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Citations to this article

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
Young-Ho Ahn, … , Elsa R. Flores, Jonathan M. Kurie
Young-Ho Ahn, … , Elsa R. Flores, Jonathan M. Kurie
Published August 1, 2012
Citation Information: J Clin Invest. 2012;122(9):3170-3183. https://doi.org/10.1172/JCI63608.
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Research Article Oncology Article has an altmetric score of 11

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

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Abstract

Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient’s likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through downregulation of microRNAs (miRs) that are strong inducers of epithelial differentiation and inhibitors of stem cell factors. Given that each miR can target multiple genes with diverse functions, we posited that the prometastatic network controlled by ZEB1 extends beyond these processes. We tested this hypothesis using a mouse model of human lung adenocarcinoma metastasis driven by ZEB1, human lung carcinoma cells, and human breast carcinoma cells. Transcriptional profiling studies revealed that ZEB1 controls the expression of numerous oncogenic and tumor-suppressive miRs, including miR-34a. Ectopic expression of miR-34a decreased tumor cell invasion and metastasis, inhibited the formation of promigratory cytoskeletal structures, suppressed activation of the RHO GTPase family, and regulated a gene expression signature enriched in cytoskeletal functions and predictive of outcome in human lung adenocarcinomas. We identified several miR-34a target genes, including Arhgap1, which encodes a RHO GTPase activating protein that was required for tumor cell invasion. These findings demonstrate that ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression and provide a compelling rationale to develop miR-34a as a therapeutic agent in lung cancer patients.

Authors

Young-Ho Ahn, Don L. Gibbons, Deepavali Chakravarti, Chad J. Creighton, Zain H. Rizvi, Henry P. Adams, Alexander Pertsemlidis, Philip A. Gregory, Josephine A. Wright, Gregory J. Goodall, Elsa R. Flores, Jonathan M. Kurie

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Total
Citations: 2 2 6 6 12 11 11 13 7 11 8 11 8 2 110
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2017 (7)

Title and authors Publication Year
Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma
DK Singh, RK Kollipara, V Vemireddy, XL Yang, Y Sun, N Regmi, S Klingler, KJ Hatanpaa, J Raisanen, SK Cho, S Sirasanagandla, S Nannepaga, S Piccirillo, T Mashimo, S Wang, CG Humphries, B Mickey, EA Maher, H Zheng, RS Kim, R Kittler, RM Bachoo
Cell Reports 2017
Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition
J Yang, B Tian, H Sun, RP Garofalo, AR Brasier
Nature Microbiology 2017
An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer
Y Chen, Z Zhao, Y Chen, Z Lv, X Ding, R Wang, H Xiao, C Hou, B Shen, J Feng, R Guo, Y Li, H Peng, G Han, G Chen
Scientific Reports 2017
Alternative mechanisms of miR-34a regulation in cancer
E Slabáková, Z Culig, J Remšík, K Souček
Cell Death and Disease 2017
MicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion
S Imani, C Wei, J Cheng, MA Khan, S Fu, L Yang, M Tania, X Zhang, X Xiao, X Zhang, J Fu
Oncotarget 2017
ARHGAP1 overexpression inhibits proliferation, migration and invasion of C-33A and SiHa cell lines
J Li, Y Liu, Y Yin
OncoTargets and therapy 2017
Exosome mediated phenotypic changes in lung cancer pathophysiology
Y Shimada, JD Minna
Translational cancer research 2017

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