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Elizabeth J. Parks, … , Richard A. Neese, Marc K. Hellerstein
Published October 15, 1999
Citation Information: J Clin Invest. 1999;104(8):1087-1096. https://doi.org/10.1172/JCI6572.
Citation Information: J Clin Invest. 1999;104(8):1087-1096. https://doi.org/10.1172/JCI6572.
Abstract
Low-fat, high-carbohydrate (LF/HC) diets commonly elevate plasma triglyceride (TG) concentrations, but the kinetic mechanisms responsible for this effect remain uncertain. Subjects with low TG (normolipidemic [NL]) and those with moderately elevated TG (hypertriglyceridemic [HTG]) were studied on both a control and an LF/HC diet. We measured VLDL particle and TG transport rates, plasma nonesterified fatty acid (NEFA) flux, and sources of fatty acids used for the assembly of VLDL-TG. The LF/HC diet resulted in a 60% elevation in TG, a 37% reduction in VLDL-TG clearance, and an 18% reduction in whole-body fat oxidation, but no significant change in VLDL-apo B or VLDL-TG secretion rates. Significant elevations in fasting apo B-48 concentrations were observed on the LF/HC in HTG subjects. In both groups, fasting de novo lipogenesis was low regardless of diet. The NEFA pool contributed the great majority of fatty acids to VLDL-TG in NL subjects on both diets, whereas in HTG subjects, the contribution of NEFA was somewhat lower overall and was reduced further in individuals on the LF/HC diet. Between 13% and 29% of VLDL-TG fatty acids remained unaccounted for by the sum of de novo lipogenesis and plasma NEFA input in HTG subjects. We conclude that (a) whole-food LF/HC diets reduce VLDL-TG clearance and do not increase VLDL-TG secretion or de novo lipogenesis; (b) sources of fatty acids for assembly of VLDL-TG differ between HTG and NL subjects and are further affected by diet composition; (c) the presence of chylomicron remnants in the fasting state on LF/HC diets may contribute to elevated TG levels by competing for VLDL-TG lipolysis and by providing a source of fatty acids for hepatic VLDL-TG synthesis; and (d) the assembly, production, and clearance of elevated plasma VLDL-TG in response to LF/HC diets therefore differ from those for elevated TG on higher-fat diets.
Authors
Elizabeth J. Parks, Ronald M. Krauss, Mark P. Christiansen, Richard A. Neese, Marc K. Hellerstein
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Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass
B Knebel, J Haas, S Hartwig, S Jacob, C Köllmer, U Nitzgen, D MullerWieland, J Kotzka, SK Ahuja |
PloS one | 2012 |
|
Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates
V Vaidyanathan, RA Bastarrachea, PB Higgins, VS Voruganti, S Kamath, NV DiPatrizio, D Piomelli, AG Comuzzie, EJ Parks |
American journal of physiology. Endocrinology and metabolism | 2012 |
|
Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity
MA Ramos-Roman, L Sweetman, MJ Valdez, EJ Parks |
Metabolism | 2011 |
|
Protocol for the measurement of fatty acid and glycerol turnover in vivo in baboons[S]
RA Bastarrachea, SM Veron, V Vaidyanathan, M Garcia-Forey, VS Voruganti, PB Higgins, EJ Parks |
Journal of lipid research | 2011 |
|
Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?
AP Jensen-Urstad, CF Semenkovich |
Biochimica et Biophysica Acta | 2011 |
|
Is Fructose a Story of Mice but Not Men?
