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Citations to this article

IL-33–dependent induction of allergic lung inflammation by FcγRIII signaling
Melissa Y. Tjota, … , Paul J. Bryce, Anne I. Sperling
Melissa Y. Tjota, … , Paul J. Bryce, Anne I. Sperling
Published April 15, 2013
Citation Information: J Clin Invest. 2013;123(5):2287-2297. https://doi.org/10.1172/JCI63802.
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Research Article Pulmonology Article has an altmetric score of 12

IL-33–dependent induction of allergic lung inflammation by FcγRIII signaling

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Abstract

Atopic asthma is a chronic inflammatory disease of the lungs generally marked by excessive Th2 inflammation. The role of allergen-specific IgG in asthma is still controversial; however, a receptor of IgG–immune complexes (IgG-ICs), FcγRIII, has been shown to promote Th2 responses through an unknown mechanism. Herein, we demonstrate that allergen-specific IgG-ICs, formed upon reexposure to allergen, promoted Th2 responses in two different models of IC-mediated inflammation that were independent of a preformed T cell memory response. Development of Th2-type airway inflammation was shown to be both FcγRIII and TLR4 dependent, and T cells were necessary and sufficient for this process to occur, even in the absence of type 2 innate lymphoid cells. We sought to identify downstream targets of FcγRIII signaling that could contribute to this process and demonstrated that bone marrow–derived DCs, alveolar macrophages, and respiratory DCs significantly upregulated IL-33 when activated through FcγRIII and TLR4. Importantly, IC-induced Th2 inflammation was dependent on the ST2/IL-33 pathway. Our results suggest that allergen-specific IgG can enhance secondary responses by ligating FcγRIII on antigen-presenting cells to augment development of Th2-mediated responses in the lungs via an IL-33–dependent mechanism.

Authors

Melissa Y. Tjota, Jesse W. Williams, Tiffany Lu, Bryan S. Clay, Tiara Byrd, Cara L. Hrusch, Donna C. Decker, Claudia Alves de Araujo, Paul J. Bryce, Anne I. Sperling

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 2 1 3 6 4 8 9 6 1 7 3 1 51
Citation information
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Citations to this article in year 2016 (6)

Title and authors Publication Year
Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator ligand
D Rigas, G Lewis, JL Aron, B Wang, H Banie, I Sankaranarayanan, L Galle-Treger, H Maazi, R Lo, GJ Freeman, AH Sharpe, P Soroosh, O Akbari
Journal of Allergy and Clinical Immunology 2016
IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis
LK Johnston, CL Hsu, RA Krier-Burris, KD Chhiba, KB Chien, A McKenzie, S Berdnikovs, PJ Bryce
Journal of immunology (Baltimore, Md. : 1950) 2016
Regulation of Th2 Cell Immunity by Dendritic Cells
H Na, M Cho, Y Chung
Immune Network 2016
Controlling the burn and fueling the fire: defining the role for the alarmin interleukin-33 in alloimmunity
Q Liu, HR Turnquist
Current Opinion in Organ Transplantation 2016
Altered Treg and cytokine responses in RSV-infected infants
AF Christiaansen, MA Syed, PP Eyck, SM Hartwig, L Durairaj, SS Kamath, SM Varga
Pediatric Research 2016
Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD
BM Matta, DK Reichenbach, X Zhang, L Mathews, BH Koehn, GK Dwyer, JM Lott, FM Uhl, D Pfeifer, CJ Feser, MJ Smith, Q Liu, R Zeiser, BR Blazar, HR Turnquist
Blood 2016

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