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Antti Virkamäki, … , Kohjiro Ueki, C. Ronald Kahn
Published April 1, 1999
Citation Information: J Clin Invest. 1999;103(7):931-943. https://doi.org/10.1172/JCI6609.
Citation Information: J Clin Invest. 1999;103(7):931-943. https://doi.org/10.1172/JCI6609.
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Antti Virkamäki, Kohjiro Ueki, C. Ronald Kahn
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Citations to this article (616)
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Medical Hypotheses | 2014 |
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Eccentric Exercise Leads to Performance Decrease and Insulin Signaling Impairment:
BC Pereira, JR Pauli, CT de Souza, ER Ropelle, DE Cintra, EC Freitas, AS da Silva |
Medicine and Science in Sports and Exercise | 2014 |
|
Contrôle de la signalisation et de l’action de l’insuline par la protéine Grb14
A Gondoin, L Morzyglod, B Desbuquois, AF Burnol |
Biologie Aujourd hui | 2014 |
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Synthesis and characterization of biocompatible gymnemic acid–gold nanoparticles: a study on glucose uptake stimulatory effect in 3T3-L1 adipocytes
T Rajarajeshwari, C Shivashri, P Rajasekar |
RSC Advances | 2014 |
|
Adipokines and dementia
H Wehr, M Bednarska-Makaruk |
Postępy Psychiatrii i Neurologii | 2014 |
|
Association of the ADIPOQ T45G polymorphism with insulin resistance and blood glucose: A meta-analysis
D Cao, S Ouyang, Z Liu, F Ma, J Wu |
Endocrine Journal | 2014 |
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Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic β-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation
K Orime, J Shirakawa, Y Togashi, K Tajima, H Inoue, Y Ito, K Sato, A Nakamura, K Aoki, Y Goshima, Y Terauchi |
Endocrinology | 2013 |
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Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction
W Pang, Y Wang, N Wei, R Xu, Y Xiong, P Wang, Q Shen, G Yang, J Li |
PloS one | 2013 |
|
Microbiota and nonalcoholic steatohepatitis
K Imajo, M Yoneda, Y Ogawa, K Wada, A Nakajima |
Seminars in Immunopathology | 2013 |
|
Lipid-mediated Protein Signaling
DG Capelluto |
Lipid-mediated Protein Signaling | 2013 |
|
Lipid-mediated Protein Signaling
DG Capelluto |
Lipid-mediated Protein Signaling | 2013 |
|
Translational Endocrinology of Bone
S Bhatt, RN Kulkarni |
Translational Endocrinology of Bone | 2013 |
|
Skeletal muscle-derived cell cultures as potent models in regenerative medicine research: Skeletal Muscle-Derived Cell Cultures
R Kelc, M Trapecar, M Vogrin, A Cencic |
Muscle & Nerve | 2013 |
|
Inhibition of 72 kDa inositol polyphosphate 5-phosphatase E improves insulin signal transduction in diet-induced obesity
DF Bertelli, A Coope, AM Caricilli, PO Prada, MJ Saad, LA Velloso, EP Araujo |
Journal of Endocrinology | 2013 |
|
Electrochemical Characterization of Dehaloperoxidase Adsorbates on COOH/OH Mixed Self-Assembled Monolayers
TK Chen, EF Bowden |
Journal of Electroanalytical Chemistry | 2013 |
|
Phytochemicals targeting genes relevant for type 2 diabetes 1
CV Anuradha |
Canadian Journal of Physiology and Pharmacology | 2013 |
|
Topology Mapping of Insulin-Regulated Glucose Transporter GLUT4 Using Computational Biology
C Chakraborty, S Bandyopadhyay, U Maulik, G Agoramoorthy |
Cell Biochemistry and Biophysics | 2013 |
|
Metabolic Syndrome and Neurological Disorders: Farooqui/Metabolic
AA Farooqui, T Farooqui |
Metabolic Syndrome and Neurological Disorders: Farooqui/Metabolic | 2013 |
|
Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells
T Geetha, SD Rege, SE Mathews, SO Meakin, MF White, JR Babu |
The Journal of biological chemistry | 2013 |
|
Cyclooxygenase-2 over-expression inhibits liver apoptosis induced by hyperglycemia
DE Francés, PI Ingaramo, R Mayoral, P Través, M Casado, ÁM Valverde, P Martín-Sanz, CE Carnovale |
Journal of Cellular Biochemistry | 2013 |
|
The interrelationship between insulin resistane and Alzheimer development
DA Ghareeb, S Mohamed, M El-Sayed |
Journal of Biomedical Science and Engineering | 2013 |
|
Insulin receptor expression in subcellular fractions of muscular and adipose tissue as the factor of the tissue insulin resistance development in rats under conditions of the high-energy diet
MM Kondro, TI Halenova, MI Kuznietsova, OM Savchuk |
Fiziolohichnyĭ zhurnal | 2013 |
|
Insulin-like effect of the phosphodiesterase type 5 inhibitor tadalafil onto male human skeletal muscle cells
C Crescioli, N Sturli, M Sottili, P Bonini, A Lenzi, L Di Luigi |
Journal of Endocrinological Investigation | 2013 |
|
Fanconi anemia links reactive oxygen species to insulin resistance and obesity
J Li, J Sipple, S Maynard, PA Mehta, SR Rose, SM Davies, Q Pang |
Antioxidants & Redox Signaling | 2012 |
|
Sex-dependent differences in rat brown adipose tissue mitochondrial biogenesis and insulin signaling parameters in response to an obesogenic diet
A Nadal-Casellas, M Bauzá-Thorbrügge, AM Proenza, M Gianotti, I Lladó |
Molecular and Cellular Biochemistry | 2012 |
|
Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates
L Ramalingam, E Oh, DC Thurmond |
Cellular and Molecular Life Sciences | 2012 |
|
Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo
KH Williams, NA Shackel, MD Gorrell, SV McLennan, SM Twigg |
Endocrine reviews | 2012 |
|
Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance
SK Bose, S Shrivastava, K Meyer, RB Ray, R Ray |
Journal of virology | 2012 |
|
Overlapped Metabolic and Therapeutic Links between Alzheimer and Diabetes
W Ahmad |
Molecular Neurobiology | 2012 |
|
Maternal immunization affects in utero programming of insulin resistance and type 2 diabetes
C Eberle, E Merki, T Yamashita, S Johnson, AM Armando, O Quehenberger, C Napoli, W Palinski |
PloS one | 2012 |
|
The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term
C Sun, L Sun, H Ma, J Peng, Y Zhen, K Duan, G Liu, W Ding, Y Zhao |
Journal of Cellular Physiology | 2012 |
|
The effect of α- or β-casein addition to waxy maize starch on postprandial levels of glucose, insulin, and incretin hormones in pigs as a model for humans
AP Kett, CM Bruen, F O'Halloran, V Chaurin, PG Lawlor, JA O'Mahony, L Giblin, MA Fenelon |
Food & Nutrition Research | 2012 |
|
Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus
J Ganugapati, A Baldwa, S Lalani |
Bioinformation | 2012 |
|
<i>Cynanchum wilfordii</i> ameliorates hypertension and endothelial dysfunction in rats fed with high fat/cholesterol diets
DH Choi, YJ Lee, JS Kim, DG Kang, HS Lee |
Immunopharmacology and Immunotoxicology | 2012 |
|
The interaction of metabolic factors with HCV infection: Does it matter?
E Bugianesi, F Salamone, F Negro |
Journal of Hepatology | 2012 |
|
Sex-dependent differences in rat hepatic lipid accumulation and insulin sensitivity in response to diet-induced obesity
A Nadal-Casellas, AM Proenza, I Lladó, M Gianotti |
Biochemistry and Cell Biology | 2012 |
|
Glucose uptake stimulatory effect of 4-hydroxypipecolic acid by increased GLUT 4 translocation in skeletal muscle cells
G Naresh, N Jaiswal, P Sukanya, AK Srivastava, AK Tamrakar, T Narender |
Bioorganic & Medicinal Chemistry Letters | 2012 |
|
Octaphlorethol A, a novel phenolic compound isolated from a brown alga, Ishige foliacea, increases glucose transporter 4-mediated glucose uptake in skeletal muscle cells
SH Lee, SM Kang, SC Ko, DH Lee, YJ Jeon |
Biochemical and Biophysical Research Communications | 2012 |
|
Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling
J Mathew, A Loranger, S Gilbert, R Faure, N Marceau |
Experimental Cell Research | 2012 |
|
Role for membrane remodeling in cell death: Implication for health and disease
X Tekpli, JA Holme, O Sergent, D Lagadic-Gossmann |
Toxicology | 2012 |
|
The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling
F Thameem, S Puppala, J Schneider, B Bhandari, R Arya, NH Arar, TL Vasylyeva, VS Farook, S Fowler, L Almasy, J Blangero, R Duggirala, HE Abboud |
Diabetes | 2012 |
|
Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein
T Geetha, C Zheng, N Vishwaprakash, TL Broderick, JR Babu |
The Journal of biological chemistry | 2012 |
|
Sequestosome 1/p62, a Scaffolding Protein, Is a Newly Identified Partner of IRS-1 Protein*
T Geetha, C Zheng, N Vishwaprakash, TL Broderick, JR Babu |
The Journal of biological chemistry | 2012 |
|
Plasma membrane sphingomyelin modulates insulin sensitivity
Zhiqiang Li, Hongqi Zhang, Jing Liu, Chien-Ping Liang, Yan Li, Gladys Teitelman, Thomas Beyer, Hai Bui, David Peake, Youyan Zhang, Phillip Sanders, Ming-Shang Kuo, Tae-Sik Park, Guoqing Cao, Xian-Cheng Jiang |
Molecular and cellular biology | 2011 |
|
Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways*
S Kang, ER Chemaly, RJ Hajjar, D Lebeche |
The Journal of biological chemistry | 2011 |
|
Implication of Low Level Inflammation in the Insulin Resistance of Adipose Tissue at Late Pregnancy
J de Castro, J Sevillano, J Marciniak, R Rodriguez, C González-Martín, M Viana, OH Eun-suk, SH de Mouzon, E Herrera, MP Ramos |
Endocrinology | 2011 |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
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Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
Diabetes - Perspectives in Drug Therapy
M Schwanstecher |
2011 | |
|
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
B Vandanmagsar, YH Youm, A Ravussin, JE Galgani, K Stadler, RL Mynatt, E Ravussin, JM Stephens, VD Dixit |
Nature Medicine | 2011 |
|
ENPP1 affects insulin action and secretion: evidences from in vitro studies
RD Paola, N Caporarello, A Marucci, C Dimatteo, C Iadicicco, SD Guerra, S Prudente, D Sudano, C Miele, C Parrino, S Piro, F Beguinot, P Marchetti, V Trischitta, L Frittitta |
PloS one | 2011 |
|
Akt2: A Critical Regulator of Cardiomyocyte Survival and Metabolism
AJ Muslin |
Pediatric Cardiology | 2011 |
|
The study of aqueous extract of Ficus religiosa Linn. on cytokine TNF-α in type 2 diabetic rats
H Kirana, MV Jali, BP Srinivasan |
Pharmacognosy research | 2011 |
|
PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism
SD Narasimhan, K Yen, A Bansal, ES Kwon, S Padmanabhan, HA Tissenbaum |
PLoS genetics | 2011 |
|
The Influence of Down-Regulation of Suppressor of Cellular Signaling Proteins by RNAi on Glucose Transport of Intrauterine Growth Retardation Rats
L Liao, R Zheng, C Wang, J Gao, Y Ying, Q Ning, X Luo |
Pediatric Research | 2011 |
|
Insights into structure and function of SHIP2-SH2: homology modeling, docking, and molecular dynamics study
U Saqib, MI Siddiqi |
Journal of Chemical Biology | 2011 |
|
Anti-inflammatory effects of yerba maté extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity
DP Arçari, W Bartchewsky, TW Santos, KA Oliveira, CC DeOliveira, ÉM Gotardo, J Pedrazzoli, A Gambero, LF Ferraz, PO Carvalho, ML Ribeiro |
Molecular and Cellular Endocrinology | 2011 |
|
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
T Glatter, RB Schittenhelm, O Rinner, K Roguska, A Wepf, MA Jünger, K Köhler, I Jevtov, H Choi, A Schmidt, AI Nesvizhskii, H Stocker, E Hafen, R Aebersold, M Gstaiger |
Molecular Systems Biology | 2011 |
|
Current understanding of insulin resistance in hepatitis C
V Kaddai, F Negro |
Expert Review of Gastroenterology and Hepatology | 2011 |
|
Serum amyloid A is a growth factor for 3T3-L1 adipocytes, inhibits differentiation and promotes insulin resistance
FB Filippin-Monteiro, EM de Oliveira, S Sandri, FH Knebel, RC Albuquerque, A Campa |
International Journal of Obesity | 2011 |
|
Physiopathological function of hematoside (GM3 ganglioside)
J Inokuchi |
Proceedings of the Japan Academy. Series B, Physical and biological sciences | 2011 |
|
A New Highly Efficient Substrate-trapping Mutant of Protein Tyrosine Phosphatase 1B (PTP1B) Reveals Full Autoactivation of the Insulin Receptor Precursor*
S Boubekeur, N Boute, P Pagesy, V Zilberfarb, N Christeff, T Issad |
The Journal of biological chemistry | 2011 |
|
Current perspectives of insulin resistance and polycystic ovary syndrome : Insulin resistance and polycystic ovary syndrome
JM Pauli, N Raja-Khan, X Wu, RS Legro |
Diabetic Medicine | 2011 |
|
Accuracy of functional surfaces on comparatively modeled protein structures
J Zhao, J Dundas, S Kachalo, Z Ouyang, J Liang |
Journal of Structural and Functional Genomics | 2011 |
|
mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine307 residues after burn
C Xin-Long, X Zhao-Fan, B Dao-Feng, D Wei |
Burns | 2011 |
|
Osmotic Regulation of Bile Acid Transport, Apoptosis and Proliferation in Rat Liver
D Häussinger, R Reinehr |
Cellular Physiology and Biochemistry | 2011 |
|
Escharectomy and Allografting During Shock Stage Reduces Insulin Resistance Induced by Major Burn:
XL Chen, ZF Xia, HF Wei |
Journal of Burn Care & Research | 2011 |
|
Thyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes
Y Lin, Z Sun |
Journal of Cellular Physiology | 2011 |
|
Molecular mechanisms of development of cellular insulin resistance
NG Raksha, OM Savchuk, LI Ostapchenko |
Biopolymers and Cell | 2011 |
|
Electrochemically monitoring the binding of concanavalin A and ovalbumin
K Sugawara, A Yugami, T Kadoya, K Hosaka |
Talanta | 2011 |
|
ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies
RD Paola, N Caporarello, A Marucci, C Dimatteo, C Iadicicco, SD Guerra, S Prudente, D Sudano, C Miele, C Parrino, S Piro, F Beguinot, P Marchetti, V Trischitta, L Frittitta, K Maedler |
PloS one | 2011 |
|
PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism
SD Narasimhan, K Yen, A Bansal, ES Kwon, S Padmanabhan, HA Tissenbaum, SK Kim |
PLoS genetics | 2011 |
|
Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways
S Kang, ER Chemaly, RJ Hajjar, D Lebeche |
The Journal of biological chemistry | 2011 |
|
A New Highly Efficient Substrate-trapping Mutant of Protein Tyrosine Phosphatase 1B (PTP1B) Reveals Full Autoactivation of the Insulin Receptor Precursor
S Boubekeur, N Boute, P Pagesy, V Zilberfarb, N Christeff, T Issad |
The Journal of biological chemistry | 2011 |
|
Cryptotanshinone reverses reproductive and metabolic disturbances in prenatally androgenized rats via regulation of ovarian signaling mechanisms and androgen synthesis
X Yang, Y Zhang, X Wu, CS Bae, L Hou, H Kuang, Y Wang, E Stener-Victorin |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2011 |
|
Insulin Resistance and Cancer
IG Fantus |
2011 | |
|
Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice
X Xu, CX Zhao, L Wang, L Tu, X Fang, C Zheng, ML Edin, DC Zeldin, DW Wang |
Diabetes | 2010 |
|
Maternal overweight programs insulin and adiponectin signaling in the offspring
K Shankar, P Kang, A Harrell, Y Zhong, JC Marecki, MJ Ronis, TM Badger |
Endocrinology | 2010 |
|
Hepatitis C Virus Differentially Modulates Activation of Forkhead Transcription Factors and Insulin-Induced Metabolic Gene Expression
A Banerjee, K Meyer, B Mazumdar, RB Ray, R Ray |
Journal of virology | 2010 |
|
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance
H Yang, YH Youm, B Vandanmagsar, A Ravussin, JM Gimble, F Greenway, JM Stephens, RL Mynatt, VD Dixit |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
|
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart
J Wang, H Ma, C Tong, H Zhang, GB Lawlis, Y Li, M Zang, J Ren, MJ Nijland, SP Ford, PW Nathanielsz, J Li |
The FASEB Journal | 2010 |
|
Pathogenesis of insulin resistance in skeletal muscle
MA Abdul-Ghani, RA DeFronzo |
Journal of biomedicine & biotechnology | 2010 |
|
A novel non-alcoholic steatohepatitis animal model featured with insulin resistance, hepatic inflammation and fibrosis
J Zhao, G Zhou, M Li, W Li, J Lü, L Xiong, L Liang, Y Zhao, D Xu, J Yu |
Scandinavian Journal of Gastroenterology | 2010 |
|
Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1
S Leng, W Zhang, Y Zheng, Z Liberman, CJ Rhodes, H Eldar-Finkelman, XJ Sun |
The Journal of endocrinology | 2010 |
|
Textbook of Diabetes
PM Jones, SJ Persaud |
Textbook of Diabetes | 2010 |
|
The glucose-induced synthesis of insulin in liver
R Ghosh, SK Karmohapatra, G Bhattacharya, AK Sinha |
Endocrine | 2010 |
|
The metabolic syndrome in overweight epileptic patients treated with valproic acid
A Verrotti, R Manco, S Agostinelli, G Coppola, F Chiarelli |
Epilepsia | 2010 |
|
The study of aqueous extract of Pterocarpus marsupium Roxb. on cytokine TNF-α in type 2 diabetic rats
K Halagappa, HN Girish, BP Srinivasan |
Indian journal of pharmacology | 2010 |
|
Anti-Inflammatory Action of Insulin via Induction of Gadd45-β Transcription by the mTOR Signaling Pathway
KD Bortoff, AB Keeton, JL Franklin, JL Messina |
Hepatic medicine : evidence and research | 2010 |
|
Insulin induces swelling-dependent activation of the epidermal growth factor receptor in rat liver
R Reinehr, A Sommerfeld, D Häussinger |
The Journal of biological chemistry | 2010 |
|
SOCS3 inhibits insulin signaling in porcine primary adipocytes
SJ Yang, CQ Xu, JW Wu, GS Yang |
Molecular and Cellular Biochemistry | 2010 |
|
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
|
Membrane microdomains and insulin resistance
J Inokuchi |
FEBS Letters | 2010 |
|
Interventions for improving metabolic risk in overweight Latino youth
JN Davis, EE Ventura, GQ Shaibi, CE Byrd-Williams, KE Alexander, AK Vanni, MR Meija, MJ Weigensberg, D Spruijt-Metz, MI Goran |
International Journal of Pediatric Obesity | 2010 |
|
Effects of Teucrium polium on Insulin Resistance in Nonalcoholic Steatohepatitis
N Nosrati, S Aghazadeh, R Yazdanparast |
Journal of Acupuncture and Meridian Studies | 2010 |
|
Plasma membrane microdomains in aging and disease: Lipid rafts in aging and disease
Y Ohno-Iwashita, Y Shimada, M Hayashi, M Inomata |
Geriatrics & Gerontology International | 2010 |
|
xPharm: The Comprehensive Pharmacology Reference
A Vinh |
xPharm: The Comprehensive Pharmacology Reference | 2010 |
|
Diabetes, Insulin and Alzheimer's Disease
S Craft, Y Christen |
2010 | |
|
Impact of Differential P450c17 Phosphorylation by cAMP Stimulation and by Starvation Conditions on Enzyme Activities and Androgen Production in NCI-H295R Cells
P Kempná, A Hirsch, G Hofer, PE Mullis, CE Flück |
Endocrinology | 2010 |
|
Molecular mechanisms involved in NAFLD progression
M Malaguarnera, MD Rosa, F Nicoletti, L Malaguarnera |
Journal of Molecular Medicine | 2009 |
|
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin
QL Ma, F Yang, ER Rosario, OJ Ubeda, W Beech, DJ Gant, PP Chen, B Hudspeth, C Chen, Y Zhao, HV Vinters, SA Frautschy, GM Cole |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2009 |
|
Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice
J Yang, Y Park, H Zhang, X Xu, GA Laine, KC Dellsperger, C Zhang |
American journal of physiology. Heart and circulatory physiology | 2009 |
|
Oleic acid inhibits hepatic insulin signaling through deregulation of STAT3 activation and C/EBPα expression
KJ Kim, HY Kim, EJ Son, J Heo, JH Cheong |
Cellular Signalling | 2009 |
|
Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM)
HY Liu, SY Cao, T Hong, J Han, Z Liu, W Cao |
The Journal of biological chemistry | 2009 |
|
Sensing the insulin signaling pathway with an antibody array
HJ He, Y Zong, M Bernier, L Wang |
Proteomics. Clinical applications | 2009 |
|
The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2
S Hanke, M Mann |
Molecular & cellular proteomics : MCP | 2009 |
|
Visfatin Is a Positive Regulator of MCP-1 in Human Adipocytes In Vitro and in Mice In Vivo
G Sommer, S Kralisch, N Kloting, M Kamprad, K Schrock, J Kratzsch, A Tonjes, U Lossner, M Bluher, M Stumvoll, M Fasshauer |
Obesity | 2009 |
|
Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2)
S Rome, E Meugnier, V Lecomte, V Berbe, J Besson, C Cerutti, S Pesenti, A Granjon, E Disse, K Clement, E Lefai, M Laville, H Vidal |
Diabetologia | 2009 |
|
Phosphatidylinositol 3-kinase p85 regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome
JJ Kim, YM Choi, MA Hong, SS Hwang, SH Yoon, SJ Chae, BC Jee, SY Ku, JG Kim, SY Moon |
Human Reproduction | 2009 |
|
The link between insulin resistance and preeclampsia: new perspectives
M Scioscia, K Gumaa, TW Rademacher |
Journal of Reproductive Immunology | 2009 |
|
Non-alcoholic fatty liver disease pathogenesis: The present and the future
S Petta, C Muratore, A Craxì |
Digestive and Liver Disease | 2009 |
|
Sex steroids deficiency impairs glucose transporter 4 expression and its translocation through defective Akt phosphorylation in target tissues of adult male rat
T Muthusamy, P Murugesan, K Balasubramanian |
Metabolism | 2009 |
|
The ginsenoside Rg3 has a stimulatory effect on insulin signaling in L6 myotubes
M Kim, BY Ahn, JS Lee, SS Chung, S Lim, SG Park, HS Jung, HK Lee, KS Park |
Biochemical and Biophysical Research Communications | 2009 |
|
Molecular mechanisms behind clinical benefits of intensive insulin therapy during critical illness: Glucose versus insulin
I Vanhorebeek, L Langouche |
Best Practice & Research Clinical Anaesthesiology | 2009 |
|
RAPGEF1 gene variants associated with type 2 diabetes in the Korean population
KW Hong, HS Jin, JE Lim, HJ Ryu, MJ Go, JY Lee, JT Woo, HK Park, B Oh |
Diabetes Research and Clinical Practice | 2009 |
|
Is there a link between insulin resistance and inflammatory activation in preeclampsia?