JL Sievenpiper, RJ de Souza, CW Kendall, DJ Jenkins |
Journal of the American Dietetic Association | 2011 |
|
Effect of short-term low- and high-fat diets on low-density lipoprotein particle size in normolipidemic subjects
V Guay, B Lamarche, A Charest, AJ Tremblay, P Couture |
Metabolism | 2011 |
|
Author's Response
RH Lustig |
Journal of the American Dietetic Association | 2011 |
|
Dietary protein restriction induces steatohepatitis and alters leptin/signal transducers and activators of transcription 3 signaling in lactating rats
DH Kwon, W Kang, YS Nam, MS Lee, IY Lee, HJ Kim, P Rajasekar, JH Lee, M Baik |
The Journal of Nutritional Biochemistry | 2011 |
|
Hypoglycemia: A Possible Link between Insulin Resistance, Metabolic Dyslipidemia, and Heart and Kidney Disease (the Cardiorenal Syndrome)
M Ensling, W Steinmann, A Whaley-Connell |
Cardiorenal Medicine | 2011 |
|
Dietary Carbohydrate Modifies the Inverse Association Between Saturated Fat Intake and Cholesterol on Very Low-Density Lipoproteins
AC Wood, EK Kabagambe, IB Borecki, HK Tiwari, JM Ordovas, DK Arnett |
Lipid insights | 2011 |
|
A High Fat Diet and theThr54 polymorphism of FABP2 Reduces Plasma Triglyceride-Rich Lipoproteins
SP McColley, A Georgopoulos, LR Young, MS Kurzer, JB Redmon, SK Raatz |
Nutrition research (New York, N.Y.) | 2011 |
|
Effect of dietary energy source on deposition and fatty acid synthesis in the liver of the laying hen
JW Zhang, DW Chen, B Yu, YM Wang |
British Poultry Science | 2011 |
|
Authors' Response
RH Lustig, JM Schwarz |
Journal of the American Dietetic Association | 2011 |
|
Protocol for the measurement of fatty acid and glycerol turnover in vivo in baboons
RA Bastarrachea, SM Veron, V Vaidyanathan, M Garcia-Forey, VS Voruganti, PB Higgins, EJ Parks |
Journal of lipid research | 2011 |
|
Dietary Carbohydrate Modifies the Inverse Association between Saturated Fat Intake and Cholesterol on Very Low-Density Lipoproteins
AC Wood, EK Kabagambe, IB Borecki, HK Tiwari, JM Ordovas, DK Arnett |
Lipid insights | 2011 |
|
Gut-liver interaction in triglyceride-rich lipoprotein metabolism
C Xiao, J Hsieh, K Adeli, GF Lewis |
American journal of physiology. Endocrinology and metabolism | 2011 |
|
Oxidation of Dietary Stearic, Oleic, and Linoleic Acids in Growing Pigs Follows a Biphasic Pattern
E Bruininx, J van den Borne, E van Heugten, J van Milgen, M Verstegen, W Gerrits |
The Journal of nutrition | 2011 |
|
Dynamics of fat absorption and impact of sham feeding on postprandial lipema
RN Chavez-Jauregui, RD Mattes, EJ Parks |
Gastroenterology | 2010 |
|
High-Carbohydrate Diet Selectively Induces Tumor Necrosis Factor-α Production in Mice Liver
AV Ferreira, ÉG Mario, LC Porto, SP Andrade, LM Botion |
Inflammation | 2010 |
|
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease
J Westerbacka, A Kotronen, BA Fielding, J Wahren, L Hodson, J Perttilä, T Seppänen-Laakso, T Suortti, J Arola, R Hultcrantz, S Castillo, VM Olkkonen, KN Frayn, M Orešič, H Yki-Järvinen |
Gastroenterology | 2010 |
|
Trafficking and partitioning of fatty acids: the transition from fasted to fed state
L Hodson, BA Fielding |
Clinical Lipidology | 2010 |
|
Lifestyle Intervention Leading to Moderate Weight Loss Normalizes Postprandial Triacylglycerolemia Despite Persisting Obesity
MI Maraki, N Aggelopoulou, N Christodoulou, CA Anastasiou, M Toutouza, DB Panagiotakos, SA Kavouras, F Magkos, LS Sidossis |
Obesity | 2010 |
|
Effects of energy balance on postprandial triacylglycerol metabolism
M Maraki, LS Sidossis |
Current Opinion in Clinical Nutrition and Metabolic Care | 2010 |
|
Long-TE 1H MRS suggests that liver fat is more saturated than subcutaneous and visceral fat
J Lundbom, A Hakkarainen, S Söderlund, J Westerbacka, N Lundbom, MR Taskinen |
NMR in Biomedicine | 2010 |
|
Preliminary post-prandial studies of Burmese cats with elevated triglyceride concentrations and/or presumed lipid aqueous
EK Kluger, M Caslake, RM Baral, R Malik, M Govendir |
Journal of Feline Medicine & Surgery | 2010 |
|
Preliminary post-prandial studies of Burmese cats with elevated triglyceride concentrations and/or presumed lipid aqueous.
Kluger EK, Caslake M, Baral RM, Malik R, Govendir M |
Journal of feline medicine and surgery | 2010 |
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Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis
MK Pickens, JS Yan, RK Ng, H Ogata, JP Grenert, C Beysen, SM Turner, JJ Maher |
Journal of lipid research | 2009 |
|
Heterogeneous effects of fructose on blood lipids in individuals with type 2 diabetes: systematic review and meta-analysis of experimental trials in humans
JL Sievenpiper, AJ Carleton, S Chatha, HY Jiang, RJ de Souza, J Beyene, CW Kendall, DJ Jenkins |
Diabetes care | 2009 |
|
Frontiers in Neuroscience
K Panickar, S Bhathena |
Fat Detection | 2009 |
|
Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humansin vivo
F Magkos, B Mittendorfer |
Clinical Lipidology | 2009 |
|
The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?
PJ Babin, GF Gibbons |
Progress in Lipid Research | 2009 |
|
Effects of Dietary Coconut Oil on the Biochemical and Anthropometric Profiles of Women Presenting Abdominal Obesity
ML Assunção, HS Ferreira, AF Santos, CR Cabral, TM Florêncio |
Lipids | 2009 |
|
The potential role of the intestinal gut microbiota in obesity and the metabolic syndrome
F Fava, JA Lovegrove, KM Tuohy, GR Gibson |
Food Science & Technology Bulletin: Functional Foods | 2009 |
|
Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo
F Magkos, B Mittendorfer |
Clinical Lipidology | 2009 |
|
Comparison of time course changes in blood glucose, insulin and lipids between high carbohydrate and high fat meals in healthy young women
Y Shin, S Park, R Choue |
Nutrition Research and Practice | 2009 |
|
Associations between dietary macronutrient intake and plasma lipids demonstrate criterion performance of the Multi-Ethnic Study of Atherosclerosis (MESA) food-frequency questionnaire
JA Nettleton, CL Rock, Y Wang, NS Jenny, DR Jacobs |
The British journal of nutrition | 2009 |
|
The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease
CJ North, CS Venter, JC Jerling |
European Journal of Clinical Nutrition | 2009 |
|
Effects of low-fat and low-GI diets on health
TA Apekey, AJ Morris, S Fagbemi, GJ Griffiths |
Nutrition & Food Science | 2009 |
|
Bidis — hand-rolled, Indian cigarettes: Induced biochemical changes in plasma and red cell membranes of human male volunteers
P Padmavathi, VD Reddy, M Narendra, N Varadacharyulu |
Clinical Biochemistry | 2009 |
|
Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis
MK Pickens, JS Yan, RK Ng, H Ogata, JP Grenert, C Beysen, SM Turner, JJ Maher |
Journal of lipid research | 2009 |
|
Effects of Dietary Coconut Oil on the Biochemical and Anthropometric Profiles of Women Presenting Abdominal Obesity
ML Assunção, HS Ferreira, AF dos Santos, CR Cabral, TM Florêncio |
Lipids | 2009 |
|
The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects
LC Hudgins, A Baday, MK Hellerstein, TS Parker, DM Levine, CE Seidman, RA Neese, JD Tremaroli, J Hirsch |
The Journal of Nutritional Biochemistry | 2008 |
|
Sex-specific interaction between APOE genotype and carbohydrate intake affects plasma HDL-C levels: the Strong Heart Family Study
MJ Mosher, LA Lange, BV Howard, ET Lee, LG Best, RR Fabsitz, JW Maccluer, KE North |
Genes & Nutrition | 2008 |
|
Fatty liver, insulin resistance, and dyslipidemia
M Adiels, MR Taskinen, J Borén |
Current Diabetes Reports | 2008 |
|
Dietary sugars stimulate fatty acid synthesis in adults
EJ Parks, LE Skokan, MT Timlin, CS Dingfelder |
The Journal of nutrition | 2008 |
|
Dietary monounsaturated fat activates metabolic pathways for triglyceride-rich lipoproteins that involve apolipoproteins E and C-III
C Zheng, C Khoo, J Furtado, K Ikewaki, FM Sacks |
The American journal of clinical nutrition | 2008 |
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Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin
CE Smith, KL Tucker, N Yiannakouris, B Garcia-Bailo, J Mattei, CQ Lai, LD Parnell, JM Ordovás |
The Journal of nutrition | 2008 |
|
Moderate protein intake improves total and regional body composition and insulin sensitivity in overweight adults
PJ Arciero, CL Gentile, R Pressman, M Everett, MJ Ormsbee, J Martin, J Santamore, L Gorman, PC Fehling, MD Vukovich, BC Nindl |
Metabolism | 2008 |
|
Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice
MB Diaz, A Krones-Herzig, D Metzger, A Ziegler, A Vegiopoulos, M Klingenspor, K Müller-Decker, S Herzig |
Hepatology | 2008 |
|
Reduced oxidation of dietary fat after a short term high-carbohydrate diet
R Roberts, AS Bickerton, BA Fielding, EE Blaak, AJ Wagenmakers, MF Chong, M Gilbert, F Karpe, KN Frayn |
The American journal of clinical nutrition | 2008 |
|
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding
MF Chong, L Hodson, AS Bickerton, R Roberts, M Neville, F Karpe, KN Frayn, BA Fielding |
The American journal of clinical nutrition | 2008 |
|
Lipid Metabolism in Diet-Induced Obese Rabbits Is Similar to That of Obese Humans
X Zhang, DL Chinkes, A Aarsland, DN Herndon, RR Wolfe |
The Journal of nutrition | 2008 |
|
The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state
L Hodson, AS Bickerton, SE McQuaid, R Roberts, F Karpe, KN Frayn, BA Fielding |
Diabetes | 2007 |
|
Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis
MF Chong, BA Fielding, KN Frayn |
Proceedings of the Nutrition Society | 2007 |
|
Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism
J Lopez-Miranda, C Williams, D Lairon |
British Journal of Nutrition | 2007 |
|
Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats
O Hussein, M Grosovski, E Lasri, S Svalb, U Ravid, N Assy |
World journal of gastroenterology : WJG | 2007 |
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Dietas hiperglicídicas: efeitos da substituição isoenergética de gordura por carboidratos sobre o metabolismo de lipídios, adiposidade corporal e sua associação com atividade física e com o risco de doença cardiovascular
VO Polacow, AH Lancha |
Arquivos brasileiros de endocrinologia e metabologia | 2007 |
|
Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state
RB Heath, F Karpe, RW Milne, GC Burdge, SA Wootton, KN Frayn |
American journal of physiology. Endocrinology and metabolism | 2007 |
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Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions
JL Gardner, SM Turner, A Bautista, G Lindwall, M Awada, MK Hellerstein |
AJP Gastrointestinal and Liver Physiology | 2007 |
|
A Combination of Caffeine, Arginine, Soy Isoflavones, and l-Carnitine Enhances Both Lipolysis and Fatty Acid Oxidation in 3T3-L1 and HepG2 Cells in Vitro and in KK Mice in Vivo
S Murosaki, TR Lee, K Muroyama, ES Shin, SY Cho, Y Yamamoto, SJ Lee |
The Journal of nutrition | 2007 |
|
Carbohydrates in Food, Second Edition
C Edwards, A Parrett, S Khanna |
Carbohydrates in Food, Second Edition | 2006 |
|
Very Low-Carbohydrate versus Isocaloric High-Carbohydrate Diet in Dietary Obese Rats*
KV Axen, K Axen |
Obesity | 2006 |
|
The role of exercise in modulating the impact of an ultralow-fat diet on serum lipids and apolipoproteins in patients with or at risk for coronary artery disease
DA Marshall, MN Vernalis, AT Remaley, EM Walizer, JP Scally, AJ Taylor |
American Heart Journal | 2006 |
|
Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans
A Vedala, W Wang, RA Neese, MP Christiansen, MK Hellerstein |
Journal of lipid research | 2006 |
|
L-Rhamnose and Lactulose Decrease Serum Triacylglycerols and Their Rates of Synthesis, but Do Not Affect Serum Cholesterol Concentrations in Men
JA Vogt, KB Ishii-Schrade, PB Pencharz, PJ Jones, TM Wolever |
The Journal of nutrition | 2006 |
|
Sesame Ingestion Affects Sex Hormones, Antioxidant Status, and Blood Lipids in Postmenopausal Women
WH Wu, YP Kang, NH Wang, HJ Jou, TA Wang |
The Journal of nutrition | 2006 |
|
Sources of Fatty Acids Stored in Liver and Secreted via Lipoproteins in Patients with Nonalcoholic Fatty Liver Disease
Kerry Donnelly Peterson, Coleman I. Smith, Sarah J. Schwarzenberg, Jose Jessurun, Mark D. Boldt, Elizabeth J. Parks |
Journal of Clinical Investigation | 2005 |
|
The Spot 14 protein is required for de novo lipid synthesis in the lactating mammary gland
Q Zhu, GW Anderson, GT Mucha, EJ Parks, JK Metkowski, CN Mariash |
Endocrinology | 2005 |
|
Lipid Metabolism and Health
S Navare, P Thompson |
Lipid Metabolism and Health | 2005 |
|
Influence of dietary carbohydrate and fat on LDL and HDL particle distributions
PW Siri, RM Krauss |
Current Atherosclerosis Reports | 2005 |
|
Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction
JS Volek, RD Feinman |
Nutrition & Metabolism | 2005 |
|
Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids
T Reinehr, W Kiess, W Andler |
Metabolism | 2005 |
|
Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men
MT Timlin, BR Barrows, EJ Parks |
Diabetes | 2005 |
|
Spillover of Dietary Fatty Acids and Use of Serum Nonesterified Fatty Acids for the Synthesis of VLDL-Triacylglycerol Under Two Different Feeding Regimens
BR Barrows, MT Timlin, EJ Parks |
Diabetes | 2005 |
|
Hyperglycemia, Lipoprotein Glycation, and Vascular Disease
A Veiraiah |
Angiology | 2005 |
|
Investigation of in vivo fatty acid metabolism in AFABP/aP2 −/− mice
RA Baar, CS Dingfelder, LA Smith, DA Bernlohr, C Wu, AJ Lange, EJ Parks |
American journal of physiology. Endocrinology and metabolism | 2005 |
|
Temporal pattern of de novo lipogenesis in the postprandial state in healthy men
MT Timlin, EJ Parks |
The American journal of clinical nutrition | 2005 |
|
Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women
M Noakes, JB Keogh, PR Foster, PM Clifton |
The American journal of clinical nutrition | 2005 |
|
A mathematical model of fatty acid metabolism and VLDL assembly in human liver
PR Shorten, GC Upreti |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2005 |
|
Measuring very low density lipoprotein-triglyceride kinetics in man in vivo: how different the various methods really are
F Magkos, LS Sidossis |
Current Opinion in Clinical Nutrition and Metabolic Care | 2004 |
|
Stable isotope tracer dilution for quantifying very low-density lipoprotein-triacylglycerol kinetics in man
LS Sidossis, F Magkos, B Mittendorfer, RR Wolfe |
Clinical Nutrition | 2004 |
|
Effect of Low and High Fat Diets on Nutrient Intakes and Selected Cardiovascular Risk Factors in Sedentary Men and Women
K Meksawan, DR Pendergast, JJ Leddy, M Mason, PJ Horvath, AB Awad |
Journal of the American College of Nutrition | 2004 |
|
