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Citations to this article

miR-122 regulates hepatic lipid metabolism and tumor suppression
Jessica Wen, Joshua R. Friedman
Jessica Wen, Joshua R. Friedman
Published July 23, 2012
Citation Information: J Clin Invest. 2012;122(8):2773-2776. https://doi.org/10.1172/JCI63966.
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Commentary Article has an altmetric score of 6

miR-122 regulates hepatic lipid metabolism and tumor suppression

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Abstract

In this issue of JCI, two independent groups describe the effects of germline and liver-specific deletion of Mir122a, the predominant liver miRNA. Their findings reveal a critical role for miR-122 in fat and cholesterol metabolism but suggest that other metabolic actions of the liver are independent of miR-122. Knockout mice also displayed hepatic inflammation, fibrosis, and a high incidence of hepatocellular carcinoma, suggesting that miR-122 has a tumor suppressor role in hepatocytes.

Authors

Jessica Wen, Joshua R. Friedman

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Total
Citations: 3 6 5 6 6 2 6 5 4 4 7 3 1 58
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Citations to this article (58)

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