Citations to this article

ATP11B mediates platinum resistance in ovarian cancer
Myrthala Moreno-Smith, … , Gabriel Lopez-Berestein, Anil K. Sood
Myrthala Moreno-Smith, … , Gabriel Lopez-Berestein, Anil K. Sood
Published April 15, 2013
Citation Information: J Clin Invest. 2013;123(5):2119-2130. https://doi.org/10.1172/JCI65425.
View: Text | PDF | Expression of Concern | Corrigendum | Corrigendum
Research Article Article has an altmetric score of 25

ATP11B mediates platinum resistance in ovarian cancer

Abstract

Platinum compounds display clinical activity against a wide variety of solid tumors; however, resistance to these agents is a major limitation in cancer therapy. Reduced platinum uptake and increased platinum export are examples of resistance mechanisms that limit the extent of DNA damage. Here, we report the discovery and characterization of the role of ATP11B, a P-type ATPase membrane protein, in cisplatin resistance. We found that ATP11B expression was correlated with higher tumor grade in human ovarian cancer samples and with cisplatin resistance in human ovarian cancer cell lines. ATP11B gene silencing restored the sensitivity of ovarian cancer cell lines to cisplatin in vitro. Combined therapy of cisplatin and ATP11B-targeted siRNA significantly decreased cancer growth in mice bearing ovarian tumors derived from cisplatin-sensitive and -resistant cells. In vitro mechanistic studies on cellular platinum content and cisplatin efflux kinetics indicated that ATP11B enhances the export of cisplatin from cells. The colocalization of ATP11B with fluorescent cisplatin and with vesicular trafficking proteins, such as syntaxin-6 (STX6) and vesicular-associated membrane protein 4 (VAMP4), strongly suggests that ATP11B contributes to secretory vesicular transport of cisplatin from Golgi to plasma membrane. In conclusion, inhibition of ATP11B expression could serve as a therapeutic strategy to overcome cisplatin resistance.

Authors

Myrthala Moreno-Smith, J.B. Halder, Paul S. Meltzer, Tamas A. Gonda, Lingegowda S. Mangala, Rajesha Rupaimoole, Chunhua Lu, Archana S. Nagaraja, Kshipra M. Gharpure, Yu Kang, Cristian Rodriguez-Aguayo, Pablo E. Vivas-Mejia, Behrouz Zand, Rosemarie Schmandt, Hua Wang, Robert R. Langley, Nicholas B. Jennings, Cristina Ivan, Jeremy E. Coffin, Guillermo N. Armaiz, Justin Bottsford-Miller, Sang Bae Kim, Margaret S. Halleck, Mary J.C. Hendrix, William Bornman, Menashe Bar-Eli, Ju-Seog Lee, Zahid H. Siddik, Gabriel Lopez-Berestein, Anil K. Sood

×

Total citations by year

Year: 2025 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 Total
Citations: 2 1 6 1 3 1 3 9 2 3 2 33
Citation information

Citations to this article (33)