An elevation of triglycerides reflecting decreased triglyceride clearance may not be pathogenic – relevance to high-carbohydrate diets
MF McCarty |
Medical Hypotheses | 2004 |
|
Regulation of Hepatic Apolipoprotein B-lipoprotein Assembly and Secretion by the Availability of Fatty Acids: I. DIFFERENTIAL RESPONSE TO THE DELIVERY OF FATTY ACIDS VIA ALBUMIN OR REMNANT-LIKE EMULSION PARTICLES
YL Zhang, A Hernandez-Ono, C Ko, K Yasunaga, LS Huang, HN Ginsberg |
The Journal of biological chemistry | 2004 |
|
Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians
K Shiwaku, M Hashimoto, K Kitajima, A Nogi, E Anuurad, B Enkhmaa, JM Kim, IS Kim, SK Lee, T Oyunsuren, O Shido, Y Yamane |
Journal of lipid research | 2004 |
|
Concept of fat balance in human obesity revisited with particular reference to de novo lipogenesis
Y Schutz |
International Journal of Obesity | 2004 |
|
Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans
K Minehira, N Vega, H Vidal, K Acheson, L Tappy |
International Journal of Obesity | 2004 |
|
Higher dietary carbohydrate content during intensified running training results in better maintenance of performance and mood state
J Achten, SL Halson, L Moseley, MP Rayson, A Casey, AE Jeukendrup |
Journal of applied physiology | 2004 |
|
Increased Lipogenesis and Fatty Acid Reesterification Contribute to Hepatic Triacylglycerol Stores in Hyperlipidemic Txnip−/− Mice
KL Donnelly, MR Margosian, SS Sheth, AJ Lusis, EJ Parks |
The Journal of nutrition | 2004 |
|
PPARdelta is a very low-density lipoprotein sensor in macrophages
A Chawla, CH Lee, Y Barak, W He, J Rosenfeld, D Liao, J Han, H Kang, RM Evans |
Proceedings of the National Academy of Sciences | 2003 |
|
Effect of sex and obesity on basal VLDL-triacylglycerol kinetics
S Klein, RR Wolfe |
Journal of Clinical Investigation | 2003 |
|
Nutrition and Heart Disease
A R.P.Walker |
Nutrition and Heart Disease | 2003 |
|
INVIVOMEASUREMENT OFFLUXES THROUGHMETABOLICPATHWAYS: The Missing Link in Functional Genomics and Pharmaceutical Research
MK Hellerstein |
Annual Review of Nutrition | 2003 |
|
Postprandial lipemia and cardiovascular disease
D Hyson, JC Rutledge, L Berglund |
Current Atherosclerosis Reports | 2003 |
|
Hyperphagia modifies FA profiles of plasma phospholipids, plasma FFA, and adipose tissue TAG
GV Skuladottir, PI Olason, L Jonsson, JO Skarphedinsson, VH Eriksdottir, PT Atlason, L Franzson, HB Schiöth |
Lipids | 2003 |
|
Effect of isoenergetic low- and high-carbohydrate diets on substrate kinetics and oxidation in healthy men
C Koutsari, LS Sidossis |
British Journal of Nutrition | 2003 |
|
The effect of fiber-rich carbohydrates on features of Syndrome X
BM Davy, CL Melby |
Journal of the American Dietetic Association | 2003 |
|
Effect of sex and obesity on basal VLDL-triacylglycerol kinetics
S Klein, RR Wolfe |
Journal of Clinical Investigation | 2003 |
|
Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
K Promrat, G Lutchman, GI Uwaifo, RJ Freedman, A Soza, T Heller, E Doo, M Ghany, A Premkumar, Y Park, TJ Liang, JA Yanovski, DE Kleiner, JH Hoofnagle |
The American journal of clinical nutrition | 2003 |
|
Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans
D Letexier, F Diraison, M Beylot |
The American journal of clinical nutrition | 2003 |
|
Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition
C Bouclaous, N Torbay, C Nassar, NH (Baba) |
Nutrition Research | 2003 |
|
Does postprandial storage of triglycerides in endothelial cells contribute to the endothelial dysfunction associated with insulin resistance and fatty diets?
