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Juliana Idoyaga, … , Miriam Merad, Ralph M. Steinman
Published January 9, 2013
Citation Information: J Clin Invest. 2013;123(2):844-854. https://doi.org/10.1172/JCI65260.
Citation Information: J Clin Invest. 2013;123(2):844-854. https://doi.org/10.1172/JCI65260.
Abstract
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with tissue self antigens. We hypothesized that these DC populations have a specialized role in the maintenance of peripheral tolerance, specifically, to generate suppressive Foxp3+ Tregs. To examine the differential capacity of migratory DCs versus blood-derived lymphoid-resident DCs for Treg generation in vivo, we targeted a self antigen, myelin oligodendrocyte glycoprotein, using antibodies against cell surface receptors differentially expressed in these DC populations. Using this approach together with mouse models that lack specific DC populations, we found that migratory DCs have a superior ability to generate Tregs in vivo, which in turn drastically improve the outcome of experimental autoimmune encephalomyelitis. These results provide a rationale for the development of novel therapies targeting migratory DCs for the treatment of autoimmune diseases.
Authors
Juliana Idoyaga, Christopher Fiorese, Lori Zbytnuik, Ashira Lubkin, Jennifer Miller, Bernard Malissen, Daniel Mucida, Miriam Merad, Ralph M. Steinman
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Dendritic Cells As Inducers of Peripheral Tolerance
CA Iberg, A Jones, D Hawiger |
Trends in Immunology | 2017 |
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High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization
M Alcántara-Hernández, R Leylek, LE Wagar, EG Engleman, T Keler, MP Marinkovich, MM Davis, GP Nolan, J Idoyaga |
Immunity | 2017 |
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RelB+ Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3+ Regulatory T Cells
A Döhler, T Schneider, I Eckert, E Ribechini, N Andreas, M Riemann, B Reizis, F Weih, MB Lutz |
Frontiers in immunology | 2017 |
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Ontogeny and function of murine epidermal Langerhans cells
DH Kaplan |
Nature Immunology | 2017 |
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Bioconjugate Strategies for the Induction of Antigen-Specific Tolerance in Autoimmune Diseases
C Yu, , M Li, M An, H Liu |
Bioconjugate Chemistry | 2017 |
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Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation
BV Lugt, J Riddell, AA Khan, JA Hackney, J Lesch, J DeVoss, MT Weirauch, H Singh, I Mellman |
The Journal of Cell Biology | 2017 |
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Induction of CD4 + Regulatory and Polarized Effector/helper T Cells by Dendritic Cells
MB Lutz |
Immune Network | 2016 |
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Dendritic cell-based immunotherapy
RL Sabado, S Balan, N Bhardwaj |
Cell Research | 2016 |
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Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance
D Esterházy, J Loschko, M London, V Jove, TY Oliveira, D Mucida |
Nature Immunology | 2016 |
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Altered dendritic cell functions in autoimmune diseases: distinct and overlapping profiles
F Coutant, P Miossec |
Nature Reviews Rheumatology | 2016 |
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Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies
C Lehmann, L Heger, G Heidkamp, A Baranska, J Lühr, A Hoffmann, D Dudziak |
Human vaccines | 2016 |
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Functions of Murine Dendritic Cells
V Durai, KM Murphy |
Immunity | 2016 |
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CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells
BD Evers, DR Engel, AM Bohner, AP Tittel, TA Krause, C Heuser, N Garbi, W Kastenmuller, M Mack, G Tiegs, U Panzer, P Boor, I Ludwig-Portugall, C Kurts |
Journal of the American Society of Nephrology : JASN | 2016 |
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Visualization of immediate immune responses to pioneer metastatic cells in the lung
MB Headley, A Bins, A Nip, EW Roberts, MR Looney, A Gerard, MF Krummel |
Nature | 2016 |
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The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity
CC Clement, A Becerra, L Yin, V Zolla, L Huang, S Merlin, A Follenzi, SA Shaffer, LJ Stern, L Santambrogio |
The Journal of biological chemistry | 2016 |
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Antibody Targeting of “Steady-State” Dendritic Cells Induces Tolerance Mediated by Regulatory T Cells
K Mahnke, S Ring, AH Enk |
Frontiers in immunology | 2016 |
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Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells
N Goudin, P Chappert, J Mégret, DA Gross, B Rocha, O Azogui, IR Cohen |
PloS one | 2016 |
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Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells
DS Leventhal, DC Gilmore, JM Berger, S Nishi, V Lee, S Malchow, DE Kline, J Kline, DJ Vander Griend, H Huang, ND Socci, PA Savage |
Immunity | 2016 |
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The melting pot of the MHC II peptidome
LJ Stern, L Santambrogio |
Current Opinion in Immunology | 2016 |
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Immune Tolerance for Autoimmune Disease and Cell Transplantation
X Luo, SD Miller, LD Shea |
Annual Review of Biomedical Engineering | 2016 |
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Antigen Presenting Properties of a Myeloid Dendritic-Like Cell in Murine Spleen
Y Hey, HC ONeill, A Haziot |
PloS one | 2016 |
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Metabolites: deciphering the molecular language between DCs and their environment
L Minarrieta, P Ghorbani, T Sparwasser, L Berod |
Seminars in Immunopathology | 2016 |
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Neuroimmune interactions: dendritic cell modulation by the sympathetic nervous system
MC Takenaka, MG Guereschi, AS Basso |
Seminars in Immunopathology | 2016 |
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A Key Role for Inhibins in Dendritic Cell Maturation and Function
R Olguín-Alor, M la Fuente-Granada, LC Bonifaz, L Antonio-Herrera, EA García-Zepeda, G Soldevila, S Kovats |
PloS one | 2016 |
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Tolerogenic dendritic cells
MC Takenaka, FJ Quintana |
Seminars in Immunopathology | 2016 |
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Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells
A Jones, J Bourque, L Kuehm, A Opejin, RM Teague, C Gross, D Hawiger |
Immunity | 2016 |
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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
A Broggi, C Cigni, I Zanoni, F Granucci |
Journal of visualized experiments : JoVE | 2016 |
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Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T Cell Auto-Reactivity
M Meister, A Tounsi, E Gaffal, T Bald, M Papatriantafyllou, J Ludwig, G Pougialis, F Bestvater, L Klotz, G Moldenhauer, T Tüting, GJ Hämmerling, B Arnold, T Oelert |
Journal of Investigative Dermatology | 2015 |
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CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis
QQ Huang, H Perlman, R Birkett, R Doyle, D Fang, GK Haines, W Robinson, S Datta, Z Huang, QZ Li, H Phee, RM Pope |
Nature Communications | 2015 |
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DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice
JE Park, J Jang, JH Choi, M Kang, YJ Woo, YR Seong, CB Choi, HS Lee, SC Bae, YS Bae |
Journal of Immunology Research | 2015 |
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Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression
A Jones, A Opejin, JG Henderson, C Gross, R Jain, JA Epstein, RA Flavell, D Hawiger |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Tailored immunity by skin antigen-presenting cells
C Levin, H Perrin, B Combadiere |
Human Vaccines & Immunotherapeutics | 2015 |
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The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases
JD Price, KV Tarbell |
Frontiers in immunology | 2015 |
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Emerging and Novel Functions of Complement Protein C1q
L Kouser, SP Madhukaran, A Shastri, A Saraon, J Ferluga, M Al-Mozaini, U Kishore |
Frontiers in immunology | 2015 |
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TREML4 adds fuel to the TLR7 fire
MG Netea, FL van de Veerdonk |
Nature Immunology | 2015 |
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Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy
J Leleux, A Atalis, K Roy |
Journal of Controlled Release | 2015 |
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Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance
CJ Nirschl, N Anandasabapathy |
Human Vaccines & Immunotherapeutics | 2015 |
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Skin dendritic cells induce follicular helper T cells and protective humoral immune responses
C Yao, SM Zurawski, ES Jarrett, B Chicoine, J Crabtree, EJ Peterson, G Zurawski, DH Kaplan, BZ Igyártó |
Journal of Allergy and Clinical Immunology | 2015 |
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Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming
MP Matheu, S Othy, ML Greenberg, TX Dong, M Schuijs, K Deswarte, H Hammad, BN Lambrecht, I Parker, MD Cahalan |
Nature Communications | 2015 |
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Impact of dietary components on NK and Treg cell function for cancer prevention: DIETARY COMPONENTS AND CANCER: IMPACT ON NK AND TREG FUNCTION
YS Kim, TJ Sayers, NH Colburn, JA Milner, HA Young |
Molecular Carcinogenesis | 2015 |
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Biodegradable polymeric microsphere-based vaccines and their applications in infectious diseases
CY Lin, SJ Lin, YC Yang, DY Wang, HF Cheng, MK Yeh |
Human Vaccines & Immunotherapeutics | 2015 |
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DCIR2 + cDC2 DCs and Zbtb32 Restore CD4 + T-Cell Tolerance and Inhibit Diabetes
JD Price, C Hotta-Iwamura, Y Zhao, NM Beauchamp, KV Tarbell |
Diabetes | 2015 |
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CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation
JG Price, J Idoyaga, H Salmon, B Hogstad, CL Bigarella, S Ghaffari, M Leboeuf, M Merad |
Nature Immunology | 2015 |
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Dissolving Microneedle Delivery of Nanoparticle-Encapsulated Antigen Elicits Efficient Cross-Priming and Th1 Immune Responses by Murine Langerhans Cells
M Zaric, O Lyubomska, C Poux, ML Hanna, MT McCrudden, B Malissen, RJ Ingram, UF Power, CJ Scott, RF Donnelly, A Kissenpfennig |
Journal of Investigative Dermatology | 2015 |
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Advancing drug delivery systems for the treatment of multiple sclerosis
I Tabansky, MD Messina, C Bangeranye, J Goldstein, KM Blitz-Shabbir, S Machado, V Jeganathan, P Wright, S Najjar, Y Cao, W Sands, DB Keskin, JN Stern |
Immunologic Research | 2015 |
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Mechanisms regulating skin immunity and inflammation
M Pasparakis, I Haase, FO Nestle |
Nature Reviews Immunology | 2014 |
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Trial watch: Dendritic cell-based anticancer therapy
N Bloy, J Pol, F Aranda, A Eggermont, I Cremer, WH Fridman, J Fučíková, J Galon, E Tartour, R Spisek, MV Dhodapkar, L Zitvogel, G Kroemer, L Galluzzi |
OncoImmunology | 2014 |
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Regulatory dendritic cells for immunotherapy in immunologic diseases
JR Gordon, Y Ma, L Churchman, SA Gordon, W Dawicki |
Frontiers in immunology | 2014 |
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Antigen-Conjugated Human IgE Induces Antigen-Specific T Cell Tolerance in a Humanized Mouse Model
G Baravalle, AM Greer, TN Laflam, JS Shin |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
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The origins and functions of dendritic cells and macrophages in the skin
B Malissen, S Tamoutounour, S Henri |
Nature Reviews Immunology | 2014 |
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Dendritic cell-targeted vaccines — hope or hype?
W Kastenmüller, K Kastenmüller, C Kurts, RA Seder |
Nature Reviews Immunology | 2014 |
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Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance
V Flacher, CH Tripp, DG Mairhofer, RM Steinman, P Stoitzner, J Idoyaga, N Romani |
EMBO Molecular Medicine | 2014 |
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Dendritic Cell-Targeted Vaccines
L Cohn, LÃ Delamarre |
Frontiers in immunology | 2014 |
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Helminth Infections Decrease Host Susceptibility to Immune-Mediated Diseases
JV Weinstock, DE Elliott |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
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The nature of activatory and tolerogenic dendritic cell-derived signal 2
F Granucci, MB Lutz, I Zanoni |
Frontiers in immunology | 2014 |
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Adaptation in the innate immune system and heterologous innate immunity
SF Martin |
Cellular and Molecular Life Sciences | 2014 |
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Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors
P Stoitzner, S Schaffenrath, CH Tripp, D Reider, K Komenda, BD Frari, G Djedovic, S Ebner, N Romani |
Experimental Dermatology | 2014 |
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Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity
M Yadav, S Stephan, JA Bluestone |
Frontiers in immunology | 2013 |
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Dendritic Cells in the Periphery Control Antigen-Specific Natural and Induced Regulatory T Cells
S Yamazaki, A Morita |
Frontiers in immunology | 2013 |
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Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases
ML Berres, CE Allen, M Merad |
Advances in immunology | 2013 |
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Trial watch
E Vacchelli, I Vitale, A Eggermont, WH Fridman, J Fučíková, I Cremer, J Galon, E Tartour, L Zitvogel, G Kroemer, L Galluzzi |
OncoImmunology | 2013 |
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Human dendritic cell subsets in vaccination
K Palucka, J Banchereau |
Current Opinion in Immunology | 2013 |
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Dendritic Cells: Cellular Mediators for Immunological Tolerance
CY Chung, D Ysebaert, ZN Berneman, N Cools |
Clinical and Developmental Immunology | 2013 |
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New approaches to transcutaneous immunotherapy: targeting dendritic cells with novel allergen conjugates
R Weiss, S Scheiblhofer, Y Machado, J Thalhamer |
Current Opinion in Allergy and Clinical Immunology | 2013 |
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Immunogenicity of subcutaneously administered therapeutic proteins--a mechanistic perspective
AM Fathallah, RB Bankert, SV Balu-Iyer |
The AAPS Journal | 2013 |
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It's Time to Bring Dendritic Cell Therapy to Type 1 Diabetes
RJ Creusot, N Giannoukakis, M Trucco, MJ Clare-Salzler, CG Fathman |
Diabetes | 2013 |
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Targeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccination
C Petzold, S Schallenberg, JN Stern, K Kretschmer |
The review of diabetic studies : RDS | 2012 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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