Title and authors Publication Year
Substrates, regulation, cellular functions, and disease associations of P4-ATPases
Shin HW, Takatsu H 		Communications Biology 2025
Syntaxin-6 mediated autophagy confers lenvatinib resistance in hepatocellular carcinoma.
Zhang GP, Song ZB, Chen DH, Yu Y, Wu FF, Kuang M, Li SQ 		Oncogene 2025
Type IV P-Type ATPases: Recent Updates in Cancer Development, Progression, and Treatment
Yazlovitskaya EM, Graham TR 		Cancers 2023
Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells
R Rabelo-Fernández, G Santiago-Sánchez, R Sharma, A Roche-Lima, K Carrion, R Rivera, B Quiñones-Díaz, S Rajasekaran, J Siddiqui, W Miles, Y Rivera, F Valiyeva, P Vivas-Mejia 		International journal of molecular sciences 2022
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
T Tang, X Huang, G Zhang, M Lu, Z Hong, M Wang, J Huang, X Zhi, T Liang 		Journal for ImmunoTherapy of Cancer 2022
Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis
R Bajaj, A Warner, J Fradette, D Gibbons 		Cells 2022
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice
Liu C, Zhang S, Shi H, Zhou H, Zhuang J, Cao Y, Ward N, Wang J 		Brain Sciences 2022
Lipid Transport by Candida albicans Dnf2 Is Required for Hyphal Growth and Virulence.
Jain BK, Wagner AS, Reynolds TB, Graham TR 		Infection and immunity 2022
Genetic analysis of the ATP11B gene in Chinese Han population with cerebral small vessel disease.
Yu WK, Wang YC, Gao Y, Shi CH, Fan Y, Yu LL, Zhao ZC, Li SS, Xu YM, Li YS 		BMC Genomics 2022
Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
C Pan, JH Kang, JS Hwang, J Li, AC Boese, X Wang, L Yang, TJ Boggon, GZ Chen, NF Saba, DM Shin, KR Magliocca, L Jin, S Kang 		Nature Communications 2021
DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN–WEE1 Signaling
J Li, C Pan, AC Boese, JH Kang, AD Umano, KR Magliocca, W Yang, Y Zhang, S Lonial, L Jin, S Kang 		Clinical cancer research 2020
Oncolytic HSV Therapy Modulates Vesicular Trafficking Inducing Cisplatin Sensitivity and Antitumor Immunity
B Hong, V Chapa, U Saini, P Modgil, DE Cohn, G He, ZH Siddik, AK Sood, Y Yan, K Selvendiran, G Pei, Z Zhao, JY Yoo, B Kaur 		Clinical cancer research 2020
TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
D Ennishi, S Healy, A Bashashati, S Saberi, C Hother, A Mottok, FC Chan, L Chong, L Abraham, R Kridel, M Boyle, B Meissner, T Aoki, K Takata, BW Woolcock, E Viganò, M Gold, LL Molday, RS Molday, A Telenius, MY Li, N Wretham, ND Santos, M Wong, NN Viller, RA Uger, G Duns, A Baticados, A Madero, BN Bristow, P Farinha, GW Slack, S Ben-Neriah, D Lai, AW Zhang, S Salehi, HP Shulha, DS Chiu, S Mostafavi, AS Gerrie, DW Huang, C Rushton, D Villa, LH Sehn, KJ Savage, AJ Mungall, AP Weng, MB Bally, RD Morin, GV Freue, LM Staudt, JM Connors, MA Marra, SP Shah, RD Gascoyne, DW Scott, C Steidl 		Nature Medicine 2020
MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
L Jin, J Chun, C Pan, D Li, R Lin, GN Alesi, X Wang, HB Kang, L Song, D Wang, G Zhang, J Fan, TJ Boggon, L Zhou, J Kowalski, CK Qu, CE Steuer, GZ Chen, NF Saba, LH Boise, TK Owonikoko, FR Khuri, KR Magliocca, DM Shin, S Lonial, S Kang 		Cancer Cell 2018
Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
J Cai, L Fang, Y Huang, R Li, X Xu, Z Hu, L Zhang, Y Yang, X Zhu, H Zhang, J Wu, Y Huang, J Li, M Zeng, E Song, Y He, L Zhang, M Li 		Nature Communications 2017
ADAMTS16 mutations sensitize ovarian cancer cells to platinum-based chemotherapy
