Secreted protein acidic and rich in cysteine (SPARC) has been implicated in multiple aspects of human cancer. However, its role in bladder carcinogenesis and metastasis are unclear,with some studies suggesting it may be a promoter and others arguing the opposite. Using a chemical carcinogenesis model in
Neveen Said, Henry F. Frierson, Marta Sanchez-Carbayo, Rolf A. Brekken, Dan Theodorescu
Title and authors | Publication | Year |
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RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10
Yu J, Chen L, Wang G, Qian K, Weng H, Yang Z, Zheng H, Lu M |
Communications Biology | 2025 |
Senolytic treatment for low back pain
Mannarino M, Cherif H, Ghazizadeh S, Martinez OW, Sheng K, Cousineau E, Lee S, Millecamps M, Gao C, Gilbert A, Peirs C, Naeini RS, Ouellet JA, S. Stone L, Haglund L |
Science Advances | 2025 |
Cloning, characterization, and spatio-temporal expression patterns of HdhSPARC and its responses to multiple stressors.
Hanif MA, Hossen S, Choi CY, Kho KH |
Scientific Reports | 2024 |
Effects of Exercise-Induced Changes in Myokine Expression on the Tumor Microenvironment
Gunasekara N, Clauss D, Bloch W |
2024 | |
Evidence of the Link between Stroma Remodeling and Prostate Cancer Prognosis
Vecchiotti D, Clementi L, Cornacchia E, Di Vito Nolfi M, Verzella D, Capece D, Zazzeroni F, Angelucci A |
Cancers | 2024 |
Tumor-secreted LCN2 impairs gastric cancer progression via autocrine inhibition of the 24p3R/JNK/c-Jun/SPARC axis.
Huang Z, Li Y, Qian Y, Zhai E, Zhao Z, Zhang T, Liu Y, Ye L, Wei R, Zhao R, Li Z, Liang Z, Cai S, Chen J |
Cell death & disease | 2024 |
Screening and molecular mechanism research on bile microRNAs associated with chemotherapy efficacy in perihilar cholangiocarcinoma
Fu S, Du H, Dai Y, Zheng K, Cao G, Xu L, Zhong Y, Niu C, Kong Y, Wang X |
iScience | 2024 |
Angiogenesis regulators S100A4, SPARC and SPP1 correlate with macrophage infiltration and are prognostic biomarkers in colon and rectal cancers
Kazakova E, Rakina M, Sudarskikh T, Iamshchikov P, Tarasova A, Tashireva L, Afanasiev S, Dobrodeev A, Zhuikova L, Cherdyntseva N, Kzhyshkowska J, Larionova I |
Frontiers in Oncology | 2023 |
SPARC: a potential target for functional nanomaterials and drugs.
Jiang S, Sun HF, Li S, Zhang N, Chen JS, Liu JX |
Frontiers in Molecular Biosciences | 2023 |
TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC.
Yu J, Li M, Ju L, Zhou F, Wang Y, Zhang Y, Zhang R, Du W, Huang R, Qian K, Wang G, Xiao Y, Wang X |
Oncogene | 2023 |
The dynamic roles of the bladder tumour microenvironment.
Lee YC, Lam HM, Rosser C, Theodorescu D, Parks WC, Chan KS |
Nature Reviews Urology | 2022 |
A novel molecular subtypes and risk model based on inflammatory response-related lncrnas for bladder cancer
Tang F, Zhang J, Lu Z, Liao H, Hu C, Mai Y, Lai Y, Lu Z, Tang Z, Li Z, He Z |
Hereditas | 2022 |
Compound C Inhibits Ovarian Cancer Progression via PI3K-AKT-mTOR-NFκB Pathway.
Ghoneum A, Gonzalez D, Afify H, Shu J, Hegarty A, Adisa J, Kelly M, Lentz S, Salsbury F, Said N |
Cancers | 2022 |
Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells
S Yoshida, K Asanoma, H Yagi, I Onoyama, E Hori, Y Matsumura, K Okugawa, H Yahata, K Kato |
BMC Cancer | 2021 |
Stromal Protein-Mediated Immune Regulation in Digestive Cancers
P Gamradt, CD Fouchardière, A Hennino |
Cancers | 2021 |
New Angiogenic Regulators Produced by TAMs: Perspective for Targeting Tumor Angiogenesis
I Larionova, E Kazakova, T Gerashchenko, J Kzhyshkowska |
Cancers | 2021 |
Metabolomic credentialing of murine carcinogen-induced urothelial cancer
H Afify, A Ghoneum, S Almousa, AY Abdulfattah, B Warren, K Langsten, D Gonzalez, R Casals, M Bharadwaj, S Kridel, N Said |
Scientific Reports | 2021 |
Animal Models in Bladder Cancer
T Constantin, M Păvălean, Ș Bucur, MM Constantin, AC Nicolescu, I Pacu, V Mădan |
Biomedicines | 2021 |
Defining muscle-invasive bladder cancer immunotypes by introducing tumor mutation burden, CD8+ T cells, and molecular subtypes
Z Chen, G Liu, G Liu, MA Bolkov, K Shinwari, IA Tuzankina, VA Chereshnev, Z Wang |
Hereditas | 2021 |
The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer
X Huang, T Pan, L Yan, T Jin, R Zhang, B Chen, J Feng, T Duan, Y Xiang, M Zhang, X Chen, Z Yang, W Zhang, X Ding, T Xie, X Sui |
Genes & Diseases | 2021 |
SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieu
K Pan, X Huang, X Jia |
Oncology Letters | 2021 |
Identifying Diagnostic and Prognostic Biomarkers and Candidate Therapeutic Drugs of Gastric Cancer Based on Transcriptomics and Single-Cell Sequencing
X Zhao, S Wu, J Jing |
Pathology oncology research : POR | 2021 |
Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer
Enriquez C, Cancila V, Ferri R, Sulsenti R, Fischetti I, Milani M, Ostano P, Gregnanin I, Mello-Grand M, Berrino E, Bregni M, Renne G, Tripodo C, Colombo MP, Jachetti E |
Cancer research | 2021 |
SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells
L Hu, F He, M Huang, Q Zhao, L Cheng, N Said, Z Zhou, F Liu, YS Dai |
Scientific Reports | 2020 |
Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics
A Ghoneum, AY Abdulfattah, BO Warren, J Shu, N Said |
International journal of molecular sciences | 2020 |
Exercise shapes redox signaling in cancer
M Assi, S Dufresne, A Rébillard |
Redox Biology | 2020 |
SPARC Levels Modulate the Capacity of Mitomycin to Inhibit the Proliferation of Human Tenon’s Capsule Fibroblasts
Y Guo, S Ni, W Zhou, J Hou, J Shen |
Journal of Ophthalmology | 2020 |
Current updates on the role of reactive oxygen species in bladder cancer pathogenesis and therapeutics
D Liu, X Qiu, X Xiong, X Chen, F Pan |
Clinical and Translational Oncology | 2020 |
Effect of bovine leukemia virus (BLV) infection on bovine mammary epithelial cells RNA-seq transcriptome profile
LM Cuesta, JP Liron, MV Farias, GL Dolcini, MC Ceriani, M del Mar Ortega-Villaizan |
PloS one | 2020 |
Macrophage-derived SPARC Attenuates M2-mediated Pro-tumour Phenotypes
J Hu, Y Ma, J Ma, S Chen, X Zhang, S Guo, Z Huang, T Yue, Y Yang, Y Ning, J Zhu, P Wang, X Wang, G Chen, Y Liu |
Journal of Cancer | 2020 |
Impact of Fibroblast-Derived SPARC on Invasiveness of Colorectal Cancer Cells
D Drev, F Harpain, A Beer, A Stift, ES Gruber, M Klimpfinger, S Thalhammer, A Reti, L Kenner, M Bergmann, B Marian |
Cancers | 2019 |
The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer
YJ Chern, JC Wong, GS Cheng, A Yu, Y Yin, DF Schaeffer, HF Kennecke, G Morin, IT Tai |
Cell Death and Disease | 2019 |
Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies
GJ Yoshida, A Azuma, Y Miura, A Orimo |
International journal of molecular sciences | 2019 |
Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC
B John, C Naczki, C Patel, A Ghoneum, S Qasem, Z Salih, N Said |
Oncogene | 2019 |
Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in gastric cancer
S Shao, NM Zhou, DQ Dai |
World journal of gastroenterology : WJG | 2019 |
Establishing and characterization of human and murine bladder cancer organoids
N Said |
Translational andrology and urology | 2019 |
Identification of Key Genes and Circular RNAs in Human Gastric Cancer
S Hao, J Lv, Q Yang, A Wang, Z Li, Y Guo, G Zhang |
Medical science monitor : international medical journal of experimental and clinical research | 2019 |
SPARC Inhibits Metabolic Plasticity in Ovarian Cancer
C Naczki, B John, C Patel, A Lafferty, A Ghoneum, H Afify, M White, A Davis, G Jin, S Kridel, N Said |
Cancers | 2018 |
Serum microRNAs as predictors of risk for non-muscle invasive bladder cancer