M Scioscia, P Greco, LE Selvaggi, TW Rademacher |
Medical Hypotheses | 2009 |
|
Comparison of the interactomic networks of different species in terms of accessibility
FA Rodrigues, LF Costa |
Molecular BioSystems | 2009 |
|
Conservation of key members in the course of the evolution of the insulin signaling pathway
JP González, OC Farnés, AT Vasconcelos, AG Pérez |
Biosystems | 2009 |
|
Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells
M Yan, J Wang, X Wu, L Hou, H Kuang, Y Wang |
Fertility and Sterility | 2009 |
|
Insulin resistance and neurodegeneration: Roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis
Suzanne M de la Monte, Lisa Longato, Ming Tong, Jack R Wands |
Current opinion in investigational drugs (London, England : 2000) | 2009 |
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Molecular Determinants of Grb14-Mediated Inhibition of Insulin Signaling
D Goenaga, C Hampe, N Carré, K Cailliau, E Browaeys-Poly, D Perdereau, LJ Holt, RJ Daly, J Girard, I Broutin, T Issad, AF Burnol |
Molecular Endocrinology | 2009 |
|
BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca 2+ , and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner
F Zhang, D Dey, R Bränström, L Forsberg, M Lu, Q Zhang, Å Sjöholm |
American journal of physiology. Cell physiology | 2009 |
|
Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal
JD Chiu, JM Richey, LN Harrison, E Zuniga, CM Kolka, E Kirkman, M Ellmerer, RN Bergman |
Diabetes | 2008 |
|
Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis
MK Tee, Q Dong, WL Miller |
Endocrinology | 2008 |
|
Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12
M Lorenzo, S Fernández-Veledo, R Vila-Bedmar, L Garcia-Guerra, CD Alvaro, I Nieto-Vazquez |
Journal of animal science | 2008 |
|
Crucial role of insulin receptor substrate-2 in compensatory β-cell hyperplasia in response to high fat diet-induced insulin resistance
I Takamoto, Y Terauchi, N Kubota, M Ohsugi, K Ueki, T Kadowaki |
Diabetes, Obesity and Metabolism | 2008 |
|
Increased Insulin Action in SKIP Heterozygous Knockout Mice
T Ijuin, YE Yu, K Mizutani, A Pao, S Tateya, Y Tamori, A Bradley, T Takenawa |
Molecular and cellular biology | 2008 |
|
Fundamental and Clinical Cardiology Series
PD Stein |
Cardiovascular Disease in the Elderly | 2008 |
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Insulin Signaling in the Pancreatic β-Cell
IB Leibiger, B Leibiger, PO Berggren |
Annual Review of Nutrition | 2008 |
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Dietary Fiber in the Prevention and Treatment of Metabolic Syndrome: A Review
A Aleixandre, M Miguel |
Critical Reviews in Food Science and Nutrition | 2008 |
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The Correlation of Insulin Resistance With Serum Tumor Necrosis Factor-Alpha Levels in Patients With Rheumatoid Arthritis
ME Önde, C Top, O Öncül |
The Endocrinologist | 2008 |
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Impact of body weight, diet and lifestyle on nonalcoholic fatty liver disease
H Cortez-Pinto, M Machado |
Expert Review of Gastroenterology & Hepatology | 2008 |
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Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats
CX Zhao, X Xu, Y Cui, P Wang, X Wei, S Yang, ML Edin, DC Zeldin, DW Wang |
The Journal of pharmacology and experimental therapeutics | 2008 |
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Alzheimer's disease is type 3 diabetes-evidence reviewed
SM de la Monte, JR Wands |
Journal of diabetes science and technology | 2008 |
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Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells
JL Franklin, AB Keeton, KD Bortoff, JL Messina |
International journal of clinical and experimental medicine | 2008 |
|
Evaluation of the Pituitary Function with Insulin Tolerance (Hypoglycaemia) Testing: Are There Any Differences Using Insulin Lispro Compared to Regular Insulin?
KC Yuen, R Amin, MB Cook, SA Rhoads, DM Cook |
Hormone Research | 2008 |
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Secretion of atherogenic risk factor apolipoprotein B-100 is increased by a potential mechanism of JNK/PKC-mediated insulin resistance in liver cells
UH Jin, YJ Kang, YC Chang, CH Kim |
Journal of Cellular Biochemistry | 2008 |
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Insulin effect on serum potassium and auto-inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment of substrates metabolism
L Luzi, G Zoppini, G Targher, A Battezzati, M Muggeo, E Bonora |
Diabetes/Metabolism Research and Reviews | 2008 |
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Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis
S Piro, L Spadaro, M Russello, D Spampinato, CE Oliveri, E Vasquez, R Benigno, F Brancato, F Purrello, AM Rabuazzo |
Nutrition, Metabolism and Cardiovascular Diseases | 2008 |
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Role of Sp1 and SREBP-1a in the insulin-mediated regulation of glucokinase transcription in the liver of gilthead sea bream (Sparus aurata)
M Egea, I Metón, M Córdoba, F Fernández, IV Baanante |
General and Comparative Endocrinology | 2008 |
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Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome?
A Corbould |
Diabetes/Metabolism Research and Reviews | 2008 |
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A novel single nucleotide polymorphism of INSR gene for polycystic ovary syndrome
EJ Lee, B Oh, JY Lee, K Kimm, SH Lee, KH Baek |
Fertility and Sterility | 2008 |
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Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease
L Spadaro, O Magliocco, D Spampinato, S Piro, C Oliveri, C Alagona, G Papa, AM Rabuazzo, F Purrello |
Digestive and Liver Disease | 2008 |
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Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulin
T Wada, M Azegami, M Sugiyama, H Tsuneki, T Sasaoka |
Diabetes Research and Clinical Practice | 2008 |
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Meta-analysis of the Effects of Paclitaxel-Eluting Stents Versus Bare Metal Stents on Volumetric Intravascular Ultrasound in Patients With Versus Without Diabetes Mellitus
M Kimura, GS Mintz, NJ Weissman, KD Dawkins, E Grube, SG Ellis, LA Cannon, Z Masud, L Mandinov, D Baim, GW Stone |
The American Journal of Cardiology | 2008 |
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Modulation of Growth Factor Receptors in Membrane Microdomains
J Inokuchi, K Kabayama |
Trends in Glycoscience and Glycotechnology | 2008 |
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5-Substituted isophthalamides as insulin receptor sensitizers
L Robinson, S Bajjalieh, N Cairns, RT Lum, RW Macsata, VP Manchem, SJ Park, S Rao, SR Schow, S Shi, WR Spevak |
Bioorganic & Medicinal Chemistry Letters | 2008 |
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Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway
NJ Shimwell, A Martin, RK Bruton, AN Blackford, GG Sedgwick, PH Gallimore, AS Turnell, RJ Grand |
Oncogene | 2008 |
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Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed
SM de la Monte, JR Wands |
Journal of diabetes science and technology | 2008 |
|
The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2
S Hanke, M Mann |
Molecular & cellular proteomics : MCP | 2008 |
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Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase CβII in the diabetic fat tissue
Z Liberman, B Plotkin, T Tennenbaum, H Eldar-Finkelman |
American journal of physiology. Endocrinology and metabolism | 2008 |
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The Development of Insulin Resistance in Type 2 Diabetes: Insights from Knockout Studies
R Pattaranit, HA Berg, D Spanswick |
Science Progress | 2008 |
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Oxidative Stress in Aging
S Miwa, KB Beckman, FL Muller |
2008 | |
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Hepatitis C Virus Core Protein Upregulates Serine Phosphorylation of Insulin Receptor Substrate-1 and Impairs the Downstream Akt/Protein Kinase B Signaling Pathway for Insulin Resistance
S Banerjee, K Saito, M Ait-Goughoulte, K Meyer, RB Ray, R Ray |
Journal of virology | 2008 |
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The development of insulin resistance in Type 2 diabetes: insights from knockout studies.
Pattaranit R, van den Berg HA, Spanswick D |
Science Progress | 2008 |
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Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
F Tremblay, S Brûlé, SH Um, Y Li, K Masuda, M Roden, XJ Sun, M Krebs, RD Polakiewicz, G Thomas, A Marette |
Proceedings of the National Academy of Sciences | 2007 |
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The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance
CM Taniguchi, JO Aleman, K Ueki, J Luo, T Asano, H Kaneto, G Stephanopoulos, LC Cantley, CR Kahn |
Molecular and cellular biology | 2007 |
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Role of Insulin Receptor Substrate-1 Serine 307 Phosphorylation and Adiponectin in Adipose Tissue Insulin Resistance in Late Pregnancy
J Sevillano, J de Castro, C Bocos, E Herrera, MP Ramos |
Endocrinology | 2007 |
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Aldose Reductase-Regulated Tumor Necrosis Factor-α Production Is Essential for High Glucose-Induced Vascular Smooth Muscle Cell Growth
KV Ramana, R Tammali, AB Reddy, A Bhatnagar, SK Srivastava |
Endocrinology | 2007 |
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Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways
G Yuan, J Deng, T Wang, C Zhao, X Xu, P Wang, JW Voltz, ML Edin, X Xiao, L Chao, J Chao, XA Zhang, DC Zeldin, DW Wang |
Endocrinology | 2007 |
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Defective Insulin and Acetylcholine Induction of Endothelial Cell-Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats
HG Zecchin, FB Priviero, CT Souza, KG Zecchin, PO Prada, JB Carvalheira, LA Velloso, E Antunes, MJ Saad |
Diabetes | 2007 |
|
Novel food ingredients for weight control
G Gerstner, M Vrese |
Novel food ingredients for weight control | 2007 |
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Fructose and the Metabolic Syndrome: Pathophysiology and Molecular Mechanisms
AC Rutledge, K Adeli |
Nutrition Reviews | 2007 |
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Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator
SH Jung, YJ Ha, EK Shim, SY Choi, JL Jin, HS Yun-Choi, JR Lee |
Biochemical Journal | 2007 |
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Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance
S Banerjee, K Saito, M Ait-Goughoulte, K Meyer, RB Ray, R Ray |
Journal of virology | 2007 |
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Testosterone deficiency impairs glucose oxidation through defective insulin and its receptor gene expression in target tissues of adult male rats
T Muthusamy, S Dhevika, P Murugesan, K Balasubramanian |
Life Sciences | 2007 |
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The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle
X Wu, J Wang, X Cui, L Maianu, B Rhees, J Rosinski, WV So, SM Willi, MV Osier, HS Hill, GP Page, DB Allison, M Martin, WT Garvey |
Endocrine | 2007 |
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Peptide rescues GLUT4 recruitment, but not GLUT4 activation, in insulin resistance
M Funaki, K Benincasa, PK Randhawa |
Biochemical and Biophysical Research Communications | 2007 |
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Molecular mechanism of insulin resistance
S Bhattacharya, D Dey, SS Roy |
Journal of Biosciences | 2007 |
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Insulin Resistance as a Membrane Microdomain Disorder
J INOKUCHI |
YAKUGAKU ZASSHI | 2007 |
|
The use of bioluminescence resonance energy transfer for the study of therapeutic targets: application to tyrosine kinase receptors
T Issad, C Blanquart, C Gonzalez-Yanes |
Expert Opinion on Therapeutic Targets | 2007 |
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CAN NITRIC OXIDE-GENERATING COMPOUNDS IMPROVE THE OXIDATIVE STRESS RESPONSE IN EXPERIMENTALLY DIABETIC RATS?
AM Mohamadin, LN Hammad, MF El-Bab, HS Gawad |
Clinical and Experimental Pharmacology and Physiology | 2007 |
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Physical activity: An effective way to control weight in children?
