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Citations to this article

Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions
Jens Mittag, … , Anders Arner, Björn Vennström
Jens Mittag, … , Anders Arner, Björn Vennström
Published December 21, 2012
Citation Information: J Clin Invest. 2013;123(1):509-516. https://doi.org/10.1172/JCI65252.
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Research Article Article has an altmetric score of 54

Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions

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Abstract

Thyroid hormone is well known for its profound direct effects on cardiovascular function and metabolism. Recent evidence, however, suggests that the hormone also regulates these systems indirectly through the central nervous system. While some of the molecular mechanisms underlying the hormone’s central control of metabolism have been identified, its actions in the central cardiovascular control have remained enigmatic. Here, we describe a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus that requires thyroid hormone receptor signaling for proper development. Specific stereotaxic ablation of these cells in the mouse resulted in hypertension and temperature-dependent tachycardia, indicating a role in the central autonomic control of blood pressure and heart rate. Moreover, the neurons exhibited intrinsic temperature sensitivity in patch-clamping experiments, providing a new connection between cardiovascular function and core temperature. Thus, the data identify what we believe to be a novel hypothalamic cell population potentially important for understanding hypertension and indicate developmental hypothyroidism as an epigenetic risk factor for cardiovascular disorders. Furthermore, the findings may be beneficial for treatment of the recently identified patients that have a mutation in thyroid hormone receptor α1.

Authors

Jens Mittag, David J. Lyons, Johan Sällström, Milica Vujovic, Susi Dudazy-Gralla, Amy Warner, Karin Wallis, Anneke Alkemade, Kristina Nordström, Hannah Monyer, Christian Broberger, Anders Arner, Björn Vennström

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 2012 Total
Citations: 2 1 6 1 2 3 1 3 4 4 6 3 1 37
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (4)

Title and authors Publication Year
Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice
H Rakov, K Engels, GS Hönes, KH Strucksberg, LC Moeller, J Köhrle, D Zwanziger, D Führer
Biology of sex differences 2016
Maternal thyroid function in pregnancy may program offspring blood pressure, but not adiposity at 20 y of age
D Rytter, SL Andersen, BH Bech, TI Halldorsson, TB Henriksen, P Laurberg, SF Olsen
Pediatric Research 2016
Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance
M Alvarez-Crespo, RI Csikasz, N Martínez-Sánchez, C Diéguez, B Cannon, J Nedergaard, M López
Molecular Metabolism 2016
Cardiac autonomic function and vascular profile in subclinical hypothyroidism: Increased beat-to-beat QT variability
P Kalra, VK Yeragani, KM Kumar
Indian journal of endocrinology and metabolism 2016

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ISSN: 0021-9738 (print), 1558-8238 (online)

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