P Fogar, Z Wang, C Bassi, M Ryska, GE Theodoropoulos, C Kooperberg, D Li, W Greenhalf, C Pasquali, T Hackert, CS Fuchs, B Mohelnikova-Duchonova, C Sperti, N Funel, AK Dieffenbach, NJ Wareham, J Buring, I Holcátová, E Costello, CF Zambon, J Kupcinskas, HA Risch, P Kraft, PM Bracci, R Pezzilli, SH Olson, HD Sesso, P Hartge, O Strobel, E Małecka-Panas, K Visvanathan, AA Arslan, S Pedrazzoli, P Souček, D Gioffreda, TJ Key, R Talar-Wojnarowska, A Scarpa, A Mambrini, EJ Jacobs, K Jamroziak, A Klein, F Tavano, F Bambi, S Landi, MA Austin, L Vodickova, H Brenner, SJ Chanock, GD Fave, A Piepoli, M Cantore, W Zheng, BM Wolpin, LT Amundadottir, F Canzian |
International Journal of Cancer | 2015 |
Telomere Length in Peripheral Blood Leukocytes Is Associated with Severity of Biliary Atresia
W Udomsinprasert, Y Poovorawan, V Chongsrisawat, P Vejchapipat, D Zhan, S Honsawek, G Saretzki |
PloS one | 2015 |
PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases
S Xiong, N Patrushev, F Forouzandeh, L Hilenski, RW Alexander |
Cell Reports | 2015 |
Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation
I Pusceddu, M Herrmann, SH Kirsch, C Werner, U Hübner, M Bodis, U Laufs, S Wagenpfeil, J Geisel, W Herrmann |
European Journal of Nutrition | 2015 |
Telomere homeostasis in mammalian germ cells: a review
R Reig-Viader, M Garcia-Caldés, A Ruiz-Herrera |
Chromosoma | 2015 |
Associations of TERC Single Nucleotide Polymorphisms with Human Leukocyte Telomere Length and the Risk of Type 2 Diabetes Mellitus
RA Khaldi, O Mojiminiyi, F AlMulla, N Abdella, G Saretzki |
PloS one | 2015 |
Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quantification in Whole Blood
A Tolios, D Teupser, LM Holdt, G Saretzki |
PloS one | 2015 |
Telomerase mutations in smokers with emphysema
Susan Stanley, Julian Chen, Joshua Podlevsky, Jonathan K. Alder, Nadia Hansel, RAsika Mathias, Xiaodong Qi, Nicholas Rafaels, Robert Wise, Edwin Silverman, Kathleen Barnes, Mary Armanios |
Journal of Clinical Investigation | 2014 |
Adult Stem Cells and Diseases of Aging
L Boyette, R Tuan |
Journal of Clinical Medicine | 2014 |
Functional Role of Calstabin2 in Age-related Cardiac Alterations
Q Yuan, Z Chen, G Santulli, L Gu, ZG Yang, ZQ Yuan, YT Zhao, HB Xin, KY Deng, SQ Wang, G Ji |
2014 | |
APE1 Incision Activity at Abasic Sites in Tandem Repeat Sequences
M Li, J Völker, KJ Breslauer, DM Wilson |
Journal of Molecular Biology | 2014 |
Telomere length, family history, and paternal age in schizophrenia
D Malaspina, R Dracxler, J Walsh-Messinger, S Harlap, RR Goetz, D Keefe, MC Perrin |
Molecular Genetics & Genomic Medicine | 2014 |
Cell biology of disease: Telomeropathies: An emerging spectrum disorder
B Holohan, WE Wright, JW Shay |
The Journal of Cell Biology | 2014 |
Telomere Length Reprogramming in Embryos and Stem Cells
K Kalmbach, LR Robinson, F Wang, L Liu, D Keefe |
BioMed Research International | 2014 |
Lung transplantation in telomerase mutation carriers with pulmonary fibrosis
LL Silhan, PD Shah, DC Chambers, LD Snyder, GC Riise, CL Wagner, E Hellström-Lindberg, JB Orens, JF Mewton, SK Danoff, MO Arcasoy, M Armanios |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2014 |
Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study
L González-Guardia, EM Yubero-Serrano, O Rangel-Zuñiga, C Marin, A Camargo, P Pérez-Martínez, J Delgado-Lista, F Gómez-Delgado, A Garcia-Rios, FJ Tinahones, HM Roche, F Pérez-Jiménez, J López-Miranda |
AGE | 2014 |
Age-Related Declines and Disease-Associated Variation in Immune Cell Telomere Length in a Wild Mammal
C Beirne, R Delahay, M Hares, A Young, RJ Wellinger |
PloS one | 2014 |
Short telomeres, telomeropathy and subclinical extra-pulmonary organ damage in patients with interstitial lung disease
G George, IO Rosas, Y Cui, C McKane, GM Hunninghake, PC Camp, BA Raby, HJ Goldberg, S El-Chemaly |
Chest | 2014 |
Antiproliferative Effect of the Isoquinoline Alkaloid Papaverine in Hepatocarcinoma HepG-2 Cells — Inhibition of Telomerase and Induction of Senescence
S Noureini, M Wink |
Molecules (Basel, Switzerland) | 2014 |
Coming of age: molecular drivers of aging and therapeutic opportunities
Christopher Newgard, Norman Sharpless |
Journal of Clinical Investigation | 2013 |
Mechanistic links between aging and lung fibrosis
VJ Thannickal |
Biogerontology | 2013 |
The janus head of T cell aging - autoimmunity and immunodeficiency
JJ Goronzy, G Li, Z Yang, CM Weyand |
Frontiers in immunology | 2013 |
Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins
AT Ludlow, LW Ludlow, SM Roth |
BioMed Research International | 2013 |
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function
NK Kim, Q Zhang, J Feigon |
Nucleic Acids Research | 2013 |
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence
JM Platt, P Ryvkin, JJ Wanat, G Donahue, MD Ricketts, SP Barrett, HJ Waters, S Song, A Chavez, KO Abdallah, SR Master, LS Wang, FB Johnson |
Genes & development | 2013 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |