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Daniel W. Foster
Published June 1, 2012
Citation Information: J Clin Invest. 2012;122(6):1958-1959. https://doi.org/10.1172/JCI63967.
Citation Information: J Clin Invest. 2012;122(6):1958-1959. https://doi.org/10.1172/JCI63967.
Abstract
In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. Subsequent experiments have borne out this finding and furthered our understanding of molecular metabolism.
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Daniel W. Foster
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Journal of Hepatology | 2019 |
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Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold
M Adlanmerini, BJ Carpenter, JR Remsberg, Y Aubert, LC Peed, HJ Richter, MA Lazar |
Proceedings of the National Academy of Sciences | 2019 |
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Hyperinsulinaemia: does it tip the balance toward intrahepatic fat accumulation?
L Hodson, F Karpe |
Endocrine Connections | 2019 |
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Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis
M AlvesBezerra, Y Li, M Acuña, AA Ivanova, KE Corey, EA Ortlund, DE Cohen |
Hepatology | 2019 |
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Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
MJ Bueno, V Jimenez-Renard, S Samino, J Capellades, A Junza, ML López-Rodríguez, J Garcia-Carceles, I Lopez-Fabuel, JP Bolaños, NS Chandel, O Yanes, R Colomer, M Quintela-Fandino |
Nature Communications | 2019 |
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Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
Rafikov, James, McClain, Tofovic, Rafikova |
Antioxidants | 2019 |
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Redox control of non-shivering thermogenesis
D Lettieri-Barbato |
Molecular Metabolism | 2019 |
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Metabolic adaptation and maladaptation in adipose tissue
ET Chouchani, S Kajimura |
Nature metabolism | 2019 |
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3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish
KH Park, Z Ye, J Zhang, SM Hammad, DM Townsend, DC Rockey, SH Kim |
Scientific Reports | 2019 |
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Genomic, Transcriptomic, and Epigenomic Features Differentiate Genes That Are Relevant for Muscular Polyunsaturated Fatty Acids in the Common Carp
H Zhang, P Xu, Y Jiang, Z Zhao, J Feng, R Tai, C Dong, J Xu |
Frontiers in Genetics | 2019 |
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Using Clinical Indices to Distinguish MODY2 (GCK Mutation) and MODY3 (HNF1A Mutation) from Type 1 Diabetes in a Young Chinese Population
J Fu, T Wang, J Liu, X Wang, Q Zhang, M Li, X Xiao |
Diabetes Therapy | 2019 |
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Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota
MT Liu, YJ Huang, TY Zhang, LB Tan, , J Qin |
World journal of gastroenterology : WJG | 2019 |
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Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indicus
J Afonso, LL Coutinho, PC Tizioto, WJ da Silva Diniz, AO de Lima, MI Rocha, CE Buss, BG Andrade, O Piaya, JV da Silva, LA Lins, CF Gromboni, AR Nogueira, MR Fortes, GB Mourao, LC de Almeida Regitano |
Scientific Reports | 2019 |
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The relationship between plasma β-hydroxybutyric acid and conjugated linoleic acid in milk as a biomarker for early diagnosis of ketosis in postpartum Polish Holstein-Friesian cows
K Puppel, M Gołębiewski, P Solarczyk, G Grodkowski, J Slósarz, M Kunowska-Slósarz, M Balcerak, T Przysucha, A Kalińska, B Kuczyńska |
BMC veterinary research | 2019 |
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Current and Emerging Approaches for Nonalcoholic Steatohepatitis Treatment
MM Chen, JJ Cai, Y Yu, ZG She, H Li |
Gene expression | 2019 |
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A clinical and computational study on anti-obesity effects of hydroxycitric acid.