M Yasukawa, Y Liu, L Hu, D Cogdell, KM Gharpure, S Pradeep, AS Nagaraja, AK Sood, W Zhang 		Oncotarget 2017
Gene Expression Profiling Reveals Novel Candidate Markers of Ovarian Carcinoma Intraperitoneal Metastasis
K Elsnerova, A Bartakova, J Tihlarik, J Bouda, L Rob, P Skapa, M Hruda, I Gut, B Mohelnikova-Duchonova, P Soucek, R Vaclavikova 		Journal of Cancer 2017
Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4
VA van der Mark, M Ghiboub, C Marsman, J Zhao, R Dijk, JK Hiralall, KS Ho-Mok, Z Castricum, WJ de Jonge, RP Elferink, CC Paulusma 		Cellular and Molecular Life Sciences 2016
A Comprehensive Review on the Genetic Regulation of Cisplatin-induced Nephrotoxicity
Z Herrera-Pérez, N Gretz, H Dweep 		Current genomics 2016
TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor-Positive Breast Cancer
R Jeselsohn, WT Barry, I Migliaccio, C Biagioni, J Zhao, JD Tribolet-Hardy, C Guarducci, M Bonechi, N Laing, EP Winer, M Brown, AD Leo, L Malorni 		Clinical cancer research 2016
ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes: de Waart, Naik et al
DR de Waart, J Naik, KS Utsunomiya, S Duijst, K Ho-Mok, AR Bolier, J Hiralall, LN Bull, PJ Bosma, RP Elferink, CC Paulusma 		Hepatology 2016
Selective inhibition of tumor cell associated Vacuolar-ATPase ‘a2’ isoform overcomes cisplatin resistance in ovarian cancer cells
A Kulshrestha, GK Katara, J Ginter, S Pamarthy, SA Ibrahim, MK Jaiswal, C Sandulescu, R Periakaruppan, J Dolan, A Gilman-Sachs, KD Beaman 		Molecular Oncology 2016
Biological characteristics of side population cells in a self-established human ovarian cancer cell line
Z Wei, S Lv, Y Wang, M Sun, G Chi, J Guo, P Song, X Fu, S Zhang, Y Li 		Oncology Letters 2016
Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells
P Kanlikilicer, M Saber, R Bayraktar, R Mitra, C Ivan, B Aslan, X Zhang, J Filant, AM Silva, C Rodriguez-Aguayo, E Bayraktar, M Pichler, B Ozpolat, GA Calin, AK Sood, G Lopez-Berestein 		Cancer research 2016
Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types
AL Fonseca, VL da Silva, MM da Fonsêca, IT Meira, TE da Silva, JE Kroll, AM Ribeiro-dos-Santos, CR Freitas, R Furtado, JE de Souza, B Stransky, SJ de Souza 		International Journal of Genomics 2016
The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer
Y He, Q Zhu, M Chen, Q Huang, W Wang, Q Li, Y Huang, W Di 		Oncotarget 2016
Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer
V Gonzalez-Villasana, E Fuentes-Mattei, C Ivan, HJ Dalton, C Rodriguez-Aguayo, RJ Thomas, B Aslan, PC Monroig, G Velazquez-Torres, RA Previs, S Pradeep, N Kahraman, H Wang, P Kanlikilicer, B Ozpolat, G Calin, AK Sood, G Lopez-Berestein 		Clinical cancer research 2015
Stimulation of the hypoxia pathway modulates chemotherapy resistance in Hodgkin’s lymphoma cells
S Kewitz, L Kurch, I Volkmer, MS Staege 		Tumor Biology 2015
Systems biology of cisplatin resistance: past, present and future
L Galluzzi, I Vitale, J Michels, C Brenner, G Szabadkai, A Harel-Bellan, M Castedo, G Kroemer 		Cell Death and Disease 2014
MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis
P Jia, Q Wang, Q Chen, KE Hutchinson, W Pao, Z Zhao 		Genome biology 2014
Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin
S Spreckelmeyer, C Orvig, A Casini 		Molecules (Basel, Switzerland) 2014
Raft-like membranes from the trans-Golgi network and endosomal compartments
MG Waugh 		Nature Protocols 2013
Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer
SJ Klempner, AP Myers, GB Mills, SN Westin 		Expert Opinion on Pharmacotherapy 2013

Advertisement