MF McCarty |
Medical Hypotheses | 2003 |
|
Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity
B Mittendorfer, BW Patterson, S Klein |
American journal of physiology. Endocrinology and metabolism | 2003 |
|
VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity
B Mittendorfer, BW Patterson, S Klein, LS Sidossis |
American journal of physiology. Endocrinology and metabolism | 2003 |
|
Exercise and postprandial lipid metabolism: an update on potential mechanisms and interactions with high-carbohydrate diets (review)
JM Gill, AE Hardman |
The Journal of Nutritional Biochemistry | 2003 |
|
Effects of dietary carbohydrate on the development of obesity in heterozygous Zucker rats
KL Morris, TC Namey, MB Zemel |
The Journal of Nutritional Biochemistry | 2003 |
|
Sugars, hypertriglyceridemia, and cardiovascular disease
SK Fried, SP Rao |
The American journal of clinical nutrition | 2003 |
|
Whole-body fat oxidation rate and plasma triacylglycerol concentrations in men consuming an ad libitum high-carbohydrate or low-carbohydrate diet
N Landry, N Bergeron, R Archer, P Samson, L Corneau, J Bergeron, O Dériaz |
The American journal of clinical nutrition | 2003 |
|
Changes in fat synthesis influenced by dietary macronutrient content
EJ Parks |
Proceedings of the Nutrition Society | 2002 |
|
Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk
MK Hellerstein |
Current Opinion in Lipidology | 2002 |
|
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
GF Lewis, A Carpentier, K Adeli, A Giacca |
Endocrine reviews | 2002 |
|
Sensitivity to acute insulin-mediated suppression of plasma free fatty acids is not a determinant of fasting VLDL triglyceride secretion in healthy humans
A Carpentier, BW Patterson, N Leung, GF Lewis |
Diabetes | 2002 |
|
Fatty liver in familial hypobetalipoproteinemia: triglyceride assembly into VLDL particles is affected by the extent of hepatic steatosis
G Schonfeld, BW Patterson, DA Yablonskiy, TS Tanoli, M Averna, N Elias, P Yue, J Ackerman |
Journal of lipid research | 2002 |
|
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
AD Attie, RM Krauss, MP Gray-Keller, A Brownlie, M Miyazaki, JJ Kastelein, AJ Lusis, AF Stalenhoef, JP Stoehr, MR Hayden, JM Ntambi |
Journal of lipid research | 2002 |
|
High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men
BM Davy, KP Davy, RC Ho, SD Beske, LR Davrath, CL Melby |
The American journal of clinical nutrition | 2002 |
|
Extended effects of evening meal carbohydrate-to-fat ratio on fasting and postprandial substrate metabolism
MD Robertson, RA Henderson, GE Vist, RD Rumsey |
The American journal of clinical nutrition | 2002 |
|
Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover
BW Patterson, B Mittendorfer, N Elias, R Satyanarayana, S Klein |
Journal of lipid research | 2002 |
|
A Practical Approach to the Dietary Treatment of Hypertriglyceridemia
WM Mueller-Cunningham, D Hyson |
Preventive Cardiology | 2001 |
|
Exercise prevents the augmentation of postprandial lipaemia attributable to a low-fat high-carbohydrate diet
C Koustsair, AE Hardman |
British Journal of Nutrition | 2001 |
|
Coconut fat and serum lipoproteins: effects of partial replacement with unsaturated fats
S Mendis, U Samarajeewa, RO Thattil |
British Journal of Nutrition | 2001 |
|
Effects of Monounsaturated Enriched Sunflower Oil on CHD Risk Factors Including LDL Size and Copper-Induced LDL Oxidation
EL Ashton, JD Best, MJ Ball |
Journal of the American College of Nutrition | 2001 |
|
Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism
C Vidon, P Boucher, A Cachefo, O Peroni, F Diraison, M Beylot |
The American journal of clinical nutrition | 2001 |
|
Effect of nicotinic acid administration on hepatic very low density lipoprotein-triglyceride production