C Maffeis, M Castellani |
Nutrition Metabolism and Cardiovascular Diseases | 2007 |
|
Pathogenesis of Non-alcoholic Steatohepatitis: Human Data
J Edmison, AJ McCullough |
Clinics in Liver Disease | 2007 |
|
Inositol phosphoglycan P-type in healthy and preeclamptic pregnancies
M Scioscia, K Gumaa, M Whitten, LE Selvaggi, CH Rodeck, TW Rademacher |
Journal of Reproductive Immunology | 2007 |
|
Comprehensive Management of High Risk Cardiovascular Patients: Identification and Management of the Patient at High Risk for Cardiovascular Disease
C Reasner |
Comprehensive Management of High Risk Cardiovascular Patients | 2007 |
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Ketosis-Prone Type 2 Diabetes: Effect of Hyperglycemia on β-Cell Function and Skeletal Muscle Insulin Signaling
GE Umpierrez, D Smiley, A Gosmanov, D Thomason |
Endocrine Practice | 2007 |
|
Les stéatopathies métaboliques : conséquences hépatiques du syndrome métabolique
R Anty, P Gual, PM Huet, YL Marchand-Brustel, A Tran |
Gastroentérologie Clinique et Biologique | 2007 |
|
Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways
WL Bennett, AB Keeton, S Ji, J Xu, JL Messina |
Endocrine | 2007 |
|
Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway
E Vairaktaris, L Goutzanis, G Kalokerinos, S Vassiliou, S Spyridonidou, D Avgoustidis, P Strantzias, A Lazaris, G Papageorgiou, V Ragos, C Yapijakis, E Patsouris |
Journal of Cranio-Maxillofacial Surgery | 2007 |
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Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins
CJ Hupfeld, JM Olefsky |
Annual Review of Physiology | 2007 |
|
NF-kappaB-Dependent Apoptotic Hair Cell Death in the Auditory System
I Nagy, A Caelers, A Monge, S Bonabi, AM Huber, D Bodmer |
Audiology and Neurotology | 2007 |
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Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease
K Qureshi, GA Abrams |
World journal of gastroenterology : WJG | 2007 |
|
Comprehensive Glycoscience
S Kelm, R Ravindran |
Comprehensive Glycoscience | 2007 |
|
Handbook of Neurochemistry and Molecular Neurobiology
VH Routh, JJ McArdle, NM Sanders, Z Song, R Wang |
Handbook of Neurochemistry and Molecular Neurobiology | 2007 |
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The Relationship between Left Ventricular Mass Index and Insulin Sensitivity, Postprandial Glycaemia, and Fasting Serum Triglyceride and Adiponectin Levels in Patients with Type 2 Diabetes
C Top, B Şahan, ME Önde |
J INT MED RES | 2007 |
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GRK2 Negatively Regulates Glycogen Synthesis in Mouse Liver FL83B Cells
G Shahid, T Hussain |
The Journal of biological chemistry | 2007 |
|
Amelioration of insulin resistance in women with PCOS via reduced insulin receptor substrate-1 Ser312 phosphorylation following laparoscopic ovarian electrocautery
KM Seow, CC Juan, YP Hsu, JL Hwang, LW Huang, LT Ho |
Human Reproduction | 2007 |
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Selective gene activation by spatial segregation of insulin receptor B signaling
S Uhles, T Moede, B Leibiger, PO Berggren, IB Leibiger |
The FASEB Journal | 2007 |
|
Androgen Excess Disorders in Women
R Azziz, JE Nestler, D Dewailly |
2007 | |
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Mechanisms of Insulin Action
AR Saltiel, JE Pessin |
2007 | |
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Insulin Resistance and Polycystic Ovarian Syndrome
E Diamanti-Kandarakis, JE Nestler, D Panidis, R Pasquali |
2007 | |
|
Chronic Nicotine Exposure Enhances Insulin-Induced Mitogenic Signaling via Up-Regulation of α7 Nicotinic Receptors in Isolated Rat Aortic Smooth Muscle Cells
T Wada, M Naito, H Kenmochi, H Tsuneki, T Sasaoka |
Endocrinology | 2007 |
|
Phosphatase and Tensin Homolog Deleted on Chromosome 10 Suppression Is an Important Process in Peroxisome Proliferator-Activated Receptor-γ Signaling in Adipocytes and Myotubes
KY Kim, HS Cho, WH Jung, SS Kim, HG Cheon |
Molecular pharmacology | 2007 |
|
Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome
A Corbould, H Zhao, S Mirzoeva, F Aird, A Dunaif |
Diabetes | 2006 |
|
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation: Reversal of diet-induced insulin resistance with acute exercise
ER Ropelle, JR Pauli, PO Prada, CT de Souza, PK Picardi, MC Faria, DE Cintra, MF de Fernandes, MB Flores, LA Velloso, MJ Saad, JB Carvalheira |
The Journal of Physiology | 2006 |
|
Insulin Resistance and Cardiovascular Risk: New Insights From Molecular and Cellular Biology
C Morisco, G Lembo, B Trimarco |
Trends in Cardiovascular Medicine | 2006 |
|
Altered Subcellular Distribution of Estrogen Receptor α Is Implicated in Estradiol-Induced Dual Regulation of Insulin Signaling in 3T3-L1 Adipocytes
K Nagira, T Sasaoka, T Wada, K Fukui, M Ikubo, S Hori, H Tsuneki, S Saito, M Kobayashi |
Endocrinology | 2006 |
|
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN
CM Taniguchi, TT Tran, T Kondo, J Luo, K Ueki, LC Cantley, CR Kahn |
Proceedings of the National Academy of Sciences | 2006 |
|
Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase
KM Beard, H Lu, K Ho, IG Fantus |
Diabetes | 2006 |
|
Serum- and Glucocorticoid-Inducible Kinase 1 Mediates Salt Sensitivity of Glucose Tolerance
KM Boini, AM Hennige, DY Huang, B Friedrich, M Palmada, C Boehmer, F Grahammer, F Artunc, S Ullrich, D Avram, H Osswald, P Wulff, D Kuhl, V Vallon, HU Haring, F Lang |
Diabetes | 2006 |
|
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
Y Zhang, FY Lee, G Barrera, H Lee, C Vales, FJ Gonzalez, TM Willson, PA Edwards |
Proceedings of the National Academy of Sciences | 2006 |
|
Increased PC-1 phosphodiesterase activity and inhibition of glucose uptake in adipocytes of type 2 diabetic rats
K Barrett, D McGrowder, P Brown, D Ragoobirsingh |
Molecular and Cellular Biochemistry | 2006 |
|
Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle
A Chen, B Brar, CS Choi, D Rousso, J Vaughan, Y Kuperman, SN Kim, C Donaldson, SM Smith, P Jamieson, C Li, TR Nagy, GI Shulman, KF Lee, W Vale |
Proceedings of the National Academy of Sciences | 2006 |
|
Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors
I Rakatzi, M Stosik, T Gromke, K Siddle, J Eckel |
Archives Of Physiology And Biochemistry | 2006 |
|
Lipid and lipoprotein dysregulation in insulin resistant states
RK Avramoglu, H Basciano, K Adeli |
Clinica Chimica Acta | 2006 |
|
PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling
M Vinciguerra, M Foti |
Archives Of Physiology And Biochemistry | 2006 |
|
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia
J Luo, CL Sobkiw, MF Hirshman, MN Logsdon, TQ Li, LJ Goodyear, LC Cantley |
Cell Metabolism | 2006 |
|
Critical nodes in signalling pathways: insights into insulin action
CM Taniguchi, B Emanuelli, CR Kahn |
Nature Reviews Molecular Cell Biology | 2006 |
|
The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma
PP Rose, JM Carroll, PA Carroll, VR DeFilippis, M Lagunoff, AV Moses, CT Roberts, K Früh |
Oncogene | 2006 |
|
Membrane microdomain malfunction and insulin resistance in type 2 diabetes
J Inokuchi |
Colloids and Surfaces A Physicochemical and Engineering Aspects | 2006 |
|
Pediatric Endocrinology: Obesity, Diabetes Mellitus, Insulin Resistance, and Hypoglycemia
M Haller, J Silverstein, A Rosenbloom |
Pediatric Endocrinology: Obesity, Diabetes Mellitus, Insulin Resistance, and Hypoglycemia | 2006 |
|
Role of Obesity, Insulin Resistance, and Steatosis in Hepatitis C Virus Infection
P Puri, AJ Sanyal |
Clinics in Liver Disease | 2006 |
|
Association of Insulin Resistance and Hematologic Parameters: Study of a Middle-aged and Elderly Chinese Population in Taiwan
LK Chen, MH Lin, ZJ Chen, SJ Hwang, ST Chiou |
Journal of the Chinese Medical Association | 2006 |
|
Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond
G Liu, H Zhao, B Liu, Z Xin, M Liu, C Kosogof, BG Szczepankiewicz, S Wang, JE Clampit, RJ Gum, DL Haasch, JM Trevillyan, HL Sham |
Bioorganic & Medicinal Chemistry Letters | 2006 |
|
Association of SH-2 Containing Inositol 5???-Phosphatase 2 Gene Polymorphisms and Hyperglycemia:
S Ishida, A Funakoshi, K Miyasaka, H Shimokata, F Ando, S Takiguchi |
Pancreas | 2006 |
|
The cytohesin Steppke is essential for insulin signalling in Drosophila
B Fuss, T Becker, I Zinke, M Hoch |
Nature | 2006 |
|
Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes
F He, JM Stephens |
Biochemical and Biophysical Research Communications | 2006 |
|
An Overview of the TAXUS � Express � , Paclitaxel-Eluting Stent Clinical Trial Program
JM Lasala, GW Stone, KD Dawkins, PW Serruys, A Colombo, E Grube, J Koglin, S Ellis |
Journal of Interventional Cardiology | 2006 |
|
SGK1 kinase upregulates GLUT1 activity and plasma membrane expression
Monica Palmada, Christoph Boehmer, Ahmad Akel, Jeyaganesh Rajamanickam, Sankarganesh Jeyaraj, Konrad Keller, Florian Lang |
Diabetes | 2006 |
|
Insulin signaling in human visceral and subcutaneous adipose tissue in vivo
Luigi Laviola, Sebastio Perrini, Angelo Cignarelli, Annalisa Natalicchio, Anna Leonardini, Francesca De Stefano, Marilena Cuscito, Michele De Fazio, Vincenzo Memeo, Vincenzo Neri, Mauro Cignarelli, Riccardo Giorgino, Francesco Giorgino |
Diabetes | 2006 |
|
Chronic Ethanol Intake Impairs Insulin Signaling in Rats by Disrupting Akt Association with the Cell Membrane: ROLE OF TRB3 IN INHIBITION OF Akt/PROTEIN KINASE B ACTIVATION
L He, FA Simmen, HM Mehendale, MJ Ronis, TM Badger |
The Journal of biological chemistry | 2006 |
|
The Diabetic Kidney
P Cortes, CE Mogensen |
2006 | |
|
Calcium in Human Health
CM Weaver, RP Heaney |
2006 | |
|
Sphingolipid Biology
Y Hirabayashi, Y Igarashi, AH Merrill |
2006 | |
|
Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2
M Scioscia, K Gumaa, S Kunjara, MA Paine, LE Selvaggi, CH Rodeck, TW Rademacher |
The Journal of clinical endocrinology and metabolism | 2005 |
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Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism
YB Kim, OD Peroni, WG Aschenbach, Y Minokoshi, K Kotani, A Zisman, CR Kahn, LJ Goodyear, BB Kahn |
Molecular and cellular biology | 2005 |
|
New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass
RN Kulkarni |
Reviews in Endocrine and Metabolic Disorders | 2005 |
|
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
J Luo, SJ Field, JY Lee, JA Engelman, LC Cantley |
The Journal of Cell Biology | 2005 |
|
Oral antihyperglycemic therapy for type 2 diabetes mellitus
AY Cheng, IG Fantus |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2005 |
|
AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells
K Nakamaru, K Matsumoto, T Taguchi, M Suefuji, Y Murata, M Igata, J Kawashima, T Kondo, H Motoshima, K Tsuruzoe, N Miyamura, T Toyonaga, E Araki |
Biochemical and Biophysical Research Communications | 2005 |
|
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
Y Nakagawa, H Shimano, T Yoshikawa, T Ide, M Tamura, M Furusawa, T Yamamoto, N Inoue, T Matsuzaka, A Takahashi, AH Hasty, H Suzuki, H Sone, H Toyoshima, N Yahagi, N Yamada |
Nature Medicine | 2005 |
|
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
F Giorgino, L Laviola, JW Eriksson |
Acta Physiologica Scandinavica | 2005 |
|
Drug-induced diabetes mellitus
H Izzedine, V Launay-Vacher, C Deybach, E Bourry, B Barrou, G Deray |
Expert Opinion on Drug Safety | 2005 |
|
Utilization of the Insulin-Signaling Network in the Metabolic Actions of α-Lipoic Acid—Reduction or Oxidation?
D Konrad |
Antioxidants & Redox Signaling | 2005 |
|
Effect of obesity on insulin signaling through JAK2 in rat aorta
HG Zecchin, CT de Souza, PO Prada, JB Carvalheira, LA Velloso, MJ Saad |
Vascular Pharmacology | 2005 |
|
Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of rapamycin nutrient sensing pathway
F Tremblay, H Jacques, A Marette |
Current Opinion in Clinical Nutrition and Metabolic Care | 2005 |
|
Insulin resistance: A metabolic pathway to chronic liver disease
E Bugianesi, AJ McCullough, G Marchesini |
Hepatology | 2005 |
|
Outcomes with the polymer-based paclitaxel-eluting TAXUS stent in patients with diabetes mellitus
JB Hermiller, A Raizner, L Cannon, PA Gurbel, MA Kutcher, SC Wong, ME Russell, SG Ellis, R Mehran, GW Stone |
Journal of the American College of Cardiology | 2005 |
|
Serum Levels of Soluble Tumor Necrosis Factor-α Receptor 2 are Linked to Insulin Resistance and Glucose Intolerance in Children
A Gupta, S Ten, H Anhalt |
Journal of Pediatric Endocrinology and Metabolism | 2005 |
|
The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance
AM Valverde, M Benito, M Lorenzo |
Acta Physiologica Scandinavica | 2005 |
|
Review article: diabetes and atherosclerosis - running on a common road
M Federici, R Lauro |
Alimentary Pharmacology and Therapeutics | 2005 |
|
Sp-family of transcription factors regulates human SHIP2 gene expression
S Ishida, A Funakoshi, K Miyasaka, H Iguchi, S Takiguchi |
Gene | 2005 |
|
Pathophysiology of type 2 diabetes: Rationale for different oral antidiabetic treatment strategies
F Giorgino, L Laviola, A Leonardini |
Diabetes Research and Clinical Practice | 2005 |
|
The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes
K Okazawa, Y Yoshimasa, Y Miyamoto, A Takahashi-Yasuno, T Miyawaki, H Masuzaki, T Hayashi, K Hosoda, G Inoue, K Nakao |
Diabetes Research and Clinical Practice | 2005 |
|
Lipid Microdomains and Insulin Resistance: Is There a Connection?
E Ikonen, S Vainio |
Science signaling | 2005 |
|
Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: Role of IRS phosphorylation
Q Zhang, EA Carter, BY Ma, M White, AJ Fischman, RG Tompkins |
Life Sciences | 2005 |
|
Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens
Y Seki, K Sato, Y Akiba |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 2005 |
|
PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis
F Furlong, D Finlay, F Martin |
Biochemical and Biophysical Research Communications | 2005 |
|
Isoproterenol, TNFα, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes
S Kralisch, J Klein, U Lossner, M Bluher, R Paschke, M Stumvoll, M Fasshauer |
Molecular and Cellular Endocrinology | 2005 |
|
The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2
M Palmada, A Speil, S Jeyaraj, C Böhmer, F Lang |
Biochemical and Biophysical Research Communications | 2005 |
|
Insulin Signaling in Adipocytes Differentiated from Mouse Stromal MC3T3-G2/PA6 Cells
S Morito, K Yaguchi, M Imada, C Tachikawa, M Nomura, S Moritani, M Igarashi, K Yokogawa, K Miyamoto |
Biological & Pharmaceutical Bulletin | 2005 |
|
Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 Isoforms in Adipocytes and Their Potential Role in Glycolytic Regulation
T Atsumi, T Nishio, H Niwa, J Takeuchi, H Bando, C Shimizu, N Yoshioka, R Bucala, T Koike |
Diabetes | 2005 |
|
PTEN, but Not SHIP2, Suppresses Insulin Signaling through the Phosphatidylinositol 3-Kinase/Akt Pathway in 3T3-L1 Adipocytes
X Tang, AM Powelka, NA Soriano, MP Czech, A Guilherme |
The Journal of biological chemistry | 2005 |
|
Genetic Association, Post-translational Modification, and Protein-Protein Interactions in Type 2 Diabetes Mellitus
A Sharma, S Chavali, A Mahajan, R Tabassum, V Banerjee, N Tandon, D Bharadwaj |
Molecular & cellular proteomics : MCP | 2005 |
|
Gene expression profiling of the left ventricles in a rat model of intrinsic aerobic running capacity
SJ Lee, JA Ways, JC Barbato, D Essig, K Pettee, SJ DeRaedt, S Yang, DA Weaver, LG Koch, GT Cicila |
Physiological genomics | 2005 |
|
Melatonin enhances leptin expression by rat adipocytes in the presence of insulin
MI Alonso-Vale, S Andreotti, SB Peres, GF Anhê, CN Borges-Silva, JC Neto, FB Lima |
American journal of physiology. Endocrinology and metabolism | 2005 |
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Insulin potentiates AVP-induced AQP2 expression in cultured renal collecting duct principal cells
M Bustamante, U Hasler, O Kotova, AV Chibalin, D Mordasini, M Rousselot, A Vandewalle, PY Martin, E Féraille |
American journal of physiology. Renal physiology | 2005 |
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Inhibition of endogenous SHIP2 ameliorates insulin resistance caused by chronic insulin treatment in 3T3-L1 adipocytes
T Sasaoka, K Fukui, T Wada, S Murakami, J Kawahara, H Ishihara, M Funaki, T Asano, M Kobayashi |
Diabetologia | 2005 |
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Cell Signaling in Vascular Inflammation
J Bhattacharya |
2005 | |
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Impact of Src Homology 2-Containing Inositol 5′-Phosphatase 2 Gene Polymorphisms Detected in a Japanese Population on Insulin Signaling
S Kagawa, T Sasaoka, S Yaguchi, H Ishihara, H Tsuneki, S Murakami, K Fukui, T Wada, S Kobayashi, I Kimura, M Kobayashi |
The Journal of clinical endocrinology and metabolism | 2005 |
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Blockade of Rapid Versus Prolonged Extracellularly Regulated Kinase 1/2 Activation Has Differential Effects on Insulin-Induced Gene Expression
AB Keeton, KD Bortoff, JL Franklin, JL Messina |
Endocrinology | 2005 |
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Insulin receptor substrate-2 plays a crucial role in b cells and the hypothalamus
Naoto Kubota, Yasuo Terauchi, Kazuyuki Tobe, Wataru Yano, Ryo Suzuki, Kohjiro Ueki, Iseki Takamoto, Hidemi Satoh, Toshiyuki Maki, Tetsuya Kubota, Masao Moroi, Miki Okada-Iwabu, Osamu Ezaki, Ryozo Nagai, Yoichi Ueta, Takashi Kadowaki, and Tetsuo Noda |
Journal of Clinical Investigation | 2004 |
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Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha
Y Ma, B Toth, AB Keeton, LT Holland, IH Chaudry, JL Messina |
Endocrinology | 2004 |
|
The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes
C Bouché, S Serdy, CR Kahn, AB Goldfine |
Endocrine reviews | 2004 |
|
Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes
A Xu, LC Wong, Y Wang, JY Xu, GJ Cooper, KS Lam |
FEBS Letters | 2004 |
|
Berson, Yalow, and the JCI: the agony and the ecstasy
CR Kahn, J Roth |
Journal of Clinical Investigation | 2004 |
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Human skeletal muscle cell differentiation is associated with changes in myogenic markers and enhanced insulin-mediated MAPK and PKB phosphorylation
L Al-Khalili, D Kramer, P Wretenberg, A Krook |
Acta Physiologica Scandinavica | 2004 |
|
Encyclopedia of Biological Chemistry
S DiMauro |
Encyclopedia of Biological Chemistry | 2004 |
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Hepatocytes: critical for glucose homeostasis
PJ Klover, RA Mooney |
The International Journal of Biochemistry & Cell Biology | 2004 |
|
Treatment of insulin resistance in diabetes mellitus
HE Lebovitz, MA Banerji |
European Journal of Pharmacology | 2004 |
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The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat
PM Le, A Benhaddou-Andaloussi, A Elimadi, A Settaf, Y Cherrah, PS Haddad |
Journal of Ethnopharmacology | 2004 |
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Pathogenesis of type 2 diabetes mellitus
RA DeFronzo |
Medical Clinics of North America | 2004 |
|
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
EE Calle, R Kaaks |
Nature Reviews Cancer | 2004 |
|
Inhibitory mechanism of caffeine on insulin-stimulated glucose uptake in adipose cells
T Akiba, K Yaguchi, K Tsutsumi, T Nishioka, I Koyama, M Nomura, K Yokogawa, S Moritani, K Miyamoto |
Biochemical Pharmacology | 2004 |
|
The metabolic syndrome and coronary heart disease in older women: findings from the British Women's Heart and Health Study
DA Lawlor, S Ebrahim, GD Smith |
Diabetic Medicine | 2004 |
|
The insulin sensitizing effect of homoisoflavone-enriched fraction in Liriope platyphylla Wang et Tang via PI3-kinase pathway
SB Choi, JD Wha, S Park |
Life Sciences | 2004 |
|
Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase α
HT Le, S Ponniah, CJ Pallen |
Biochemical and Biophysical Research Communications | 2004 |
|
Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor
Stephen B Wheatcroft, Ajay M Shah, Jian-Mei Li, Edward Duncan, Brian T Noronha, Paul A Crossey, Mark T Kearney |
Diabetes | 2004 |
|
Inhibition of Phosphatidylinositol-3-kinase Enhances Insulin Stimulation of Insulin Receptor Substrate 1 Tyrosine Phosphorylation and Extracellular Signal-Regulated Kinases in Mouse R − Fibroblasts
WS Choi, CK Sung |
Journal of Receptors and Signal Transduction | 2004 |
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The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats
GD Wadley, CR Bruce, N Konstantopoulos, SL Macaulay, KF Howlett, JA Hawley, D Cameron-Smith |
Diabetologia | 2004 |
|
Participação do zinco na resistência à insulina
DN Marreiro, B Geloneze, MA Tambascia, AC Lerário, A Halpern, SM Cozzolino |
Arquivos brasileiros de endocrinologia e metabologia | 2004 |
|
Human Insulin Receptor Substrate-1 (IRS-1) Polymorphism G972R Causes IRS-1 to Associate with the Insulin Receptor and Inhibit Receptor Autophosphorylation
AJ McGettrick, EP Feener, CR Kahn |
The Journal of biological chemistry | 2004 |
|
Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302
ED Werner, J Lee, L Hansen, M Yuan, SE Shoelson |
The Journal of biological chemistry | 2004 |
|
Protein Kinase C-ζ and Protein Kinase B Regulate Distinct Steps of Insulin Endocytosis and Intracellular Sorting
F Fiory, F Oriente, C Miele, C Romano, A Trencia, AT Alberobello, I Esposito, R Valentino, F Beguinot, P Formisano |
The Journal of biological chemistry | 2004 |
|
Serine 332 Phosphorylation of Insulin Receptor Substrate-1 by Glycogen Synthase Kinase-3 Attenuates Insulin Signaling
Z Liberman, H Eldar-Finkelman |
The Journal of biological chemistry | 2004 |
|
Protein Phosphatase 4 Interacts with and Down-regulates Insulin Receptor Substrate 4 following Tumor Necrosis Factor-α Stimulation
KA Mihindukulasuriya, G Zhou, J Qin, TH Tan |
The Journal of biological chemistry | 2004 |
|
Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia
C Pender, ID Goldfine, CJ Tanner, WJ Pories, KG MacDonald, PJ Havel, JA Houmard, JF Youngren |
International Journal of Obesity | 2004 |
|
Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis
HA Franch, S Raissi, X Wang, B Zheng, JL Bailey, SR Price |
American journal of physiology. Renal physiology | 2004 |
|
Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes
AR Gosmanov, GE Umpierrez, AH Karabell, R Cuervo, DB Thomason |
American journal of physiology. Endocrinology and metabolism | 2004 |
|
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms
K Ueki, T Kondo, CR Kahn |
Molecular and cellular biology | 2004 |
|
Impact of Src Homology 2-Containing Inositol 5′-Phosphatase 2 on the Regulation of Insulin Signaling Leading to Protein Synthesis in 3T3-L1 Adipocytes Cultured with Excess Amino Acids
S Murakami, T Sasaoka, T Wada, K Fukui, K Nagira, H Ishihara, I Usui, M Kobayashi |
Endocrinology | 2004 |
|
Insulin Augmentation of 17α-Hydroxylase Activity Is Mediated by Phosphatidyl Inositol 3-Kinase But Not Extracellular Signal-Regulated Kinase-1/2 in Human Ovarian Theca Cells
I Munir, HW Yen, DH Geller, D Torbati, RM Bierden, SR Weitsman, SK Agarwal, DA Magoffin |
Endocrinology | 2004 |
|
In Vitro Phosphorylation of Insulin Receptor Substrate 1 by Protein Kinase C-ζ: Functional Analysis and Identification of Novel Phosphorylation Sites
MR Sommerfeld, S Metzger, M Stosik, N Tennagels, J Eckel |
Biochemistry | 2004 |
|
Insulin-Induced Cell Cycle Progression Is Impaired in Chinese Hamster Ovary Cells Overexpressing Insulin Receptor Substrate-3
Y Kaburagi, R Yamashita, Y Ito, H Okochi, R Yamamoto-Honda, K Yasuda, H Sekihara, T Sasazuki, T Kadowaki, Y Yazaki |
Endocrinology | 2004 |
|
The allelic variant of LAR gene promoter –127 bp T→A is associated with reduced risk of obesity and other features related to insulin resistance
G Miscio, V Tassi, A Coco, T Soccio, RD Paola, S Prudente, R Baratta, L Frittitta, O Ludovico, L Padovano, B Dallapiccola, UD Mario, SD Cosmo, V Trischitta |
Journal of Molecular Medicine | 2004 |
|
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
RN Kulkarni, K Almind, HJ Goren, JN Winnay, K Ueki, T Okada, CR Kahn |
Diabetes | 2003 |
|
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
|
Intermediate metabolism in normal pregnancy and in gestational diabetes
GD Cianni, R Miccoli, L Volpe, C Lencioni, SD Prato |
Diabetes/Metabolism Research and Reviews | 2003 |
|
The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle
JR Zierath, Y Kawano |
Best Practice & Research Clinical Endocrinology & Metabolism | 2003 |
|
Pathophysiological implications of insulin resistance on vascular endothelial function
SB Wheatcroft, IL Williams, AM Shah, MT Kearney |
Diabetic Medicine | 2003 |
|
A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription
D Foti, R Iuliano, E Chiefari, A Brunetti |
Molecular and cellular biology | 2003 |
|
Isoform-specific insulin receptor signaling involves different plasma membrane domains
S Uhles, T Moede, B Leibiger, PO Berggren, IB Leibiger |
The Journal of Cell Biology | 2003 |
|
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
ZY Jiang, QL Zhou, KA Coleman, M Chouinard, Q Boese, MP Czech |
Proceedings of the National Academy of Sciences | 2003 |
|
The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice
CR Kahn |
Transactions of the American Clinical and Climatological Association | 2003 |
|
Carbohydrates, dietary glycaemic load and glycaemic index, and risk of acute myocardial infarction
A Tavani, C Bosetti, E Negri, LS Augustin, DJ Jenkins, CL Vecchia |
Heart (British Cardiac Society) | 2003 |
|
Gene expression in human cells with mutant insulin receptors
R Melis, PB Pruett, Y Wang, N Longo |
Biochemical and Biophysical Research Communications | 2003 |
|
Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake
JC O’Connor, GG Freund |
Metabolism | 2003 |
|
Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3-kinase signalling
K Tobe, S Asai, K Matuoka, T Yamamoto, K Chida, Y Kaburagi, Y Akanuma, T Kuroki, T Takenawa, S Kimura, R Nagai, T Kadowaki |
Genes to Cells | 2003 |
|
Looking for an insulin pill? Use the BRET methodology!
