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Rapalogs and mTOR inhibitors as anti-aging therapeutics
Dudley W. Lamming, … , David M. Sabatini, Joseph A. Baur
Dudley W. Lamming, … , David M. Sabatini, Joseph A. Baur
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):980-989. https://doi.org/10.1172/JCI64099.
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Review Series Article has an altmetric score of 86

Rapalogs and mTOR inhibitors as anti-aging therapeutics

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Abstract

Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR), has the strongest experimental support to date as a potential anti-aging therapeutic in mammals. Unlike many other compounds that have been claimed to influence longevity, rapamycin has been repeatedly tested in long-lived, genetically heterogeneous mice, in which it extends both mean and maximum life spans. However, the mechanism that accounts for these effects is far from clear, and a growing list of side effects make it doubtful that rapamycin would ultimately be beneficial in humans. This Review discusses the prospects for developing newer, safer anti-aging therapies based on analogs of rapamycin (termed rapalogs) or other approaches targeting mTOR signaling.

Authors

Dudley W. Lamming, Lan Ye, David M. Sabatini, Joseph A. Baur

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ISSN: 0021-9738 (print), 1558-8238 (online)

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