Tomar M, Rao RP, Dorairaj P, Koshta A, Suresh S, Rafiq M, Kumawat R, Paramesh R, V BU, Venkatesh KV |
RSC Advances | 2019 |
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Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer
T Du, MJ Sikora, KM Levine, N Tasdemir, RB Riggins, SG Wendell, BV Houten, S Oesterreich |
Breast Cancer Research | 2018 |
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(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis
L Ren, Y Sun, H Lu, D Ye, L Han, N Wang, A Daugherty, F Li, M Wang, F Su, W Tao, J Sun, N Zelcer, AE Mullick, AH Danser, Y Jiang, Y He, X Ruan, X Lu |
Circulation research | 2018 |
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Multi-tissue transcriptomic study reveals the main role of liver in the chicken adaptive response to a switch in dietary energy source through the transcriptional regulation of lipogenesis
C Desert, E Baéza, M Aite, M Boutin, AL Cam, J Montfort, M Houee-Bigot, Y Blum, PF Roux, C Hennequet-Antier, C Berri, S Metayer-Coustard, A Collin, S Allais, EL Bihan, D Causeur, F Gondret, MJ Duclos, S Lagarrigue |
BMC Genomics | 2018 |
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Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism
CE Bowman, MJ Wolfgang |
Advances in Biological Regulation | 2018 |
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Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells
D Grünig, U Duthaler, S Krähenbühl |
Frontiers in pharmacology | 2018 |
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Glycine N -methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates
CC Hughey, E Trefts, DP Bracy, FD James, EP Donahue, DH Wasserman |
The Journal of biological chemistry | 2018 |
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Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
S Park, JH Jeon, BK Min, CM Ha, T Thoudam, BY Park, IK Lee |
Diabetes & Metabolism Journal | 2018 |
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HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology
N Berndt, S Bulik, I Wallach, T Wünsch, M König, M Stockmann, D Meierhofer, HG Holzhütter |
Nature Communications | 2018 |
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Lipopolysaccharide (LPS)-induced septic shock causes profound changes in myocardial energy metabolites in pigs
J Lado-Abeal, N Martinez-Sánchez, JA Cocho, M Martín-, I Castro-Piedras, ML Couce-Pico, AK Saha, M López |
Metabolomics | 2018 |
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Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis
Rachel Perry, Liang Peng, Abudukadier Abulizi, Lynn Kennedy, Gary Cline, Gerald I. Shulman |
Journal of Clinical Investigation | 2017 |
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Adipose tissue NAD + -homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health
R Jokinen, S Pirnes-Karhu, KH Pietiläinen, E Pirinen |
Redox Biology | 2017 |
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Treatment options for alcoholic and non-alcoholic fatty liver disease: A review
S Singh, NA Osna, KK Kharbanda |
World journal of gastroenterology : WJG | 2017 |
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The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency
CE Bowman, S Rodriguez, ES Alpergin, MG Acoba, L Zhao, T Hartung, SM Claypool, PA Watkins, MJ Wolfgang |
Cell Chemical Biology | 2017 |
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Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism
R Pereira, J Botezelli, KC Rodrigues, R Mekary, D Cintra, J Pauli, A Silva, E Ropelle, L Moura |
Nutrients | 2017 |
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Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid
Y González-Giraldo, LM Garcia-Segura, V Echeverria, GE Barreto |
Molecular Neurobiology | 2017 |
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Atypical Ketoacidosis and Protracted Hyperglycosuria after Treatment with Ipragliflozin, an SGLT2 Inhibitor
M Miyauchi, M Toyoda, M Fukagawa |
Internal Medicine | 2017 |
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Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weight
D Ramachandran, R Clara, S Fedele, J Hu, E Lackzo, JY Huang, E Verdin, W Langhans, A Mansouri |
Molecular Metabolism | 2017 |
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A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity
M Knobloch, GA Pilz, B Ghesquière, WJ Kovacs, T Wegleiter, DL Moore, M Hruzova, N Zamboni, P Carmeliet, S Jessberger |
Cell Reports | 2017 |
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Current and future pharmacological therapies for NAFLD/NASH
Y Sumida, M Yoneda |
Journal of Gastroenterology | 2017 |
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Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD
Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall H, Taskinen M, Boren J |
Molecular Systems Biology | 2017 |
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Insights into the Hexose Liver Metabolism—Glucose versus Fructose
Geidl-Flueck B, Gerber PA |
Nutrients | 2017 |
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Regulation of Ketone Body Metabolism and the Role of PPARα
M Grabacka, M Pierzchalska, M Dean, K Reiss |
International journal of molecular sciences | 2016 |
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Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
E Roh, DK Song, MS Kim |
Experimental & molecular medicine | 2016 |
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Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice
Q Kong, H Zhang, T Zhao, W Zhang, M Yan, X Dong, P Li |
International journal of molecular medicine | 2016 |
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Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity
L Jia, W Li, J Li, Y Li, H Song, Y Luan, H Qi, L Ma, X Lu, Y Yang |
Scientific Reports | 2016 |
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Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations
D Meierhofer, M Halbach, NE Şen, S Gispert, G Auburger |
Molecular & cellular proteomics : MCP | 2016 |
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A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43 A315T mutant C57BL6/J mice
KS Coughlan, L Halang, I Woods, JH Prehn |
Disease models & mechanisms | 2016 |
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The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity
HH Chen, YJ Tseng, SY Wang, YS Tsai, CS Chang, TC Kuo, WJ Yao, CC Shieh, CH Wu, PH Kuo |
International Journal of Obesity | 2015 |
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AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral Sclerosis
ND Perera, BJ Turner |
Neurochemical Research | 2015 |
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SGLT2 Inhibitors May Predispose to Ketoacidosis
SI Taylor, JE Blau, KI Rother |
The Journal of clinical endocrinology and metabolism | 2015 |
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RNAi knockdown of acetyl-CoA carboxylase gene eliminates jinggangmycin-enhanced reproduction and population growth in the brown planthopper, Nilaparvata lugens
YX Zhang, LQ Ge, YP Jiang, XL Lu, X Li, D Stanley, QS Song, JC Wu |
Scientific Reports | 2015 |
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Metabolic changes in serum metabolome in response to a meal
A Shrestha, E Müllner, K Poutanen, H Mykkänen, AA Moazzami |
European Journal of Nutrition | 2015 |
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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
L Chen, Y Shu, X Liang, EC Chen, SW Yee, AA Zur, S Li, L Xu, KR Keshari, MJ Lin, HC Chien, Y Zhang, KM Morrissey, J Liu, J Ostrem, NS Younger, J Kurhanewicz, KM Shokat, K Ashrafi, KM Giacomini |
Proceedings of the National Academy of Sciences | 2014 |
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Palmitate attenuates osteoblast differentiation of fetal rat calvarial cells
LC Yeh, JJ Ford, JC Lee, ML Adamo |
Biochemical and Biophysical Research Communications | 2014 |
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Deregulated coenzyme A, loss of metabolic flexibility and diabetes
S Jackowski, R Leonardi |
Biochemical Society Transactions | 2014 |
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Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma
K Tech, M Deshmukh, TR Gershon |
Cancer Letters | 2014 |
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The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
S Zhang, MW Hulver, RP McMillan, MA Cline, ER Gilbert |
Nutrition & Metabolism | 2014 |
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Futility Sustains Memory T Cells
SE Weinberg, NS Chandel |
Immunity | 2014 |
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Thioesterase Superfamily Member 2 (Them2) and Phosphatidylcholine Transfer Protein (PC-TP) Interact To Promote Fatty Acid Oxidation and Control Glucose Utilization
Y Kawano, BA Ersoy, Y Li, S Nishiumi, M Yoshida, DE Cohen |
Molecular and cellular biology | 2014 |
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Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
Y Kawano, DE Cohen |
Journal of Gastroenterology | 2013 |
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Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
SH Koo |
Clinical and Molecular Hepatology | 2013 |
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Relationship between central and peripheral fatty acids in humans
J Guest, M Garg, A Bilgin, R Grant |
Lipids in Health and Disease | 2013 |
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Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex
JH Lim, Z Gerhart-Hines, JE Dominy, Y Lee, S Kim, M Tabata, YK Xiang, P Puigserver |
The Journal of biological chemistry | 2013 |
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