T Issad, N Boute, S Boubekeur, D Lacasa, K Pernet |
Diabetes & Metabolism | 2003 |
|
Emergence of the metabolic syndrome in childhood: an epidemiological overview and mechanistic link to dyslipidemia
R Kohen-Avramoglu, A Theriault, K Adeli |
Clinical Biochemistry | 2003 |
|
The Ovary
BC Vanderhyden, TJ Shaw, K Garson, AM Tonary |
The Ovary | 2003 |
|
Genetic variants of modulators of insulin action
V Tassi, RD Paola, A Pizzuti, L Frittitta, V Trischitta |
International Congress Series | 2003 |
|
Association of the polymorphisms in the 5′-untranslated region of PTEN gene with type 2 diabetes in a Japanese population
H Ishihara, T Sasaoka, S Kagawa, S Murakami, K Fukui, Y Kawagishi, K Yamazaki, A Sato, M Iwata, M Urakaze, M Ishiki, T Wada, S Yaguchi, H Tsuneki, I Kimura, M Kobayashi |
FEBS Letters | 2003 |
|
Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats
F Tremblay, C Lavigne, H Jacques, A Marette |
Diabetes | 2003 |
|
Cold Exposure Induces Tissue-Specific Modulation of the Insulin-Signalling Pathway in Rattus Norvegicus
AL Gasparetti, CT de Souza, M Pereira-da-Silva, RL Oliveira, MJ Saad, EM Carneiro, LA Velloso |
The Journal of Physiology | 2003 |
|
Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment
H Eldar-Finkelman, R Ilouz |
Expert Opinion on Investigational Drugs | 2003 |
|
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes
Angela M Valverde, Deborah J Burks, Isabel Fabregat, Tracey L Fisher, José Carretero, Morris F White, Manuel Benito |
Diabetes | 2003 |
|
Up-regulation of phosphatidylinositol 3-kinase and glucose transporter 4 in muscle of rats subjected to maternal undernutrition
Marta Sampaio de Freitas, Erica Patricia Garcia De Souza, Simone Vargas da Silva, Andrea da Rocha Kaezer, Rafael da Silva Vieira, Anibal Sanchez Moura, Christina Barja-Fidalgo |
Biochimica et Biophysica Acta | 2003 |
|
Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane
Sebastio Perrini, Annalisa Natalicchio, Luigi Laviola, Gaetana Belsanti, Carmela Montrone, Angelo Cignarelli, Vincenza Minielli, Maria Grano, Giovanni De Pergola, Riccardo Giorgino, Francesco Giorgino |
Diabetes | 2003 |
|
Role of the pleckstrin homology domain of PLCγ1 in its interaction with the insulin receptor
YK Kwon, HJ Jang, S Kole, HJ He, M Bernier |
The Journal of Cell Biology | 2003 |
|
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
SE Kahn |
Diabetologia | 2003 |
|
Insulin Induces the Expression of the SHARP-2/Stra13/DEC1 Gene via a Phosphoinositide 3-Kinase Pathway
K Yamada, H Kawata, Z Shou, T Mizutani, T Noguchi, K Miyamoto |
The Journal of biological chemistry | 2003 |
|
Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes
JJ Senn, PJ Klover, IA Nowak, TA Zimmers, LG Koniaris, RW Furlanetto, RA Mooney |
The Journal of biological chemistry | 2003 |
|
Extracellular Matrix Proteins Modulate Endocytosis of the Insulin Receptor
S Boura-Halfon, H Voliovitch, R Feinstein, K Paz, Y Zick |
The Journal of biological chemistry | 2003 |
|
Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling
K Ueki, DA Fruman, CM Yballe, M Fasshauer, J Klein, T Asano, LC Cantley, CR Kahn |
The Journal of biological chemistry | 2003 |
|
Insulin modulates PC-1 processing and recruitment in cultured human cells
C Menzaghi, RD Paola, G Baj, A Funaro, A Arnulfo, T Ercolino, N Surico, F Malavasi, V Trischitta |
American journal of physiology. Endocrinology and metabolism | 2003 |
|
Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes
E Heart, CK Sung |
Journal of Cellular Biochemistry | 2003 |
|
Platelet-Derived Growth Factor (PDGF) Stimulates Glucose Transport in 3T3-L1 Adipocytes Overexpressing PDGF Receptor by a Pathway Independent of Insulin Receptor Substrates
EL Whiteman, JJ Chen, MJ Birnbaum |
Endocrinology | 2003 |
|
Metabolic and molecular basis of insulin resistance
M Bajaj |
Journal of Nuclear Cardiology | 2003 |
|
Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells
M Federici, R Menghini, A Mauriello, ML Hribal, F Ferrelli, D Lauro, P Sbraccia, LG Spagnoli, G Sesti, R Lauro |
Circulation | 2002 |
|
Tissue-Specific Targeting of the Insulin Receptor Gene
RN Kulkarni, T Okada |
Endocrine | 2002 |
|
Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α*
D Hallmann, K Trümper, H Trusheim, K Ueki, CR Kahn, LC Cantley, DA Fruman, D Hörsch |
The Journal of biological chemistry | 2002 |
|
Wiley Encyclopedia of Molecular Medicine
WT Morgan |
Wiley Encyclopedia of Molecular Medicine | 2002 |
|
Effects of pulsatile secretion of growth hormone (GH) on fat deposition in human GH transgenic rats
Y Furuhata, M Nishihara, M Takahashi |
Nutrition Research Reviews | 2002 |
|
From Receptor to Effector: Insulin Signal Transduction in Skeletal Muscle from Type II Diabetic Patients
JR Zierath, H Wallberg-Henriksson |
Annals of the New York Academy of Sciences | 2002 |
|
Potential Utility of Insulin Sensitizers in the Treatment of Patients with Polycystic Ovary Syndrome
F Bayram, K Unluhizarci, F Kelestimur |
Treatments in Endocrinology | 2002 |
|
Insulin-sensitising agents: beyond thiazolidinediones
JR Petrie, CG Perry |
Expert Opinion on Emerging Drugs | 2002 |
|
Novel insulin sensitizers: pharmacogenomic aspects
C Otto, M Lehrke, B Göke |
Pharmacogenomics | 2002 |
|
Dominant Negative α-Subunit of FTase Inhibits Effects of Insulin and IGF-I in MCF-7 Cells
CS Solomon, ML Goalstone |
Biochemical and Biophysical Research Communications | 2002 |
|
The metabolic abnormalities associated with non-alcoholic fatty liver disease
M Haque, AJ Sanyal |
Best Practice & Research Clinical Gastroenterology | 2002 |
|
Obesity and gender differences in the risk of type 2 diabetes mellitus in Uganda
D Lasky, E Becerra, W Boto, M Otim, J Ntambi |
Nutrition | 2002 |
|
Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
H Song, N Shojima, H Sakoda, T Ogihara, M Fujishiro, H Katagiri, M Anai, Y Onishi, H Ono, K Inukai, Y Fukushima, M Kikuchi, H Shimano, N Yamada, Y Oka, T Asano |
Biochemical and Biophysical Research Communications | 2002 |
|
Glucose Transport by Osmotic Shock and Vanadate Is Impaired by Glucosamine
E Heart, CK Sung |
Biochemical and Biophysical Research Communications | 2002 |
|
The role of glycogen synthase kinase-3 in insulin resistance and Type 2 diabetes
H Eldar-Finkelman, O Kaidanovich |
Expert Opinion on Therapeutic Targets | 2002 |
|
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
F Mauvais-Jarvis, RN Kulkarni, CR Kahn |
Clinical Endocrinology | 2002 |
|
Hormonal Regulation of Adiponectin Gene Expression in 3T3-L1 Adipocytes
M Fasshauer, J Klein, S Neumann, M Eszlinger, R Paschke |
Biochemical and Biophysical Research Communications | 2002 |
|
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
CE Berg, BE Lavan, CM Rondinone |
Biochemical and Biophysical Research Communications | 2002 |
|
Diabetic flies? Using Drosophila melanogaster to understand the causes of monogenic and genetically complex diseases
P Lasko |
Clinical Genetics | 2002 |
|
Paradoxical regulation of Sp1 transcription factor by glucagon
CN Keembiyehetty, RP Candelaria, G Majumdar, R Raghow, A Martinez-Hernandez, SS Solomon |
Endocrinology | 2002 |
|
Chronic Fatigue Syndrome: A Biological Approach
M Verhas, T Verbinnen, KD Meirleir, CV Herst, M Frémont, P Englebienne |
Chronic Fatigue Syndrome: A Biological Approach | 2002 |
|
Insulin Resistance and Insulin Resistance Syndrome
A Cincotta |
Insulin Resistance and Insulin Resistance Syndrome | 2002 |
|
Insulin Resistance and Insulin Resistance Syndrome: Recent Insights from Cellular and Animal Studies
B Goldstein |
Insulin Resistance and Insulin Resistance Syndrome | 2002 |
|
Medical Management of Diabetes and Heart Disease
M LeWinter |
Medical Management of Diabetes and Heart Disease | 2002 |
|
Racial Differences in Insulin Resistance and Mid-Thigh Fat Deposition in Postmenopausal Women
AS Ryan, BJ Nicklas, DM Berman |
Obesity research | 2002 |
|
Insulin resistance in type 2 diabetes: role of fatty acids
P Arner |
Diabetes/Metabolism Research and Reviews | 2002 |
|
Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes
CM Rondinone, D Kramer |
Biochemical and Biophysical Research Communications | 2002 |
|
Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects
TP Ciaraldi, AP Kong, NV Chu, DD Kim, S Baxi, M Loviscach, R Plodkowski, R Reitz, M Caulfield, S Mudaliar, RR Henry |
Diabetes | 2002 |
|
Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes
MM Meyer, K Levin, T Grimmsmann, N Perwitz, A Eirich, H Beck-Nielsen, HH Klein |
Diabetes | 2002 |
|
Isoform-Specific Regulation of 5' AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction
BR Barnes, JW Ryder, TL Steiler, LG Fryer, D Carling, JR Zierath |
Diabetes | 2002 |
|
Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals
K Eto, T Yamashita, Y Tsubamoto, Y Terauchi, K Hirose, N Kubota, S Yamashita, J Taka, S Satoh, H Sekihara, K Tobe, M Iino, M Noda, S Kimura, T Kadowaki |
Diabetes | 2002 |
|
A Variation in 3′ UTR of hPTP1B Increases Specific Gene Expression and Associates with Insulin Resistance
RD Paola, L Frittitta, G Miscio, M Bozzali, R Baratta, M Centra, D Spampinato, MG Santagati, T Ercolino, C Cisternino, T Soccio, S Mastroianno, V Tassi, P Almgren, A Pizzuti, R Vigneri, V Trischitta |
The American Journal of Human Genetics | 2002 |
|
Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice
H Hori, T Sasaoka, H Ishihara, T Wada, S Murakami, M Ishiki, M Kobayashi |
Diabetes | 2002 |
|
Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling: Sam68 Associates With the SH3 Domains of Grb2
S Najib, V Sánchez-Margalet |
Journal of Cellular Biochemistry | 2002 |
|
Effects of Fluvastatin Treatment on Insulin Sensitivity in Patients with Hyperlipidaemia
BY Cingözbay, C Top, H Terekeci, Ö Keskin, ME Önde |
J INT MED RES | 2002 |
|
Akt Signaling Mediates Postnatal Heart Growth in Response to Insulin and Nutritional Status
I Shiojima, M Yefremashvili, Z Luo, Y Kureishi, A Takahashi, J Tao, A Rosenzweig, CR Kahn, ED Abel, K Walsh |
The Journal of biological chemistry | 2002 |
|
Insulin Stimulates Phosphorylation of the β 2 -Adrenergic Receptor by the Insulin Receptor, Creating a Potent Feedback Inhibitor of Its Tyrosine Kinase
S Doronin, H Wang, CC Malbon |
The Journal of biological chemistry | 2002 |
|
Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α
D Hallmann, K Trümper, H Trusheim, K Ueki, CR Kahn, LC Cantley, DA Fruman, D Hörsch |
The Journal of biological chemistry | 2002 |
|
Transactivation of ErbB2 and ErbB3 by Tumor Necrosis Factor-α and Anisomycin Leads to Impaired Insulin Signaling through Serine/Threonine Phosphorylation of IRS Proteins
R Hemi, K Paz, N Wertheim, A Karasik, Y Zick, H Kanety |
The Journal of biological chemistry | 2002 |
|
Insulin and Sterol-regulatory Element-binding Protein-1c (SREBP-1C) Regulation of Gene Expression in 3T3-L1 Adipocytes: IDENTIFICATION OF CCAAT/ENHANCER-BINDING PROTEIN β AS AN SREBP-1C TARGET
SL Lay, I Lefrère, C Trautwein, I Dugail, S Krief |
The Journal of biological chemistry | 2002 |
|
Insulin Signal Transduction Pathways and Insulin-induced Gene Expression
AB Keeton, MO Amsler, DY Venable, JL Messina |
The Journal of biological chemistry | 2002 |
|
Epidermal Growth Factor and Transforming Growth Factor α Mimic the Effects of Insulin in Human Fat Cells and Augment Downstream Signaling in Insulin Resistance
S Gogg, U Smith |
The Journal of biological chemistry | 2002 |
|
Differential Roles of Insulin Receptor Substrates in the Anti-apoptotic Function of Insulin-like Growth Factor-1 and Insulin
YH Tseng, K Ueki, KM Kriauciunas, CR Kahn |
The Journal of biological chemistry | 2002 |
|
Serum Interleukin 2 Levels in Patients with Rheumatoid Arthritis and Correlation with Insulin Sensitivity
O Öncül, C Top, S Özkan, Ş Çavuşlu, M Danaci |
J INT MED RES | 2002 |
|
Glycemic index in chronic disease: a review
LS Augustin, S Franceschi, DJ Jenkins, CW Kendall, CL Vecchia |
European Journal of Clinical Nutrition | 2002 |
|
Lipid rafts and insulin signaling
PE Bickel |
American journal of physiology. Endocrinology and metabolism | 2002 |
|
Invited Review: Exercise training-induced changes in insulin signaling in skeletal muscle
JR Zierath |
Journal of applied physiology | 2002 |
|
Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases
HL Goel, CS Dey |
Journal of Cellular Physiology | 2002 |
|
Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1
R Zhande, JJ Mitchell, J Wu, XJ Sun |
Molecular and cellular biology | 2002 |
|
Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-κB through an AKT/P70S6K/p38-MAPK pathway
R Conejo, C de Alvaro, M Benito, A Cuadrado, M Lorenzo |
Oncogene | 2002 |
|
Molecular Links Between Obesity and Cardiovascular Disease:
A Sorisky |
American Journal of Therapeutics | 2002 |
|
Lysophosphatidylcholine Inhibits Insulin-Induced Akt Activation Through Protein Kinase C-α in Vascular Smooth Muscle Cells
ED Motley, SM Kabir, CD Gardner, K Eguchi, GD Frank, T Kuroki, M Ohba, T Yamakawa, S Eguchi |
Hypertension | 2002 |
|
NO Attenuates Insulin Signaling and Motility in Aortic Smooth Muscle Cells via Protein Tyrosine Phosphatase 1B–Mediated Mechanism
N Sreejayan, Y Lin, A Hassid |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
|
Requirement for PIKfyve Enzymatic Activity in Acute and Long-Term Insulin Cellular Effects
OC Ikonomov, D Sbrissa, K Mlak, A Shisheva |
Endocrinology | 2002 |
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Cloning of the Mouse Insulin Receptor Substrate-3 (mIRS-3) Promoter, and Its Regulation by p53
S Sciacchitano, A Orecchio, L Lavra, S Misiti, A Giacchini, M Zani, D Danese, A Gurtner, S Soddu, UD Mario, M Andreoli |
Molecular Endocrinology | 2002 |
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Brain Somatic Cross-Talk and the Central Control of Metabolism
C Kordon, I Robinson, J Hanoune, R Dantzer, Y Christen |
2002 | |
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Positive and Negative Regulatory Role of Insulin Receptor Substrate 1 and 2 (IRS-1 and IRS-2) Serine/Threonine Phosphorylation
MW Greene, RS Garofalo |
Biochemistry | 2002 |
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Lipoatrophic diabetes in Irs1 −/− /Irs3 −/− double knockout mice
PG Laustsen, MD Michael, BE Crute, SE Cohen, K Ueki, RN Kulkarni, SR Keller, GE Lienhard, CR Kahn |
Genes & development | 2002 |
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Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance
Carmen Guerra, Paloma Navarro, Angela M. Valverde, Monica Arribas, Jens. Brüning, Leslie P. Kozak, C. Ronald Kahn, Manuel Benito |
Journal of Clinical Investigation | 2001 |
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Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected]
H Storgaard, XM Song, CB Jensen, S Madsbad, M Björnholm, A Vaag, JR Zierath |
Diabetes | 2001 |
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Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle
WA Chutkow, V Samuel, PA Hansen, J Pu, CR Valdivia, JC Makielski, CF Burant |
Proceedings of the National Academy of Sciences | 2001 |
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Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells
B Leibiger, IB Leibiger, T Moede, S Kemper, RN Kulkarni, CR Kahn, LM de Vargas, PO Berggren |
Molecular Cell | 2001 |
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CURRENTCONCEPTS IN THEPOLYCYSTICOVARYSYNDROME
A Dunaif, A Thomas |
Annual Review of Medicine | 2001 |
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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
ON Ozes, H Akca, LD Mayo, JA Gustin, T Maehama, JE Dixon, DB Donner |
Proceedings of the National Academy of Sciences | 2001 |
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Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA
J Ostrowski, Y Kawata, DS Schullery, ON Denisenko, Y Higaki, CK Abrass, K Bomsztyk |
Proceedings of the National Academy of Sciences | 2001 |
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Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients
E Lefai, M Roques, N Vega, M Laville, H Vidal |
Biochemical Journal | 2001 |
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Oxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytes
A Tirosh, A Rudich, R Potashnik, N Bashan |
Biochemical Journal | 2001 |
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Inevitability of beta cell failure in type 2 diabetes
T Siegmund, KH Usadel |
Current Opinion in Endocrinology & Diabetes | 2001 |
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Surfing the insulin signaling web
EV Obberghen, V Baron, L Delahaye, B Emanuelli, N Filippa, S Giorgetti-Peraldi, P Lebrun, I Mothe-Satney, P Peraldi, S Rocchi, D Sawka-Verhelle, S Tartare-Deckert, J Giudicelli |
European Journal of Clinical Investigation | 2001 |
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Identification of a cis-Acting Element and a Novel trans-Acting Factor of the Human Insulin Receptor Gene in HepG2 and Rat Liver Cells
K Yoshizato, T Shirotani, N Furukawa, T Taguchi, H Motoshima, T Toyonaga, Y Hirashima, J Kawashima, Y Ebina, M Shichiri, E Araki |
Biochemical and Biophysical Research Communications | 2001 |
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Moving the insulin-regulated glucose transporter GLUT4 into and out of storage
GD Holman, IV Sandoval |
Trends in Cell Biology | 2001 |
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Insulin resistance: a phosphorylation-based uncoupling of insulin signaling
Y Zick |
Trends in Cell Biology | 2001 |
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Focal adhesion kinase and Src mediate integrin regulation of insulin receptor phosphorylation
SE Annabi, N Gautier, V Baron |
FEBS Letters | 2001 |
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C-peptide attenuates protein tyrosine phosphatase activity and enhances glycogen synthesis in L6 myoblasts
ZG Li, X Qiang, AA Sima, G Grunberger |
Biochemical and Biophysical Research Communications | 2001 |
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Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y)
A Brunetti, G Manfioletti, E Chiefari, ID Goldfine, D Foti |
The FASEB Journal | 2001 |
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Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease
C Rask-Madsen, N Ihlemann, T Krarup, E Christiansen, L Kober, CN Kistorp, C Torp-Pedersen |
Diabetes | 2001 |
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The role of protein kinase C isoforms in insulin action
P Formisano, F Beguinot |
Journal of Endocrinological Investigation | 2001 |
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Selective insulin-induced activation of class IA phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes
D Sbrissa, O Ikonomov, A Shisheva |
Molecular and Cellular Endocrinology | 2001 |
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The Q Allele Variant (GLN121) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS121)
BV Costanzo, V Trischitta, RD Paola, D Spampinato, A Pizzuti, R Vigneri, L Frittitta |
Diabetes | 2001 |
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High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans: A Potential Role for Regulation of Specific Bcl Family Genes Toward an Apoptotic Cell Death Program
M Federici, M Hribal, L Perego, M Ranalli, Z Caradonna, C Perego, L Usellini, R Nano, P Bonini, F Bertuzzi, LN Marlier, AM Davalli, O Carandente, AE Pontiroli, G Melino, P Marchetti, R Lauro, G Sesti, F Folli |
Diabetes | 2001 |
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Recent Advances in Our Understanding of Insulin Action and Insulin Resistance
DL Roith, Y Zick |
Diabetes care | 2001 |
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Effects of Streptozocin Diabetes and Diabetes Treatment by Islet Transplantation on In Vivo Insulin Signaling in Rat Heart
L Laviola, G Belsanti, AM Davalli, R Napoli, S Perrini, GC Weir, R Giorgino, F Giorgino |
Diabetes | 2001 |
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Serine/Threonine Phosphorylation of IRS-1 Triggers Its Degradation: Possible Regulation by Tyrosine Phosphorylation
TM Pederson, DL Kramer, CM Rondinone |
Diabetes | 2001 |
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New Amino Acid Substitutions in the IRS-2 Gene in Finnish and Chinese Subjects With Late-Onset Type 2 Diabetes
H Wang, J Rissanen, R Miettinen, P Karkkainen, P Kekalainen, J Kuusisto, L Mykkanen, P Karhapaa, M Laakso |
Diabetes | 2001 |
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Small Molecule Insulin Receptor Activators Potentiate Insulin Action in Insulin-Resistant Cells
M Li, JF Youngren, VP Manchem, M Kozlowski, BB Zhang, BA Maddux, ID Goldfine |
Diabetes | 2001 |
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A Cluster of Three Single Nucleotide Polymorphisms in the 3'-Untranslated Region of Human Glycoprotein PC-1 Gene Stabilizes PC-1 mRNA and Is Associated With Increased PC-1 Protein Content and Insulin Resistance-Related Abnormalities
L Frittitta, T Ercolino, M Bozzali, A Argiolas, S Graci, MG Santagati, D Spampinato, RD Paola, C Cisternino, V Tassi, R Vigneri, A Pizzuti, V Trischitta |
Diabetes | 2001 |
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Protein Kinase C (PKC)- Activation Inhibits PKC- and Mediates the Action of PED/PEA-15 on Glucose Transport in the L6 Skeletal Muscle Cells
G Condorelli, G Vigliotta, A Trencia, MA Maitan, M Caruso, C Miele, F Oriente, S Santopietro, P Formisano, F Beguinot |
Diabetes | 2001 |
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Growth Hormone Induces Cellular Insulin Resistance by Uncoupling Phosphatidylinositol 3-Kinase and Its Downstream Signals in 3T3-L1 Adipocytes
A Takano, T Haruta, M Iwata, I Usui, T Uno, J Kawahara, E Ueno, T Sasaoka, M Kobayashi |
Diabetes | 2001 |
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A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo
VP Manchem, ID Goldfine, RA Kohanski, CP Cristobal, RT Lum, SR Schow, S Shi, WR Spevak, E Laborde, DK Toavs, HO Villar, MM Wick, MR Kozlowski |
Diabetes | 2001 |
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Phosphatidylinositol 3-Kinase and Ras/Mitogen-Activated Protein Kinase Signaling Pathways Are Required for the Regulation of 5-Aminolevulinate Synthase Gene Expression by Insulin
ME Scassa, AS Guberman, CL Varone, ET Cánepa |
Experimental Cell Research | 2001 |
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Insulin receptor antibodies inhibit insulin uptake by the liver: in vivo 123I-insulin scintigraphic scanning and in vitro characterization in autoimmune hypoglycemia
N Dozio, E Sarugeri, M Scavini, A Beretta, C Belloni, F Dosio, A Savi, F Fazio, F Sodoyez-Goffaux, G Pozza |
Journal of Investigative Medicine | 2001 |
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NEW INSIGHTS INTO INSULIN RESISTANCE PATHOPHYSIOLOGY: HOW IT AFFECTS GLUCOSE AND LIPID METABOLISM
V Col |
ACTA CLINICA BELGICA | 2001 |
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Insulin Induces Suppressor of Cytokine Signaling-3 Tyrosine Phosphorylation through Janus-activated Kinase
P Peraldi, C Filloux, B Emanuelli, DJ Hilton, EV Obberghen |
The Journal of biological chemistry | 2001 |
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Phosphorylation of Ser 307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action
V Aguirre, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White |
The Journal of biological chemistry | 2001 |
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Insulin Stimulates PKCζ-mediated Phosphorylation of Insulin Receptor Substrate-1 (IRS-1): A SELF-ATTENUATED MECHANISM TO NEGATIVELY REGULATE THE FUNCTION OF IRS PROTEINS
YF Liu, K Paz, A Herschkovitz, A Alt, T Tennenbaum, SR Sampson, M Ohba, T Kuroki, D LeRoith, Y Zick |
The Journal of biological chemistry | 2001 |
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Suppressors of Cytokine Signaling-1 and -6 Associate with and Inhibit the Insulin Receptor: A POTENTIAL MECHANISM FOR CYTOKINE-MEDIATED INSULIN RESISTANCE
RA Mooney, J Senn, S Cameron, N Inamdar, LM Boivin, Y Shang, RW Furlanetto |
The Journal of biological chemistry | 2001 |
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Are 5-Hydroxytryptamine-preloaded β-Cells an Appropriate Physiologic Model System for Establishing That Insulin Stimulates Insulin Secretion?
