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Nancy Klauber-DeMore
Published November 26, 2012
Citation Information: J Clin Invest. 2012;122(12):4341-4343. https://doi.org/10.1172/JCI66171.
Citation Information: J Clin Invest. 2012;122(12):4341-4343. https://doi.org/10.1172/JCI66171.
Abstract
Solid tumor growth requires the formation of new blood vessels to supply nutrients and oxygen to the malignant cells; one approach to cancer therapy is to block this process by inhibiting VEGF signaling. In this issue of the JCI, Pasula et al. demonstrate a surprising role of epsins — proteins involved in endocytosis — in tumor angiogenesis via their modulation of VEGF signaling. Their findings suggest that these proteins might represent a new target for the development of cancer therapeutics.
Authors
Nancy Klauber-DeMore
Citation information
Citations to this article (5)
| Title and authors | Publication | Year |
|---|---|---|
|
Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-β Signaling Constrains Endothelial-to-Mesenchymal-Transition in Atherosclerosis
Dong Y, Wang B, Du M, Zhu B, Cui K, Li K, Yuan K, Cowan DB, Bhattacharjee S, Wong S, Shi J, Wang DZ, Chen K, Bischoff J, Linton MF, Chen H |
Circulation | 2023 |
|
Epsins in vascular development, function and disease
S Bhattacharjee, Y Lee, B Zhu, H Wu, Y Chen, H Chen |
Cellular and Molecular Life Sciences | 2020 |
|
Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis
K Song, H Wu, HN Rahman, Y Dong, A Wen, ML Brophy, S Wong, S Kwak, DR Bielenberg, H Chen |
Cellular and Molecular Life Sciences | 2016 |
|
Motif mimetic of epsin perturbs tumor growth and metastasis
Yunzhou Dong, Hao Wu, H.N. Ashiqur Rahman, YANJUN LIU, Satish Pasula, Kandice Tessneer, Xiaofeng Cai, Xiaolei Liu, Baojun Chang, John McManus, Scott Hahn, Jiali Dong, Megan Brophy, Lili Yu, Kai Song, Robert Silasi-Mansat, Debra Saunders, Charity Njoku, Hoogeun Song, Padmaja Mehta-D'souza, Rheal Towner, Florea Lupu, Rodger P. McEver, Lijun Xia, Derek Boerboom, Sathish Srinivasan, Hong Chen |
Journal of Clinical Investigation | 2015 |
|
Tpl2 Inhibitors Thwart Endothelial Cell Function in Angiogenesis and Peritoneal Dissemination
Lee WJ, Lan KH, Chou CT, Yi YC, Chen WC, Pan HC, Peng YC, Wang KB, Chen YC, Chao TH, Tien HR, Sheu WH, Sheu ML |
Neoplasia (New York, N.Y.) | 2013 |
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