W Wang, A Basinger, RA Neese, B Shane, SA Myong, M Christiansen, MK Hellerstein |
American journal of physiology. Endocrinology and metabolism | 2001 |
|
Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short-term, high-carbohydrate diets
B Mittendorfer, LS Sidossis |
The American journal of clinical nutrition | 2001 |
|
High density lipoprotein cholesteryl ester metabolism in the pony, an animal species without plasma cholesteryl ester transfer protein activity: transfer of high density lipoprotein cholesteryl esters to lower density lipoproteins and the effect of the amount of fat in the diet
SN Geelen, AG Lemmens, AH Terpstra, T Wensing, AC Beynen |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 2001 |
|
Acute Hyperinsulinism Modulates Plasma Apolipoprotein B-48 Triglyceride--Rich Lipoproteins in Healthy Subjects During the Postprandial Period
A Harbis, C Defoort, H Narbonne, C Juhel, M Senft, C Latge, B Delenne, H Portugal, C Atlan-Gepner, B Vialettes, D Lairon |
Diabetes | 2001 |
|
Low-fat diet alters intramuscular substrates and reduces lipolysis and fat oxidation during exercise
EF Coyle, AE Jeukendrup, MC Oseto, BJ Hodgkinson, TW Zderic |
American journal of physiology. Endocrinology and metabolism | 2001 |
|
Effects of different nutrient intakes on daytime triacylglycerolemia in healthy, normolipemic, free-living men
JP van Wijk, MC Cabezas, CJ Halkes, DW Erkelens |
The American journal of clinical nutrition | 2001 |
|
Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men
I Marques-Lopes, D Ansorena, I Astiasaran, L Forga, JA Martínez |
The American journal of clinical nutrition | 2001 |
|
Effect of Dietary Carbohydrate on Triglyceride Metabolism in Humans
EJ Parks |
The Journal of nutrition | 2001 |
|
Predictors of Plasma Triglyceride Elevation in Patients Participating in a Coronary Atherosclerosis Treatment Program:
EJ Parks, JC Rutledge, PA Davis, DA Hyson, BO Schneeman, CT Kappagoda |
Journal of Cardiopulmonary Rehabilitation | 2001 |
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Effect of High-Carbohydrate Feeding on Triglyceride and Saturated Fatty Acid Synthesis
LC Hudgins |
Proceedings of the Society for Experimental Biology and Medicine | 2000 |
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Dependence of plasma α-tocopherol flux on very low-density triglyceride clearance in humans
EJ Parks, D Dare, KB Frazier, MK Hellerstein, RA Neese, E Hughes, MG Traber |
Free radical biology & medicine | 2000 |
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One-Year Effects of Increasingly Fat-Restricted, Carbohydrate-Enriched Diets on Lipoprotein Levels in Free-Living Subjects
RH Knopp, B Retzlaff, C Walden, B Fish, B Buck, B McCann |
Proceedings of the Society for Experimental Biology and Medicine | 2000 |
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Low-fat, High-carbohydrate Diets and Atherogenic Risk
CL Baum, M Brown |
Nutrition Reviews | 2000 |
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Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
LC Hudgins, MK Hellerstein, CE Seidman, RA Neese, JD Tremaroli, J Hirsch |
Journal of lipid research | 2000 |
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Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms
EJ Parks, MK Hellerstein |
The American journal of clinical nutrition | 2000 |
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Carbohydrate-Induced Hypertriglyceridemia: An Insight into the Link between Plasma Insulin and Triglyceride Concentrations*
T McLaughlin, F Abbasi, C Lamendola, H Yeni-Komshian, G Reaven |
The Journal of clinical endocrinology and metabolism | 2000 |
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