WS Zawalich, GJ Tesz, KC Zawalich |
The Journal of biological chemistry | 2001 |
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Insulin Induction of SOCS-2 and SOCS-3 mRNA Expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5 *
CL Sadowski, TS Choi, M Le, TT Wheeler, LH Wang, HB Sadowski |
The Journal of biological chemistry | 2001 |
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Insulin Signals to Prenyltransferases via the Shc Branch of Intracellular Signaling
ML Goalstone, JW Leitner, P Berhanu, PM Sharma, JM Olefsky, B Draznin |
The Journal of biological chemistry | 2001 |
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A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling
ZY Jiang, A Chawla, A Bose, M Way, MP Czech |
The Journal of biological chemistry | 2001 |
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Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2 −/− Mouse Liver
K Tobe, R Suzuki, M Aoyama, T Yamauchi, J Kamon, N Kubota, Y Terauchi, J Matsui, Y Akanuma, S Kimura, J Tanaka, M Abe, J Ohsumi, R Nagai, T Kadowaki |
The Journal of biological chemistry | 2001 |
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Insulin Receptor Substrate-2 Phosphorylation Is Necessary for Protein Kinase Cζ Activation by Insulin in L6hIR Cells
F Oriente, P Formisano, C Miele, F Fiory, MA Maitan, G Vigliotta, A Trencia, S Santopietro, M Caruso, EV Obberghen, F Beguinot |
The Journal of biological chemistry | 2001 |
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Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts
R Conejo, M Lorenzo |
Journal of Cellular Physiology | 2001 |
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Mechanisms of Hepatic Very Low-Density Lipoprotein Overproduction in Insulin Resistance
K Adeli, C Taghibiglou, SC van Iderstine, GF Lewis |
Trends in Cardiovascular Medicine | 2001 |
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Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport
M Yu, E Blomstrand, AV Chibalin, H Wallberg-Henriksson, JR Zierath, A Krook |
Journal of applied physiology | 2001 |
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Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training
JF Youngren, S Keen, JL Kulp, CJ Tanner, JA Houmard, ID Goldfine |
American journal of physiology. Endocrinology and metabolism | 2001 |
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Impaired PI 3-kinase activation in adipocytes from early growth-restricted male rats
SE Ozanne, MW Dorling, CL Wang, BT Nave |
American journal of physiology. Endocrinology and metabolism | 2001 |
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Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)
A Dunaif, X Wu, A Lee, E Diamanti-Kandarakis |
American journal of physiology. Endocrinology and metabolism | 2001 |
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Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes
J Kang, E Heart, CK Sung |
American journal of physiology. Endocrinology and metabolism | 2001 |
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TNF-α inhibits flow and insulin signaling leading to NO production in aortic endothelial cells
F Kim, B Gallis, MA Corson |
American journal of physiology. Cell physiology | 2001 |
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Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
G Sesti, M Federici, ML Hribal, DA Lauro, P Sbraccia, R Lauro |
The FASEB Journal | 2001 |
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Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes
M Buyse, S VIENGCHAREUN, A Bado, M Lombès |
The FASEB Journal | 2001 |
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Metabolic programming in animals
SE Ozanne |
British Medical Bulletin | 2001 |
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Obesity, Body Fat Distribution, Insulin Sensitivity and Islet β-Cell Function as Explanations for Metabolic Diversity
SE Kahn, RL Prigeon, RS Schwartz, WY Fujimoto, RH Knopp, JD Brunzell, D Porte |
The Journal of nutrition | 2001 |
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Molecular Basis of Pancreas Development and Function
JF Habener, MA Hussain |
2001 | |
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Glucose-Dependent Insulinotropic Polypeptide Is a Growth Factor for β (INS-1) Cells by Pleiotropic Signaling
A Trümper, K Trümper, H Trusheim, R Arnold, B Göke, D Hörsch |
Molecular Endocrinology | 2001 |
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Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5′-Phosphatase Catalytic Activity
T Wada, T Sasaoka, M Funaki, H Hori, S Murakami, M Ishiki, T Haruta, T Asano, W Ogawa, H Ishihara, M Kobayashi |
Molecular and cellular biology | 2001 |
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Effects of Age on Elements of Insulin-Signaling Pathway in Central Nervous System of Rats
ML de L. A. Fernandes, MJ Saad, LA Velloso |
Endocrine | 2001 |
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Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK)
J C Byon, S S Dadke, S Rulli, A B Kusari, J Kusari |
Molecular and Cellular Biochemistry | 2001 |
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Physiologic and Molecular Alterations in Carbohydrate Metabolism During Pregnancy and Gestational Diabetes Mellitus
H Yamashita, J Shao, JE Friedman |
Clinical Obstetrics and Gynecology | 2000 |
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Insulin receptor substrate polymorphisms and Type 2 diabetes mellitus
G Sesti |
Pharmacogenomics | 2000 |
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Coordinate control of muscle cell survival by distinct insulin-like growth factor activated signaling pathways
MA Lawlor, P Rotwein |
The Journal of Cell Biology | 2000 |
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Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors
AW Lee, DJ States |
Molecular and cellular biology | 2000 |
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Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene
JC Bruning, JA Gillette, Y Zhao, C Bjorbaeck, J Kotzka, B Knebel, H Avci, B Hanstein, P Lingohr, DE Moller, W Krone, CR Kahn, D Muller-Wieland |
Proceedings of the National Academy of Sciences | 2000 |
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Molecular mechanisms of contraction-regulated cardiac glucose transport
M Till, DM Ouwens, A Kessler, J Eckel |
Biochemical Journal | 2000 |
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Preoperative feeding does not reverse postoperative insulin resistance in skeletal muscle in the rat
L Strömmer, B Isaksson, U Arnelo, I Lundkvist, CG Östenson, M Wickbom, M Herrington, J Permert |
Metabolism | 2000 |
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Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
I Shimomura, M Matsuda, RE Hammer, Y Bashmakov, MS Brown, JL Goldstein |
Molecular Cell | 2000 |
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Integrative Mitogenic Role of Protein Kinase B/Akt in β-Cells
K Trümper, A Trümper, H Trusheim, R Arnold, B Göke, D Hörsch |
Annals of the New York Academy of Sciences | 2000 |
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Insulin Resistance with Aging: Effects of Diet and Exercise
AS Ryan |
Sports Medicine | 2000 |
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Bradykinin enhances insulin receptor tyrosine kinase in 32D cells reconstituted with bradykinin and insulin signaling pathways
H Motoshima, E Araki, T Nishiyama, T Taguchi, K Kaneko, Y Hirashima, K Yoshizato, A Shirakami, K Sakai, J Kawashima, T Shirotani, H Kishikawa, M Shichiri |
Diabetes Research and Clinical Practice | 2000 |
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Dysregulation of IRS-proteins causes insulin resistance and diabetes:
V Aguirre, MF White |
Current Opinion in Endocrinology & Diabetes | 2000 |
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Complexes Formation between Insulin Receptor and Extracellular Signal-Regulated Kinases ERKs
YL Lin, C Mettling, CK Chou |
Molecular Cell Biology Research Communications | 2000 |
|
Insulin produces myogenesis in C2C12 myoblasts by induction of NF-?B and downregulation of AP-1 activities
R Conejo, AM Valverde, M Benito, M Lorenzo |
Journal of Cellular Physiology | 2000 |
|
Dietary fibre, lente carbohydrates and the insulin-resistant diseases
DJ Jenkins, M Axelsen, CW Kendall, LS Augustin, V Vuksan, U Smith |
British Journal of Nutrition | 2000 |
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Cross talk of pp125(FAK) and pp59(Lyn) non-receptor tyrosine kinases to insulin-mimetic signaling in adipocytes
G Müller, S Wied, W Frick |
Molecular and cellular biology | 2000 |
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Cross Talk of pp125FAK and pp59Lyn Non-Receptor Tyrosine Kinases to Insulin-Mimetic Signaling in Adipocytes
G Müller, S Wied, W Frick |
Molecular and cellular biology | 2000 |
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Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control
S Parpal, M Karlsson, H Thorn, P Strålfors |
The Journal of biological chemistry | 2000 |
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SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling
B Emanuelli, P Peraldi, C Filloux, D Sawka-Verhelle, D Hilton, EV Obberghen |
The Journal of biological chemistry | 2000 |
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Increased Insulin Receptor Substrate-1 and Enhanced Skeletal Muscle Insulin Sensitivity in Mice Lacking CCAAT/Enhancer-binding Protein β
LQ Wang, J Shao, P Muhlenkamp, S Liu, P Klepcyk, J Ren, JE Friedman |
The Journal of biological chemistry | 2000 |
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Identification of Shc as the Primary Protein Binding to the Tyrosine-phosphorylated β 3 Subunit of α IIb β 3 during Outside-in Integrin Platelet Signaling
KJ Cowan, DA Law, DR Phillips |
The Journal of biological chemistry | 2000 |
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The c-Jun NH 2 -terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser 307
V Aguirre, T Uchida, L Yenush, R Davis, MF White |
The Journal of biological chemistry | 2000 |
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Signalling aspects of insulin resistance in skeletal muscle
C Schmitz-Peiffer |
Cellular Signalling | 2000 |
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Insulin-Mediated Cellular Insulin Resistance Decreases Osmotic Shock-Induced Glucose Transport in 3T3-L1 Adipocytes**This work was supported by NIH Grant DK-33651 and the Veterans Administration Medical Research Service. Andrej Janez was supported by a grant from Slovenian Ministry of Science and Technology (sklad za mlade raziskovalce)
A Janez, DS Worrall, JM Olefsky |
Endocrinology | 2000 |
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Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit
K Ueki, P Algenstaedt, F Mauvais-Jarvis, CR Kahn |
Molecular and cellular biology | 2000 |
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Both Src-Dependent and -Independent Mechanisms Mediate Phosphatidylinositol 3-Kinase Regulation of Colony-Stimulating Factor 1-Activated Mitogen-Activated Protein Kinases in Myeloid Progenitors
AW Lee, DJ States |
Molecular and cellular biology | 2000 |
|
Cross Talk of pp125 FAK and pp59 Lyn Non-Receptor Tyrosine Kinases to Insulin-Mimetic Signaling in Adipocytes
G Müller, S Wied, W Frick |
Molecular and cellular biology | 2000 |
|
Protein kinases as therapeutic targets
R Sridhar, O Hanson-Painton, D R Cooper |
Pharmaceutical Research | 2000 |
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IGF and insulin action in the mammary gland: lessons from transgenic and knockout models
D L Hadsell, S G Bonnette |
Journal of Mammary Gland Biology and Neoplasia | 2000 |
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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells
H Ishihara, H Wang, LR Drewes, CB Wollheim |
Journal of Clinical Investigation | 1999 |
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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
I Shimomura, Y Bashmakov, S Ikemoto, JD Horton, MS Brown, JL Goldstein |
Proceedings of the National Academy of Sciences | 1999 |
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ADD-1 provides major new insight into the mechanism of insulin action
JS Flier, AN Hollenberg |
Proceedings of the National Academy of Sciences | 1999 |
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Role of protein tyrosine phosphatase-1B in diabetes and obesity
BP Kennedy |
Biomedicine & Pharmacotherapy | 1999 |
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Apoptosis in the rat brown adipose tissue after insulin treatment
A Korać, J Radovanović, V Davidović, V Koko, M Nedeljković |
Journal of Thermal Biology | 1999 |
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Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications
JF Wojtaszewski, J Lynge, AB Jakobsen, LJ Goodyear, EA Richter |
American journal of physiology. Endocrinology and metabolism | 1999 |
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Molecular Mysteries of Polycystic Ovary Syndrome
JF Strauss, A Dunaif |
Molecular Endocrinology | 1999 |
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International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |
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