J Lian, SH Lin, Y Ye, DW Chang, M Huang, CP Dinney, X Wu |
Oncotarget | 2018 |
Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cells
CH Wu, CR Silvers, EM Messing, YF Lee |
The Journal of biological chemistry | 2018 |
Insights from animal models of bladder cancer: recent advances, challenges, and opportunities
BA John, N Said |
Oncotarget | 2017 |
The Roles of Matricellular Proteins in Oncogenic Virus-Induced Cancers and Their Potential Utilities as Therapeutic Targets
N Maeda, K Maenaka |
International journal of molecular sciences | 2017 |
Racial health disparities in ovarian cancer: not just black and white
SK Srivastava, A Ahmad, O Miree, GK Patel, S Singh, RP Rocconi, AP Singh |
Journal of Ovarian Research | 2017 |
Epigenetic basis of cancer health disparities: Looking beyond genetic differences
A Ahmad, S Azim, H Zubair, MA Khan, S Singh, JE Carter, RP Rocconi, AP Singh |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2017 |
Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone
S Sharma, F Xing, Y Liu, K Wu, N Said, R Pochampally, Y Shiozawa, HK Lin, KC Balaji, K Watabe |
The Journal of biological chemistry | 2016 |
Roles of SPARC in urothelial carcinogenesis, progression and metastasis
N Said |
Oncotarget | 2016 |
Elevated matrix metalloproteinase‑9 expression may contribute to the pathogenesis of bladder cancer
FC Zeng, S Cen, ZY Tang, XL Kang |
Oncology Letters | 2016 |
SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As+3- and Cd+2-Transformed Human Urothelial Cells (UROtsa) Stably Transfected with SPARC
A Slusser-Nore, JL Larson-Casey, R Zhang, XD Zhou, S Somji, SH Garrett, DA Sens, JR Dunlevy, RA Winn |
PloS one | 2016 |
Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors
J Hensel, JE Duex, C Owens, GM Dancik, MG Edwards, HF Frierson, D Theodorescu |
Molecular cancer research : MCR | 2015 |
Loss of Sparc in p 53 -null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival: Sparc Loss Promotes Phagocytosis of p53-null Cells
SL Thomas, CR Schultz, E Mouzon, WA Golembieski, RE Naili, A Radakrishnan, N Lemke, LM Poisson, JA Gutiérrez, S Cottingham, SA Rempel |
Brain Pathology | 2015 |
Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer
L McBeth, M Grabnar, S Selman, TD Hinds |
International Journal of Endocrinology | 2015 |
The wound healing, chronic fibrosis, and cancer progression triad
B Rybinski, J Franco-Barraza, E Cukierman |
Physiological genomics | 2014 |
SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression
G Botti, G Scognamiglio, L Marra, F Collina, MD Bonito, M Cerrone, B Grilli, A Anniciello, R Franco, F Fulciniti, PA Ascierto, M Cantile |
Virchows Archiv | 2014 |
SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations
F Mateo, Ó Meca-Cortés, T Celià-Terrassa, Y Fernández, I Abasolo, L Sánchez-Cid, R Bermudo, A Sagasta, L Rodríguez-Carunchio, M Pons, V Cánovas, M Marín-Aguilera, L Mengual, A Alcaraz, S Schwartz, B Mellado, KY Aguilera, R Brekken, PL Fernández, R Paciucci, TM Thomson |
Molecular Cancer | 2014 |
Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model
V Riabov, S Yin, B Song, A Avdic, K Schledzewski, I Ovsiy, A Gratchev, ML Verdiell, C Sticht, C Schmuttermaier, H Schönhaber, C Weiss, AP Fields, K Simon-Keller, F Pfister, S Berlit, A Marx, B Arnold, S Goerdt, J Kzhyshkowska |
Oncotarget | 2014 |
Modelling bladder cancer in mice: opportunities and challenges
T Kobayashi, TB Owczarek, JM McKiernan, C Abate-Shen |
Nature Reviews Cancer | 2014 |
Insidious Changes in Stromal Matrix Fuel Cancer Progression
FL Miles, RA Sikes |
Molecular cancer research : MCR | 2014 |
Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell’s Journey
W Liu, CJ Vivian, AE Brinker, KR Hampton, E Lianidou, DR Welch |
Cancer Microenvironment | 2014 |
Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
MA Knowles, CD Hurst |
Nature Reviews Cancer | 2014 |
Re-sensitization of 5-FU resistance by SPARC through negative regulation of glucose metabolism in hepatocellular carcinoma
HW Hua, F Jiang, Q Huang, ZJ Liao, G Ding |
Tumor Biology | 2014 |
Expression analysis of SPARC/osteonectin in oral squamous cell carcinoma patients: from saliva to surgical specimen
G Aquino, R Sabatino, M Cantile, C Aversa, F Ionna, G Botti, EL Mantia, F Collina, G Malzone, G Pannone, NS Losito, R Franco, F Longo |
BioMed Research International | 2013 |
Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma
MF Kaiser, DC Johnson, P Wu, BA Walker, A Brioli, F Mirabella, CP Wardell, L Melchor, FE Davies, GJ Morgan |
Blood | 2013 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |