Cardiac hypertrophy often presages the development of heart failure. Numerous cytosolic signaling pathways have been implicated in the hypertrophic response in cardiomyocytes in culture, but their roles in the hypertrophic response to physiologically relevant stimuli in vivo is unclear. We previously reported that adenovirus-mediated gene transfer of SEK-1(KR), a dominant inhibitory mutant of the immediate upstream activator of the stress-activated protein kinases (SAPKs), abrogates the hypertrophic response of neonatal rat cardiomyocytes to endothelin-1 in culture. We now report that gene transfer of SEK-1(KR) to the adult rat heart blocks SAPK activation by pressure overload, demonstrating that the activity of cytosolic signaling pathways can be inhibited by gene transfer of loss-of-function mutants in vivo. Furthermore, gene transfer of SEK-1(KR) inhibited pressure overload–induced cardiac hypertrophy, as determined by echocardiography and several postmortem measures including left ventricular (LV) wall thickness, the ratio of LV weight to body weight, cardiomyocyte diameter, and inhibition of atrial natriuretic factor expression. Our data suggest that the SAPKs are critical regulators of cardiac hypertrophy in vivo, and therefore may serve as novel drug targets in the treatment of hypertrophy and heart failure.
Gabriel Choukroun, Roger Hajjar, Stefanie Fry, Federica del Monte, Syed Haq, J. Luis Guerrero, Michael Picard, Anthony Rosenzweig, Thomas Force
Title and authors | Publication | Year |
---|---|---|
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X He, T Du, T Long, X Liao, Y Dong, Z Huang |
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Jubaidi FF, Zainalabidin S, Taib IS, Abdul Hamid Z, Mohamad Anuar NN, Jalil J, Mohd Nor NA, Budin SB |
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Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies
M Ramos-Kuri, SH Meka, F Salamanca-Buentello, RJ Hajjar, L Lipskaia, ER Chemaly |
Biological research | 2021 |
Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice
F Huang, N Na, T Ijichi, X Wu, K Miyamoto, A Ciullo, M Tran, L Li, A Ibrahim, E Marbán, G de Couto |
Molecular Therapy — Nucleic Acids | 2021 |
JNK and cardiometabolic dysfunction
SM Craige, K Chen, RM Blanton, JF Keaney, S Kant |
Bioscience Reports | 2019 |
Mechanobiology of mice cervix: expression profile of mechano-related molecules during pregnancy
J Gordon, CN Mowa |
Cell and Tissue Research | 2019 |
Mixed Lineage Kinase 3 (MLK3) Prevents Cardiac Dysfunction and Structural Remodeling with Pressure Overload
TD Calamaras, RA Baumgartner, MJ Aronovitz, AL McLaughlin, K Tam, DA Richards, CW Cooper, N Li, WE Baur, X Qiao, GR Wang, RJ Davis, NK Kapur, RH Karas, RM Blanton |
American journal of physiology. Heart and circulatory physiology | 2018 |
Emerging role of the Jun N-terminal kinase interactome in human health: The JNK interactome
XX Guo, S An, Y Yang, Y Liu, Q Hao, T Tang, TR Xu |
Cell Biology International | 2018 |
The p21-activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration: Pak1 in the heart
Y Wang, S Wang, M Lei, M Boyett, H Tsui, W Liu, X Wang |
British Journal of Pharmacology | 2017 |
Caffeic acid phenethyl ester attenuates pathological cardiac hypertrophy by regulation of MEK/ERK signaling pathway in vivo and vitro
J Ren, N Zhang, H Liao, S Chen, L Xu, J Li, Z Yang, W Deng, Q Tang |
Life Sciences | 2017 |
Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK–ERK1/2 signalling pathway
Y Li, X Tang, X Li, H Dai, R Miao, J Cai, Z Huang, AF Chen, X Xing, Y Lu, H Yuan |
Basic Research in Cardiology | 2016 |
Tomoregulin-1 prevents cardiac hypertrophy after pressure overload in mice by inhibiting TAK1-JNK pathways
D Bao, D Lu, N Liu, W Dong, YD Lu, C Qin, LF Zhang |
Disease models & mechanisms | 2015 |
Comprehensive Physiology
KC Hermans, WM Blankesteijn |
Comprehensive Physiology | 2015 |
Diet‐induced obesity promotes altered remodeling and exacerbated cardiac hypertrophy following pressure overload
KM Holzem, JT Marmerstein, EJ Madden, IR Efimov |
Physiological Reports | 2015 |
Electrical and Mechanical Stimulation of Cardiac Cells and Tissue Constructs
WL Stoppel, DL Kaplan, LD Black |
Advanced Drug Delivery Reviews | 2015 |
Dominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophy
M Ramos-Kuri, K Rapti, H Mehel, S Zhang, PS Dhandapany, L Liang, A García-Carrancá, R Bobe, R Fischmeister, S Adnot, D Lebeche, RJ Hajjar, L Lipskaia, ER Chemaly |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2015 |
Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway
D Lu, D Bao, W Dong, N Liu, X Zhang, S Gao, W Ge, X Gao, L Zhang |
Laboratory Investigation | 2015 |
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives
S Javadov, S Jang, B Agostini |
Pharmacology & Therapeutics | 2014 |
In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart
M Obradovic, AJ Stewart, SJ Pitt, M Labudovic-Borovic, E Sudar, V Petrovic, S Zafirovic, V Maravic-Stojkovic, V Vasic, ER Isenovic |
Molecular and Cellular Endocrinology | 2014 |
Map2k4δ — Identification and functional characterization of a novel Map2k4 splice variant
W Haeusgen, L Tueffers, T Herdegen, V Waetzig |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2014 |
Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential: The Wnt-Frizzled system in cardiac pathophysiology
K Dawson, M Aflaki, S Nattel |
The Journal of Physiology | 2013 |
MEK and the inhibitors: from bench to bedside
A Akinleye, M Furqan, N Mukhi, P Ravella, D Liu |
Journal of Hematology & Oncology | 2013 |
Cardiac Remodeling
BI Jugdutt, NS Dhalla |
2013 | |
JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure
AH Chaanine, D Jeong, L Liang, ER Chemaly, K Fish, RE Gordon, RJ Hajjar |
Cell Death and Disease | 2012 |
The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth
FM Drawnel, CR Archer, HL Roderick |
British Journal of Pharmacology | 2012 |
Augmented Cardiac Hypertrophy in Response to Pressure Overload in Mice Lacking ELTD1
J Xiao, H Jiang, R Zhang, G Fan, Y Zhang, D Jiang, H Li, LJ de Windt |
PloS one | 2012 |
Role of Endothelin in the Induction of Cardiac Hypertrophy In Vitro
T Bupha-Intr, KM Haizlip, PM Janssen |
PloS one | 2012 |
The bottleneck of JNK signaling: Molecular and functional characteristics of MKK4 and MKK7
W Haeusgen, T Herdegen, V Waetzig |
European Journal of Cell Biology | 2011 |
Garlic Oil Alleviates MAPKs- and IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats
SH Chang, CJ Liu, CH Kuo, H Chen, WY Lin, KY Teng, SW Chang, CH Tsai, FJ Tsai, CY Huang, BS Tzang, WW Kuo |
Evidence-Based Complementary and Alternative Medicine | 2011 |
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale
BA Rose, T Force, Y Wang |
Physiological reviews | 2010 |
Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies
BC Bernardo, KL Weeks, L Pretorius, JR McMullen |
Pharmacology & Therapeutics | 2010 |
Cdc42 is an anti-hypertrophic molecular switch in the heart
Marjorie Maillet, Jeffrey M. Lynch, Bastiano Sanna, Allen J. York, Yi Zheng, Jeffery D. Molkentin |
Journal of Clinical Investigation | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Therapeutic Targets of the TNF Superfamily
IS Grewal |
2009 | |
Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases
H Lal, SK Verma, HB Golden, DM Foster, M Smith, DE Dostal |
Journal of Molecular and Cellular Cardiology | 2008 |
Is cardiac hypertrophy a required compensatory mechanism in pressure-overloaded heart?
JL Samuel, B Swynghedauw |
Journal of Hypertension | 2008 |
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)
Y Asano, S Kitamura, T Ohra, F Itoh, M Kajino, T Tamura, M Kaneko, S Ikeda, H Igata, T Kawamoto, S Sogabe, S Matsumoto, T Tanaka, M Yamaguchi, H Kimura, S Fukumoto |
Bioorganic & Medicinal Chemistry | 2008 |
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)
Y Asano, S Kitamura, T Ohra, K Aso, H Igata, T Tamura, T Kawamoto, T Tanaka, S Sogabe, S Matsumoto, M Yamaguchi, H Kimura, F Itoh |
Bioorganic & Medicinal Chemistry | 2008 |
Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells
CJ Liu, YC Cheng, KW Lee, HH Hsu, CH Chu, FJ Tsai, CH Tsai, CY Chu, JY Liu, WW Kuo, CY Huang |
Molecular and Cellular Biochemistry | 2008 |
Studies in Natural Products Chemistry
M Seki |
Studies in Natural Products Chemistry | 2008 |
Designing Heart Performance by Gene Transfer
J Davis, MV Westfall, D Townsend, M Blankinship, TJ Herron, G Guerrero-Serna, W Wang, E Devaney, JM Metzger |
Physiological reviews | 2008 |
Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells
CJ Liu, YC Cheng, KW Lee, HH Hsu, CH Chu, FJ Tsai, CH Tsai, CY Chu, JY Liu, WW Kuo, CY Huang |
Molecular and Cellular Biochemistry | 2008 |
Helix-Loop-Helix Protein p8, a Transcriptional Regulator Required for Cardiomyocyte Hypertrophy and Cardiac Fibroblast Matrix Metalloprotease Induction
S Goruppi, RD Patten, T Force, JM Kyriakis |
Molecular and cellular biology | 2007 |
Mitogen-activated protein kinases in heart development and diseases
Y Wang |
Circulation | 2007 |
Physiological roles of MKK4 and MKK7: Insights from animal models
X Wang, A Destrument, C Tournier |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2007 |
Role of mitogen-activated protein kinase kinase 4 in cancer
AJ Whitmarsh, RJ Davis |
Oncogene | 2007 |
Glycogen Synthase Kinase-3β—Actively Inhibiting Hypertrophy
R Kerkelä, K Woulfe, T Force |
Trends in Cardiovascular Medicine | 2007 |
Calcium signaling phenomena in heart diseases: a perspective
S Chakraborti, S Das, P Kar, B Ghosh, K Samanta, S Kolley, S Ghosh, S Roy, T Chakraborti |
Molecular and Cellular Biochemistry | 2006 |
Blockade of NF-κB improves cardiac function and survival after myocardial infarction
S Kawano, T Kubota, Y Monden, T Tsutsumi, T Inoue, N Kawamura, H Tsutsui, K Sunagawa |
American journal of physiology. Heart and circulatory physiology | 2006 |
Principles of Molecular Medicine
MS Runge, C Patterson |
2006 | |
17β-Estradiol Improves Survival in Male Mice with Cardiomyopathy Induced by Cardiac-Specific Tumor Necrosis Factor-α Overexpression
T Kadokami, CF McTiernan, Y Higuichi, CS Frye, T Kubota, AM Feldman |
Journal of Interferon & Cytokine Research | 2005 |
Neuropeptide Y induces cardiomyocyte hypertrophy via calcineurin signaling in rats
M Chen, X Li, Q Dong, Y Li, W Liang |
Regulatory Peptides | 2005 |
Complete Inhibition of Anisomycin and UV Radiation but Not Cytokine Induced JNK and p38 Activation by an Aryl-substituted Dihydropyrrolopyrazole Quinoline and Mixed Lineage Kinase 7 Small Interfering RNA
X Wang, MM Mader, JE Toth, X Yu, N Jin, RM Campbell, JK Smallwood, ME Christe, A Chatterjee, T Goodson, CJ Vlahos, WF Matter, LJ Bloem |
The Journal of biological chemistry | 2005 |
Principles of Molecular Cardiology
MS Runge, C Patterson |
2005 | |
Cell Engineering
M Al-Rubeai, M Fussenegger |
2005 | |
Molecular Cardiology
Z Sun |
2005 | |
Mechanotransduction in Cardiac Myocytes
J Lammerding, RD Kamm, RT Lee |
Annals of the New York Academy of Sciences | 2004 |
Tachycardia-Induced Heart Failure Does Not Alter Myocardial P-glycoprotein Expression
JJ Sims, BL Neudeck, JM Loeb, NA Wiegert |
Pharmacotherapy | 2004 |
Glycogen Synthase Kinase-3β is Involved in the Process of Myocardial Hypertrophy Stimulated by Insulin-Like Growth Factor-1
SK Seimi, K Seinosuke, S Tsuyoshi, U Tomomi, H Tetsuaki, K Miki, T Ryuji, I Kenji, Y Mitsuhiro |
Circulation Journal | 2004 |
Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury
H Takahashi, Y Takeishi, T Miyamoto, T Shishido, T Arimoto, T Konta, T Miyashita, M Ito, I Kubota |
European Journal of Clinical Investigation | 2004 |
Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic β-adrenergic stimulation
M Christe, N Jin, X Wang, KE Gould, PW Iversen, X Yu, JN Lorenz, V Kadambi, SH Zuckerman, LJ Bloem |
Journal of Molecular and Cellular Cardiology | 2004 |
c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart
W Nadruz, CB Kobarg, J Kobarg, KG Franchini |
American journal of physiology. Heart and circulatory physiology | 2004 |
Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
JR McMullen, T Shioi, L Zhang, O Tarnavski, MC Sherwood, PM Kang, S Izumo |
Proceedings of the National Academy of Sciences | 2003 |
Deletion of cytosolic phospholipase A2 promotes striated muscle growth
S Haq, H Kilter, A Michael, J Tao, E O'Leary, XM Sun, B Walters, K Bhattacharya, X Chen, L Cui, M Andreucci, A Rosenzweig, JL Guerrero, R Patten, R Liao, J Molkentin, M Picard, JV Bonventre, T Force |
Nature Medicine | 2003 |
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
AA Mangi, N Noiseux, D Kong, H He, M Rezvani, JS Ingwall, VJ Dzau |
Nature Medicine | 2003 |
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth
S Haq, A Michael, M Andreucci, K Bhattacharya, P Dotto, B Walters, J Woodgett, H Kilter, T Force |
Proceedings of the National Academy of Sciences | 2003 |
c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling
Q Liang, OF Bueno, BJ Wilkins, CY Kuan, Y Xia, JD Molkentin |
The EMBO Journal | 2003 |
CARDIACHYPERTROPHY: The Good, the Bad, and the Ugly
N Frey, EN Olson |
Annual Review of Physiology | 2003 |
Emerging therapeutic targets in chronic heart failure: Part II
V Roenicke, S Leclair, A Hoffmann, M Becker, T Szado, T Kirsch, O Stoss, BT Navé, T Henkel |
Expert Opinion on Therapeutic Targets | 2003 |
Chronic activation of extracellular-signal-regulated protein kinases by phenylephrine is required to elicit a hypertrophic response in cardiac myocytes
AJ Barron, SG Finn, SJ Fuller |
Biochemical Journal | 2003 |
Role of mitogen-activated protein kinase in cardiac hypertrophy and heart failure
W Zhang, V Elimban, MS Nijjar, SK Gupta, NS Dhalla |
Experimental and clinical cardiology | 2003 |
Non-apoptotic Fas signaling
H Wajant, K Pfizenmaier, P Scheurich |
Cytokine & Growth Factor Reviews | 2003 |
Smooth muscle γ-actin promoter regulation by RhoA and serum response factor signaling
JA Carson, DE Culberson, RW Thompson, RA Fillmore, W Zimmer |
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 2003 |
Vascular rarefaction in peripheral skeletal muscle after experimental heart failure
JW Knowles, G Esposito, L Mao, JR Hagaman, JE Fox, O Smithies, HA Rockman, N Maeda |
Journal of Clinical Investigation | 2003 |
Stretch-induced IL-8 depends on c-Jun NH 2 -terminal and nuclear factor-κB-inducing kinases
LF Li, B Ouyang, G Choukroun, R Matyal, M Mascarenhas, B Jafari, JV Bonventre, T Force, DA Quinn |
American journal of physiology. Lung cellular and molecular physiology | 2003 |
p21CIP1 Controls Proliferating Cell Nuclear Antigen Level in Adult Cardiomyocytes
FB Engel, L Hauck, M Boehm, EG Nabel, R Dietz, R von Harsdorf |
Molecular and cellular biology | 2003 |
Temporal activation of c‐Jun N‐terminal kinase in adult transgenic heart via cre‐loxP‐mediated DNA recombination
BG Petrich, JD Molkentin, Y Wang |
The FASEB Journal | 2003 |
Fas receptor signaling inhibits GSK3beta in cardiomyocytes and is required for pressure overload-induced hypertrophy
Cornel Badorff, Hartmut Ruetten, Sven Mueller, Meike Stahmer, Doris Gehring, Frank Jung, Christian Ihling, Andreas M. Zeiher, Stefanie Dimmeler |
Journal of Clinical Investigation | 2002 |
The MEKK1-JNK pathway plays a protective role in pressure overload, but does not mediate cardiac hypertrophy
Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L Johnson, Dorothy E Vatner, Stephen F Vatner |
Journal of Clinical Investigation | 2002 |
Seven-transmembrane-spanning receptors and heart function
HA Rockman, WJ Koch, RJ Lefkowitz |
Nature | 2002 |
Emerging therapeutic targets in chronic heart failure: Part I
V Roenicke, S Leclair, A Hoffmann, M Becker, T Szado, T Kirsch, O Stoss, BT Navé, T Henkel |
Expert Opinion on Therapeutic Targets | 2002 |
Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy
S Goruppi, JV Bonventre, JM Kyriakis |
The EMBO Journal | 2002 |
Catecholamine-induced cardiac hypertrophy in rats is associated with the activation of p70 kinase and c-Jun NH(2)-terminal kinase 2
M Leicht, N Greipel, B Raßler, HG Zimmer |
Experimental and clinical cardiology | 2002 |
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq
T Minamino, T Yujiri, N Terada, GE Taffet, LH Michael, GL Johnson, MD Schneider |
Proceedings of the National Academy of Sciences | 2002 |
Heme Oxygenase-1 Reduces Murine Monocrotaline-Induced Pulmonary Inflammatory Responses and Resultant Right Ventricular Overload
J Goto, K Ishikawa, K Kawamura, Y Watanabe, H Matumoto, D Sugawara, Y Maruyama |
Antioxidants & Redox Signaling | 2002 |
Echocardiography improves detection of rejection after heterotopic mouse cardiac transplantation
M Scherrer-Crosbie, T Glysing-Jensen, SJ Fry, AC Vançon, S Gadiraju, MH Picard, ME Russell |
Journal of the American Society of Echocardiography | 2002 |
Calcineurin and hypertrophic heart disease: novel insights and remaining questions
OF Bueno, E Rooij, JD Molkentin, PA Doevendans, LJ de Windt |
Cardiovascular Research | 2002 |
Targeted Inhibition of Calcineurin in Pressure-overload Cardiac Hypertrophy: PRESERVATION OF SYSTOLIC FUNCTION
JA Hill, B Rothermel, KD Yoo, B Cabuay, E Demetroulis, RM Weiss, W Kutschke, R Bassel-Duby, RS Williams |
The Journal of biological chemistry | 2002 |
Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart
T Matsui, L Li, JC Wu, SA Cook, T Nagoshi, MH Picard, R Liao, A Rosenzweig |
The Journal of biological chemistry | 2002 |
c-Jun N-Terminal Kinase Activation Mediates Downregulation of Connexin43 in Cardiomyocytes
BG Petrich, X Gong, DL Lerner, X Wang, JH Brown, JE Saffitz, Y Wang |
Circulation research | 2002 |
Apoptosis Signal-Regulating Kinase/Nuclear Factor-κB: A Novel Signaling Pathway Regulates Cardiomyocyte Hypertrophy
T Force, S Haq, H Kilter, A Michael |
Circulation | 2002 |
Cardiovascular Genomics: New Pathophysiological Concepts
PA Doevendans, S Kääb |
2002 | |
Pressure independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A deficient mice
Joshua W. Knowles, Giovanni Esposito, Lan Mao, John R. Hagaman, Jennifer E. Fox, Oliver Smithies, Howard A. Rockman, Nobuyo Maeda |
Journal of Clinical Investigation | 2001 |
Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival
H Oh, GE Taffet, KA Youker, ML Entman, PA Overbeek, LH Michael, MD Schneider |
Proceedings of the National Academy of Sciences | 2001 |
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
LJ de Windt, HW Lim, OF Bueno, Q Liang, U Delling, JC Braz, BJ Glascock, TF Kimball, F Monte, RJ Hajjar, JD Molkentin |
Proceedings of the National Academy of Sciences | 2001 |
c-Jun N-terminal kinase-interacting protein 1 inhibits gene expression in response to hypertrophic agonists in neonatal rat ventricular myocytes
SG Finn, M Dickens, SJ Fuller |
Biochemical Journal | 2001 |
Heart Physiology and Pathophysiology
NS Dhalla, RM Temsah, T Netticadan, MS Sandhu |
Heart Physiology and Pathophysiology | 2001 |
Cytoplasmic signaling pathways that regulate cardiac hypertrophy
JD Molkentin, GW 2nd |
Annual Review of Physiology | 2001 |
Gene therapy in heart failure
U Schmidt, RJ Hajjar |
Best Practice & Research Clinical Anaesthesiology | 2001 |
Angiotensin Blockade Inhibits Increased JNKs, AP-1 and NF- κ B DNA-binding Activities in Myocardial Infarcted Rats
M Yoshiyama, T Omura, K Takeuchi, S Kim, K Shimada, H Yamagishi, M Teragaki, K Akioka, H Iwao, J Yoshikawa |
Journal of Molecular and Cellular Cardiology | 2001 |
Tissue Distribution and Functional Expression of a cDNA Encoding a Novel Mixed Lineage Kinase
LJ Bloem, TR Pickard, S Acton, M Donoghue, RC Beavis, MD Knierman, X Wang |
Journal of Molecular and Cellular Cardiology | 2001 |
A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1β-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology
DC Ng, CS Long, MA Bogoyevitch |
The Journal of biological chemistry | 2001 |
The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo
OF Bueno, LJ Windt, HW Lim, KM Tymitz, SA Witt, TR Kimball, JD Molkentin |
Circulation research | 2001 |
Cardiac Overexpression of a G q Inhibitor Blocks Induction of Extracellular Signal–Regulated Kinase and c-Jun NH 2 -Terminal Kinase Activity in In Vivo Pressure Overload
G Esposito, SV Prasad, A Rapacciuolo, L Mao, WJ Koch, HA Rockman |
Circulation | 2001 |
Activation of Cardiac c-Jun NH 2 -Terminal Kinases and p38-Mitogen–Activated Protein Kinases With Abrupt Changes in Hemodynamic Load
TA Fischer, S Ludwig, E Flory, S Gambaryan, K Singh, P Finn, MA Pfeffer, RA Kelly, JM Pfeffer |
Hypertension | 2001 |
Cytoprotection by Jun Kinase During Nitric Oxide–Induced Cardiac Myocyte Apoptosis
P Andreka, J Zang, C Dougherty, TI Slepak, KA Webster, NH Bishopric |
Circulation research | 2001 |
Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure
S Haq, G Choukroun, H Lim, KM Tymitz, F del Monte, J Gwathmey, L Grazette, A Michael, R Hajjar, T Force, JD Molkentin |
Circulation | 2001 |
Deactivation of the peroxisome proliferation-activated receptor alpha during cardiac myocyte hypertrophic growth
Philip M. Barger, Jon M. Brandt, Teresa C. Leone, Carla J. Weinheimer, Daniel P. Kelly |
Journal of Clinical Investigation | 2000 |
FROM THESARCOMERE TO THENUCLEUS: Role of Genetics and Signaling in Structural Heart Disease
RL Nicol, N Frey, EN Olson |
Annual Review of Genomics and Human Genetics | 2000 |
Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro
H Aoki, M Richmond, S Izumo, J Sadoshima |
Biochemical Journal | 2000 |
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy
S Haq, G Choukroun, ZB Kang, H Ranu, T Matsui, A Rosenzweig, JD Molkentin, A Alessandrini, J Woodgett, R Hajjar, A Michael, T Force |
The Journal of Cell Biology | 2000 |
Studying heterotrimeric G-protein-linked signal transduction using replication-deficient adenoviruses
MM Cummins, P Poronnik, LM O'Mullane, DI Cook |
Immunology and Cell Biology | 2000 |
Vasopressin-induced hypertrophy in H9c2 heart-derived myocytes
MA Brostrom, BA Reilly, FJ Wilson, CO Brostrom |
The International Journal of Biochemistry & Cell Biology | 2000 |
Cardiac signal transduction
KH Lee, RJ Hajjar, T Matsui, G Choukroun, TL Force, A Rosenzweig |
Journal of Nuclear Cardiology | 2000 |
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
JA Hill, M Karimi, W Kutschke, RL Davisson, K Zimmerman, Z Wang, RE Kerber, RM Weiss |
Circulation | 2000 |
Isoenzyme-Specific Protein Kinase C and c-Jun N-terminal Kinase Activation by Electrically Stimulated Contraction of Neonatal Rat Ventricular Myocytes
JB Strait, AM Samarel |
Journal of Molecular and Cellular Cardiology | 2000 |
Glycogen Synthase Kinase-3 Is a Negative Regulator of Cardiomyocyte Hypertrophy
S Haq, G Choukroun, ZB Kang, H Ranu, T Matsui, A Rosenzweig, JD Molkentin, A Alessandrini, J Woodgett, R Hajjar, A Michael, T Force |
The Journal of Cell Biology | 2000 |
Calcineurin Promotes Protein Kinase C and c-Jun NH 2 -terminal Kinase Activation in the Heart: CROSS-TALK BETWEEN CARDIAC HYPERTROPHIC SIGNALING PATHWAYS
LJ de Windt, HW Lim, S Haq, T Force, JD Molkentin |
The Journal of biological chemistry | 2000 |
The Akt-Glycogen Synthase Kinase 3β Pathway Regulates Transcription of Atrial Natriuretic Factor Induced by β-Adrenergic Receptor Stimulation in Cardiac Myocytes
C Morisco, D Zebrowski, G Condorelli, P Tsichlis, SF Vatner, J Sadoshima |
The Journal of biological chemistry | 2000 |
Integrin signaling's potential for mediating gene expression in hypertrophying skeletal muscle
JA Carson, L Wei |
Journal of applied physiology | 2000 |
Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement
C Fink, S Ergün, D Kralisch, U Remmers, J Weil, T Eschenhagen |
The FASEB Journal | 2000 |
Prospects for Gene Therapy for Heart Failure
RJ Hajjar, F del Monte, T Matsui, A Rosenzweig |
Circulation research | 2000 |
Calcineurin and Beyond: Cardiac Hypertrophic Signaling
JD Molkentin |
Circulation research | 2000 |
Important Role of Angiotensin II–Mediated c-Jun NH 2 -Terminal Kinase Activation in Cardiac Hypertrophy in Hypertensive Rats
Y Izumi, S Kim, Y Zhan, M Namba, H Yasumoto, H Iwao |
Hypertension | 2000 |
Molecular Approaches to Heart Failure Therapy
G Hasenfuss, E Marbán |
2000 | |
Signaling pathways mediating the response to hypertrophic stress in the heart
T Force, R Hajjar, FD Monte, A Rosenzweig, G Choukroun |
Gene expression | 1999 |